Aniza Hassan - Academia.edu (original) (raw)

Papers by Aniza Hassan

The significance of BAP1 and MTAP/CDKN2A expression in well-differentiated papillary mesothelial tumour: a series of 21 cases and a review of the literature

Pathology, May 1, 2024

Pulmonary artery intimal sarcoma presenting as lung mass

Human pathology reports, Mar 1, 2023

BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia

Oman Medical Journal, Jul 15, 2021

ObjectivesWe sought to determine the immunohistochemistry expression of mismatch repair (MMR) and... more ObjectivesWe sought to determine the immunohistochemistry expression of mismatch repair (MMR) and BRAF V600E proteins in sporadic young-onset colorectal cancer (CRC) and their association with clinicopathological features in the Kelantan population.MethodsThis was a cross-sectional study of sporadic young-onset CRC over 11 years from 1 January 2006 to 31 December 2017 in Kelantan. Formalin-fixed paraffin-embedded tissue blocks were immunohistochemically stained with antibodies for MMR (MLH1, MSH2, MSH6, and PMS2) and BRAF V600E. These expressions were correlated with clinicopathological parameters.ResultsOur patient sample included 31 patients with a mean age of 31.5 years. More than half (61.3%) of the patients were women. The majority presented with abdominal pain (41.9%), and 71.0% had a tumor located on the right side of the colon, with 83.9% being moderately differentiated adenocarcinoma. The majority of patients presented at stage IV (54.8%). The most frequent pattern was all MMR protein expressions, which constituted patients in the microsatellite stable group (64.5%). Nine (29.0%) were microsatellite instability (MSI-high), and two (6.5%) were MSI-low. Positive BRAF V600E expression was observed in 83.9% of patients. Only histopathological subtypes revealed a significant association with BRAF V600E positive expression (p = 0.015).ConclusionsThe majority of sporadic young-onset CRC presented with abdominal pain and advanced cancer stage. Most were microsatellite stable, and most cases showed positive expressions in all MMR markers and BRAF V600E by immunohistochemistry method. This finding will pave the way for further research on this disease.

Pediatria i Medycyna Rodzinna, May 31, 2022

Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises ... more Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises between the muscle fibres and passes through the intermuscular septa. Due to the infiltrative nature of the tumour, recurrence rate is higher than in other subcutaneous lipomas. Complete surgical excision of lipoma is often regarded as a definitive treatment modality and longterm follow-up is mandatory. Here we report a case of a 49-year-old male presenting with huge left neck mass measuring 12 × 10 cm, which was successfully removed. Computed tomography scan of the neck showed a well-defined septated lesion with a fat component in the right sternocleidomastoid muscle, and the histopathology examination confirmed the diagnosis of well-circumscribed intramuscular sternocleidomastoid lipoma. Follow-up after one year showed no evidence of recurrence.

Real-world prevalence of PD-L1 expression in non-small cell lung cancer: an Australia-wide multi-centre retrospective observational study

Pathology

Pulmonary artery intimal sarcoma presenting as lung mass

Human Pathology Reports

Pediatria i Medycyna Rodzinna

Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises ... more Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises between the muscle fibres and passes through the intermuscular septa. Due to the infiltrative nature of the tumour, recurrence rate is higher than in other subcutaneous lipomas. Complete surgical excision of lipoma is often regarded as a definitive treatment modality and longterm follow-up is mandatory. Here we report a case of a 49-year-old male presenting with huge left neck mass measuring 12 × 10 cm, which was successfully removed. Computed tomography scan of the neck showed a well-defined septated lesion with a fat component in the right sternocleidomastoid muscle, and the histopathology examination confirmed the diagnosis of well-circumscribed intramuscular sternocleidomastoid lipoma. Follow-up after one year showed no evidence of recurrence.

BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia

Oman Medical Journal, 2021

Objectives: We sought to determine the immunohistochemistry expression of mismatch repair (MMR) a... more Objectives: We sought to determine the immunohistochemistry expression of mismatch repair (MMR) and BRAF V600E proteins in sporadic young-onset colorectal cancer (CRC) and their association with clinicopathological features in the Kelantan population. Methods: This was a cross-sectional study of sporadic young-onset CRC over 11 years from 1 January 2006 to 31 December 2017 in Kelantan. Formalin-fixed paraffin-embedded tissue blocks were immunohistochemically stained with antibodies for MMR (MLH1, MSH2, MSH6, and PMS2) and BRAF V600E. These expressions were correlated with clinicopathological parameters. Results: Our patient sample included 31 patients with a mean age of 31.5 years. More than half (61.3%) of the patients were women. The majority presented with abdominal pain (41.9%), and 71.0% had a tumor located on the right side of the colon, with 83.9% being moderately differentiated adenocarcinoma. The majority of patients presented at stage IV (54.8%). The most frequent pattern ...

Journal of Taibah University Medical Sciences, 2018

Lipoma is the most common benign soft tissue tumour with most located in the superficial subcutan... more Lipoma is the most common benign soft tissue tumour with most located in the superficial subcutaneous plane. However, some are located in the deeper plane. Location in the head and neck regions are less common compared to the other parts of the body. Deep seated lipomas are either inter-muscular or intramuscular. We present a case of a simple subcutaneous neck lipoma in a 60-year-old Malay man which turned out to be an intramuscular sternocleidomastoid lipoma.

Urology, 2012

Fibrosarcoma is rare in the pediatric age group. It generally involves the extremities and the tr... more Fibrosarcoma is rare in the pediatric age group. It generally involves the extremities and the trunk but rarely involves the genital area. We report a case of a large fungating infantile fibrosarcoma of the penis in a 2-year-old Malay boy. Partial recovery of the penile structure was achieved after chemotherapy. The difficulty in managing the social and surgical aspect of this case is discussed in our report. To the best of our knowledge, this is the first case report of infantile fibrosarcoma involving the penis in an Asian region. UROLOGY 80: 931-933, 2012.

Pediatric Case Report Infantile Fibrosarcoma of the Penis in a 2-Year-Old Boy

Fibrosarcoma is a rare nonrhabdomyosarcoma soft tissue tumor that arises from fibrous tissue. The... more Fibrosarcoma is a rare nonrhabdomyosarcoma soft tissue tumor that arises from fibrous tissue. The common sites for fibrosarcoma are the limbs and axial area. There are 2 main groups of fibrosarcoma— infantile and adult. Currently, fewer than 300 cases of infantile fibrosarcoma have been reported, with even fewer reports involving the penis in the pediatric age group. Most of the reported cases of fibrosarcoma involving the penis have been of adult patients. We report a case of fibrosarcoma involving the proximal half of the penis. Only 5 case reports have been documented in the Indian subcontinent. None of those cases involved the penile area. The largest case series, which included 29 patients with infantile fibrosarcoma of the penis, did not have a patient as young as our patient. 1

The significance of BAP1 and MTAP/CDKN2A expression in well-differentiated papillary mesothelial tumour: a series of 21 cases and a review of the literature

Pathology, May 1, 2024

Pulmonary artery intimal sarcoma presenting as lung mass

Human pathology reports, Mar 1, 2023

BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia

Oman Medical Journal, Jul 15, 2021

ObjectivesWe sought to determine the immunohistochemistry expression of mismatch repair (MMR) and... more ObjectivesWe sought to determine the immunohistochemistry expression of mismatch repair (MMR) and BRAF V600E proteins in sporadic young-onset colorectal cancer (CRC) and their association with clinicopathological features in the Kelantan population.MethodsThis was a cross-sectional study of sporadic young-onset CRC over 11 years from 1 January 2006 to 31 December 2017 in Kelantan. Formalin-fixed paraffin-embedded tissue blocks were immunohistochemically stained with antibodies for MMR (MLH1, MSH2, MSH6, and PMS2) and BRAF V600E. These expressions were correlated with clinicopathological parameters.ResultsOur patient sample included 31 patients with a mean age of 31.5 years. More than half (61.3%) of the patients were women. The majority presented with abdominal pain (41.9%), and 71.0% had a tumor located on the right side of the colon, with 83.9% being moderately differentiated adenocarcinoma. The majority of patients presented at stage IV (54.8%). The most frequent pattern was all MMR protein expressions, which constituted patients in the microsatellite stable group (64.5%). Nine (29.0%) were microsatellite instability (MSI-high), and two (6.5%) were MSI-low. Positive BRAF V600E expression was observed in 83.9% of patients. Only histopathological subtypes revealed a significant association with BRAF V600E positive expression (p = 0.015).ConclusionsThe majority of sporadic young-onset CRC presented with abdominal pain and advanced cancer stage. Most were microsatellite stable, and most cases showed positive expressions in all MMR markers and BRAF V600E by immunohistochemistry method. This finding will pave the way for further research on this disease.

Pediatria i Medycyna Rodzinna, May 31, 2022

Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises ... more Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises between the muscle fibres and passes through the intermuscular septa. Due to the infiltrative nature of the tumour, recurrence rate is higher than in other subcutaneous lipomas. Complete surgical excision of lipoma is often regarded as a definitive treatment modality and longterm follow-up is mandatory. Here we report a case of a 49-year-old male presenting with huge left neck mass measuring 12 × 10 cm, which was successfully removed. Computed tomography scan of the neck showed a well-defined septated lesion with a fat component in the right sternocleidomastoid muscle, and the histopathology examination confirmed the diagnosis of well-circumscribed intramuscular sternocleidomastoid lipoma. Follow-up after one year showed no evidence of recurrence.

Real-world prevalence of PD-L1 expression in non-small cell lung cancer: an Australia-wide multi-centre retrospective observational study

Pathology

Pulmonary artery intimal sarcoma presenting as lung mass

Human Pathology Reports

Pediatria i Medycyna Rodzinna

Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises ... more Intramuscular lipoma is rare benign tumour rarely located in the head and neck region. It arises between the muscle fibres and passes through the intermuscular septa. Due to the infiltrative nature of the tumour, recurrence rate is higher than in other subcutaneous lipomas. Complete surgical excision of lipoma is often regarded as a definitive treatment modality and longterm follow-up is mandatory. Here we report a case of a 49-year-old male presenting with huge left neck mass measuring 12 × 10 cm, which was successfully removed. Computed tomography scan of the neck showed a well-defined septated lesion with a fat component in the right sternocleidomastoid muscle, and the histopathology examination confirmed the diagnosis of well-circumscribed intramuscular sternocleidomastoid lipoma. Follow-up after one year showed no evidence of recurrence.

BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia

Oman Medical Journal, 2021

Objectives: We sought to determine the immunohistochemistry expression of mismatch repair (MMR) a... more Objectives: We sought to determine the immunohistochemistry expression of mismatch repair (MMR) and BRAF V600E proteins in sporadic young-onset colorectal cancer (CRC) and their association with clinicopathological features in the Kelantan population. Methods: This was a cross-sectional study of sporadic young-onset CRC over 11 years from 1 January 2006 to 31 December 2017 in Kelantan. Formalin-fixed paraffin-embedded tissue blocks were immunohistochemically stained with antibodies for MMR (MLH1, MSH2, MSH6, and PMS2) and BRAF V600E. These expressions were correlated with clinicopathological parameters. Results: Our patient sample included 31 patients with a mean age of 31.5 years. More than half (61.3%) of the patients were women. The majority presented with abdominal pain (41.9%), and 71.0% had a tumor located on the right side of the colon, with 83.9% being moderately differentiated adenocarcinoma. The majority of patients presented at stage IV (54.8%). The most frequent pattern ...

Journal of Taibah University Medical Sciences, 2018

Lipoma is the most common benign soft tissue tumour with most located in the superficial subcutan... more Lipoma is the most common benign soft tissue tumour with most located in the superficial subcutaneous plane. However, some are located in the deeper plane. Location in the head and neck regions are less common compared to the other parts of the body. Deep seated lipomas are either inter-muscular or intramuscular. We present a case of a simple subcutaneous neck lipoma in a 60-year-old Malay man which turned out to be an intramuscular sternocleidomastoid lipoma.

Urology, 2012

Fibrosarcoma is rare in the pediatric age group. It generally involves the extremities and the tr... more Fibrosarcoma is rare in the pediatric age group. It generally involves the extremities and the trunk but rarely involves the genital area. We report a case of a large fungating infantile fibrosarcoma of the penis in a 2-year-old Malay boy. Partial recovery of the penile structure was achieved after chemotherapy. The difficulty in managing the social and surgical aspect of this case is discussed in our report. To the best of our knowledge, this is the first case report of infantile fibrosarcoma involving the penis in an Asian region. UROLOGY 80: 931-933, 2012.

Pediatric Case Report Infantile Fibrosarcoma of the Penis in a 2-Year-Old Boy

Fibrosarcoma is a rare nonrhabdomyosarcoma soft tissue tumor that arises from fibrous tissue. The... more Fibrosarcoma is a rare nonrhabdomyosarcoma soft tissue tumor that arises from fibrous tissue. The common sites for fibrosarcoma are the limbs and axial area. There are 2 main groups of fibrosarcoma— infantile and adult. Currently, fewer than 300 cases of infantile fibrosarcoma have been reported, with even fewer reports involving the penis in the pediatric age group. Most of the reported cases of fibrosarcoma involving the penis have been of adult patients. We report a case of fibrosarcoma involving the proximal half of the penis. Only 5 case reports have been documented in the Indian subcontinent. None of those cases involved the penile area. The largest case series, which included 29 patients with infantile fibrosarcoma of the penis, did not have a patient as young as our patient. 1