Ann Tweddel - Academia.edu (original) (raw)

Papers by Ann Tweddel

Research paper thumbnail of Early white cell and platelet deposition folloving coronary artery bypass

Research paper thumbnail of Patient self-referral in acute myocardial infarction

The Quarterly Journal of Medicine, Mar 1, 1993

Research paper thumbnail of Inferior perfusion defects on SPET thallium scanning

Research paper thumbnail of Improved detection of coronary artery disease by estimated myocardial thallium uptake

European Journal of Nuclear Medicine and Molecular Imaging, Feb 1, 1989

Myocardial thallium uptake has been assessed at the time of thallium scanning in a group of 50 ma... more Myocardial thallium uptake has been assessed at the time of thallium scanning in a group of 50 male patients undergoing coronary arteriography and 10 young healthy volunteers. The net thallium dose injected was obtained by counting the dose prior to injection using the gamma camera and counting the syringe and IV cannula after injection. Significantly higher levels of myocardial thallium uptake were obtained in both the volunteers and patients with normal coronary anatomy (1.36%+0.32%, n=lO and 0.93%+0.26%, n=9, respectively) compared to patients with single, double or triple vessel coronary artery disease (0.63% _+0.19%, n=ll; 0.70% _+0.20%, n=15; 0.67 + 0.18, n = 15, respectively). Exercise tests were positive in 46% of patients with coronary artery disease with an overall predictive accuracy of 56%. Thallium scans were positive in 68% of patients at a specificity of 89%. If the range of myocardial thallium uptake from the patients with normal coronary arteries is used to define a lower limit of normal, then the sensitivity of the thallium scan with thallium uptake is 90% with a predictive accuracy of 90% in the detection of significant coronary artery disease in this group of patients. Thus, estimation of total % thallium uptake is a simple index which yields useful diagnostic clinical information.

Research paper thumbnail of 540 Heterogeneity of myocardial velocities of long-axis left ventricular contraction can differentiate between hypertrophic cardiomyopathy and left ventricular hypertrophy due to arterial hypertension

Research paper thumbnail of 743 Strain rate best quantifies regional contractile reserve during dobutamine stress echocardiography in patients with ischemic left ventricular dysfunction

Research paper thumbnail of The geometrical dependence of radionuclide ejection fraction

Research paper thumbnail of A7 Feasibility of gated SPECT myocardial perfusion scintigraphy using 201Tl

Research paper thumbnail of 73. Thallium scans in patients with thyrotoxicosis

Research paper thumbnail of SCIENTIFIC NOTE: Geometrical dependence of radionuclide ejection fraction

Research paper thumbnail of 115 Resolution of post-systolic strain as a non-invasive marker of successful revascularisation of viable myocardium in patients with ischaemic left ventricular dysfunction

European Heart Journal – Cardiovascular Imaging

ABSTRACT

Research paper thumbnail of Prevalence and prognostic impact of right ventricular dilation in patients with moderate chronic heart failure. A cardiac-MRI study

European Journal of Heart Failure Supplements, 2008

gene polymorphisms (pms) resulted in an altered BAR function and regulations have been described.... more gene polymorphisms (pms) resulted in an altered BAR function and regulations have been described. Aims: To determine a possible usefulness of BAR1 (Ser49Gly; Arg389Gly) and BAR2 (Thr164Ile; Arg16Gly; Gln27Glu) genetic pms in the survival determination of patients with advanced HF referred for heart transplantation. Methods: The survival was assessed in 398 HF patients, with mean age 49±10 years, left ventricle dysfunction (systolic/diastolic diameter 62±13/73±11 mm; EF 21±8%), pulmonary hypertension (systolic pulmonary/mean wedge pressure 43±18/21±10 mmHg), reduced VO2max (13±4 mL/kg/min), elevated NTproBNP (4101±6372 pg/ml), hsCRP (8.3±23 mg/dl) and Aaronson score (7.69±0.9). The mean follow up period was 20±14 months. The end-point was defined as death or urgent heart transplantation. Statistical analysis was performed with the chi2, analysis of variance, the Kaplan-Meier methods. Results: Among assessed BAR1 pms, using the Kaplan-Meier methods we found that Ser49Gly pms influenced the survival rate significantly (Log-rank =6.7749, p =0.0338). The frequency of the Gly vs Ser vs Ser/Gly allele was 1.5%/78.5%/20% respectively. There were no significant differences in any clinical parameters in relation to BAR1 (Ser49Gly) pms. Among assessed BAR2 pms, using the Kaplan-Meier methods we found that Arg16Gly pms influenced the survival rate significantly (Log-rank =6.1289, p =0.0467). The frequency of the Arg vs Gly vs Arg/Gly allele was 20%/41%/39% respectively. There were no significant differences in any clinical parameter in relation to BAR2 (Arg16Gly) pms. Using the Kaplan-Meier and Cox proportional hazards method analyses we confirmed that the level of NTproBNP (Log-rank =15.3388, p =0.0005; HR=1.002, p=0.0008; respectively), Aaronson score (Log-rank = 13.8226, p = 0.0010; HR=0.629, p=0.0011), also hsCRP (Log-rank =2.0677, p=0.3556; HR=1.011, p<0.0001) were independent predictors of death. Conclusions: Among all assessed BAR pms, the genetic variants -BAR1 and also BAR2 genes may be associated with the survival rate. However their potential role in risk stratification needs to be further investigated. The classical risk factors NTproBNP, hsCRP levels and Aronson score proved their well known value in the assessment of the death risk in advanced HF.

Research paper thumbnail of 540 Heterogeneity of myocardial velocities of long-axis left ventricular contraction can differentiate between hypertrophic cardiomyopathy and left ventricular hypertrophy due to arterial hypertension

European Journal of Echocardiography, 1999

Research paper thumbnail of A survey of nuclear cardiological practice in Great Britain. The British Nuclear Cardiology Group

Heart, 1992

There is little information on the practice of nuclear cardiology in Great Britain. On behalf of ... more There is little information on the practice of nuclear cardiology in Great Britain. On behalf of the British Nuclear Cardiology Group in October 1988 we sent a postal questionnaire to 143 hospitals with nuclear medicine facilities (at least 70% of such hospitals). Sixty nine replies were received (48%), of which 23 (33%) were from teaching hospitals and 46 (39%) non-teaching.

Research paper thumbnail of 4. Rest-exercise thallium scans as an alternative to reperfusion

Nuclear Medicine Communications, 1992

Research paper thumbnail of 109. A theoretical model of attenuation-induced measurement errors in ejection fraction during blood pool imaging

Nuclear Medicine Communications, 1992

Research paper thumbnail of 73. Thallium scans in patients with thyrotoxicosis

Nuclear Medicine Communications, 1996

Research paper thumbnail of 71. Comparison of 201Tl and 99Tcm perfusion imaging in microvascular angina

Nuclear Medicine Communications, 1996

Research paper thumbnail of Imaging in Microvascular Angina - What’s New ?

Developments in Cardiovascular Medicine, 1999

Normal or near normal coronary arteriography is a prerequisite for the diagnosis of microvascular... more Normal or near normal coronary arteriography is a prerequisite for the diagnosis of microvascular angina. However it is often forgotten that arteriography provides merely a luminogram of the artery. This is exemplified by the demonstration of fibrous or lipid containing plaques within the artery wall using intracoronary ultrasound and Doppler, which may escape detection by contrast arteriography, particularly when located

Research paper thumbnail of Physiciansʼ Attitudes to Nuclear Cardiology

Nuclear Medicine Communications, 1983

Research paper thumbnail of Early white cell and platelet deposition folloving coronary artery bypass

Research paper thumbnail of Patient self-referral in acute myocardial infarction

The Quarterly Journal of Medicine, Mar 1, 1993

Research paper thumbnail of Inferior perfusion defects on SPET thallium scanning

Research paper thumbnail of Improved detection of coronary artery disease by estimated myocardial thallium uptake

European Journal of Nuclear Medicine and Molecular Imaging, Feb 1, 1989

Myocardial thallium uptake has been assessed at the time of thallium scanning in a group of 50 ma... more Myocardial thallium uptake has been assessed at the time of thallium scanning in a group of 50 male patients undergoing coronary arteriography and 10 young healthy volunteers. The net thallium dose injected was obtained by counting the dose prior to injection using the gamma camera and counting the syringe and IV cannula after injection. Significantly higher levels of myocardial thallium uptake were obtained in both the volunteers and patients with normal coronary anatomy (1.36%+0.32%, n=lO and 0.93%+0.26%, n=9, respectively) compared to patients with single, double or triple vessel coronary artery disease (0.63% _+0.19%, n=ll; 0.70% _+0.20%, n=15; 0.67 + 0.18, n = 15, respectively). Exercise tests were positive in 46% of patients with coronary artery disease with an overall predictive accuracy of 56%. Thallium scans were positive in 68% of patients at a specificity of 89%. If the range of myocardial thallium uptake from the patients with normal coronary arteries is used to define a lower limit of normal, then the sensitivity of the thallium scan with thallium uptake is 90% with a predictive accuracy of 90% in the detection of significant coronary artery disease in this group of patients. Thus, estimation of total % thallium uptake is a simple index which yields useful diagnostic clinical information.

Research paper thumbnail of 540 Heterogeneity of myocardial velocities of long-axis left ventricular contraction can differentiate between hypertrophic cardiomyopathy and left ventricular hypertrophy due to arterial hypertension

Research paper thumbnail of 743 Strain rate best quantifies regional contractile reserve during dobutamine stress echocardiography in patients with ischemic left ventricular dysfunction

Research paper thumbnail of The geometrical dependence of radionuclide ejection fraction

Research paper thumbnail of A7 Feasibility of gated SPECT myocardial perfusion scintigraphy using 201Tl

Research paper thumbnail of 73. Thallium scans in patients with thyrotoxicosis

Research paper thumbnail of SCIENTIFIC NOTE: Geometrical dependence of radionuclide ejection fraction

Research paper thumbnail of 115 Resolution of post-systolic strain as a non-invasive marker of successful revascularisation of viable myocardium in patients with ischaemic left ventricular dysfunction

European Heart Journal – Cardiovascular Imaging

ABSTRACT

Research paper thumbnail of Prevalence and prognostic impact of right ventricular dilation in patients with moderate chronic heart failure. A cardiac-MRI study

European Journal of Heart Failure Supplements, 2008

gene polymorphisms (pms) resulted in an altered BAR function and regulations have been described.... more gene polymorphisms (pms) resulted in an altered BAR function and regulations have been described. Aims: To determine a possible usefulness of BAR1 (Ser49Gly; Arg389Gly) and BAR2 (Thr164Ile; Arg16Gly; Gln27Glu) genetic pms in the survival determination of patients with advanced HF referred for heart transplantation. Methods: The survival was assessed in 398 HF patients, with mean age 49±10 years, left ventricle dysfunction (systolic/diastolic diameter 62±13/73±11 mm; EF 21±8%), pulmonary hypertension (systolic pulmonary/mean wedge pressure 43±18/21±10 mmHg), reduced VO2max (13±4 mL/kg/min), elevated NTproBNP (4101±6372 pg/ml), hsCRP (8.3±23 mg/dl) and Aaronson score (7.69±0.9). The mean follow up period was 20±14 months. The end-point was defined as death or urgent heart transplantation. Statistical analysis was performed with the chi2, analysis of variance, the Kaplan-Meier methods. Results: Among assessed BAR1 pms, using the Kaplan-Meier methods we found that Ser49Gly pms influenced the survival rate significantly (Log-rank =6.7749, p =0.0338). The frequency of the Gly vs Ser vs Ser/Gly allele was 1.5%/78.5%/20% respectively. There were no significant differences in any clinical parameters in relation to BAR1 (Ser49Gly) pms. Among assessed BAR2 pms, using the Kaplan-Meier methods we found that Arg16Gly pms influenced the survival rate significantly (Log-rank =6.1289, p =0.0467). The frequency of the Arg vs Gly vs Arg/Gly allele was 20%/41%/39% respectively. There were no significant differences in any clinical parameter in relation to BAR2 (Arg16Gly) pms. Using the Kaplan-Meier and Cox proportional hazards method analyses we confirmed that the level of NTproBNP (Log-rank =15.3388, p =0.0005; HR=1.002, p=0.0008; respectively), Aaronson score (Log-rank = 13.8226, p = 0.0010; HR=0.629, p=0.0011), also hsCRP (Log-rank =2.0677, p=0.3556; HR=1.011, p<0.0001) were independent predictors of death. Conclusions: Among all assessed BAR pms, the genetic variants -BAR1 and also BAR2 genes may be associated with the survival rate. However their potential role in risk stratification needs to be further investigated. The classical risk factors NTproBNP, hsCRP levels and Aronson score proved their well known value in the assessment of the death risk in advanced HF.

Research paper thumbnail of 540 Heterogeneity of myocardial velocities of long-axis left ventricular contraction can differentiate between hypertrophic cardiomyopathy and left ventricular hypertrophy due to arterial hypertension

European Journal of Echocardiography, 1999

Research paper thumbnail of A survey of nuclear cardiological practice in Great Britain. The British Nuclear Cardiology Group

Heart, 1992

There is little information on the practice of nuclear cardiology in Great Britain. On behalf of ... more There is little information on the practice of nuclear cardiology in Great Britain. On behalf of the British Nuclear Cardiology Group in October 1988 we sent a postal questionnaire to 143 hospitals with nuclear medicine facilities (at least 70% of such hospitals). Sixty nine replies were received (48%), of which 23 (33%) were from teaching hospitals and 46 (39%) non-teaching.

Research paper thumbnail of 4. Rest-exercise thallium scans as an alternative to reperfusion

Nuclear Medicine Communications, 1992

Research paper thumbnail of 109. A theoretical model of attenuation-induced measurement errors in ejection fraction during blood pool imaging

Nuclear Medicine Communications, 1992

Research paper thumbnail of 73. Thallium scans in patients with thyrotoxicosis

Nuclear Medicine Communications, 1996

Research paper thumbnail of 71. Comparison of 201Tl and 99Tcm perfusion imaging in microvascular angina

Nuclear Medicine Communications, 1996

Research paper thumbnail of Imaging in Microvascular Angina - What’s New ?

Developments in Cardiovascular Medicine, 1999

Normal or near normal coronary arteriography is a prerequisite for the diagnosis of microvascular... more Normal or near normal coronary arteriography is a prerequisite for the diagnosis of microvascular angina. However it is often forgotten that arteriography provides merely a luminogram of the artery. This is exemplified by the demonstration of fibrous or lipid containing plaques within the artery wall using intracoronary ultrasound and Doppler, which may escape detection by contrast arteriography, particularly when located

Research paper thumbnail of Physiciansʼ Attitudes to Nuclear Cardiology

Nuclear Medicine Communications, 1983