Angel Serrano - Academia.edu (original) (raw)
Teaching Documents by Angel Serrano
procesos pedagogicos
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Papers by Angel Serrano
Inorganic chemistry, Jan 22, 2015
The diiridium complex [{Ir(ABPN2)(CO)}2(μ-CO)] (1; [ABPN2](-) = [(allyl)B(Pz)2(CH2PPh2)](-)) reac... more The diiridium complex [{Ir(ABPN2)(CO)}2(μ-CO)] (1; [ABPN2](-) = [(allyl)B(Pz)2(CH2PPh2)](-)) reacts with diphenylphosphane affording [Ir(ABPN2)(CO)(H) (PPh2)] (2), the product of the oxidative addition of the P-H bond to the metal. DFT studies revealed a large contribution of the terminal phosphanido lone pair to the HOMO of 2, indicating nucleophilic character of this ligand, which is evidenced by reactions of 2 with typical electrophiles such as H(+), Me(+), and O2. Products from the reaction of 2 with methyl chloroacetate were found to be either [Ir(ABPN2)(CO)(H)(PPh2CH2CO2Me)][PF6] ([6]PF6) or [Ir(ABPN2)(CO)(Cl)(H)] (7) and the free phosphane (PPh2CH2CO2Me), both involving P-C bond formation, depending on the reaction conditions. New complexes having iridacyclophosphapentenone and iridacyclophosphapentanone moieties result from reactions of 2 with dimethyl acetylenedicarboxylate and dimethyl maleate, respectively, as a consequence of a further incorporation of the carbonyl ligan...
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Angewandte Chemie International Edition, 2014
Complexes with terminal phosphanido (MPR2 ) functionalities are believed to be crucial intermedi... more Complexes with terminal phosphanido (MPR2 ) functionalities are believed to be crucial intermediates in new catalytic processes involving the formation of PP and PC bonds. We showcase here the isolation and characterization of mononuclear phosphanide rhodium complexes ([RhTp(H)(PR2 )L]) that result from the oxidative addition of secondary phosphanes, a reaction that was also explored computationally. These compounds are active catalysts for the dehydrocoupling of PHPh2 to Ph2 PPPh2 . The hydrophosphination of dimethyl maleate and the unactivated olefin ethylene is also reported. Reliable evidence for the prominent role of mononuclear phosphanido rhodium species in these reactions is also provided.
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Inorganic Chemistry, 2013
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Energy Conversion and Management, 2014
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Sol-Gel Optics II, 1992
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IEEE Photonics Technology Letters, 2014
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IEEE Photonics Technology Letters, 2000
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European Journal of Medicinal Chemistry, Aug 1, 2009
Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to ex... more Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to explore the influence of each series on the affinity for dopamine receptors. All the compounds displayed a high affinity for D(1)-like and/or D(2)-like dopamine receptors in striatal membranes, although they were unable to inhibit [(3)H]-dopamine uptake in striatal synaptosomes. The halogen placed on the benzylic ring in 1-benzyl-THIQs, compounds of the series 1, 2'-bromobenzyl derivatives with K(i) values into the nanomolar range, and the series 2, 2',4'-dichlorobenzyl-THIQ homologues, proves to be an important factor to modulate affinity at dopamine receptor.
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J Nat Prod, 1995
... M. CARMEN GONZALEZ, hGEL SERRANO, M. CARMEN ZAFRA-POLO, DIEGO CORTES,* Departamento de Farmac... more ... M. CARMEN GONZALEZ, hGEL SERRANO, M. CARMEN ZAFRA-POLO, DIEGO CORTES,* Departamento de Farmacologrb, Famognosia y Farmacodinamia, Faultad de Farmacia, Uniwrsiahi de ... P. Djura, DB Stierle, B. Sullivan, DJ Faulkner, E. Arnold, and J. Clardy, J. Org. ...
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Tecnologia Del Agua, 2012
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Tecnoaqua, 2013
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Pratiques et Organisation des Soins, 2009
... Claudette Carole1, Sébastien Bonenfant1, Dominique Coste2, Patrick Lepinay3, Brigitte Varsat4... more ... Claudette Carole1, Sébastien Bonenfant1, Dominique Coste2, Patrick Lepinay3, Brigitte Varsat4, Bertrand Wadoux5, Marcel Goldberg6, Marie Zins1, Matthieu Carton1. ... Caen, Chambéry, Douai, Le Havre, Nîmes, Orléans, Paris, Poitiers, Saint-Brieuc, Saint-Nazaire et Toulouse. ...
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Epidemiologia e prevenzione
In France, 15 000-20 000 cancers attributable to occupational exposure occur each year. These can... more In France, 15 000-20 000 cancers attributable to occupational exposure occur each year. These cancers appear most often after the worker has retired. Since 1995, a system of post-retirement medical surveillance (PRMS) has been set up for former workers, but it remains largely underused. The SPIRALE program is a public health intervention aimed at identifying the former workers having been exposed to asbestos or wood dust during their working life and to propose them a PRMS. Additionally, it is also an epidemiologic research on the longterm effects of occupational exposure.We report the results of first years of the program conducted in 2006-2008, in 13 districts. a self-administered questionnaire was sent to 50 000 newly retired men, to identify potential past occupational carcinogen exposure. For respondents detected as possibly exposed, exposure was assessed in Health Screening Centres and a PRMS was recommended if necessary. Participation rate, rate of confirmed exposure, increas...
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Optical Metrology in Production Engineering, 2004
The accuracy and precision of the thin wires still requiring special attention. Both theoretical ... more The accuracy and precision of the thin wires still requiring special attention. Both theoretical and experimental studies together may give closest approximation to the "real" value. Concerning the optical technique of measurement, perhaps one may analyze more in detail the interaction between light and matter (wire) which can lead to a simple mathematical approach. Besides this, a calibrating system and
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International Journal of Endocrinology, 2014
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Revista de Calidad Asistencial, 2005
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procesos pedagogicos
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Inorganic chemistry, Jan 22, 2015
The diiridium complex [{Ir(ABPN2)(CO)}2(μ-CO)] (1; [ABPN2](-) = [(allyl)B(Pz)2(CH2PPh2)](-)) reac... more The diiridium complex [{Ir(ABPN2)(CO)}2(μ-CO)] (1; [ABPN2](-) = [(allyl)B(Pz)2(CH2PPh2)](-)) reacts with diphenylphosphane affording [Ir(ABPN2)(CO)(H) (PPh2)] (2), the product of the oxidative addition of the P-H bond to the metal. DFT studies revealed a large contribution of the terminal phosphanido lone pair to the HOMO of 2, indicating nucleophilic character of this ligand, which is evidenced by reactions of 2 with typical electrophiles such as H(+), Me(+), and O2. Products from the reaction of 2 with methyl chloroacetate were found to be either [Ir(ABPN2)(CO)(H)(PPh2CH2CO2Me)][PF6] ([6]PF6) or [Ir(ABPN2)(CO)(Cl)(H)] (7) and the free phosphane (PPh2CH2CO2Me), both involving P-C bond formation, depending on the reaction conditions. New complexes having iridacyclophosphapentenone and iridacyclophosphapentanone moieties result from reactions of 2 with dimethyl acetylenedicarboxylate and dimethyl maleate, respectively, as a consequence of a further incorporation of the carbonyl ligan...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Angewandte Chemie International Edition, 2014
Complexes with terminal phosphanido (MPR2 ) functionalities are believed to be crucial intermedi... more Complexes with terminal phosphanido (MPR2 ) functionalities are believed to be crucial intermediates in new catalytic processes involving the formation of PP and PC bonds. We showcase here the isolation and characterization of mononuclear phosphanide rhodium complexes ([RhTp(H)(PR2 )L]) that result from the oxidative addition of secondary phosphanes, a reaction that was also explored computationally. These compounds are active catalysts for the dehydrocoupling of PHPh2 to Ph2 PPPh2 . The hydrophosphination of dimethyl maleate and the unactivated olefin ethylene is also reported. Reliable evidence for the prominent role of mononuclear phosphanido rhodium species in these reactions is also provided.
Bookmarks Related papers MentionsView impact
Inorganic Chemistry, 2013
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Energy Conversion and Management, 2014
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Sol-Gel Optics II, 1992
Bookmarks Related papers MentionsView impact
IEEE Photonics Technology Letters, 2014
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IEEE Photonics Technology Letters, 2000
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European Journal of Medicinal Chemistry, Aug 1, 2009
Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to ex... more Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to explore the influence of each series on the affinity for dopamine receptors. All the compounds displayed a high affinity for D(1)-like and/or D(2)-like dopamine receptors in striatal membranes, although they were unable to inhibit [(3)H]-dopamine uptake in striatal synaptosomes. The halogen placed on the benzylic ring in 1-benzyl-THIQs, compounds of the series 1, 2'-bromobenzyl derivatives with K(i) values into the nanomolar range, and the series 2, 2',4'-dichlorobenzyl-THIQ homologues, proves to be an important factor to modulate affinity at dopamine receptor.
Bookmarks Related papers MentionsView impact
J Nat Prod, 1995
... M. CARMEN GONZALEZ, hGEL SERRANO, M. CARMEN ZAFRA-POLO, DIEGO CORTES,* Departamento de Farmac... more ... M. CARMEN GONZALEZ, hGEL SERRANO, M. CARMEN ZAFRA-POLO, DIEGO CORTES,* Departamento de Farmacologrb, Famognosia y Farmacodinamia, Faultad de Farmacia, Uniwrsiahi de ... P. Djura, DB Stierle, B. Sullivan, DJ Faulkner, E. Arnold, and J. Clardy, J. Org. ...
Bookmarks Related papers MentionsView impact
Tecnologia Del Agua, 2012
Bookmarks Related papers MentionsView impact
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Tecnoaqua, 2013
Bookmarks Related papers MentionsView impact
Pratiques et Organisation des Soins, 2009
... Claudette Carole1, Sébastien Bonenfant1, Dominique Coste2, Patrick Lepinay3, Brigitte Varsat4... more ... Claudette Carole1, Sébastien Bonenfant1, Dominique Coste2, Patrick Lepinay3, Brigitte Varsat4, Bertrand Wadoux5, Marcel Goldberg6, Marie Zins1, Matthieu Carton1. ... Caen, Chambéry, Douai, Le Havre, Nîmes, Orléans, Paris, Poitiers, Saint-Brieuc, Saint-Nazaire et Toulouse. ...
Bookmarks Related papers MentionsView impact
Epidemiologia e prevenzione
In France, 15 000-20 000 cancers attributable to occupational exposure occur each year. These can... more In France, 15 000-20 000 cancers attributable to occupational exposure occur each year. These cancers appear most often after the worker has retired. Since 1995, a system of post-retirement medical surveillance (PRMS) has been set up for former workers, but it remains largely underused. The SPIRALE program is a public health intervention aimed at identifying the former workers having been exposed to asbestos or wood dust during their working life and to propose them a PRMS. Additionally, it is also an epidemiologic research on the longterm effects of occupational exposure.We report the results of first years of the program conducted in 2006-2008, in 13 districts. a self-administered questionnaire was sent to 50 000 newly retired men, to identify potential past occupational carcinogen exposure. For respondents detected as possibly exposed, exposure was assessed in Health Screening Centres and a PRMS was recommended if necessary. Participation rate, rate of confirmed exposure, increas...
Bookmarks Related papers MentionsView impact
Optical Metrology in Production Engineering, 2004
The accuracy and precision of the thin wires still requiring special attention. Both theoretical ... more The accuracy and precision of the thin wires still requiring special attention. Both theoretical and experimental studies together may give closest approximation to the "real" value. Concerning the optical technique of measurement, perhaps one may analyze more in detail the interaction between light and matter (wire) which can lead to a simple mathematical approach. Besides this, a calibrating system and
Bookmarks Related papers MentionsView impact
International Journal of Endocrinology, 2014
Bookmarks Related papers MentionsView impact
Revista de Calidad Asistencial, 2005
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Endocrinología y Nutrición (English Edition), 2013
Worldwide incidence of thyroid cancer has increased in recent decades. To provide evidence of the... more Worldwide incidence of thyroid cancer has increased in recent decades. To provide evidence of the diagnostic and care efficiency of a monographic thyroid nodule clinic integrating clinical examination, ultrasound examination, and cytology with on site evaluation. Patients attending the monographic thyroid nodule clinic from January 2004 to June 2010. Two periods may be distinguished based on availability of ultrasound equipment at the time of the visit: a first period (P1: 01/2004-09/2007) where no ultrasound equipment was available at the clinic and FNA by palpation was performed, and a second period (P2: 10/2007-06/2010) where this equipment was available and ultrasound-guided FNA was performed. A total of 1036 patients [P1: 537 (52%), P2: 499 (48%)] were seen and enrolled. Diagnostic efficiency (P1 vs P2): 143 vs 181 patients were seen annually, p<0.001; FNA number/nodule: 1.68 vs 1.17, p<0.001; percent FNAs with inadequate material: 26% vs 5.3%, p<0.001; mean (SD) nodule size: 23.6 (12.4) vs 21.7 (11.7) mm, p 0.040; proportion of nodules examined less than 10mm in size: 9.9% vs 13.7%, p 0.030. Care efficiency: mean time (range) from the first visit to surgery indication: 332 (0-2177) vs 108 (0-596) days, p<0.001; proportion of patients referred for surgery due to suspect cytology/other reasons: 1.06 vs 2.21, p<0.001; and operated benign neoplasm/pathology: 0.47 vs 0.93, p=0.002. A monographic thyroid nodule clinic integrating clinical examination, ultrasound, and cytology evaluated on site increases diagnostic and care efficiency in patients with thyroid nodules.
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