Anglita Yantisetiasti - Academia.edu (original) (raw)

Papers by Anglita Yantisetiasti

Althea Medical Journal

Background: Carcinoma of the cervix is the most common gynecological malignancy, which ranks firs... more Background: Carcinoma of the cervix is the most common gynecological malignancy, which ranks first among carcinomas in Indonesia. Lymph node metastasis is a risk of recurrence, affecting survival and therapy. The purpose of this study was to determine the clinicopathological characteristics of cervical carcinoma with pelvic lymph node metastasis that had undergone radical hysterectomy and lymphadenectomy at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This study used a cross-sectional retrospective descriptive study. Data on the clinical stage I-II cervical cancer patients with pelvic lymph node metastasis were collected from the archives of the pathological anatomy laboratory during period from 2013 to 2021. Data were presented in percentage.Results: There were 64 data patients, and the most common age of cervical carcinoma ranged from 40 to 50 years old (51.6%), the most common stage was stage II (62.5%), and the most frequent histopathological type was squamous cell car...

The Fairchild Books Dictionary of Fashion, 2022

European Urology Open Science, 2020

Jurnal llmu Bedah Indonesia, 2014

Pendahuluan. Irigasi usus melalui rektum atau washout merupakan suatu prosedur menggunakan sebuah... more Pendahuluan. Irigasi usus melalui rektum atau washout merupakan suatu prosedur menggunakan sebuah pipa yang dimasukkan melalui anus dan sejumlah cairan dimasukkan melalui pipa tersebut dengan tujuan untuk membersikan usus. NaCl 0,9% sering digunakan pada pasien–pasien penderita penyakit Hirschsprung sebagai cairan washout. Ada berbagai jenis cairan washout yang digunakan, beberapa diantaranya berupa cairan siap pakai yang dapat dibeli di apotek atau toko obat, cairan lainnya dapat dibuat di rumah yaitu larutan garam. Larutan garam ini dianggap sama dengan NaCl 0,9%. Larutan ini selain mudah dibuat dengan biaya yang relatif lebih rendah, tentu saja diharapkan efektivitasnya sama dengan NaCl 0,9%. Namun, garam yang beredar di Indonesia sebagian besar telah mengalami fortifikasi iodium.Tujuan penelitian ini untuk melihat perubahan histopatologi setelah dilakukan washout menggunakan larutan garam meja 1% dibandingkan dengan NaCl 0,9%. Metode. Penelitian ini merupakan penelitian eksperim...

Journal of Medical & Surgical Pathology, 2017

Objectives: We look for the difference of CTGF expression in urethral stricture due to infection ... more Objectives: We look for the difference of CTGF expression in urethral stricture due to infection and trauma with Immunohistochemistry (IHC) and Enzyme-linked Immunosorbent Assay (ELISA) methods. Methods: We measure the CTGF level from 5 urethral stricture tissue of patient with infection, 18 patients with traumatic urethral stricture. We used IHC and ELISA as method of CTGF measurement. We also compared the result between IHC and ELISA in our subjects. Statistical analysis was done using SPSS version 22.0. Results: From ELISA measurement, the CTGF level of traumatic urethral stricture patients was significantly higher than patients with infection (5.294 ± 7.213 pg/dl vs. 2.62 ± 2.156 pg/dl, p=0.002). From IHC examination CTGF expression in trauma group was significantly stronger than infection group (p=0.041). There was no significant difference between the result of ELISA examination and IHC examination in measuring CTGF level in urethral infection stricture tissue (p=1.000) and trauma stricture tissue (p=0.112). Conclusions: CTGF expression is higher in traumatic urethral stricture patients compared to urethral stricture patients due to infection. There were no significant difference between the result of both ELISA and IHC.

Background: Meningioma is a tumor composed of cells of neoplastic meningothelial (arachnoidal) ce... more Background: Meningioma is a tumor composed of cells of neoplastic meningothelial (arachnoidal) cells that a rise from the arachnoid membrane and the layer of the arachnoid villi associated with intradural venous sinuses and surrounding tissue. Meningiomas tumors is one of the central nervous system (CNS) the most commonly found (the second sequence) and generally grow slowly. Approximately 60-95% activity of telomerase (hTERT ) found on meningiomas and can induces VEGF . The aim of this study is to determine the role of hTERT and VEGF in meningiomas grading . Methods : This study is conducted using analytic observasional cross sectional method and had been analyzed with unpaired categorical analysis of the 60 cases of meningioma (46 cases grade I, 7 cases grade II, and7 cases grade III). The sample were obtained the archive of Anatomical Pathology Department, Faculty of Medicine, Padjadjaran University/Dr. Hasan Sadikin Hospital Result : The result of this study showed: 44 cases (9...

Background Locally advanced breast cancer (LABC) were stage III breast carcinoma based on TNM sys... more Background Locally advanced breast cancer (LABC) were stage III breast carcinoma based on TNM system, with an incidence >50% of all breast cancers in developing countries , including Indonesia. The first treatment of LABC is neoadjuvant chemotherapy, most often in anthracycline base. The purpose of this study is to analyze the relationship between HER-2/neu and Ki-67 with anthracycline-based neoadjuvant chemotherapy responsse in LABC. Methods The study involved 52 LABC, each of 26 patients responsding and not responsding. Paraffin block from biopsy stained with HER-2/neu and Ki-67 immunohistochemistry. HER-2/neu expression interpreted as positive and negative, while Ki-67 were categorized as

Background Histopathology definition of chronic gastritis is a chronic inflammation of the gastri... more Background Histopathology definition of chronic gastritis is a chronic inflammation of the gastric mucosa that can cause glandular atrophy and intestinal metaplasia of the gastric mucosal epithelium. Chronic gastritis can be caused by many factors. The most common etiology chronic gastritis by the bacterium Helicobacter pylori (Hp). The incidence chronic gastritis causes of Hp is more common in developing country than developed country. Histopathological picture on chronic gastritis causes of Hp similar with chronic gastritis non-Hp. The aims of this study to determine the difference of histopathological picture between chronic gastritis with Hp and chronic gastritis without Hp bacteria in the Hospital Dr Hasan Sadikin Bandung. Methods The sample used in this study were 30 cases of chronic gastritis with Helicobacter pylori (Hp) and 30 cases of chronic gastritis non-Hp bacteria from the Pathology Department of the hospital Dr. Hasan Sadikin Bandung. The research start from May 1st u...

Prostate Cancer and Prostatic Diseases, 2021

Background Risk stratification in men with suspicion of prostate cancer (PCa) requires reliable d... more Background Risk stratification in men with suspicion of prostate cancer (PCa) requires reliable diagnostic tests, not only to identify high-grade PCa, also to minimize the overdetection of low-grade PCa, and reduction of “unnecessary” prostate MRIs and biopsies. This study aimed to evaluate the SelectMDx test to detect high-grade PCa in biopsy-naïve men. Subsequently, to assess combinations of SelectMDx test and multi-parametric (mp) MRI and its potential impact on patient selection for prostate biopsy. Methods This prospective multicenter diagnostic study included 599 biopsy-naïve patients with prostate-specific antigen level ≥3 ng/ml. All patients underwent a SelectMDx test and mpMRI before systematic transrectal ultrasound-guided biopsy (TRUSGB). Patients with a suspicious mpMRI also had an in-bore MR-guided biopsy (MRGB). Histopathologic outcome of TRUSGB and MRGB was used as reference standard. High-grade PCa was defined as ISUP Grade Group (GG) ≥ 2. The primary outcome was the...

Indonesian Journal of Urology, 2012

Objective: To evaluate the effect of prednisone in unilateral testicular torsion on Sertoli cell ... more Objective: To evaluate the effect of prednisone in unilateral testicular torsion on Sertoli cell quality of contralateral testis. Material Method: Thirty Wistar rats were divided into three groups i.e. group A (sham procedure), group B (unilateral torsion + orchiectomy after 6 hours), and group C (unilateral torsion + orchiectomy after 24 hours). Group B and C were further divided into subgroup with and without Prednisone administration. Prednisone was given orally once a day an hour after torsion, continued till one month later. Orchiectomy of contralateral testis was performed one month later. Those testes were examined by a pathologist. Results: In group A, no abnormality on Sertoli cell quality was found. There is significant difference among groups in Sertoli cell quality (p = 0,01). Ischemic time is associated with Sertoli cell quality (2 rats with severe damage in group C and none in group B). In group B and C, prednisone administration inhibited Sertoli cell damage. Predniso...

Indonesian Journal of Urology, 2014

Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 pro... more Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significan...

Advanced Healthcare Materials, 2018

The Journal of Urology, 2018

INTRODUCTION AND OBJECTIVES: Patients would greatly benefit from accurate and early identificatio... more INTRODUCTION AND OBJECTIVES: Patients would greatly benefit from accurate and early identification of clinically significant prostate cancer (PCa), leading to a reduction of over-diagnosis and over-treatment. The aim of this study was to determine the complementarity between a pre-biopsy urinary biomarker-based risk score (SelectMDx) followed by a post-biopsy epigenetic biomarker assay (ConfirmMDx) to identify men with high-grade PCa. METHODS: The study population consistent of 214 men who were undergoing a 12-core prostate biopsy. Average age was 65 years (range 50-75). Prior to biopsy, urine was collected following digital rectal examination, and urine samples were tested with two urinary RNAbased assays, SelectMDx for Prostate Cancer and PCA3. Biopsy tissue samples from all cores were subsequently tested with the epigenetic DNA assay ConfirmMDx (MDxHealth, Inc, Irvine, CA). This epigenetic test quantifies the relative DNA methylation intensities of 3 genes (GSTP1, RASSF1, and APC) in each individual biopsy core to generate an epigenetic risk score. The results were expressed as areas under the receiver-operating characteristic curve (AUC). High-grade PCa was defined as Gleason Score (GS) >¼7. RESULTS: Of 214 subjects, 95 (44%) had benign pathology at biopsy, 47 (22%) were diagnosed with GS6 cancer and 72 (34%) highgrade disease (GS >¼7). The pre-biopsy urinary tests SelectMDx and PCA3 yielded AUCs of 0.88 and 0.73 respectively, for detection of highgrade cancer at biopsy. The AUC of the post-biopsy ConfirmMDx test was 0.91. A combined model using both SelectMDx and ConfirmMDx showed a further improvement in performance compared to SelectMDx alone (AUC of 0.93). CONCLUSIONS: In this evaluation study, the pre-and postbiopsy RNA and DNA biomarker assays SelectMDx and ConfirmMDx outperformed PCA3 biomarker test. Combining the urinary RNA test with the epigenetic DNA test significantly improved accuracy for the identification of men with high-grade PCa.

Research and Reports in Urology, 2017

Background: Urethral stricture has a high recurrence rate. There is a common doctrine stating tha... more Background: Urethral stricture has a high recurrence rate. There is a common doctrine stating that "once a stricture, always a stricture". This fibrotic disease pathophysiology, pathologically characterized by excessive production, deposition and contraction of extracellular matrix is unknown. Angiotensin II type 1 (AT 1) receptor primarily induces angiogenesis, cellular proliferation and inflammatory responses. AT 1 receptors are also expressed in the fibroblasts of hypertrophic scars, whereas angiotensin II (AngII) regulates DNA synthesis in hypertrophic scar fibroblasts through a negative cross talk between AT 1 and angiotensin II type 2 (AT 2) receptors, which might contribute to the formation and maturation of human hypertrophic scars. Objective: This study was conducted to determine the expression of AT 1 receptors in urethral stricture tissues. Methods: Urethral stricture tissues were collected from patients during anastomotic urethroplasty surgery. There were 24 tissue samples collected in this study with 2 samples of normal urethra for the control group. Immunohistochemistry study was performed to detect the presence of AT 1 receptor expression. Data were analyzed using Mann-Whitney U test, and statistical analysis was performed with SPSS version 20. Results: This study showed that positive staining of AT 1 receptor was found in all urethral stricture tissues (n=24). A total of 8.33% patients had low intensity, 41.67% had moderate intensity and 50% had high intensity of AT 1 receptors, while in the control group, 100% patients had no intensity of AT 1 receptors. Using the Mann-Whitney U test, it was found that urethral stricture tissue had a higher intensity of AT 1 receptors than normal urethral tissue with a p-value = 0.012. Conclusion: The results showed that AT 1 receptor had a higher intensity in the urethral stricture tissue and that AT 1 receptor may play an important role in the development of urethral stricture.

Althea Medical Journal, 2016

Background: Giant cell tumor (GCT) of bone is a primary bone tumor. It is commonly seen in South ... more Background: Giant cell tumor (GCT) of bone is a primary bone tumor. It is commonly seen in South East Asia and found in female around 20-45 years old. The GCT mostly occurs in epiphysis around the knee. The patients normally suffer from pain, swelling, limitation of joint movement, and pathologic fracture. This study aimed to determine the epidemiology of GCT of the bone based on age, sex, location, type, metastases, and recurrence in Dr. Hasan Sadikin General Hospital Bandung. Methods: A descriptive study with retrospective cohort using total sampling method was used to obtain 33 medical records of patients with GCT of bone in Department of Orthopedic & Traumatology and Anatomical Pathology Dr. Hasan Sadikin General Hospital Bandung in the period of January 2010-December 2013. Results: The GCT of bone was mostly found in female of 20 to 29 years old and around 32 years old in male. Distal femur will be the most common site while zygoma, mandibular vertebrae, proximal tibia were rare sites. Twenty nine cases were benign lesion and the rest (4 cases) were malignant. The probability of GCT of bone to metastasize to lungs was very low. Four recurrences occurred within a year. Conclusions: The GCT of bone in male mostly occurs in the third and fourth decade of age. It is found around the knee, mostly benign, rarely metastasize to the lungs and recurrence happens within a year.

Althea Medical Journal, 2015

Background: Cartilage neoplasms are less common compared to other neoplasms. Its incidence is 22%... more Background: Cartilage neoplasms are less common compared to other neoplasms. Its incidence is 22% among all the musculoskeletal neoplasms. Despite many other studies about patient characteristics of the neoplasm in other regions, descriptive data in Bandung city is still unknown. The objective of this study is to determine the distribution of both benign and malignant neoplasms based on their characteristics of histopathological type, gender, age and anatomical site. Methods: The subjects of this descriptive study were taken from the medical records of the patients who had been examined histopathologically in Anatomical Pathology Department at Dr. Hasan Sadikin General Hospital Bandung, Indonesia within the period of 2008 to2012. The sample was obtained using total sampling technique. Patients diagnosed with cartilage neoplasms were included whereas incomplete medical records were excluded. Histopathological type, gender, age and anatomical site of each patients were collected and analyzed. Results: Seventy cartilage neoplasm cases were found. The distribution of cases comprised of 48 (67%) benign and 23 (33%) malignant. The most common benign neoplasm was osteochondroma and chondroma. Benign neoplasms were more prevalent among men and patients <30 years old, while malignant neoplasm was prevalent among women and patients >60 years old. Femur was the most common site for all neoplasms except for chondroma. Conclusions: PThere are differences in characteristic of benign and malignant cartilage neoplasm patients. Both benign and malignant cartilage neoplasms showed differences on the distribution of patient characteristics. [AMJ.2015;2(4):561-7]

European Urology Supplements, 2012

Objective: To analyze the distribution features of Gleason score in the different prostate zones.... more Objective: To analyze the distribution features of Gleason score in the different prostate zones. Material & Method: Twenty paraffin block specimens of radical prostatectomy were analyzed looking for Gleason score distribution in each zone. Specimens were stained with Hematoxilin Eosin. Results: Among the 20 cancers, 16 (80%) specimens had more than one focus. Most foci were found in peripheral zone (95%), only one specimen contained foci solely found in transitional zone. More than half (55%) prostate specimens contain three different Gleason grades. Only one specimen contained a single grade. Conclusion: Our results confirm the heterogeneous, multifocal, and multizonal nature of prostate carcinomas. Most specimens had more than one tumor focus, with predominant location in the peripheral zone. Almost all transition zone foci were found concomitantly with peripheral zone foci.