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Papers by Ankita Priyadarshini

Research paper thumbnail of Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

International journal of health sciences

Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than ... more Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than non-diabetic patients. Diabetes Mellitus has certain negative effects on the genital system and increases the incidence of urinary tract infection in diabetic patients. Design: Record based retrospective study. Methods: Records of patients with type-II diabetes having symptoms of UTI were reviewed from August 2021 to January 2022. Result: Out of 210 diabetic patients, the UTI rate was higher in females 59% than male 41%. The most common agents for causing UTI were E.coli followed by Pseudomonas aeruginosa, Klebsiella spp., Candida albicans and Candida non-albicans, Enterococcus, S.aureus and other organisms. About 70.68% Gram-negative isolates were resistant against ampicillin, 75.17% resistant against gentamycin, and 48.16% resistant against amoxicillin-clavulanic acid. Gram-positive isolates were 83.33% resistant against penicillin and 83.33% resistant against ciprofloxacin. However,...

Research paper thumbnail of The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer

Clinical Cancer Drugs, 2019

Background: Breast Cancer is a recurrent problem across the world. According to a report, breast ... more Background: Breast Cancer is a recurrent problem across the world. According to a report, breast cancer has the second highest mortality rate in women globally [1]. Despite of having an advanced degree of chemotherapy, resistance is developed against the therapies. Studies showed that anthracyclins like doxorubicin used in the treatment of breast cancer are found to develop resistance, which isn’t easy to identify [2]. Mutations in the tumor suppressor gene P53 are associated with the primary resistance to doxorubicin and thus inducing an early relapse of breast tumors [2]. Resistance against Doxorubicin is not identifiable easily. Development of resistance and metastasis of tumors are two processes that cannot be separated from each other. It is widely known that endothelium has a major role in controlling metastasis and tumor cell invasion. Endothelial cells express different adhesion molecules during recruitment of leukocytes in localized area, which is called leukocyte extravasa...

Research paper thumbnail of C-reactive protein (CRP) and Lactate Dehydrogenase (LDH) as diagnostic and early prognostic marker of adverse disease outcomes in critical COVID-19 patients

International journal of health sciences

Background: We used standard laboratory test to determine tissue injury and inflammatory state on... more Background: We used standard laboratory test to determine tissue injury and inflammatory state on the physiological condition of fever, cough, headache in 672 patients tested for CRP and 407 patients tested for LDH out of a total of 994 COVID-19 admissions during the period of April 2021-September 2021 at Parul Sevashram Hospital, Vadodara. The data was stratified based on the survivor/non-survivor status and severity of disease condition based on Ward or ICU admissions. The results were correlated with the vales of serum CRP and LDH levels for determining their prognostic significance. Patients and Methods: This is a retrospective, single-centre, observational study using the data collected from MRD division through electronic records and standardized data collection template. It included patients who were tested for CRP and LDH at times of admission. Mean, Standard deviation, Median and Interquartile range (IQR) were used to present continuous variables. Student’s t-test was used ...

Research paper thumbnail of Acute kidney injury profile of COVID-19 patients and associated risk factors a rural hospital-based retrospective study from Vadodara, Gujarat

International journal of health sciences

Background: Clinical outcome of patients hospitalized with COVID-19 and acute kidney injury (AKI)... more Background: Clinical outcome of patients hospitalized with COVID-19 and acute kidney injury (AKI) are not well understood. The clinical significance of abnormal electrolytes and renal outcome in COVID-19 patients have been poorly documented. We aim to exhibit the electrolyte abnormalities, renal outcome and associated risk factors in hospitalized COVID-19 patients in rural tertiary care hospital in Vadodara district, Western India. Method: A hospital record based retrospective study was conducted. Total 994 patients hospitalized with COVID-19 between 1st April 2021 to 30th June 2021 and those meeting inclusion criteria were included for the analysis. The laboratory data of interest included electrolytes reports like Na+, K+, CL-, creatinine and blood urea. Result: Of the total hospitalized COVID-19 patients, 324 patients were eligible. For the criteria for suspected AKI - 279 (86.11%) and no AKI - 45 (13.88%) patients were found. Suspected AKI patients were classified into four cond...

Research paper thumbnail of Metabolic syndrome correlates with significantly adverse disease outcomes in COVID-19 patients during the second wave of pandemic

International journal of health sciences

Background: This Retrospective Study was conducted by collecting patient records from the COVID-1... more Background: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The goal of this study was to investigate the risk and mortality of COVID-19 patients with Metabolic Syndrome especially during the second wave of pandemic. Methods: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The record of COVID-19 patients admitted during the second wave of pandemic (April – June, 2021) were included and analyzed for Metabolic syndrome, Demographic characteristics and Clinical Outcomes. Comorbidities were classified into the following Groups: DM (having DM with or without comorbidities), only DM (having DM without other comorbidities); HT (having HT with or without other comorbidities), only HT (having HT without other comorbidities); CVD (having CVD with or without comorbidities), only CVD (having CVD without other comorbidities). Correlation analys...

Research paper thumbnail of Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

International journal of health sciences

Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than ... more Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than non-diabetic patients. Diabetes Mellitus has certain negative effects on the genital system and increases the incidence of urinary tract infection in diabetic patients. Design: Record based retrospective study. Methods: Records of patients with type-II diabetes having symptoms of UTI were reviewed from August 2021 to January 2022. Result: Out of 210 diabetic patients, the UTI rate was higher in females 59% than male 41%. The most common agents for causing UTI were E.coli followed by Pseudomonas aeruginosa, Klebsiella spp., Candida albicans and Candida non-albicans, Enterococcus, S.aureus and other organisms. About 70.68% Gram-negative isolates were resistant against ampicillin, 75.17% resistant against gentamycin, and 48.16% resistant against amoxicillin-clavulanic acid. Gram-positive isolates were 83.33% resistant against penicillin and 83.33% resistant against ciprofloxacin. However,...

Research paper thumbnail of Metabolic syndrome correlates with significantly adverse disease outcomes in COVID-19 patients during the second wave of pandemic

International journal of health sciences

Background: This Retrospective Study was conducted by collecting patient records from the COVID-1... more Background: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The goal of this study was to investigate the risk and mortality of COVID-19 patients with Metabolic Syndrome especially during the second wave of pandemic. Methods: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The record of COVID-19 patients admitted during the second wave of pandemic (April – June, 2021) were included and analyzed for Metabolic syndrome, Demographic characteristics and Clinical Outcomes. Comorbidities were classified into the following Groups: DM (having DM with or without comorbidities), only DM (having DM without other comorbidities); HT (having HT with or without other comorbidities), only HT (having HT without other comorbidities); CVD (having CVD with or without comorbidities), only CVD (having CVD without other comorbidities). Correlation analys...

Research paper thumbnail of The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer

Clinical Cancer Drugs

Background: Breast Cancer is a recurrent problem across the world. According to a report, breast ... more Background: Breast Cancer is a recurrent problem across the world. According to a report, breast cancer has the second highest mortality rate in women globally [1]. Despite of having an advanced degree of chemotherapy, resistance is developed against the therapies. Studies showed that anthracyclins like doxorubicin used in the treatment of breast cancer are found to develop resistance, which isn’t easy to identify [2]. Mutations in the tumor suppressor gene P53 are associated with the primary resistance to doxorubicin and thus inducing an early relapse of breast tumors [2]. Resistance against Doxorubicin is not identifiable easily. Development of resistance and metastasis of tumors are two processes that cannot be separated from each other. It is widely known that endothelium has a major role in controlling metastasis and tumor cell invasion. Endothelial cells express different adhesion molecules during recruitment of leukocytes in localized area, which is called leukocyte extravasa...

Research paper thumbnail of Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

International journal of health sciences

Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than ... more Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than non-diabetic patients. Diabetes Mellitus has certain negative effects on the genital system and increases the incidence of urinary tract infection in diabetic patients. Design: Record based retrospective study. Methods: Records of patients with type-II diabetes having symptoms of UTI were reviewed from August 2021 to January 2022. Result: Out of 210 diabetic patients, the UTI rate was higher in females 59% than male 41%. The most common agents for causing UTI were E.coli followed by Pseudomonas aeruginosa, Klebsiella spp., Candida albicans and Candida non-albicans, Enterococcus, S.aureus and other organisms. About 70.68% Gram-negative isolates were resistant against ampicillin, 75.17% resistant against gentamycin, and 48.16% resistant against amoxicillin-clavulanic acid. Gram-positive isolates were 83.33% resistant against penicillin and 83.33% resistant against ciprofloxacin. However,...

Research paper thumbnail of The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer

Clinical Cancer Drugs, 2019

Background: Breast Cancer is a recurrent problem across the world. According to a report, breast ... more Background: Breast Cancer is a recurrent problem across the world. According to a report, breast cancer has the second highest mortality rate in women globally [1]. Despite of having an advanced degree of chemotherapy, resistance is developed against the therapies. Studies showed that anthracyclins like doxorubicin used in the treatment of breast cancer are found to develop resistance, which isn’t easy to identify [2]. Mutations in the tumor suppressor gene P53 are associated with the primary resistance to doxorubicin and thus inducing an early relapse of breast tumors [2]. Resistance against Doxorubicin is not identifiable easily. Development of resistance and metastasis of tumors are two processes that cannot be separated from each other. It is widely known that endothelium has a major role in controlling metastasis and tumor cell invasion. Endothelial cells express different adhesion molecules during recruitment of leukocytes in localized area, which is called leukocyte extravasa...

Research paper thumbnail of C-reactive protein (CRP) and Lactate Dehydrogenase (LDH) as diagnostic and early prognostic marker of adverse disease outcomes in critical COVID-19 patients

International journal of health sciences

Background: We used standard laboratory test to determine tissue injury and inflammatory state on... more Background: We used standard laboratory test to determine tissue injury and inflammatory state on the physiological condition of fever, cough, headache in 672 patients tested for CRP and 407 patients tested for LDH out of a total of 994 COVID-19 admissions during the period of April 2021-September 2021 at Parul Sevashram Hospital, Vadodara. The data was stratified based on the survivor/non-survivor status and severity of disease condition based on Ward or ICU admissions. The results were correlated with the vales of serum CRP and LDH levels for determining their prognostic significance. Patients and Methods: This is a retrospective, single-centre, observational study using the data collected from MRD division through electronic records and standardized data collection template. It included patients who were tested for CRP and LDH at times of admission. Mean, Standard deviation, Median and Interquartile range (IQR) were used to present continuous variables. Student’s t-test was used ...

Research paper thumbnail of Acute kidney injury profile of COVID-19 patients and associated risk factors a rural hospital-based retrospective study from Vadodara, Gujarat

International journal of health sciences

Background: Clinical outcome of patients hospitalized with COVID-19 and acute kidney injury (AKI)... more Background: Clinical outcome of patients hospitalized with COVID-19 and acute kidney injury (AKI) are not well understood. The clinical significance of abnormal electrolytes and renal outcome in COVID-19 patients have been poorly documented. We aim to exhibit the electrolyte abnormalities, renal outcome and associated risk factors in hospitalized COVID-19 patients in rural tertiary care hospital in Vadodara district, Western India. Method: A hospital record based retrospective study was conducted. Total 994 patients hospitalized with COVID-19 between 1st April 2021 to 30th June 2021 and those meeting inclusion criteria were included for the analysis. The laboratory data of interest included electrolytes reports like Na+, K+, CL-, creatinine and blood urea. Result: Of the total hospitalized COVID-19 patients, 324 patients were eligible. For the criteria for suspected AKI - 279 (86.11%) and no AKI - 45 (13.88%) patients were found. Suspected AKI patients were classified into four cond...

Research paper thumbnail of Metabolic syndrome correlates with significantly adverse disease outcomes in COVID-19 patients during the second wave of pandemic

International journal of health sciences

Background: This Retrospective Study was conducted by collecting patient records from the COVID-1... more Background: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The goal of this study was to investigate the risk and mortality of COVID-19 patients with Metabolic Syndrome especially during the second wave of pandemic. Methods: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The record of COVID-19 patients admitted during the second wave of pandemic (April – June, 2021) were included and analyzed for Metabolic syndrome, Demographic characteristics and Clinical Outcomes. Comorbidities were classified into the following Groups: DM (having DM with or without comorbidities), only DM (having DM without other comorbidities); HT (having HT with or without other comorbidities), only HT (having HT without other comorbidities); CVD (having CVD with or without comorbidities), only CVD (having CVD without other comorbidities). Correlation analys...

Research paper thumbnail of Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

International journal of health sciences

Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than ... more Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than non-diabetic patients. Diabetes Mellitus has certain negative effects on the genital system and increases the incidence of urinary tract infection in diabetic patients. Design: Record based retrospective study. Methods: Records of patients with type-II diabetes having symptoms of UTI were reviewed from August 2021 to January 2022. Result: Out of 210 diabetic patients, the UTI rate was higher in females 59% than male 41%. The most common agents for causing UTI were E.coli followed by Pseudomonas aeruginosa, Klebsiella spp., Candida albicans and Candida non-albicans, Enterococcus, S.aureus and other organisms. About 70.68% Gram-negative isolates were resistant against ampicillin, 75.17% resistant against gentamycin, and 48.16% resistant against amoxicillin-clavulanic acid. Gram-positive isolates were 83.33% resistant against penicillin and 83.33% resistant against ciprofloxacin. However,...

Research paper thumbnail of Metabolic syndrome correlates with significantly adverse disease outcomes in COVID-19 patients during the second wave of pandemic

International journal of health sciences

Background: This Retrospective Study was conducted by collecting patient records from the COVID-1... more Background: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The goal of this study was to investigate the risk and mortality of COVID-19 patients with Metabolic Syndrome especially during the second wave of pandemic. Methods: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The record of COVID-19 patients admitted during the second wave of pandemic (April – June, 2021) were included and analyzed for Metabolic syndrome, Demographic characteristics and Clinical Outcomes. Comorbidities were classified into the following Groups: DM (having DM with or without comorbidities), only DM (having DM without other comorbidities); HT (having HT with or without other comorbidities), only HT (having HT without other comorbidities); CVD (having CVD with or without comorbidities), only CVD (having CVD without other comorbidities). Correlation analys...

Research paper thumbnail of The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer

Clinical Cancer Drugs

Background: Breast Cancer is a recurrent problem across the world. According to a report, breast ... more Background: Breast Cancer is a recurrent problem across the world. According to a report, breast cancer has the second highest mortality rate in women globally [1]. Despite of having an advanced degree of chemotherapy, resistance is developed against the therapies. Studies showed that anthracyclins like doxorubicin used in the treatment of breast cancer are found to develop resistance, which isn’t easy to identify [2]. Mutations in the tumor suppressor gene P53 are associated with the primary resistance to doxorubicin and thus inducing an early relapse of breast tumors [2]. Resistance against Doxorubicin is not identifiable easily. Development of resistance and metastasis of tumors are two processes that cannot be separated from each other. It is widely known that endothelium has a major role in controlling metastasis and tumor cell invasion. Endothelial cells express different adhesion molecules during recruitment of leukocytes in localized area, which is called leukocyte extravasa...