Anh Doan - Academia.edu (original) (raw)

Papers by Anh Doan

Research paper thumbnail of A Curious Use of Extra Dimension in Classical Mechanics

Cornell University - arXiv, May 11, 2021

Research paper thumbnail of Classrooms & Curriculum

Panel Chair: Lisa Roy-Davis Papers Presented: Should the State of Texas Allow Public Universities... more Panel Chair: Lisa Roy-Davis Papers Presented: Should the State of Texas Allow Public Universities and Colleges to Permit Guns on Campuses? By Devin Walz Pets in the Elementary Classroom by Anh Doan Technology Case Study of K-12 Students by Cathy Tran Abstract: Technology is an exponentially revolutionizing tool that has pushed all aspects of society to adapt and grow in the time known as the “Information Age”. The way that humans process information, and the speed at which humans can process information, with technology allows humans to grow more efficiently and effectively. Technology is continually designed to become more optimal in business environments where the amount of money and resources are dependent on the efficiently and effectiveness of product development. Similar methods of innovation using technology can be applied to public education teaching to optimize learning in the traditional grade levels of kindergarten to grade 12 (K-12). Unlike business environments, traditi...

Research paper thumbnail of An improved test of the binary black hole hypothesis for quasars with double-peaked broad Balmer lines

Monthly Notices of the Royal Astronomical Society, 2020

Research paper thumbnail of Pyrazinamide-induced hyperuricemia

P & T : a peer-reviewed journal for formulary management, Oct 1, 2014

Research paper thumbnail of Financial Freedom and Bank Efficiency: The Role of National Governance Quality

This paper investigates the impacts of fianancial freedom and national governance quality on bank... more This paper investigates the impacts of fianancial freedom and national governance quality on bank efficiency, employing data of 37 Vietnam commercial banks over the period 2003-2014. Using stochatic frontier approach to estimate bank efficiency scores, the author finds the evidence that increase in financial freedom is positively associated with bank efficiency. The results also show that most indicators of Vietnam governnance quality tend to play an important role in improving the relation between financial freedom and bank efficiency.

Research paper thumbnail of MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase

Molecular Cell, 2022

Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite t... more Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite their central role in fine-tuning gene-expression programs, we find complete loss of CDK8/19 is tolerated in colorectal cancer (CRC) cells. Using orthogonal functional genomic and pharmacological screens, we identify BET protein inhibition as a distinct vulnerability in CDK8/19-depleted cells. Combined CDK8/19 and BET inhibition led to synergistic growth retardation in human and mouse models of CRC. Strikingly, depletion of CDK8/19 in these cells led to global repression of RNA polymerase II (Pol II) promoter occupancy and transcription. Concurrently, loss of Mediator kinase led to a profound increase in MED12 and BRD4 co-occupancy at enhancer elements and increased dependence on BET proteins for the transcriptional output of cell-essential genes. In total, this work demonstrates a synthetic lethal interaction between Mediator kinase and BET proteins and exposes a therapeutic vulnerability that can be targeted using combination therapies.

Research paper thumbnail of The political personality of 2016 presidential candidate Rand Paul

Research paper thumbnail of UV Spectra of Three Changing-Look Quasars and Tests of Scenarios for Their Transformations

Research paper thumbnail of Pets in the Elementary Classroom

Research paper thumbnail of Spectroscopic Tests Of The Bound, Binary Supermassive Black Hole Hypothesis For Quasars With Broad Balmer Lines With Single And Double Displaced Peaks

Research paper thumbnail of Increase the Efficiency and Productivity of Sewing Section through Low Performing Operators Improvement by using Eight Wastes of Lean Methodology

Global Journal of Research In Engineering, 2018

This paper represents the use of some tools and techniques to increase the efficiency and product... more This paper represents the use of some tools and techniques to increase the efficiency and productivity of an apparel sewing section through low performing operators’ improvement. Now a day’s apparel manufacturing industries are trying to develop their current production system and situation and continuously looking for new production tools and techniques to keep swiftness with the rapid changes of the trend in consumers of apparel products. To deal with the current situation and fulfill customer demand within lead time, whole production system should be more capable and efficient. Full apparel is produced based on the performance and contribution of individual workforce. There is no doubt that operators are selected and appointed on the specific tasks based on their evaluation and performance level where they are capable.

Research paper thumbnail of A new, sophisticated test of the Binary Black Hole Hypothesis for Quasars with Double-peaked Broad Balmer Lines

Research paper thumbnail of Probing the Disk–Corona Systems and Broad-line Regions of Changing-look Quasars with X-Ray and Optical Observations

The Astrophysical Journal, 2021

Research paper thumbnail of Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer

Science Advances, 2021

Genome-scale CRISPR screen identifies KMT2A as a druggable target against Wnt/β-catenin signaling... more Genome-scale CRISPR screen identifies KMT2A as a druggable target against Wnt/β-catenin signaling and colorectal cancer.

Research paper thumbnail of OUP accepted manuscript

Monthly Notices of the Royal Astronomical Society, 2019

Velocity offsets in the broad Balmer lines of quasars and their temporal variations serve as indi... more Velocity offsets in the broad Balmer lines of quasars and their temporal variations serve as indirect evidence for bound supermassive black hole binaries (SBHBs) at sub-parsec separations. In this work, we test the SBHB hypothesis for 14 quasars with double-peaked broad emission lines using their long-term (14–41 years) radial velocity curves. We improve on previous work by (a) using elliptical instead of circular orbits for the SBHBs, (b) adopting a statistical model for radial velocity jitter, (c) employing a Markov Chain Monte Carlo method to explore the orbital parameter space efficiently and build posterior distributions of physical parameters and (d) incorporating new observations. We determine empirically that jitter comprises approximately Gaussian distributed fluctuations about the smooth radial velocity curves that are larger than the measurement errors by factors of order a few. We initially treat jitter by enlarging the effective error bars and then verify this approach ...

Research paper thumbnail of Determination of Optimal Location and Sizing of Solar Photovoltaic Distribution Generation Units in Radial Distribution Systems

Energies, 2019

This paper presents an effective biogeography-based optimization (BBO) for optimal location and s... more This paper presents an effective biogeography-based optimization (BBO) for optimal location and sizing of solar photovoltaic distributed generation (PVDG) units to reduce power losses while maintaining voltage profile and voltage harmonic distortion at the limits. This applied algorithm was motivated by biogeography, that the study of the distribution of biological species through time and space. This technique is able to expand the searching space and retain good solution group at each generation. Therefore, the applied method can significantly improve performance. The effectiveness of the applied algorithm is validated by testing it on IEEE 33-bus and IEEE 69-bus radial distribution systems. The obtained results are compared with the genetic algorithm (GA), the particle swarm optimization algorithm (PSO) and the artificial bee colony algorithm (ABC). As a result, the applied algorithm offers better solution quality and accuracy with faster convergence.

Research paper thumbnail of Beyond organization-centred public relations: Collective action through a civic crowdfunding campaign

Public Relations Review, 2018

Research paper thumbnail of From conventional to disruptive: upturning the HIV testing status quo among men who have sex with men in Vietnam

Journal of the International AIDS Society, 2018

HIV prevalence among men who have sex with men (MSM) in Vietnam is increasing, while annual HIV t... more HIV prevalence among men who have sex with men (MSM) in Vietnam is increasing, while annual HIV testing uptake has remained consistently low, posing a significant challenge to reaching the 90-90-90 goals. Barriers to MSM seeking HIV testing include concerns regarding confidentiality and lack of convenient testing options. Two new HIV testing strategies-HIV lay provider and HIV self-testing (HIVST)-were piloted alongside intensive social media outreach to increase access to and uptake of HIV testing among MSM not actively engaged in services. We measured the proportion of first-time MSM HIV testers opting for HIV lay or self-testing, and factors that were associated with first-time testing, as part of a larger HIV lay and self-testing study among key populations in Vietnam. We also assessed MSM satisfaction with HIV lay or self-testing, and testing location and provider preferences. Finally, we calculated linkage to care cascade among MSM that were diagnosed and enrolled in anti-retr...

Research paper thumbnail of WRINKLED1 and ACYL-COA:DIACYLGLYCEROL ACYLTRANSFERASE1 regulate tocochromanol metabolism in Arabidopsis

The New phytologist, 2018

Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, ... more Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, a group of compounds that encompasses tocopherols and tocotrienols and that exhibits vitamin E activity in animals. While most vitamin E biosynthetic genes have been identified in plant genomes, regulatory genes controlling tocopherol accumulation are currently unknown. We isolated by forward genetics Arabidopsis enhanced vitamin E (eve) mutants that overaccumulate the classic tocopherols and plastochromanol-8, and a tocochromanol unknown in this species. We mapped eve1 and eve4, and identified the unknown Arabidopsis tocochromanol by using a combination of analytical tools. In addition, we determined its biosynthetic pathway with a series of tocochromanol biosynthetic mutants and transgenic lines. eve1 and eve4 are two seed lipid mutants affecting the WRINKLED1 (WRI1) and ACYL-COA:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) genes, respectively. The unknown tocochromanol is 11'-12' γ...

Research paper thumbnail of Electrocoagulation for ammonium removal in Nam Son landfill leachate

VNU Journal of Science: Earth and Environmental Sciences, 2017

In this paper, an electrocoagulation reactor was set up to investigate the ammonium removal in Na... more In this paper, an electrocoagulation reactor was set up to investigate the ammonium removal in Nam Son landfill leachate. The research focused on studying several factors that affect to the ammonium removal namely current intensity, operating time, initial pH and electrode materials. Mono-polar electrocoagulation reactor was conducted in a batch system with iron electrodes and 1.8 L leachate. The research indicated that current intensity and operating time are directly proportional with NH4+ treatment performance. When applied current increased from 1 to 4A, the NH4+ removal percentage went up from 14.03 to 24.99% after a 1 hour treatment. The effect of initial pH in range of 5 to 10 has showed that the best NH4+ treatment efficiency in neutral and mild alkaline conditions. It is noticeable that iron electrodes had higher NH4+ removal than aluminum one during nearly the first 40 min, however this trend has been reversed later with the advantage belonging to aluminum anode. The optim...

Research paper thumbnail of A Curious Use of Extra Dimension in Classical Mechanics

Cornell University - arXiv, May 11, 2021

Research paper thumbnail of Classrooms & Curriculum

Panel Chair: Lisa Roy-Davis Papers Presented: Should the State of Texas Allow Public Universities... more Panel Chair: Lisa Roy-Davis Papers Presented: Should the State of Texas Allow Public Universities and Colleges to Permit Guns on Campuses? By Devin Walz Pets in the Elementary Classroom by Anh Doan Technology Case Study of K-12 Students by Cathy Tran Abstract: Technology is an exponentially revolutionizing tool that has pushed all aspects of society to adapt and grow in the time known as the “Information Age”. The way that humans process information, and the speed at which humans can process information, with technology allows humans to grow more efficiently and effectively. Technology is continually designed to become more optimal in business environments where the amount of money and resources are dependent on the efficiently and effectiveness of product development. Similar methods of innovation using technology can be applied to public education teaching to optimize learning in the traditional grade levels of kindergarten to grade 12 (K-12). Unlike business environments, traditi...

Research paper thumbnail of An improved test of the binary black hole hypothesis for quasars with double-peaked broad Balmer lines

Monthly Notices of the Royal Astronomical Society, 2020

Research paper thumbnail of Pyrazinamide-induced hyperuricemia

P & T : a peer-reviewed journal for formulary management, Oct 1, 2014

Research paper thumbnail of Financial Freedom and Bank Efficiency: The Role of National Governance Quality

This paper investigates the impacts of fianancial freedom and national governance quality on bank... more This paper investigates the impacts of fianancial freedom and national governance quality on bank efficiency, employing data of 37 Vietnam commercial banks over the period 2003-2014. Using stochatic frontier approach to estimate bank efficiency scores, the author finds the evidence that increase in financial freedom is positively associated with bank efficiency. The results also show that most indicators of Vietnam governnance quality tend to play an important role in improving the relation between financial freedom and bank efficiency.

Research paper thumbnail of MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase

Molecular Cell, 2022

Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite t... more Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite their central role in fine-tuning gene-expression programs, we find complete loss of CDK8/19 is tolerated in colorectal cancer (CRC) cells. Using orthogonal functional genomic and pharmacological screens, we identify BET protein inhibition as a distinct vulnerability in CDK8/19-depleted cells. Combined CDK8/19 and BET inhibition led to synergistic growth retardation in human and mouse models of CRC. Strikingly, depletion of CDK8/19 in these cells led to global repression of RNA polymerase II (Pol II) promoter occupancy and transcription. Concurrently, loss of Mediator kinase led to a profound increase in MED12 and BRD4 co-occupancy at enhancer elements and increased dependence on BET proteins for the transcriptional output of cell-essential genes. In total, this work demonstrates a synthetic lethal interaction between Mediator kinase and BET proteins and exposes a therapeutic vulnerability that can be targeted using combination therapies.

Research paper thumbnail of The political personality of 2016 presidential candidate Rand Paul

Research paper thumbnail of UV Spectra of Three Changing-Look Quasars and Tests of Scenarios for Their Transformations

Research paper thumbnail of Pets in the Elementary Classroom

Research paper thumbnail of Spectroscopic Tests Of The Bound, Binary Supermassive Black Hole Hypothesis For Quasars With Broad Balmer Lines With Single And Double Displaced Peaks

Research paper thumbnail of Increase the Efficiency and Productivity of Sewing Section through Low Performing Operators Improvement by using Eight Wastes of Lean Methodology

Global Journal of Research In Engineering, 2018

This paper represents the use of some tools and techniques to increase the efficiency and product... more This paper represents the use of some tools and techniques to increase the efficiency and productivity of an apparel sewing section through low performing operators’ improvement. Now a day’s apparel manufacturing industries are trying to develop their current production system and situation and continuously looking for new production tools and techniques to keep swiftness with the rapid changes of the trend in consumers of apparel products. To deal with the current situation and fulfill customer demand within lead time, whole production system should be more capable and efficient. Full apparel is produced based on the performance and contribution of individual workforce. There is no doubt that operators are selected and appointed on the specific tasks based on their evaluation and performance level where they are capable.

Research paper thumbnail of A new, sophisticated test of the Binary Black Hole Hypothesis for Quasars with Double-peaked Broad Balmer Lines

Research paper thumbnail of Probing the Disk–Corona Systems and Broad-line Regions of Changing-look Quasars with X-Ray and Optical Observations

The Astrophysical Journal, 2021

Research paper thumbnail of Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer

Science Advances, 2021

Genome-scale CRISPR screen identifies KMT2A as a druggable target against Wnt/β-catenin signaling... more Genome-scale CRISPR screen identifies KMT2A as a druggable target against Wnt/β-catenin signaling and colorectal cancer.

Research paper thumbnail of OUP accepted manuscript

Monthly Notices of the Royal Astronomical Society, 2019

Velocity offsets in the broad Balmer lines of quasars and their temporal variations serve as indi... more Velocity offsets in the broad Balmer lines of quasars and their temporal variations serve as indirect evidence for bound supermassive black hole binaries (SBHBs) at sub-parsec separations. In this work, we test the SBHB hypothesis for 14 quasars with double-peaked broad emission lines using their long-term (14–41 years) radial velocity curves. We improve on previous work by (a) using elliptical instead of circular orbits for the SBHBs, (b) adopting a statistical model for radial velocity jitter, (c) employing a Markov Chain Monte Carlo method to explore the orbital parameter space efficiently and build posterior distributions of physical parameters and (d) incorporating new observations. We determine empirically that jitter comprises approximately Gaussian distributed fluctuations about the smooth radial velocity curves that are larger than the measurement errors by factors of order a few. We initially treat jitter by enlarging the effective error bars and then verify this approach ...

Research paper thumbnail of Determination of Optimal Location and Sizing of Solar Photovoltaic Distribution Generation Units in Radial Distribution Systems

Energies, 2019

This paper presents an effective biogeography-based optimization (BBO) for optimal location and s... more This paper presents an effective biogeography-based optimization (BBO) for optimal location and sizing of solar photovoltaic distributed generation (PVDG) units to reduce power losses while maintaining voltage profile and voltage harmonic distortion at the limits. This applied algorithm was motivated by biogeography, that the study of the distribution of biological species through time and space. This technique is able to expand the searching space and retain good solution group at each generation. Therefore, the applied method can significantly improve performance. The effectiveness of the applied algorithm is validated by testing it on IEEE 33-bus and IEEE 69-bus radial distribution systems. The obtained results are compared with the genetic algorithm (GA), the particle swarm optimization algorithm (PSO) and the artificial bee colony algorithm (ABC). As a result, the applied algorithm offers better solution quality and accuracy with faster convergence.

Research paper thumbnail of Beyond organization-centred public relations: Collective action through a civic crowdfunding campaign

Public Relations Review, 2018

Research paper thumbnail of From conventional to disruptive: upturning the HIV testing status quo among men who have sex with men in Vietnam

Journal of the International AIDS Society, 2018

HIV prevalence among men who have sex with men (MSM) in Vietnam is increasing, while annual HIV t... more HIV prevalence among men who have sex with men (MSM) in Vietnam is increasing, while annual HIV testing uptake has remained consistently low, posing a significant challenge to reaching the 90-90-90 goals. Barriers to MSM seeking HIV testing include concerns regarding confidentiality and lack of convenient testing options. Two new HIV testing strategies-HIV lay provider and HIV self-testing (HIVST)-were piloted alongside intensive social media outreach to increase access to and uptake of HIV testing among MSM not actively engaged in services. We measured the proportion of first-time MSM HIV testers opting for HIV lay or self-testing, and factors that were associated with first-time testing, as part of a larger HIV lay and self-testing study among key populations in Vietnam. We also assessed MSM satisfaction with HIV lay or self-testing, and testing location and provider preferences. Finally, we calculated linkage to care cascade among MSM that were diagnosed and enrolled in anti-retr...

Research paper thumbnail of WRINKLED1 and ACYL-COA:DIACYLGLYCEROL ACYLTRANSFERASE1 regulate tocochromanol metabolism in Arabidopsis

The New phytologist, 2018

Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, ... more Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, a group of compounds that encompasses tocopherols and tocotrienols and that exhibits vitamin E activity in animals. While most vitamin E biosynthetic genes have been identified in plant genomes, regulatory genes controlling tocopherol accumulation are currently unknown. We isolated by forward genetics Arabidopsis enhanced vitamin E (eve) mutants that overaccumulate the classic tocopherols and plastochromanol-8, and a tocochromanol unknown in this species. We mapped eve1 and eve4, and identified the unknown Arabidopsis tocochromanol by using a combination of analytical tools. In addition, we determined its biosynthetic pathway with a series of tocochromanol biosynthetic mutants and transgenic lines. eve1 and eve4 are two seed lipid mutants affecting the WRINKLED1 (WRI1) and ACYL-COA:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) genes, respectively. The unknown tocochromanol is 11'-12' γ...

Research paper thumbnail of Electrocoagulation for ammonium removal in Nam Son landfill leachate

VNU Journal of Science: Earth and Environmental Sciences, 2017

In this paper, an electrocoagulation reactor was set up to investigate the ammonium removal in Na... more In this paper, an electrocoagulation reactor was set up to investigate the ammonium removal in Nam Son landfill leachate. The research focused on studying several factors that affect to the ammonium removal namely current intensity, operating time, initial pH and electrode materials. Mono-polar electrocoagulation reactor was conducted in a batch system with iron electrodes and 1.8 L leachate. The research indicated that current intensity and operating time are directly proportional with NH4+ treatment performance. When applied current increased from 1 to 4A, the NH4+ removal percentage went up from 14.03 to 24.99% after a 1 hour treatment. The effect of initial pH in range of 5 to 10 has showed that the best NH4+ treatment efficiency in neutral and mild alkaline conditions. It is noticeable that iron electrodes had higher NH4+ removal than aluminum one during nearly the first 40 min, however this trend has been reversed later with the advantage belonging to aluminum anode. The optim...