Angelina Rogliardo - Academia.edu (original) (raw)
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Papers by Angelina Rogliardo
La signalisation mTOR induite par le récepteur 5-HT 6 de la sérotonine comme nouvelle cible théra... more La signalisation mTOR induite par le récepteur 5-HT 6 de la sérotonine comme nouvelle cible thérapeutique pour prévenir l'apparition des déficits cognitifs de la schizophrénie Présentée par Angelina ROGLIARDO Le 10 décembre 2021 Sous la direction de Carine BECAMEL
Embo Molecular Medicine, Sep 7, 2022
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Embo Molecular Medicine, Sep 7, 2022
Cannabis abuse during adolescence confers an increased risk for developing later in life cognitiv... more Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized. In line with previous findings that revealed a role of 5-HT 6 receptor-operated mTOR activation in cognitive deficits of rodent developmental models of schizophrenia, we show that chronic administration of Δ9-tetrahydrocannabinol (THC) to mice during adolescence induces a longlasting activation of mTOR in prefrontal cortex (PFC), alterations of excitatory/inhibitory balance, intrinsic properties of layer V pyramidal neurons, and long-term depression, as well as cognitive deficits in adulthood. All are prevented by administrating a 5-HT 6 receptor antagonist or rapamycin, during adolescence. In contrast, they are still present 2 weeks after the same treatments delivered at the adult stage. Collectively, these findings suggest a role of 5-HT 6 receptor-operated mTOR signaling in abnormalities of cortical network wiring elicited by THC at a critical period of PFC maturation and highlight the potential of 5-HT 6 receptor antagonists as early therapy to prevent cognitive symptom onset in adolescent cannabis abusers.
EMBO Molecular Medicine, Apr 24, 2020
La signalisation mTOR induite par le récepteur 5-HT 6 de la sérotonine comme nouvelle cible théra... more La signalisation mTOR induite par le récepteur 5-HT 6 de la sérotonine comme nouvelle cible thérapeutique pour prévenir l'apparition des déficits cognitifs de la schizophrénie Présentée par Angelina ROGLIARDO Le 10 décembre 2021 Sous la direction de Carine BECAMEL
Embo Molecular Medicine, Sep 7, 2022
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Embo Molecular Medicine, Sep 7, 2022
Cannabis abuse during adolescence confers an increased risk for developing later in life cognitiv... more Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized. In line with previous findings that revealed a role of 5-HT 6 receptor-operated mTOR activation in cognitive deficits of rodent developmental models of schizophrenia, we show that chronic administration of Δ9-tetrahydrocannabinol (THC) to mice during adolescence induces a longlasting activation of mTOR in prefrontal cortex (PFC), alterations of excitatory/inhibitory balance, intrinsic properties of layer V pyramidal neurons, and long-term depression, as well as cognitive deficits in adulthood. All are prevented by administrating a 5-HT 6 receptor antagonist or rapamycin, during adolescence. In contrast, they are still present 2 weeks after the same treatments delivered at the adult stage. Collectively, these findings suggest a role of 5-HT 6 receptor-operated mTOR signaling in abnormalities of cortical network wiring elicited by THC at a critical period of PFC maturation and highlight the potential of 5-HT 6 receptor antagonists as early therapy to prevent cognitive symptom onset in adolescent cannabis abusers.
EMBO Molecular Medicine, Apr 24, 2020