Angeles Colin Garcia - Academia.edu (original) (raw)

Papers by Angeles Colin Garcia

Revista Española de Derecho Canónico, 2001

Canadian Journal of Public Health, 2008

Objective: To investigate the long-term effects of the Canadian folic acid fortification program ... more Objective: To investigate the long-term effects of the Canadian folic acid fortification program in older adults' whole blood cell folate (folate) and cobalamin (Cbl) status, including homocysteine (tHcy) and methylmalonic acid (MMA), with and without voluntary B-vitamin intake, from 1997 to 2004. Methods: Cohort of community-dwelling volunteer older adults. Clinical and biochemical data, including intake of B-vitamin supplements, were obtained at 2-to 2.5-year intervals and divided in 4 periods. Random coefficients (mixed effects) models were used to estimate the linear trend in folate and to compare levels of biochemical parameters between periods. All models were estimated by restricted maximum likelihood as implemented in PROC MIXED of SAS V8.2. Results: Folate levels increased continuously at a yearly rate of 234 ng/mL (95% CI 213-254; p<0.001) and had not plateaued by the last period when 84% of subjects without B-vitamins had elevated folate. Homocysteine did not remain suppressed. Elevated tHcy was as prevalent in the last study period as in the first. No significant deficits of Cbl or increases of MMA were observed, but MMA levels tended to increase with time in subjects without B-vitamins. B-vitamin supplements significantly affected all results, reducing tHcy and MMA levels. Conclusion: In this population, fortification with folic acid has resulted in cumulative increases of folate with no long-term reduction in tHcy or changes in Cbl or MMA. Possible deleterious effects of cumulative increases of folate, and beneficial effects of B-vitamin supplements in reducing tHcy and MMA, should be investigated.

Canadian journal on aging = La revue canadienne du vieillissement, 2018

ABSTRACTSeveral determinants of developing fear of falling (FoF) overlap with the consequences of... more ABSTRACTSeveral determinants of developing fear of falling (FoF) overlap with the consequences of diabetes mellitus (DM). We compared the prevalence and severity of FoF in older adults with and without DM and identified which FoF determinants contribute to FoF severity in older adults with DM. We used Canadian baseline data from the International Mobility in Aging Study (IMIAS) which identified 141 older adults with DM (DM-group;age:68.88±2.80years) and 620 without DM (noDM-group;age:68.81±2.68years). FoF was quantified with Falls Efficacy Scale-International (FES-I). FoF determinants were evaluated in demographic/health-related, physical, psychological, and social domains. High concern of FoF was more prevalent and of higher severity in 10/16 FES-I activities in the DM-group compared to the noDM-group. Higher FoF severity in the DM-group was associated with poor physical performance, being female, fall history, and clinical depressive symptoms. Protocols developed for screening and...

NeuroImage, Jan 15, 2018

Cognitive decline during aging includes impairments in frontal executive functions like reduced i... more Cognitive decline during aging includes impairments in frontal executive functions like reduced inhibitory control. However, decline is not uniform across the population, suggesting individual brain response variability to the aging process. Here we tested the hypothesis, within the oculomotor system, that older adults compensate for age-related neural alterations by changing neural activation levels of the oculomotor areas, or even by recruiting additional areas to assist with cognitive performance. We established that the observed changes had to be related to better cognitive performance to be considered as compensatory. To probe this hypothesis we used the antisaccade paradigm and analyzed the effect of aging on brain activations during the inhibition of prepotent responses to visual stimuli. While undergoing a fMRI scan with concurrent eye tracking, 25 young adults (21.7 y/o ± 1.9 SDM) and 25 cognitively normal older adults (66.2 y/o ± 9.8 SDM) performed an interleaved pro/antis...

Journal of Alzheimer's Disease, 2008

Dysregulation of iron homeostasis is implicated in Alzheimer's disease (AD). In this pilot study,... more Dysregulation of iron homeostasis is implicated in Alzheimer's disease (AD). In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998. Laboratory studies also were done to search for genetic effects on blood markers of iron status, red cell folates and serum B12. Participants included 58 healthy volunteers (25 males, 33 females) and 54 patients with probable AD (20 males, 34 females). Statistical analyses were interpreted at the 95% confidence level. Contingency table and odds ratio analyses supported the hypothesis that in females of the given age range, E4 significantly predisposed to AD in the presence but not absence of H63D. In males, E4 significantly predisposed to AD in the absence of H63D, and H63D in the absence of E4 appeared protective against AD. Among E4+ AD patients, H63D was associated with significant lowering of red cell folate concentration, possibly as the result of excessive oxidative stress. However, folate levels in the lowest population quartile did not affect the risk of AD. A model is presented to explain the experimental findings.

Journal of Alzheimer's disease : JAD, Jan 3, 2017

This study validates and expands on our previous work that assessed three-dimensional (3D) nuclea... more This study validates and expands on our previous work that assessed three-dimensional (3D) nuclear telomere profiling in buccal cells of Alzheimer's disease (AD) patients and non-AD controls (Mathur et al., J Alzheimers Dis 39, 35-48, 2014). While the previous study used age- and gender-matched caregiver controls, the current study consented a new cohort of 44 age- and gender-matched healthy non-caregiver controls and 44 AD study participants. 3D telomeric profiles of buccal cells of AD patients and their non-AD controls were examined with participant information blinded to the analysis. In agreement with our previous study, we demonstrate that 3D telomeric profiles allow for the distinction between AD and non-AD individuals. This validation cohort provides an indication that the total number of 3D telomeric signals and their telomere lengths may be a suitable biomarker to differentiate between AD and non-AD and between mild, moderate, and severe AD. Further studies with larger ...

Archives of Gerontology and Geriatrics, 2017

Objective: To compare diurnal cortisol profiles across samples of older adults from diverse popul... more Objective: To compare diurnal cortisol profiles across samples of older adults from diverse populations and to examine if differences in circadian cortisol secretion are associated with poor physical performance (SPPB<9). Methods: Data were collected during the baseline survey of the International Mobility in Aging Study conducted in 2012 in Kingston (Canada), Saint-Hyacinthe (Canada), Tirana (Albania) and Manizales (Colombia). Salivary cortisol was collected from a subsample of 309 participants instructed to collect saliva on two consecutive days, and 5 different intervals each day: upon awakening (M1), 30 minutes (M2) and 60 minutes after awakening, at 15:00 hours and before bedtime (E). Cortisol was analyzed using enzyme immunoassay kits. Physical performance was measured by the Short Physical Performance Battery (SPPB). Mixed linear models were fit to assess the associations between cortisol diurnal output and physical performance, adjusting for potential confounders. Results: Kingston, Saint-Hyacinthe and Tirana residents had significantly higher cortisol values than their Manizales counterparts, with the population from Tirana showing the highest levels. Attenuated morning cortisol peak (M2) (p=0.025), higher cortisol bed time (E) (p=0.005), and lower M2/E ratio (p<0.001) were found among those with SPPB<9 compared with those with good physical performance (SPPB ≥9). These results were not altered after adjustment by potential confounders. Conclusion: Cortisol profiles varied across four diverse populations of older adults. Circadian cortisol secretion is associated with physical performance as an attenuated morning response and higher bed time values were observed in older adults with SPPB<9.

Journal of cellular physiology, Jan 20, 2016

The advent of super-resolution microscopy allowed for new insights into cellular and physiologica... more The advent of super-resolution microscopy allowed for new insights into cellular and physiological processes of normal and diseased cells. In this study, we report for the first time on the super-resolved DNA structure of buccal cells from patients with Alzheimer's disease (AD) vs. age- and gender-matched healthy, non-caregiver controls. In this super-resolution study cohort of 74 participants, buccal cells were collected and their spatial DNA organization in the nucleus examined by 3D Structured Illumination Microscopy (3D-SIM). Quantitation of the super-resolution DNA structure revealed that the nuclear super-resolution DNA structure of individuals with AD significantly differs from that of their controls (p < 0.05) with an overall increase in the measured DNA-free/poor spaces. This represents a significant increase in the interchromatin compartment. We also find that the DNA structure of AD significantly differs in mild, moderate and severe disease with respect to the DNA-...

Dementia and Geriatric Cognitive Disorders Extra, 2016

Background/Aims: Superficial white matter provides extensive cortico-cortical connections. This t... more Background/Aims: Superficial white matter provides extensive cortico-cortical connections. This tractography study aimed to assess the diffusion characteristics of superficial white matter tracts in Alzheimer's disease. Methods: Diffusion tensor 3T magnetic resonance imaging scans were acquired in 24 controls and 16 participants with Alzheimer's disease. Neuropsychological test scores were available in some participants. Tractography was performed by the Fiber Assignment by Continuous Tracking (FACT) method. The superficial white matter was manually segmented and divided into frontal, parietal, temporal and occipital lobes. The mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AxD) and fractional anisotropy (FA) of these tracts were compared between controls and participants with Alzheimer's disease and correlated with available cognitive tests while adjusting for age and white matter hyperintensity volume. Results: Alzheimer's disease was associated...

Luchas De Genero En La Historia a Traves De La Imagen Ponencias Y Comunicaciones Vol 3 2002 Isbn 8477854653 Pags 317 326, 2002

del tratamiento del slurry con la lacasa sobre el crecimiento de S. cerevisiae y la producción de... more del tratamiento del slurry con la lacasa sobre el crecimiento de S. cerevisiae y la producción de etanol…………………..

Archives of Gerontology and Geriatrics, 2016

Background: Fear of falling (FoF) is a common health problem among older adults. Although the rel... more Background: Fear of falling (FoF) is a common health problem among older adults. Although the relationship between FoF and limitation in daily activities has been reported, FoF's relationship to mobility disability, a transitional phase to end-stage disability, is not yet understood. We examined the relationship between FoF and mobility disability among community-dwelling older adults and explored the differences in this relationship among socio-culturally diverse sites. Design: Cross-sectional study. Setting: Community. Participants: 1875 participants (65-74 years) were recruited from five sites and included in the analysis (Kingston, Canada: 394; St-Hyacinthe, Canada: 397; Tirana, Albania: 359; Manizales, Colombia: 341; and Natal, Brazil: 384). Measurement: FoF was quantified using the Falls Efficacy Scale-International (FES-I, range: 16-64). Mobility disability was defined as difficulty climbing a flight of stairs or walking 400 m without assistance. Results: Overall, 21.5% of participants reported high FoF (FES-I > 27). The average FoF scores were significantly different between the sites (p < 0.001) and higher in women (p < 0.001). In general, 36.2% of participants reported mobility disability. The distribution of mobility disability was significantly different at the five study sites (ranged from 19.8% at Kingston, Canada to 50.7% at Tirana, Albania, p < 0.001). After adjusting for covariates, those with high and moderate FoF had about 3 times (95% CI: 2.59-3.83) and 2.5 times (95% CI: 1.99-2.91) higher risk of mobility disability, respectively, compared to those with no/low FoF. Conclusions: FoF was significantly associated with risk of mobility disability across the sites. The strength of this relationship appears to be different between the five sites. 2016 Elsevier Ireland Ltd. All rights reserved.

Boletin Economico De Ice Informacion Comercial Espanola, 2004

El Parque Cientifico y Tecnologico Cartuja 93 ha logrado, en apenas once anos, aglutinar a cerca ... more El Parque Cientifico y Tecnologico Cartuja 93 ha logrado, en apenas once anos, aglutinar a cerca de 250 empresas e instituciones que emplean a mas de 9.000 trabajadores y generan una actividad economica superior a los 1.200 millones de euros. El recinto se ha convertido en una comunidad cientifico-tecnologica, que contribuye a la busqueda constante de innovacion, factor decisivo para la mejora de la productividad y la competitividad. La transferencia del conocimiento , la innovacion continua y la busqueda de herramientas para facilitar la generacion de puestos de trabajo de calidad son sus maximas. Cartuja 93 busca ser un actor fundamental en lo que se ha venido a denominar «Segunda Modernizacion» de Andalucia.

Suma Revista Sobre Ensenanza Y Aprendizaje De Las Matematicas, 2005

Revista Espanola De Reumatologia, 2003

World Journal of Neuroscience, 2012

Alzheimer's Disease (AD) is characterized by an early and significant memory impairment, and prog... more Alzheimer's Disease (AD) is characterized by an early and significant memory impairment, and progresses to affect other cognitive domains. Impairments in Focused Attention (FA) have been observed in patients diagnosed with mild AD. A functional magnetic resonance imaging (fMRI) Stroop paradigm with verbal responses was used to investigate the neural correlates of FA in AD patients. Twenty-one patients diagnosed with mild AD performed a verbal Stroop-fMRI paradigm. Colour words were printed in an incongruent ink colour. Series 1 consisted of four blocks "Read the word" followed by four blocks "Say the colour of the ink"; Series 2 alternated between the two conditions. Functional data were analyzed using SPM5 to detect anatomical areas with significant signal intensity differences between the conditions. Withingroup analyses of the colour minus word contrast yielded significant activation in the following left hemisphere regions: precentral gyrus, inferior frontal gyrus, fusiform gyrus and supplementary motor area (p < 0.05, uncorrected). Relative to cognitively normal older adults who underwent the same experimental task, Stroop performance was significantly worse in AD patients. The fMRI task yielded similar activated brain regions between the two groups. The use of verbal responses in this novel fMRI Stroop task avoids the confusion and memorizing of button locations seen with the manual response modality, allowing the neural correlates of FA to be investigated in AD patients.