Aníbal de Freitas Santos Júnior (original) (raw)

Papers by Aníbal de Freitas Santos Júnior

Cadernos de Ciências Sociais Aplicadas, 2019

O presente artigo trata das bases epistemológicas de um estudo em andamento sobre a agrobiodivers... more O presente artigo trata das bases epistemológicas de um estudo em andamento sobre a agrobiodiversidade e as Pancs, nos povoados de Gravatá de Baixo e Baixa Grande, este último, uma comunidade quilombola. Ambas as comunidades localizam-se no município de Muritiba, Bahia, e são formadas por pequenos trabalhadores rurais, que cultivam plantas como mandioca, aipim, citros, cereais e verduras, base da cultura alimentar da região. Nesse contexto, o cultivo tradicional nas comunidades locais da região colabora para a manutenção da agrobiodiversidade. O modo próprio de plantar e de colher desses agricultores baseia-se nas tradições passadas de uma geração para a outra e pode ter influência direta na cultura alimentar da região. Dessa forma, o objetivo é dialogar sobre as bases epistemológicas que favoreçam a análise das inter-relações de cooperação entre as comunidades locais e povos tradicionais por meio da agrobiodiversidade e da utilização da Pancs, nos povoados de Gravatá de Baixo e Bai...

Molecules

Brazil has a megadiversity that includes marine species that are distributed along 800 km of shor... more Brazil has a megadiversity that includes marine species that are distributed along 800 km of shoreline. This biodiversity status holds promising biotechnological potential. Marine organisms are important sources of novel chemical species, with applications in the pharmaceutical, cosmetic, chemical, and nutraceutical fields. However, ecological pressures derived from anthropogenic actions, including the bioaccumulation of potentially toxic elements and microplastics, impact promising species. This review describes the current status of the biotechnological and environmental aspects of seaweeds and corals from the Brazilian coast, including publications from the last 5 years (from January 2018 to December 2022). The search was conducted in the main public databases (PubChem, PubMed, Science Direct, and Google Scholar) and in the Espacenet database (European Patent Office—EPO) and the Brazilian National Property Institute (INPI). Bioprospecting studies were reported for seventy-one sea...

Journal of Trace Elements in Medicine and Biology

Revista Colombiana de Ciencias Químico-Farmacéuticas, 2020

Journal of the Brazilian Chemical Society, 2020

In this study, antimicrobial activity of extracts and lupenone from A. inundata (Fabaceae, Mimoso... more In this study, antimicrobial activity of extracts and lupenone from A. inundata (Fabaceae, Mimosoideae), were tested. In addition, the multi-element composition of the leaves, bark and stems (heartwood) of A. inundata was evaluated using inductively coupled plasma optical emission spectrometry (ICP OES). Lupenone was isolated in the petroleum ether extract of leaves, for the first time. Biological assays were conducted to evaluate the antimicrobial (antibacterial, antifungal and antiparasitic) of extracts, their fractions and lupenone. The results showed antimicrobial and antileishmanial activity of these compounds, which may be useful for obtaining a chemical composition and biological activity database on Albizia species. For multi-element composition, we found the mean concentrations (minimum-maximum) of Al, Ca, Cr, Cu, Fe, K, Mg, Mn, Ni, P, V and Zn in the samples ranged between 0.06 and 265.41 μg g-1. Concentration ranges of Cu, Fe, Mn and Zn are large, which makes these samples as additional sources of these macronutrients.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2018

Furosemide can interfere with the metabolism of chemical elements, changing their levels in sever... more Furosemide can interfere with the metabolism of chemical elements, changing their levels in several tissues, thus causing imbalance. In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis (Cd, Cu, Fe, Mg, Pb, Se and Zn) after microwave-assisted digestion, to evaluate the effect of furosemide (loop diuretic) on the composition of these essential and toxic elements in biological samples (liver, kidney, heart, lung and serum) of Wistar rats. Male and female Wistar rats (n = 40, 180-350 g) were randomly divided into 2 groups (n = 20/group). The results were expressed as μg/g dry weight. The mean tissue concentrations (minimum-maximum in μg/g) of Cu, Fe, Mg and Zn in the biological samples ranged between 5.2 and 1023.5. The levels of Cd, Pb and Se were below the detection limit of the ICP OES. Accuracy was assessed by microwave-assisted digestion and recovery values of 83-116% were obtained. Liver had significantly higher tra...

Journal of the Brazilian Chemical Society, 2017

This study proposes an optimized procedure for the determination of inorganic antimony species in... more This study proposes an optimized procedure for the determination of inorganic antimony species in natural waters using hydride generation atomic fluorescence spectrometry (HG AFS) and continuous flow system. The variables of the hydride generation system, such as pre-reduction time, hydrochloric acid concentration and sodium tetrahydroborate concentration, were evaluated using full factorial design at two levels and Doehlert design. After optimized experimental conditions, the method allowed the determination of antimony with limits of detection and quantification of 9 and 30 ng L-1 , respectively. The precision (RSD) of the method was < 5% and the accuracy was confirmed by the analysis of certified reference material (SLRS-4, River water for trace metals). The method was successfully applied for inorganic antimony speciation in water samples collected in Salvador City, Bahia State, Brazil. In mineral water, total Sb concentrations ranged from 0.26 to 0.30 µg L-1 , whereas the concentrations of Sb III were below 0.03 µg L-1. On the other hand, in natural surface waters, the quantifiable concentration of total Sb and Sb III ranged from 0.41 to 1.23 µg L-1 and 0.23 to 1.04 µg L-1 , respectively. The highest average concentrations of Sb were obtained in regions with the largest urban influence, ratifying the anthropogenic impact in water bodies.

Infarma - Ciências Farmacêuticas, 2016

Nephelium lappaceum L., conhecido como Rambutã, é um fruto tropical atraente, que contém composto... more Nephelium lappaceum L., conhecido como Rambutã, é um fruto tropical atraente, que contém compostos fenólicos (taninos e flavonoides) e alcaloides. O objetivo deste trabalho foi avaliar a capacidade antioxidante e a toxicidade das cascas do fruto de Nephelium lappaceum L. (Rambutã), comercializados em Salvador, Bahia, Brasil, pelo método do 2,2-difenil-1-picrilidrazil (DPPH), e do teste de toxicidade a larvas de Artemia salina, respectivamente. Para osexperimentos, foram utilizadas as fases orgânicas hexano e acetato de etila, obtidas da partição do extrato metanólico. Foi empregado o método do 2,2– difenil-1-picrilidrazil (DPPH) e o teste de toxicidade frente Artemia salina. A fase acetato de etila apresentou maior poder antioxidante e menor efeito tóxico quando comparada à fase hexânica. Quanto à atividade antioxidante, foram obtidas CE50 de 373,72 μg/mL e 1207,4 μg/mL para as fases acetato de etila e hexânica, respectivamente. Quanto à toxicidade, foram obtidas DL50 de 799,28 μg/m...

Dissolution Technologies, 2020

Tetracyclines are widely used for the treatment of infections of the lower respiratory tract and ... more Tetracyclines are widely used for the treatment of infections of the lower respiratory tract and other systems. In Brazil, tetracyclines are available as generic and similar products. The aim of this study was to evaluate the in vitro release of tetracycline capsules (500 mg) and doxycycline tablets (100 mg) in different reaction media, from dissolution profiles, using sensitive and rapid ultraviolet spectrophotometric methods. The dissolution test was used to obtain and compare dissolution profiles and establish similarities of pharmaceutical formulations in compliance with the Brazilian (for tetracycline hydrochloride capsules) and United States (USP) (for doxycycline hydrochloride tablets) pharmacopoeia. For both drugs, the dissolution studies were conducted using an USP type 2 apparatus at 75 rpm with 1000 mL distilled water at 37.0 ± 0.5 ºC for 90 minutes, to evaluate the influence of pH (1.0-8.0) on the release of drugs. The methods were validated, showing precision, linearity, and accuracy. All the products satisfactorily released tetracycline and doxycycline, with at least 80% of the drug dissolved within 30 minutes. Tetracycline and doxycycline are weak acids, which favors their dissolution in acid media (pH range 1.0-6.0). This research contributes to studies that guarantee the quality control of tetracyclines and to the expansion of the novel methodologies established by the Brazilian Pharmacopoeia for doxycycline.

Pharmaceuticals

Flavonoids are a group of natural compounds that have been described in the literature as having ... more Flavonoids are a group of natural compounds that have been described in the literature as having anti-inflammatory, antioxidant, and neuroprotective compounds. Although they are considered versatile molecules, little has been discussed about their antiviral activities for neurotropic viruses. Hence, the present study aimed to investigate the pharmacological potential of flavonoids in the face of viruses that can affect the central nervous system (CNS). We carried out research from 2011 to 2021 using the Pubmed platform. The following were excluded: articles not in the English language, letters to editors, review articles and papers that did not include any experimental or clinical tests, and papers that showed antiviral activities against viruses that do not infect human beings. The inclusion criteria were in silico predictions and preclinical pharmacological studies, in vitro, in vivo and ex vivo, and clinical studies with flavonoids, flavonoid fractions and extracts that were acti...

Revista Baiana de Saúde Pública

Este estudo tem como objetivo descrever o perfil clínico-epidemiológico de pessoas com HIV/Aids a... more Este estudo tem como objetivo descrever o perfil clínico-epidemiológico de pessoas com HIV/Aids acompanhadas pelo Serviço Municipal de Assistência Especializada. Para isso, foi realizado um estudo descrito e retrospectivo, com dados de 125 pessoas acompanhadas pelo serviço, coletados em prontuários. Os dados foram descritos em proporção. Houve predomínio de indivíduos do sexo masculino (61,6%), faixa etária de 20 a 39 anos (37,6%), negros (93,5%), solteiros, separados ou viúvos (50,4%) e heterossexuais (60,0%). Tuberculose foi a coinfecção mais prevalente (9,6%) e sífilis foi a doença mais presente no histórico de coinfecções (28,8%). Ao todo, 48,4% dos indivíduos acessaram o serviço tardiamente e a maioria não fazia uso de drogas (76,0%). A partir das informações coletadas, conclui-se que o perfil clínico-epidemiológico é composto predominantemente de homens, entre 20 e 39 anos, negros, solteiros, separados ou viúvos, heterossexuais e não usuários de droga. Adultos jovens tiveram m...

Journal of Food Measurement and Characterization, 2022

Conventional and unconventional food plants, in addition to macronutrients, are also rich in bioa... more Conventional and unconventional food plants, in addition to macronutrients, are also rich in bioactive compounds, which have the antioxidant capacity and, therefore, are associated with the prevention of various diseases. There are several factors that can interfere with the concentration of these substances, such as: parts of the plant, extraction solvents, temperature, etc. The study was undertaken to extract and to characterize quantitatively the content of total phenolic compounds (TPC) in “Taioba” or Cocoyam (Xanthosoma sagittifolium) from Brazil, before and after heat treatments in different parts of the plant. TPC were performed by the Folin-Ciocalteu method and the antioxidant activity by DPPH, ABTS and FRAP methods. Principal component analysis (PCA) was used to explore the data generated. The variables (extraction solvent, parts of “Taioba” and heat treatment) influenced the TPC concentrations and antioxidant activity. The contents (mg/100 g) of TPC were higher in the natu...

Diálogos e Perspectivas Interventivas, 2020

Este artigo tem como objetivo discutir, através de uma abordagem descritiva e exploratória, aliad... more Este artigo tem como objetivo discutir, através de uma abordagem descritiva e exploratória, aliada à análise crítica e reflexiva, a estruturação e funcionamento do processo de avaliação dos Programas de Pós-graduação Stricto sensu (PPGSS), pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), no Brasil. São apresentados aspectos históricos, com ênfase na estruturação, desenvolvimento e avaliação, gerenciados pela CAPES. Parâmetros de alinhamento aos padrões internacionais, com dimensões e indicadores centrados em modelos de outros países, estão norteando a avaliação dos PPGSS no país e, nesse contexto, o modelo multidimensional seria uma solução? Questões alinhadas ao papel e função das Universidades e as pós-graduações brasileiras, a ausência de tratamento igualitário de financiamento às pesquisas pelo Governo (nas suas diversas esferas) e pelas Instituições, bem como a valorização das diferenças regionais são discutidas. Tais questões são heterogêneas e de difí...

Ciência e Tecnologia de Alimentos: pesquisa e práticas contemporâneas, 2021

Construção do conhecimento em organizações na perspectiva da modelagem de sistemas cognitivos, 2021

Esta obra é licenciada por uma Licença Creative Commons: Atribuição-NãoComercial-SemDerivações 4.... more Esta obra é licenciada por uma Licença Creative Commons: Atribuição-NãoComercial-SemDerivações 4.0 Internacional-CC BY-NC (CC BY-NC-ND). Os termos desta licença estão disponíveis em: <https://creativecommons.org/licenses/>. Direitos para esta edição cedidos à Pimenta Cultural. O conteúdo publicado não representa a posição oficial da Pimenta Cultural.

Revista Colombiana de Ciencias Químico-Farmacéuticas, 2020

The purpose of this study was to evaluate physicochemical properties and dissolution studies of f... more The purpose of this study was to evaluate physicochemical properties and dissolution studies of furosemide (FUR), hydrochlorothiazide (HCTZ) and nifedipine (NIF), low water solubility drugs, in raw materials and pharmaceutical formulations. Surface and physicochemical characterization techniques -scanning electronic microscopy (SEM), thermogravimetry (TG), X-ray diffraction (XRD) and infrared (IR) spectrometry- as well as physical and physicochemical tests on tablets and capsules were applied as supporting information on drug quality control. Simple, rapid, and efficient UV-Vis methods were developed and validated for the determination of FUR, HCTZ and NIF samples. SEM exhibited considerable differences in the crystal morphological structures. Among the drugs studied, except for furosemide, more than one polymorph was present in the samples. Drug release profiles were satisfactory for all products. FUR and HCTZ tablets exhibited similar dissolution profiles, with very rapid release ...

Journal of the Brazilian Chemical Society, 2020

Malaria, a parasitic infection caused by Plasmodium falciparum, is a serious global public health... more Malaria, a parasitic infection caused by Plasmodium falciparum, is a serious global public health problem. The enzyme enoyl-acyl carrier protein (ACP) reductase present in a limiting step in the biosynthesis of fatty acids type II was used to search for novel molecules with potential inhibitor by virtual screening techniques. A flavonoid library obtained in ChEMBL database (n = 4,008) was filtered through physico-chemical similarity using the Euclidean distance as a criterion. The selected molecules were subjected to molecular docking using the scoring function GridScore in the DOCK 6.5 software. The top 30 ranked molecules by molecular docking were submitted to the AuPosSOM 2.1 software with the aim of clustering molecules by means of intermolecular interactions in order to understand the patterns of these interactions with enoyl-ACP reductase from Plasmodium falciparum (PfENR). We observed the importance of flavonoid moiety to hydrophobic interactions with the active site of enzyme, this confirmed the choice to study this metabolite class as PfENR inhibitors. Moreover, it was possible to recognize which intermolecular interactions contribute to the molecular recognition process.

Brazilian Journal of Development, 2020

Conflitos emocionais em cuidadores de pacientes com doença de alzheimer Emotional conflicts in ca... more Conflitos emocionais em cuidadores de pacientes com doença de alzheimer Emotional conflicts in caregivers of patients with alzheimer's disease

Infarma - Ciências Farmacêuticas, 2014

O objetivo deste trabalho foi analisar as informações técnico-científicas contidas nas bulas de m... more O objetivo deste trabalho foi analisar as informações técnico-científicas contidas nas bulas de medicamentos anticonvulsivantes, quanto a possíveis riscos e alterações farmacológicas durante a gravidez. Foram analisadas informações, sobre os processos farmacológicos e possíveis riscos de quatro fármacos (ácido valpróico, carbamazepina, diazepam e fenitoína) usados como anticonvulsivantes, confrontando os dados obtidos nas bulas de medicamentos com as informações científicas difundidas na literatura pesquisada e na legislação de bulas vigente. A coleta de dados foi efetuada com a investigação das seções Informações ao Paciente e Informações aos Profissionais de Saúde das bulas obtidas em dicionários de especialidades farmacêuticas (DEF), em sites oficiais dos próprios fabricantes ou de instituições que exercem atividades na área da saúde. Das bulas analisadas, 100% apresentaram ausência do item alterações na farmacocinética das drogas antiepilépticas durante a gravidez; regulação das...

Cadernos de Ciências Sociais Aplicadas, 2019

O presente artigo trata das bases epistemológicas de um estudo em andamento sobre a agrobiodivers... more O presente artigo trata das bases epistemológicas de um estudo em andamento sobre a agrobiodiversidade e as Pancs, nos povoados de Gravatá de Baixo e Baixa Grande, este último, uma comunidade quilombola. Ambas as comunidades localizam-se no município de Muritiba, Bahia, e são formadas por pequenos trabalhadores rurais, que cultivam plantas como mandioca, aipim, citros, cereais e verduras, base da cultura alimentar da região. Nesse contexto, o cultivo tradicional nas comunidades locais da região colabora para a manutenção da agrobiodiversidade. O modo próprio de plantar e de colher desses agricultores baseia-se nas tradições passadas de uma geração para a outra e pode ter influência direta na cultura alimentar da região. Dessa forma, o objetivo é dialogar sobre as bases epistemológicas que favoreçam a análise das inter-relações de cooperação entre as comunidades locais e povos tradicionais por meio da agrobiodiversidade e da utilização da Pancs, nos povoados de Gravatá de Baixo e Bai...

Molecules

Brazil has a megadiversity that includes marine species that are distributed along 800 km of shor... more Brazil has a megadiversity that includes marine species that are distributed along 800 km of shoreline. This biodiversity status holds promising biotechnological potential. Marine organisms are important sources of novel chemical species, with applications in the pharmaceutical, cosmetic, chemical, and nutraceutical fields. However, ecological pressures derived from anthropogenic actions, including the bioaccumulation of potentially toxic elements and microplastics, impact promising species. This review describes the current status of the biotechnological and environmental aspects of seaweeds and corals from the Brazilian coast, including publications from the last 5 years (from January 2018 to December 2022). The search was conducted in the main public databases (PubChem, PubMed, Science Direct, and Google Scholar) and in the Espacenet database (European Patent Office—EPO) and the Brazilian National Property Institute (INPI). Bioprospecting studies were reported for seventy-one sea...

Journal of Trace Elements in Medicine and Biology

Revista Colombiana de Ciencias Químico-Farmacéuticas, 2020

Journal of the Brazilian Chemical Society, 2020

In this study, antimicrobial activity of extracts and lupenone from A. inundata (Fabaceae, Mimoso... more In this study, antimicrobial activity of extracts and lupenone from A. inundata (Fabaceae, Mimosoideae), were tested. In addition, the multi-element composition of the leaves, bark and stems (heartwood) of A. inundata was evaluated using inductively coupled plasma optical emission spectrometry (ICP OES). Lupenone was isolated in the petroleum ether extract of leaves, for the first time. Biological assays were conducted to evaluate the antimicrobial (antibacterial, antifungal and antiparasitic) of extracts, their fractions and lupenone. The results showed antimicrobial and antileishmanial activity of these compounds, which may be useful for obtaining a chemical composition and biological activity database on Albizia species. For multi-element composition, we found the mean concentrations (minimum-maximum) of Al, Ca, Cr, Cu, Fe, K, Mg, Mn, Ni, P, V and Zn in the samples ranged between 0.06 and 265.41 μg g-1. Concentration ranges of Cu, Fe, Mn and Zn are large, which makes these samples as additional sources of these macronutrients.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2018

Furosemide can interfere with the metabolism of chemical elements, changing their levels in sever... more Furosemide can interfere with the metabolism of chemical elements, changing their levels in several tissues, thus causing imbalance. In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis (Cd, Cu, Fe, Mg, Pb, Se and Zn) after microwave-assisted digestion, to evaluate the effect of furosemide (loop diuretic) on the composition of these essential and toxic elements in biological samples (liver, kidney, heart, lung and serum) of Wistar rats. Male and female Wistar rats (n = 40, 180-350 g) were randomly divided into 2 groups (n = 20/group). The results were expressed as μg/g dry weight. The mean tissue concentrations (minimum-maximum in μg/g) of Cu, Fe, Mg and Zn in the biological samples ranged between 5.2 and 1023.5. The levels of Cd, Pb and Se were below the detection limit of the ICP OES. Accuracy was assessed by microwave-assisted digestion and recovery values of 83-116% were obtained. Liver had significantly higher tra...

Journal of the Brazilian Chemical Society, 2017

This study proposes an optimized procedure for the determination of inorganic antimony species in... more This study proposes an optimized procedure for the determination of inorganic antimony species in natural waters using hydride generation atomic fluorescence spectrometry (HG AFS) and continuous flow system. The variables of the hydride generation system, such as pre-reduction time, hydrochloric acid concentration and sodium tetrahydroborate concentration, were evaluated using full factorial design at two levels and Doehlert design. After optimized experimental conditions, the method allowed the determination of antimony with limits of detection and quantification of 9 and 30 ng L-1 , respectively. The precision (RSD) of the method was < 5% and the accuracy was confirmed by the analysis of certified reference material (SLRS-4, River water for trace metals). The method was successfully applied for inorganic antimony speciation in water samples collected in Salvador City, Bahia State, Brazil. In mineral water, total Sb concentrations ranged from 0.26 to 0.30 µg L-1 , whereas the concentrations of Sb III were below 0.03 µg L-1. On the other hand, in natural surface waters, the quantifiable concentration of total Sb and Sb III ranged from 0.41 to 1.23 µg L-1 and 0.23 to 1.04 µg L-1 , respectively. The highest average concentrations of Sb were obtained in regions with the largest urban influence, ratifying the anthropogenic impact in water bodies.

Infarma - Ciências Farmacêuticas, 2016

Nephelium lappaceum L., conhecido como Rambutã, é um fruto tropical atraente, que contém composto... more Nephelium lappaceum L., conhecido como Rambutã, é um fruto tropical atraente, que contém compostos fenólicos (taninos e flavonoides) e alcaloides. O objetivo deste trabalho foi avaliar a capacidade antioxidante e a toxicidade das cascas do fruto de Nephelium lappaceum L. (Rambutã), comercializados em Salvador, Bahia, Brasil, pelo método do 2,2-difenil-1-picrilidrazil (DPPH), e do teste de toxicidade a larvas de Artemia salina, respectivamente. Para osexperimentos, foram utilizadas as fases orgânicas hexano e acetato de etila, obtidas da partição do extrato metanólico. Foi empregado o método do 2,2– difenil-1-picrilidrazil (DPPH) e o teste de toxicidade frente Artemia salina. A fase acetato de etila apresentou maior poder antioxidante e menor efeito tóxico quando comparada à fase hexânica. Quanto à atividade antioxidante, foram obtidas CE50 de 373,72 μg/mL e 1207,4 μg/mL para as fases acetato de etila e hexânica, respectivamente. Quanto à toxicidade, foram obtidas DL50 de 799,28 μg/m...

Dissolution Technologies, 2020

Tetracyclines are widely used for the treatment of infections of the lower respiratory tract and ... more Tetracyclines are widely used for the treatment of infections of the lower respiratory tract and other systems. In Brazil, tetracyclines are available as generic and similar products. The aim of this study was to evaluate the in vitro release of tetracycline capsules (500 mg) and doxycycline tablets (100 mg) in different reaction media, from dissolution profiles, using sensitive and rapid ultraviolet spectrophotometric methods. The dissolution test was used to obtain and compare dissolution profiles and establish similarities of pharmaceutical formulations in compliance with the Brazilian (for tetracycline hydrochloride capsules) and United States (USP) (for doxycycline hydrochloride tablets) pharmacopoeia. For both drugs, the dissolution studies were conducted using an USP type 2 apparatus at 75 rpm with 1000 mL distilled water at 37.0 ± 0.5 ºC for 90 minutes, to evaluate the influence of pH (1.0-8.0) on the release of drugs. The methods were validated, showing precision, linearity, and accuracy. All the products satisfactorily released tetracycline and doxycycline, with at least 80% of the drug dissolved within 30 minutes. Tetracycline and doxycycline are weak acids, which favors their dissolution in acid media (pH range 1.0-6.0). This research contributes to studies that guarantee the quality control of tetracyclines and to the expansion of the novel methodologies established by the Brazilian Pharmacopoeia for doxycycline.

Pharmaceuticals

Flavonoids are a group of natural compounds that have been described in the literature as having ... more Flavonoids are a group of natural compounds that have been described in the literature as having anti-inflammatory, antioxidant, and neuroprotective compounds. Although they are considered versatile molecules, little has been discussed about their antiviral activities for neurotropic viruses. Hence, the present study aimed to investigate the pharmacological potential of flavonoids in the face of viruses that can affect the central nervous system (CNS). We carried out research from 2011 to 2021 using the Pubmed platform. The following were excluded: articles not in the English language, letters to editors, review articles and papers that did not include any experimental or clinical tests, and papers that showed antiviral activities against viruses that do not infect human beings. The inclusion criteria were in silico predictions and preclinical pharmacological studies, in vitro, in vivo and ex vivo, and clinical studies with flavonoids, flavonoid fractions and extracts that were acti...

Revista Baiana de Saúde Pública

Este estudo tem como objetivo descrever o perfil clínico-epidemiológico de pessoas com HIV/Aids a... more Este estudo tem como objetivo descrever o perfil clínico-epidemiológico de pessoas com HIV/Aids acompanhadas pelo Serviço Municipal de Assistência Especializada. Para isso, foi realizado um estudo descrito e retrospectivo, com dados de 125 pessoas acompanhadas pelo serviço, coletados em prontuários. Os dados foram descritos em proporção. Houve predomínio de indivíduos do sexo masculino (61,6%), faixa etária de 20 a 39 anos (37,6%), negros (93,5%), solteiros, separados ou viúvos (50,4%) e heterossexuais (60,0%). Tuberculose foi a coinfecção mais prevalente (9,6%) e sífilis foi a doença mais presente no histórico de coinfecções (28,8%). Ao todo, 48,4% dos indivíduos acessaram o serviço tardiamente e a maioria não fazia uso de drogas (76,0%). A partir das informações coletadas, conclui-se que o perfil clínico-epidemiológico é composto predominantemente de homens, entre 20 e 39 anos, negros, solteiros, separados ou viúvos, heterossexuais e não usuários de droga. Adultos jovens tiveram m...

Journal of Food Measurement and Characterization, 2022

Conventional and unconventional food plants, in addition to macronutrients, are also rich in bioa... more Conventional and unconventional food plants, in addition to macronutrients, are also rich in bioactive compounds, which have the antioxidant capacity and, therefore, are associated with the prevention of various diseases. There are several factors that can interfere with the concentration of these substances, such as: parts of the plant, extraction solvents, temperature, etc. The study was undertaken to extract and to characterize quantitatively the content of total phenolic compounds (TPC) in “Taioba” or Cocoyam (Xanthosoma sagittifolium) from Brazil, before and after heat treatments in different parts of the plant. TPC were performed by the Folin-Ciocalteu method and the antioxidant activity by DPPH, ABTS and FRAP methods. Principal component analysis (PCA) was used to explore the data generated. The variables (extraction solvent, parts of “Taioba” and heat treatment) influenced the TPC concentrations and antioxidant activity. The contents (mg/100 g) of TPC were higher in the natu...

Diálogos e Perspectivas Interventivas, 2020

Este artigo tem como objetivo discutir, através de uma abordagem descritiva e exploratória, aliad... more Este artigo tem como objetivo discutir, através de uma abordagem descritiva e exploratória, aliada à análise crítica e reflexiva, a estruturação e funcionamento do processo de avaliação dos Programas de Pós-graduação Stricto sensu (PPGSS), pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), no Brasil. São apresentados aspectos históricos, com ênfase na estruturação, desenvolvimento e avaliação, gerenciados pela CAPES. Parâmetros de alinhamento aos padrões internacionais, com dimensões e indicadores centrados em modelos de outros países, estão norteando a avaliação dos PPGSS no país e, nesse contexto, o modelo multidimensional seria uma solução? Questões alinhadas ao papel e função das Universidades e as pós-graduações brasileiras, a ausência de tratamento igualitário de financiamento às pesquisas pelo Governo (nas suas diversas esferas) e pelas Instituições, bem como a valorização das diferenças regionais são discutidas. Tais questões são heterogêneas e de difí...

Ciência e Tecnologia de Alimentos: pesquisa e práticas contemporâneas, 2021

Construção do conhecimento em organizações na perspectiva da modelagem de sistemas cognitivos, 2021

Esta obra é licenciada por uma Licença Creative Commons: Atribuição-NãoComercial-SemDerivações 4.... more Esta obra é licenciada por uma Licença Creative Commons: Atribuição-NãoComercial-SemDerivações 4.0 Internacional-CC BY-NC (CC BY-NC-ND). Os termos desta licença estão disponíveis em: <https://creativecommons.org/licenses/>. Direitos para esta edição cedidos à Pimenta Cultural. O conteúdo publicado não representa a posição oficial da Pimenta Cultural.

Revista Colombiana de Ciencias Químico-Farmacéuticas, 2020

The purpose of this study was to evaluate physicochemical properties and dissolution studies of f... more The purpose of this study was to evaluate physicochemical properties and dissolution studies of furosemide (FUR), hydrochlorothiazide (HCTZ) and nifedipine (NIF), low water solubility drugs, in raw materials and pharmaceutical formulations. Surface and physicochemical characterization techniques -scanning electronic microscopy (SEM), thermogravimetry (TG), X-ray diffraction (XRD) and infrared (IR) spectrometry- as well as physical and physicochemical tests on tablets and capsules were applied as supporting information on drug quality control. Simple, rapid, and efficient UV-Vis methods were developed and validated for the determination of FUR, HCTZ and NIF samples. SEM exhibited considerable differences in the crystal morphological structures. Among the drugs studied, except for furosemide, more than one polymorph was present in the samples. Drug release profiles were satisfactory for all products. FUR and HCTZ tablets exhibited similar dissolution profiles, with very rapid release ...

Journal of the Brazilian Chemical Society, 2020

Malaria, a parasitic infection caused by Plasmodium falciparum, is a serious global public health... more Malaria, a parasitic infection caused by Plasmodium falciparum, is a serious global public health problem. The enzyme enoyl-acyl carrier protein (ACP) reductase present in a limiting step in the biosynthesis of fatty acids type II was used to search for novel molecules with potential inhibitor by virtual screening techniques. A flavonoid library obtained in ChEMBL database (n = 4,008) was filtered through physico-chemical similarity using the Euclidean distance as a criterion. The selected molecules were subjected to molecular docking using the scoring function GridScore in the DOCK 6.5 software. The top 30 ranked molecules by molecular docking were submitted to the AuPosSOM 2.1 software with the aim of clustering molecules by means of intermolecular interactions in order to understand the patterns of these interactions with enoyl-ACP reductase from Plasmodium falciparum (PfENR). We observed the importance of flavonoid moiety to hydrophobic interactions with the active site of enzyme, this confirmed the choice to study this metabolite class as PfENR inhibitors. Moreover, it was possible to recognize which intermolecular interactions contribute to the molecular recognition process.

Brazilian Journal of Development, 2020

Conflitos emocionais em cuidadores de pacientes com doença de alzheimer Emotional conflicts in ca... more Conflitos emocionais em cuidadores de pacientes com doença de alzheimer Emotional conflicts in caregivers of patients with alzheimer's disease

Infarma - Ciências Farmacêuticas, 2014

O objetivo deste trabalho foi analisar as informações técnico-científicas contidas nas bulas de m... more O objetivo deste trabalho foi analisar as informações técnico-científicas contidas nas bulas de medicamentos anticonvulsivantes, quanto a possíveis riscos e alterações farmacológicas durante a gravidez. Foram analisadas informações, sobre os processos farmacológicos e possíveis riscos de quatro fármacos (ácido valpróico, carbamazepina, diazepam e fenitoína) usados como anticonvulsivantes, confrontando os dados obtidos nas bulas de medicamentos com as informações científicas difundidas na literatura pesquisada e na legislação de bulas vigente. A coleta de dados foi efetuada com a investigação das seções Informações ao Paciente e Informações aos Profissionais de Saúde das bulas obtidas em dicionários de especialidades farmacêuticas (DEF), em sites oficiais dos próprios fabricantes ou de instituições que exercem atividades na área da saúde. Das bulas analisadas, 100% apresentaram ausência do item alterações na farmacocinética das drogas antiepilépticas durante a gravidez; regulação das...