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Papers by Anna Danielewicz

The Lancet

Background Understanding the magnitude of cancer burden attributable to potentially modifiable ri... more Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4•45 million (95% uncertainty interval 4•01-4•94) deaths and 105 million (95•0-116) DALYs for both sexes combined, representing 44•4% (41•3-48•4) of all cancer deaths and 42•0% (39•1-45•6) of all DALYs. There were 2•88 million (2•60-3•18) risk-attributable cancer deaths in males (50•6% [47•8-54•1] of all male cancer deaths) and 1•58 million (1•36-1•84) risk-attributable cancer deaths in females (36•3% [32•5-41•3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20•4% (12•6-28•4) and DALYs by 16•8% (8•8-25•0), with the greatest percentage increase in metabolic risks (34•7% [27•9-42•8] and 33•3% [25•8-42•0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Funding Bill & Melinda Gates Foundation.

Diabetes Care

BACKGROUND Due to the rapidly increasing availability of metabolomics data in prospective studies... more BACKGROUND Due to the rapidly increasing availability of metabolomics data in prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes risk is warranted. PURPOSE To conduct an updated systematic review and meta-analysis of plasma, serum, and urine metabolite markers and incident type 2 diabetes. DATA SOURCES We searched PubMed and Embase until 6 March 2021. STUDY SELECTION We selected prospective observational studies where investigators used high-throughput techniques to investigate the relationship between plasma, serum, or urine metabolites and incident type 2 diabetes. DATA EXTRACTION Baseline metabolites per-SD risk estimates and 95% CIs for incident type 2 diabetes were extracted from all eligible studies. DATA SYNTHESIS A total of 61 reports with 71,196 participants and 11,771 type 2 diabetes cases/events were included in the updated review. Meta-analysis was performed for 412 metabolites, of which 123 were statistically significantly associated...

Iranian Journal of Public Health, 2017

Dear Editor-in-ChiefAcne vulgaris is one of the most common dermatoses, which occurs adolescents ... more Dear Editor-in-ChiefAcne vulgaris is one of the most common dermatoses, which occurs adolescents and increasingly young adults (1). It is known to impair many aspects of quality of life. Acne vulgaris leads to poor body image, anxiety, depression, anger, frustration, diminished self-esteem, social isolation and restriction of activities (2). Over the years, two approaches to investigating acne were established: dermatological and epidemiological. Considering the multifactorial base, chronicity and demographic character of the acne, it could be qualified as a non-communicable disease. One of the fields of public health research is analysis of the dependence between NCDs and exposome (complement of environmental conditions), looking for modifiable risk factors (3). Irrefutably, the key role is played by diet and nutribehaviour.The cross-sectional study was conducted on 370 students aged from 14 to 19 yr (Mean=16.0± 1.5), both healthy and suffering from acne vulgaris in 2015. The legal...

Annals of Nutrition and Metabolism, 2015

Iranian Journal of Public Health, 2019

Nutrients, 2021

The study aimed to evaluate the sustainability of a multi-component education (ABC-HEat) program ... more The study aimed to evaluate the sustainability of a multi-component education (ABC-HEat) program related to healthy nutrition and lifestyle after three months and nine months and to assess the socioeconomic context in improving teenage nutrition knowledge. The study was designed as a clustered, controlled, education-based intervention. A sample was chosen and allocated into either an educated group (under intervention) or a control group (outside of intervention). The study covered 464 11–12-year-old students (educated/control 319/145). In the educated group, data were collected three times: before education, after three months and after nine months to measure the short- and the long-term effects of education, respectively. In the control group, data were collected in parallel. Changes in nutrition knowledge score (NKS, points) by sex, residence, family affluence scale (FAS) were the main outcome measures. The increase in the NKS was significantly higher in the educated group than i...

Cancers, 2021

This review article contains a concise consideration of genetic and environmental risk factors fo... more This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known risk factors associated with colorectal cancer include familial and hereditary factors and lifestyle-related and ecological factors. Lifestyle factors are significant because of the potential for improving our understanding of the disease. Physical inactivity, obesity, smoking and alcohol consumption can also be addressed through therapeutic interventions. We also made efforts to systematize available literature and data on epidemiology, diagnosis, type and nature of symptoms and disease stages. Further study of colorectal cancer and progress made globally is crucial to inform future strategies in controlling the disease’s burden through population-based preventative initiatives.

First International Electronic Conference on Nutrients, Microbiota and Chronic Disease, 2020

This study aimed to evaluate the association between diet quality, perception of benefits consump... more This study aimed to evaluate the association between diet quality, perception of benefits consumption, and fermented dairy product intake in a representative sample of the Polish population. The study was carried out in February 2020. 2009 men and women were randomly sampled from the representative Polish population stratified for two age groups (19-30 and 66-75 years). Dairy product intake was evaluated using a qualitative frequency questionnaire. Diet quality was assessed by calculating the Mediterranean Diet Adherence Screener (MEDAS) score. Perceived health benefits of dairy product consumption were assessed with a literature-based questionnaire. The Health Concern Scale was used to measure participants' attitudes toward health. Median intake of fermented dairy products was 0.8 portion/day (IQR: 0.4-1.6). Intake of fermented dairy products was associated with higher MEDAS. We observed that people with the highest intake of fermented dairy product consumed more oils, vegetables, wine, legumes, fish and seafood, sweets and pastries, nuts, and higher preference for white meat and were more likely to report perceived benefits to maintain body weight, reduce cardiovascular risk, and improve immune and dental health. Moreover, a high intake of fermented dairy products was positively related to paying more attention to health. Our study identified patterns of health behaviors associated with frequent consumption of fermented products. We observed that the intake of fermented dairy products is associated with better diet quality, consumer self-consciousness, and a greater attitude to own health.

Proceedings of the Nutrition Society, 2020

The role of nutritional status of pregnant women and birth outcomes is ambiguous. Recent studies ... more The role of nutritional status of pregnant women and birth outcomes is ambiguous. Recent studies show that pre-pregnancy body weight is equally important as weight gain during pregnancy. Body mass index (BMI) is the most accessible and easy to check a nutritional status index, which may help to control the gestation and predict infant health outcome. This study aimed to examine the associations between pre-pregnancy body mass index and the infant birth parameters. A presented observational study was offered to 200 pregnant women from Antenatal Clinic at Jersey General Hospital in 2017. Total number of 83 women agreed to take part in this project. Diet, lifestyle, socio-economic, and demographic data were obtained from participants. Delivery and birth data were taken from hospital records. Offspring feeding data and selected anthropometric measurements for mothers and their newborns were also collected. Differences between BMI for delivery type and way of feeding were verified with c...

Proceedings of the Nutrition Society, 2020

It is estimated that in Central and Eastern Europe 8–12% of men are infertile, and in the case of... more It is estimated that in Central and Eastern Europe 8–12% of men are infertile, and in the case of 20% of infertile couples in the region, indicates a 56% part of the malefactor in the occurrence of infertility. Numerous studies have shown that a healthy diet with a high intake of fish and seafood, poultry, vegetables, fruits, legumes, through the high content of antioxidants are associated with better parameters of semen quality and reduced risk of asthenozoospermia. Men's diets may affect spermatogenesis as reflected in semen quality indicators, but the literature on the relation between meat intake and semen quality is limited. Our objective was to prospectively examine the relation between meats including red, poultry, proceesed and fish and indicators of semen quality. Men in subfertile couples presenting for evaluation at the Olsztyn Hospital Fertility Center were invited to participate in an ongoing study of environmental factors and fertility. This cross-sectional study w...

Proceedings of the Nutrition Society, 2020

Breakfast is considered to be the most important meal of the day, which significantly contributes... more Breakfast is considered to be the most important meal of the day, which significantly contributes to overall dietary quality. Global trends suggest a decline in breakfast consumption frequency in all age groups over the years. Breakfast skipping is associated with increased risk of weight gain, insulin resistance and type 2 diabetes, which are crucial risk factors of cardiovascular diseases (CVD). Regular breakfast consumption as a modifiable risk factor might be of great interest for cardiovascular prevention. Several prospective cohort studies showed contradictory findings on breakfast skipping and CVD risk. To the best knowledge of authors, this topic was not covered by any previous meta-analysis. Therefore, this review aimed to summarise the evidence on the association between breakfast skipping and CVD risk in prospective studies with particular emphasis on dose-response relationship and quality of existing evidence. A comprehensive search of the literature was performed using ...

Scientific Reports, 2019

Ageing involves significant changes in skeletal muscle mass and its functioning. This study aimed... more Ageing involves significant changes in skeletal muscle mass and its functioning. This study aimed to identify the major nutrient patterns (NPs) present in a sample of adult Polish women and evaluate their associations with the skeletal muscle mass index (SMI). A cross-sectional study initially recruited 527 women, and a final analysis was carried out on 275 women aged 32–60 years. Nutrient intake was assessed using fourteen repetitions of 24-hour dietary recall. NPs were derived using principal component analysis. Associations between adherence to NPs and the SMI were evaluated using linear regression models. Three NPs were identified: ‘Animal Protein-Vitamins’, ‘Fibre-Plant Protein-Minerals’ and ‘Fats’. In the adjusted model, the upper tertile compared to the bottom tertile of the ‘Animal Protein-Vitamins’ NP was related to a higher SMI (β = 0.123 95% CI: 0.019; 0.227; P for 1-SD increase of NP score = 0.009). No associations between the SMI and the ‘Fibre-Plant Protein-Minerals’ a...

The Lancet Gastroenterology & Hepatology, 2019

Background Data about the global, regional, and country-specific variations in the levels and tre... more Background Data about the global, regional, and country-specific variations in the levels and trends of colorectal cancer are required to understand the impact of this disease and the trends in its burden to help policy makers allocate resources. Here we provide a status report on the incidence, mortality, and disability caused by colorectal cancer in 195 countries and territories between 1990 and 2017. Methods Vital registration, sample vital registration, verbal autopsy, and cancer registry data were used to generate incidence, death, and disability-adjusted life-year (DALY) estimates of colorectal cancer at the global, regional, and national levels. We also determined the association between development levels and colorectal cancer age-standardised DALY rates, and calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. All of the estimates are reported as counts and age-standardised rates per 100 000 person-years, with some estimates also presented by sex and 5-year age groups. Findings In 2017, there were 1•8 million (95% UI 1•8-1•9) incident cases of colorectal cancer globally, with an agestandardised incidence rate of 23•2 (22•7-23•7) per 100 000 person-years that increased by 9•5% (4•5-13•5) between 1990 and 2017. Globally, colorectal cancer accounted for 896 000 (876 300-915 700) deaths in 2017, with an agestandardised death rate of 11•5 (11•3-11•8) per 100 000 person-years, which decreased between 1990 and 2017 (-13•5% [-18•4 to-10•0]). Colorectal cancer was also responsible for 19•0 million (18•5-19•5) DALYs globally in 2017, with an age-standardised rate of 235•7 (229•7-242•0) DALYs per 100 000 person-years, which decreased between 1990 and 2017 (-14•5% [-20•4 to-10•3]). Slovakia, the Netherlands, and New Zealand had the highest age-standardised incidence rates in 2017. Greenland, Hungary, and Slovakia had the highest age-standardised death rates in 2017. Numbers of incident cases and deaths were higher among males than females up to the ages of 80-84 years, with the highest rates observed in the oldest age group (≥95 years) for both sexes in 2017. There was a non-linear association between the Socio-demographic Index and the Healthcare Access and Quality Index and age-standardised DALY rates. In 2017, the three largest contributors to DALYs at the global level, for both sexes, were diet low in calcium (20•5% [12•9-28•9]), alcohol use (15•2% [12•1-18•3]), and diet low in milk (14•3% [5•1-24•8]). Interpretation There is substantial global variation in the burden of colorectal cancer. Although the overall colorectal cancer age-standardised death rate has been decreasing at the global level, the increasing age-standardised incidence rate in most countries poses a major public health challenge across the world. The results of this study could be useful for policy makers to carry out cost-effective interventions and to reduce exposure to modifiable risk factors, particularly in countries with high incidence or increasing burden. Funding Bill & Melinda Gates Foundation.

PLoS ONE, 2013

Background: The aim of this systematic review of randomized controlled trials was to compare the ... more Background: The aim of this systematic review of randomized controlled trials was to compare the effects of aerobic training (AET), resistance training (RT), and combined aerobic and resistance training (CT) on anthropometric parameters, blood lipids, and cardiorespiratory fitness in overweight and obese subjects. Methods: Electronic searches for randomized controlled trials were performed in MEDLINE, EMBASE and the Cochrane Trial Register. Inclusion criteria were: Body Mass Index: $25 kg/m 2 , 19+ years of age, supervised exercise training, and a minimum intervention period of 8 weeks. Anthropometric outcomes, blood lipids, and cardiorespiratory fitness parameters were included. Pooled effects were calculated by inverse-variance random effect pairwise meta-analyses and Bayesian random effects network meta-analyses. Findings: 15 trials enrolling 741 participants were included in the meta-analysis. Compared to RT, AET resulted in a significantly more pronounced reduction of body weight [mean differences (MD):-1.15 kg, p = 0.04], waist circumference [MD:-1.10 cm, p = 0.004], and fat mass [MD:-1.15 kg, p = 0.001] respectively. RT was more effective than AET in improving lean body mass [MD: 1.26 kg, p,0.00001]. When comparing CT with RT, MD in change of body weight [MD:-2.03 kg, p,0.0001], waist circumference [MD:-1.57 cm, p = 0.0002], and fat mass [MD:-1.88 kg, p,0.00001] were all in favor of CT. Results from the network meta-analyses confirmed these findings. Conclusion: Evidence from both pairwise and network meta-analyses suggests that CT is the most efficacious means to reduce anthropometric outcomes and should be recommended in the prevention and treatment of overweight, and obesity whenever possible.

Nutrients, 2018

The etiology of diminished sperm quality in about 30% of male infertility cases generally remains... more The etiology of diminished sperm quality in about 30% of male infertility cases generally remains unexplained. Some studies have suggested that specific nutritional factors can affect semen quality. The aim of this study was to evaluate an association between dietary patterns (DPs) and the risk of abnormal semen quality parameters in men. This cross-sectional study was carried out in 114 men aged 20–55 years from Poland. Semen parameters were assessed via computer-aided semen. Diet was assessed by a food frequency questionnaire (FFQ). DPs were derived using Principal Component Analysis (PCA). Two DPs were derived: Pro-healthy and Western. After adjusting for potential confounders, the risk of abnormal progressive motility was significantly higher in the middle (OR: 2.89, 95% CI: 1.03–8.09) and upper (OR: 7.78, 95% CI: 1.52–15.06) tertiles of the Western DP. A trend for increased risk of the abnormal total count, progressive motility, and morphology (P-trend < 0.050) was found in ...

The Lancet

Background Understanding the magnitude of cancer burden attributable to potentially modifiable ri... more Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4•45 million (95% uncertainty interval 4•01-4•94) deaths and 105 million (95•0-116) DALYs for both sexes combined, representing 44•4% (41•3-48•4) of all cancer deaths and 42•0% (39•1-45•6) of all DALYs. There were 2•88 million (2•60-3•18) risk-attributable cancer deaths in males (50•6% [47•8-54•1] of all male cancer deaths) and 1•58 million (1•36-1•84) risk-attributable cancer deaths in females (36•3% [32•5-41•3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20•4% (12•6-28•4) and DALYs by 16•8% (8•8-25•0), with the greatest percentage increase in metabolic risks (34•7% [27•9-42•8] and 33•3% [25•8-42•0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Funding Bill & Melinda Gates Foundation.

Diabetes Care

BACKGROUND Due to the rapidly increasing availability of metabolomics data in prospective studies... more BACKGROUND Due to the rapidly increasing availability of metabolomics data in prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes risk is warranted. PURPOSE To conduct an updated systematic review and meta-analysis of plasma, serum, and urine metabolite markers and incident type 2 diabetes. DATA SOURCES We searched PubMed and Embase until 6 March 2021. STUDY SELECTION We selected prospective observational studies where investigators used high-throughput techniques to investigate the relationship between plasma, serum, or urine metabolites and incident type 2 diabetes. DATA EXTRACTION Baseline metabolites per-SD risk estimates and 95% CIs for incident type 2 diabetes were extracted from all eligible studies. DATA SYNTHESIS A total of 61 reports with 71,196 participants and 11,771 type 2 diabetes cases/events were included in the updated review. Meta-analysis was performed for 412 metabolites, of which 123 were statistically significantly associated...

Iranian Journal of Public Health, 2017

Dear Editor-in-ChiefAcne vulgaris is one of the most common dermatoses, which occurs adolescents ... more Dear Editor-in-ChiefAcne vulgaris is one of the most common dermatoses, which occurs adolescents and increasingly young adults (1). It is known to impair many aspects of quality of life. Acne vulgaris leads to poor body image, anxiety, depression, anger, frustration, diminished self-esteem, social isolation and restriction of activities (2). Over the years, two approaches to investigating acne were established: dermatological and epidemiological. Considering the multifactorial base, chronicity and demographic character of the acne, it could be qualified as a non-communicable disease. One of the fields of public health research is analysis of the dependence between NCDs and exposome (complement of environmental conditions), looking for modifiable risk factors (3). Irrefutably, the key role is played by diet and nutribehaviour.The cross-sectional study was conducted on 370 students aged from 14 to 19 yr (Mean=16.0± 1.5), both healthy and suffering from acne vulgaris in 2015. The legal...

Annals of Nutrition and Metabolism, 2015

Iranian Journal of Public Health, 2019

Nutrients, 2021

The study aimed to evaluate the sustainability of a multi-component education (ABC-HEat) program ... more The study aimed to evaluate the sustainability of a multi-component education (ABC-HEat) program related to healthy nutrition and lifestyle after three months and nine months and to assess the socioeconomic context in improving teenage nutrition knowledge. The study was designed as a clustered, controlled, education-based intervention. A sample was chosen and allocated into either an educated group (under intervention) or a control group (outside of intervention). The study covered 464 11–12-year-old students (educated/control 319/145). In the educated group, data were collected three times: before education, after three months and after nine months to measure the short- and the long-term effects of education, respectively. In the control group, data were collected in parallel. Changes in nutrition knowledge score (NKS, points) by sex, residence, family affluence scale (FAS) were the main outcome measures. The increase in the NKS was significantly higher in the educated group than i...

Cancers, 2021

This review article contains a concise consideration of genetic and environmental risk factors fo... more This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known risk factors associated with colorectal cancer include familial and hereditary factors and lifestyle-related and ecological factors. Lifestyle factors are significant because of the potential for improving our understanding of the disease. Physical inactivity, obesity, smoking and alcohol consumption can also be addressed through therapeutic interventions. We also made efforts to systematize available literature and data on epidemiology, diagnosis, type and nature of symptoms and disease stages. Further study of colorectal cancer and progress made globally is crucial to inform future strategies in controlling the disease’s burden through population-based preventative initiatives.

First International Electronic Conference on Nutrients, Microbiota and Chronic Disease, 2020

This study aimed to evaluate the association between diet quality, perception of benefits consump... more This study aimed to evaluate the association between diet quality, perception of benefits consumption, and fermented dairy product intake in a representative sample of the Polish population. The study was carried out in February 2020. 2009 men and women were randomly sampled from the representative Polish population stratified for two age groups (19-30 and 66-75 years). Dairy product intake was evaluated using a qualitative frequency questionnaire. Diet quality was assessed by calculating the Mediterranean Diet Adherence Screener (MEDAS) score. Perceived health benefits of dairy product consumption were assessed with a literature-based questionnaire. The Health Concern Scale was used to measure participants' attitudes toward health. Median intake of fermented dairy products was 0.8 portion/day (IQR: 0.4-1.6). Intake of fermented dairy products was associated with higher MEDAS. We observed that people with the highest intake of fermented dairy product consumed more oils, vegetables, wine, legumes, fish and seafood, sweets and pastries, nuts, and higher preference for white meat and were more likely to report perceived benefits to maintain body weight, reduce cardiovascular risk, and improve immune and dental health. Moreover, a high intake of fermented dairy products was positively related to paying more attention to health. Our study identified patterns of health behaviors associated with frequent consumption of fermented products. We observed that the intake of fermented dairy products is associated with better diet quality, consumer self-consciousness, and a greater attitude to own health.

Proceedings of the Nutrition Society, 2020

The role of nutritional status of pregnant women and birth outcomes is ambiguous. Recent studies ... more The role of nutritional status of pregnant women and birth outcomes is ambiguous. Recent studies show that pre-pregnancy body weight is equally important as weight gain during pregnancy. Body mass index (BMI) is the most accessible and easy to check a nutritional status index, which may help to control the gestation and predict infant health outcome. This study aimed to examine the associations between pre-pregnancy body mass index and the infant birth parameters. A presented observational study was offered to 200 pregnant women from Antenatal Clinic at Jersey General Hospital in 2017. Total number of 83 women agreed to take part in this project. Diet, lifestyle, socio-economic, and demographic data were obtained from participants. Delivery and birth data were taken from hospital records. Offspring feeding data and selected anthropometric measurements for mothers and their newborns were also collected. Differences between BMI for delivery type and way of feeding were verified with c...

Proceedings of the Nutrition Society, 2020

It is estimated that in Central and Eastern Europe 8–12% of men are infertile, and in the case of... more It is estimated that in Central and Eastern Europe 8–12% of men are infertile, and in the case of 20% of infertile couples in the region, indicates a 56% part of the malefactor in the occurrence of infertility. Numerous studies have shown that a healthy diet with a high intake of fish and seafood, poultry, vegetables, fruits, legumes, through the high content of antioxidants are associated with better parameters of semen quality and reduced risk of asthenozoospermia. Men's diets may affect spermatogenesis as reflected in semen quality indicators, but the literature on the relation between meat intake and semen quality is limited. Our objective was to prospectively examine the relation between meats including red, poultry, proceesed and fish and indicators of semen quality. Men in subfertile couples presenting for evaluation at the Olsztyn Hospital Fertility Center were invited to participate in an ongoing study of environmental factors and fertility. This cross-sectional study w...

Proceedings of the Nutrition Society, 2020

Breakfast is considered to be the most important meal of the day, which significantly contributes... more Breakfast is considered to be the most important meal of the day, which significantly contributes to overall dietary quality. Global trends suggest a decline in breakfast consumption frequency in all age groups over the years. Breakfast skipping is associated with increased risk of weight gain, insulin resistance and type 2 diabetes, which are crucial risk factors of cardiovascular diseases (CVD). Regular breakfast consumption as a modifiable risk factor might be of great interest for cardiovascular prevention. Several prospective cohort studies showed contradictory findings on breakfast skipping and CVD risk. To the best knowledge of authors, this topic was not covered by any previous meta-analysis. Therefore, this review aimed to summarise the evidence on the association between breakfast skipping and CVD risk in prospective studies with particular emphasis on dose-response relationship and quality of existing evidence. A comprehensive search of the literature was performed using ...

Scientific Reports, 2019

Ageing involves significant changes in skeletal muscle mass and its functioning. This study aimed... more Ageing involves significant changes in skeletal muscle mass and its functioning. This study aimed to identify the major nutrient patterns (NPs) present in a sample of adult Polish women and evaluate their associations with the skeletal muscle mass index (SMI). A cross-sectional study initially recruited 527 women, and a final analysis was carried out on 275 women aged 32–60 years. Nutrient intake was assessed using fourteen repetitions of 24-hour dietary recall. NPs were derived using principal component analysis. Associations between adherence to NPs and the SMI were evaluated using linear regression models. Three NPs were identified: ‘Animal Protein-Vitamins’, ‘Fibre-Plant Protein-Minerals’ and ‘Fats’. In the adjusted model, the upper tertile compared to the bottom tertile of the ‘Animal Protein-Vitamins’ NP was related to a higher SMI (β = 0.123 95% CI: 0.019; 0.227; P for 1-SD increase of NP score = 0.009). No associations between the SMI and the ‘Fibre-Plant Protein-Minerals’ a...

The Lancet Gastroenterology & Hepatology, 2019

Background Data about the global, regional, and country-specific variations in the levels and tre... more Background Data about the global, regional, and country-specific variations in the levels and trends of colorectal cancer are required to understand the impact of this disease and the trends in its burden to help policy makers allocate resources. Here we provide a status report on the incidence, mortality, and disability caused by colorectal cancer in 195 countries and territories between 1990 and 2017. Methods Vital registration, sample vital registration, verbal autopsy, and cancer registry data were used to generate incidence, death, and disability-adjusted life-year (DALY) estimates of colorectal cancer at the global, regional, and national levels. We also determined the association between development levels and colorectal cancer age-standardised DALY rates, and calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. All of the estimates are reported as counts and age-standardised rates per 100 000 person-years, with some estimates also presented by sex and 5-year age groups. Findings In 2017, there were 1•8 million (95% UI 1•8-1•9) incident cases of colorectal cancer globally, with an agestandardised incidence rate of 23•2 (22•7-23•7) per 100 000 person-years that increased by 9•5% (4•5-13•5) between 1990 and 2017. Globally, colorectal cancer accounted for 896 000 (876 300-915 700) deaths in 2017, with an agestandardised death rate of 11•5 (11•3-11•8) per 100 000 person-years, which decreased between 1990 and 2017 (-13•5% [-18•4 to-10•0]). Colorectal cancer was also responsible for 19•0 million (18•5-19•5) DALYs globally in 2017, with an age-standardised rate of 235•7 (229•7-242•0) DALYs per 100 000 person-years, which decreased between 1990 and 2017 (-14•5% [-20•4 to-10•3]). Slovakia, the Netherlands, and New Zealand had the highest age-standardised incidence rates in 2017. Greenland, Hungary, and Slovakia had the highest age-standardised death rates in 2017. Numbers of incident cases and deaths were higher among males than females up to the ages of 80-84 years, with the highest rates observed in the oldest age group (≥95 years) for both sexes in 2017. There was a non-linear association between the Socio-demographic Index and the Healthcare Access and Quality Index and age-standardised DALY rates. In 2017, the three largest contributors to DALYs at the global level, for both sexes, were diet low in calcium (20•5% [12•9-28•9]), alcohol use (15•2% [12•1-18•3]), and diet low in milk (14•3% [5•1-24•8]). Interpretation There is substantial global variation in the burden of colorectal cancer. Although the overall colorectal cancer age-standardised death rate has been decreasing at the global level, the increasing age-standardised incidence rate in most countries poses a major public health challenge across the world. The results of this study could be useful for policy makers to carry out cost-effective interventions and to reduce exposure to modifiable risk factors, particularly in countries with high incidence or increasing burden. Funding Bill & Melinda Gates Foundation.

PLoS ONE, 2013

Background: The aim of this systematic review of randomized controlled trials was to compare the ... more Background: The aim of this systematic review of randomized controlled trials was to compare the effects of aerobic training (AET), resistance training (RT), and combined aerobic and resistance training (CT) on anthropometric parameters, blood lipids, and cardiorespiratory fitness in overweight and obese subjects. Methods: Electronic searches for randomized controlled trials were performed in MEDLINE, EMBASE and the Cochrane Trial Register. Inclusion criteria were: Body Mass Index: $25 kg/m 2 , 19+ years of age, supervised exercise training, and a minimum intervention period of 8 weeks. Anthropometric outcomes, blood lipids, and cardiorespiratory fitness parameters were included. Pooled effects were calculated by inverse-variance random effect pairwise meta-analyses and Bayesian random effects network meta-analyses. Findings: 15 trials enrolling 741 participants were included in the meta-analysis. Compared to RT, AET resulted in a significantly more pronounced reduction of body weight [mean differences (MD):-1.15 kg, p = 0.04], waist circumference [MD:-1.10 cm, p = 0.004], and fat mass [MD:-1.15 kg, p = 0.001] respectively. RT was more effective than AET in improving lean body mass [MD: 1.26 kg, p,0.00001]. When comparing CT with RT, MD in change of body weight [MD:-2.03 kg, p,0.0001], waist circumference [MD:-1.57 cm, p = 0.0002], and fat mass [MD:-1.88 kg, p,0.00001] were all in favor of CT. Results from the network meta-analyses confirmed these findings. Conclusion: Evidence from both pairwise and network meta-analyses suggests that CT is the most efficacious means to reduce anthropometric outcomes and should be recommended in the prevention and treatment of overweight, and obesity whenever possible.

Nutrients, 2018

The etiology of diminished sperm quality in about 30% of male infertility cases generally remains... more The etiology of diminished sperm quality in about 30% of male infertility cases generally remains unexplained. Some studies have suggested that specific nutritional factors can affect semen quality. The aim of this study was to evaluate an association between dietary patterns (DPs) and the risk of abnormal semen quality parameters in men. This cross-sectional study was carried out in 114 men aged 20–55 years from Poland. Semen parameters were assessed via computer-aided semen. Diet was assessed by a food frequency questionnaire (FFQ). DPs were derived using Principal Component Analysis (PCA). Two DPs were derived: Pro-healthy and Western. After adjusting for potential confounders, the risk of abnormal progressive motility was significantly higher in the middle (OR: 2.89, 95% CI: 1.03–8.09) and upper (OR: 7.78, 95% CI: 1.52–15.06) tertiles of the Western DP. A trend for increased risk of the abnormal total count, progressive motility, and morphology (P-trend < 0.050) was found in ...