Anh Bui - Academia.edu (original) (raw)
Papers by Anh Bui
Proceedings of the AAAI Conference on Artificial Intelligence
Ensemble-based Adversarial Training is a principled approach to achieve robustness against advers... more Ensemble-based Adversarial Training is a principled approach to achieve robustness against adversarial attacks. An important technicality of this approach is to control the transferability of adversarial examples between ensemble members. We propose in this work a simple, but effective strategy to collaborate among committee models of an ensemble model. This is achieved via the secure and insecure sets defined for each model member on a given sample, hence help us to quantify and regularize the transferability. Consequently, our proposed framework provides the flexibility to reduce the adversarial transferability as well as promote the diversity of ensemble members, which are two crucial factors for better robustness in our ensemble approach. We conduct extensive and comprehensive experiments to demonstrate that our proposed method outperforms the state-of-the-art ensemble baselines, at the same time can detect a wide range of adversarial examples with a near perfect accuracy.
Computer Vision – ECCV 2020, 2020
The fact that deep neural networks are susceptible to crafted perturbations severely impacts the ... more The fact that deep neural networks are susceptible to crafted perturbations severely impacts the use of deep learning in certain domains of application. Among many developed defense models against such attacks, adversarial training emerges as the most successful method that consistently resists a wide range of attacks. In this work, based on an observation from a previous study that the representations of a clean data example and its adversarial examples become more divergent in higher layers of a deep neural net, we propose the Adversary Divergence Reduction Network which enforces local/global compactness and the clustering assumption over an intermediate layer of a deep neural network. We conduct comprehensive experiments to understand the isolating behavior of each component (i.e., local/global compactness and the clustering assumption) and compare our proposed model with state-of-the-art adversarial training methods. The experimental results demonstrate that augmenting adversarial training with our proposed components can further improve the robustness of the network, leading to higher unperturbed and adversarial predictive performances.
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 17, 2018
The design of original twisted charge transfer antennas where a non planar geometry is enforced t... more The design of original twisted charge transfer antennas where a non planar geometry is enforced thanks to one or two bulky ortho-Me substituents allows us to prepare the corresponding ultra-bright Tb(III) and Dy(III) bioprobes. The brightness of the Tb(III) derivative compares well with that of the benchmark Tb-Lumi4 complex. The first bio-imaging experiments with a Dy(III) luminescent bioprobe are also reported.
Journal of the American Chemical Society, Jun 14, 2017
Fluorescent probes that are able to directly measure viscosity are attractive candidates for the ... more Fluorescent probes that are able to directly measure viscosity are attractive candidates for the study of intracellular environments. We report a new class of luminescent rotors, based on the sensitized emission of a terbium(III) complex. A 4-fold increase in both quantum yield and luminescence lifetime was observed in viscous media for the studied complexes, with a lifetime ranging from 0.23 to 0.89 ms over a broad range of viscosities (0.6-1200 cP). The presented approach, relying on the millisecond-scale luminescence lifetime of the lanthanide ions, was applied to fixed T24 cancer cells using temporal sampling lifetime imaging microscopy.
Inorganic chemistry, Jan 18, 2016
An original cationic water-soluble cyclen-based Eu(III) complex [EuL(1)](+) featuring a chromopho... more An original cationic water-soluble cyclen-based Eu(III) complex [EuL(1)](+) featuring a chromophore-functionalized antenna to increase the two-photon (2P) absorption properties was synthesized. The photophysical properties were thoroughly studied in various solvents and rationalized with the help of theoretical calculations. The complex exhibits an optimized 2P absorption cross section. Finally, 2P microscopy imaging experiments on living T24 human cancer cells highlighted the spontaneous internalization and the biological stability of this 2P bioprobe in vitro. Macrocyclic-based antennas open new perspectives for future optimization of the photophysical properties and allows envisaging the design of Eu, Tb, Yb, and Sm bioprobes. This result also opens the way for the design of functional two-photon Ln complexes able to monitor intracellular physicochemical parameters.
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 22, 2015
An original samarium(III) complex based on a triazacyclononane platform functionalized with a cha... more An original samarium(III) complex based on a triazacyclononane platform functionalized with a charge-transfer antenna chromophore exhibited optimized brightness and was successfully used as an emissive species for two-photon microscopy experiments in both the visible and near-infrared spectral ranges.
Nature Reviews Cardiology, 2010
Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the U... more Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing HF is one in five. Although promising evidence shows that the age-adjusted incidence of HF may have plateaued, HF still carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. HF represents a considerable burden to the health-care system, responsible for costs of more than $39 billion annually in the USA alone, and high rates of hospitalizations, readmissions, and outpatient visits. HF is not a single entity, but a clinical syndrome that may have different characteristics depending on age, sex, race or ethnicity, left ventricular ejection fraction (LVEF) status, and HF etiology. Furthermore, pathophysiological differences are observed among patients diagnosed with HF and reduced LVEF compared with HF and preserved LVEF, which are beginning to be better appreciated in epidemiological studies. A number of risk factors, such as ischemic heart disease, hypertension, smoking, obesity, and diabetes, among others, have been identified that both predict the incidence of HF as well as its severity. In this Review, we discuss key features of the epidemiology and risk profile of HF.
Journal of the American College of Cardiology, 2012
Reduces visits to the emergency and hospital admissions Home Monitoring for Heart Failure Preve... more Reduces visits to the emergency and hospital admissions Home Monitoring for Heart Failure Prevent exacerbation through early warning. Patient confidence and peace of mind increases as self-management skills are learned. Support helps patients retain independence and remain in their own homes. How it Works Home monitoring service supports patients with Heart Failure through health coaching and remote monitoring. The service is free to patients.
Community Mental Health Journal, 1988
This report describes a one-year experience with a new program of group therapy for Southeast Asi... more This report describes a one-year experience with a new program of group therapy for Southeast Asians who were treated in a psychiatric program for Indochinese refugees. Cultural factors involving communication styles, respect for authority, and traditional social relationships greatly influence the group process. Socialization experiences which encouraged traditional activities and practical information were the most acceptable medium by all the groups. Psychological issues of losses, cultural conflicts, and persistent discussion of somatic symptoms were voiced throughout the activities. Formal group psychotherapy was periodically useful in some groups. Flexibility, meeting concrete needs, keeping a bicultural focus, and maintaining the individual therapy sessions contributed to the acceptance by the patient.
American Heart Journal, 2013
Background Prior studies have suggested an association between higher heart rate and higher morta... more Background Prior studies have suggested an association between higher heart rate and higher mortality, particularly in chronic heart failure (HF). Whether this relationship holds true in patients hospitalized with HF and differs between patients in sinus rhythm (SR) and atrial fibrillation (AF) has not been well studied. Methods We examined 145,221 admissions for HF from 295 hospitals enrolled in Get With The Guidelines-Heart Failure from January 2005 through September 2011. The associations of admission heart rate with in-hospital outcomes were evaluated overall and by heart rhythm. Results Patients presenting at higher heart rate tended to be younger and have less comorbidities. In-hospital mortality had a J-shaped relationship with heart rate, with the lowest mortality rate associated with heart rates between 70 and 75. However, the relationship differed between patients presenting in SR and AF: at heart rates above 100, the mortality curve for AF plateaued, whereas that for SR continued to rise. Higher heart rate was independently associated with higher mortality (SR adjusted OR 1.21, 95% CI 1.15-1.28 per 10 beat per minute increase in heart rate between 70-105; AF adjusted OR 1.20, 95% CI 1.14-1.27). Findings were similar when stratifying patients by ischemic etiology, diabetes, ejection fraction, blood pressure, and β-blocker use. Conclusions Higher admission heart rate is independently associated with worse outcomes in patients admitted for HF, including those in SR and AF. Whether early heart rate reduction improves outcomes in patients hospitalized with HF is worthy of investigation.
Proceedings of the AAAI Conference on Artificial Intelligence
Ensemble-based Adversarial Training is a principled approach to achieve robustness against advers... more Ensemble-based Adversarial Training is a principled approach to achieve robustness against adversarial attacks. An important technicality of this approach is to control the transferability of adversarial examples between ensemble members. We propose in this work a simple, but effective strategy to collaborate among committee models of an ensemble model. This is achieved via the secure and insecure sets defined for each model member on a given sample, hence help us to quantify and regularize the transferability. Consequently, our proposed framework provides the flexibility to reduce the adversarial transferability as well as promote the diversity of ensemble members, which are two crucial factors for better robustness in our ensemble approach. We conduct extensive and comprehensive experiments to demonstrate that our proposed method outperforms the state-of-the-art ensemble baselines, at the same time can detect a wide range of adversarial examples with a near perfect accuracy.
Computer Vision – ECCV 2020, 2020
The fact that deep neural networks are susceptible to crafted perturbations severely impacts the ... more The fact that deep neural networks are susceptible to crafted perturbations severely impacts the use of deep learning in certain domains of application. Among many developed defense models against such attacks, adversarial training emerges as the most successful method that consistently resists a wide range of attacks. In this work, based on an observation from a previous study that the representations of a clean data example and its adversarial examples become more divergent in higher layers of a deep neural net, we propose the Adversary Divergence Reduction Network which enforces local/global compactness and the clustering assumption over an intermediate layer of a deep neural network. We conduct comprehensive experiments to understand the isolating behavior of each component (i.e., local/global compactness and the clustering assumption) and compare our proposed model with state-of-the-art adversarial training methods. The experimental results demonstrate that augmenting adversarial training with our proposed components can further improve the robustness of the network, leading to higher unperturbed and adversarial predictive performances.
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 17, 2018
The design of original twisted charge transfer antennas where a non planar geometry is enforced t... more The design of original twisted charge transfer antennas where a non planar geometry is enforced thanks to one or two bulky ortho-Me substituents allows us to prepare the corresponding ultra-bright Tb(III) and Dy(III) bioprobes. The brightness of the Tb(III) derivative compares well with that of the benchmark Tb-Lumi4 complex. The first bio-imaging experiments with a Dy(III) luminescent bioprobe are also reported.
Journal of the American Chemical Society, Jun 14, 2017
Fluorescent probes that are able to directly measure viscosity are attractive candidates for the ... more Fluorescent probes that are able to directly measure viscosity are attractive candidates for the study of intracellular environments. We report a new class of luminescent rotors, based on the sensitized emission of a terbium(III) complex. A 4-fold increase in both quantum yield and luminescence lifetime was observed in viscous media for the studied complexes, with a lifetime ranging from 0.23 to 0.89 ms over a broad range of viscosities (0.6-1200 cP). The presented approach, relying on the millisecond-scale luminescence lifetime of the lanthanide ions, was applied to fixed T24 cancer cells using temporal sampling lifetime imaging microscopy.
Inorganic chemistry, Jan 18, 2016
An original cationic water-soluble cyclen-based Eu(III) complex [EuL(1)](+) featuring a chromopho... more An original cationic water-soluble cyclen-based Eu(III) complex [EuL(1)](+) featuring a chromophore-functionalized antenna to increase the two-photon (2P) absorption properties was synthesized. The photophysical properties were thoroughly studied in various solvents and rationalized with the help of theoretical calculations. The complex exhibits an optimized 2P absorption cross section. Finally, 2P microscopy imaging experiments on living T24 human cancer cells highlighted the spontaneous internalization and the biological stability of this 2P bioprobe in vitro. Macrocyclic-based antennas open new perspectives for future optimization of the photophysical properties and allows envisaging the design of Eu, Tb, Yb, and Sm bioprobes. This result also opens the way for the design of functional two-photon Ln complexes able to monitor intracellular physicochemical parameters.
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 22, 2015
An original samarium(III) complex based on a triazacyclononane platform functionalized with a cha... more An original samarium(III) complex based on a triazacyclononane platform functionalized with a charge-transfer antenna chromophore exhibited optimized brightness and was successfully used as an emissive species for two-photon microscopy experiments in both the visible and near-infrared spectral ranges.
Nature Reviews Cardiology, 2010
Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the U... more Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing HF is one in five. Although promising evidence shows that the age-adjusted incidence of HF may have plateaued, HF still carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. HF represents a considerable burden to the health-care system, responsible for costs of more than $39 billion annually in the USA alone, and high rates of hospitalizations, readmissions, and outpatient visits. HF is not a single entity, but a clinical syndrome that may have different characteristics depending on age, sex, race or ethnicity, left ventricular ejection fraction (LVEF) status, and HF etiology. Furthermore, pathophysiological differences are observed among patients diagnosed with HF and reduced LVEF compared with HF and preserved LVEF, which are beginning to be better appreciated in epidemiological studies. A number of risk factors, such as ischemic heart disease, hypertension, smoking, obesity, and diabetes, among others, have been identified that both predict the incidence of HF as well as its severity. In this Review, we discuss key features of the epidemiology and risk profile of HF.
Journal of the American College of Cardiology, 2012
Reduces visits to the emergency and hospital admissions Home Monitoring for Heart Failure Preve... more Reduces visits to the emergency and hospital admissions Home Monitoring for Heart Failure Prevent exacerbation through early warning. Patient confidence and peace of mind increases as self-management skills are learned. Support helps patients retain independence and remain in their own homes. How it Works Home monitoring service supports patients with Heart Failure through health coaching and remote monitoring. The service is free to patients.
Community Mental Health Journal, 1988
This report describes a one-year experience with a new program of group therapy for Southeast Asi... more This report describes a one-year experience with a new program of group therapy for Southeast Asians who were treated in a psychiatric program for Indochinese refugees. Cultural factors involving communication styles, respect for authority, and traditional social relationships greatly influence the group process. Socialization experiences which encouraged traditional activities and practical information were the most acceptable medium by all the groups. Psychological issues of losses, cultural conflicts, and persistent discussion of somatic symptoms were voiced throughout the activities. Formal group psychotherapy was periodically useful in some groups. Flexibility, meeting concrete needs, keeping a bicultural focus, and maintaining the individual therapy sessions contributed to the acceptance by the patient.
American Heart Journal, 2013
Background Prior studies have suggested an association between higher heart rate and higher morta... more Background Prior studies have suggested an association between higher heart rate and higher mortality, particularly in chronic heart failure (HF). Whether this relationship holds true in patients hospitalized with HF and differs between patients in sinus rhythm (SR) and atrial fibrillation (AF) has not been well studied. Methods We examined 145,221 admissions for HF from 295 hospitals enrolled in Get With The Guidelines-Heart Failure from January 2005 through September 2011. The associations of admission heart rate with in-hospital outcomes were evaluated overall and by heart rhythm. Results Patients presenting at higher heart rate tended to be younger and have less comorbidities. In-hospital mortality had a J-shaped relationship with heart rate, with the lowest mortality rate associated with heart rates between 70 and 75. However, the relationship differed between patients presenting in SR and AF: at heart rates above 100, the mortality curve for AF plateaued, whereas that for SR continued to rise. Higher heart rate was independently associated with higher mortality (SR adjusted OR 1.21, 95% CI 1.15-1.28 per 10 beat per minute increase in heart rate between 70-105; AF adjusted OR 1.20, 95% CI 1.14-1.27). Findings were similar when stratifying patients by ischemic etiology, diabetes, ejection fraction, blood pressure, and β-blocker use. Conclusions Higher admission heart rate is independently associated with worse outcomes in patients admitted for HF, including those in SR and AF. Whether early heart rate reduction improves outcomes in patients hospitalized with HF is worthy of investigation.