Anna Mestre - Academia.edu (original) (raw)
Papers by Anna Mestre
Journal of Cognitive Neuroscience, 2008
& An important issue in language learning is how new words are integrated in the brain representa... more & An important issue in language learning is how new words are integrated in the brain representations that sustain language processing. To identify the brain regions involved in meaning acquisition and word learning, we conducted a functional magnetic resonance imaging study. Young participants were required to deduce the meaning of a novel word presented within increasingly constrained sentence contexts that were read silently during the scanning session. Inconsistent contexts were also presented in which no meaning could be assigned to the novel word. Participants showed meaning acquisition in the consistent but not in the inconsistent condition. A distributed brain network was identified comprising the left anterior inferior frontal gyrus (BA 45), the middle temporal gyrus (BA 21), the parahippocampal gyrus, and several subcortical structures (the thalamus and the striatum). Drawing on previous neuroimaging evidence, we tentatively identify the roles of these brain areas in the retrieval, selection, and encoding of the meaning. &
Philosophical Transactions of The Royal Society B: Biological Sciences, 2009
The link between word form and meaning lies in the core of human language. The aim of the present... more The link between word form and meaning lies in the core of human language. The aim of the present investigation is to unravel the neural mechanisms implied in language acquisition and word-learning. More specifically, this project addresses the challenge that young children are facing when learning the meaning of words or similarly adults when learning a foreign language. This ability
& The meaning of a novel word can be acquired by extracting it from linguistic context. Here we s... more & The meaning of a novel word can be acquired by extracting it from linguistic context. Here we simulated word learning of new words associated to concrete and abstract concepts in a variant of the human simulation paradigm that provided linguistic context information in order to characterize the brain systems involved. Native speakers of Spanish read pairs of sentences in order to derive the meaning of a new word that appeared in the terminal position of the sentences. fMRI revealed that learning the meaning associated to concrete and abstract new words was qualitatively different and recruited similar brain regions as the processing of real concrete and abstract words. In particular, learning of new concrete words selectively boosted the activation of the ventral anterior fusiform gyrus, a region driven by imageability, which has previously been implicated in the processing of concrete words. &
Brain and Language, 2009
In natural languages some syntactic structures are simpler than others. Syntactically complex str... more In natural languages some syntactic structures are simpler than others. Syntactically complex structures require further computation that is not required by syntactically simple structures. In particular, canonical, basic word order represents the simplest sentence-structure. Natural languages have different canonical word orders, and they vary in the degree of word order freedom they allow. In the case of free word order, whether canonical word order plays any role in processing is still unclear. In this paper, we present behavioral and electrophysiological evidence that simpler, canonical word order preference is found even in a free word order language.
Journal of Cognitive Neuroscience, 2009
& The meaning of a novel word can be acquired by extracting it from linguistic context. Here we s... more & The meaning of a novel word can be acquired by extracting it from linguistic context. Here we simulated word learning of new words associated to concrete and abstract concepts in a variant of the human simulation paradigm that provided linguistic context information in order to characterize the brain systems involved. Native speakers of Spanish read pairs of sentences in order to derive the meaning of a new word that appeared in the terminal position of the sentences. fMRI revealed that learning the meaning associated to concrete and abstract new words was qualitatively different and recruited similar brain regions as the processing of real concrete and abstract words. In particular, learning of new concrete words selectively boosted the activation of the ventral anterior fusiform gyrus, a region driven by imageability, which has previously been implicated in the processing of concrete words. &
Neuroimage, 2010
A dissociation between noun and verb processing has been found in brain damaged patients leading ... more A dissociation between noun and verb processing has been found in brain damaged patients leading to the proposal that different word classes are supported by different neural representations. This notion is supported by the facts that children acquire nouns faster and adults usually perform better for nouns than verbs in a range of tasks. In the present study, we simulated word learning in a variant of the human simulation paradigm that provided only linguistic context information and required young healthy adults to map noun or verb meanings to novel words. The mapping of a meaning associated with a new-noun and a new-verb recruited different brain regions as revealed by functional magnetic resonance imaging. While new-nouns showed greater activation in the left fusiform gyrus, larger activation was observed for newverbs in the left posterior middle temporal gyrus and left inferior frontal gyrus (opercular part). Furthermore, the activation in several regions of the brain (for example the bilateral hippocampus and bilateral putamen) was positively correlated with the efficiency of new-noun but not new-verb learning. The present results suggest that the same brain regions that have previously been associated with the representation of meaning of nouns and verbs are also associated with the mapping of such meanings to novel words, a process needed in second language learning.
Cerebral Cortex, 2006
Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizi... more Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizing or, similar to meaning acquisition during infancy, by extracting it from context. Little is known about the brain mechanisms involved in word learning. Here we demonstrate, using event-related brain potentials, the rapid development of a brain signature related to lexical and semantic processing during contextual word learning. Healthy volunteers engaged in a simple word-learning task were required to discover the meaning of a novel word from a context during silent reading. After 3 exposures, brain potentials to novel words in meaningful contexts were indistinguishable from real words, although this acquisition effect was not observed for novel words, for which sentence contexts allowed no meaning derivation. Furthermore, when the learned novel words were presented in isolation, an activation of their corresponding meaning was observed, although this process was slower than for real words.
Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizi... more Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizing or, similar to meaning acquisition during infancy, by extracting it from context. Little is known about the brain mechanisms involved in word learning. Here we demonstrate, using event-related brain potentials, the rapid development of a brain signature related to lexical and semantic processing during contextual word learning. Healthy volunteers engaged in a simple word-learning task were required to discover the meaning of a novel word from a context during silent reading. After 3 exposures, brain potentials to novel words in meaningful contexts were indistinguishable from real words, although this acquisition effect was not observed for novel words, for which sentence contexts allowed no meaning derivation. Furthermore, when the learned novel words were presented in isolation, an activation of their corresponding meaning was observed, although this process was slower than for real words.
Human Brain Mapping, 2010
Children can learn the meaning of a new word from context during normal reading or listening, wit... more Children can learn the meaning of a new word from context during normal reading or listening, without any explicit instruction. It is unclear how such meaning acquisition is supported and achieved in human brain. In this functional magnetic resonance imaging (fMRI) study we investigated neural networks supporting word learning with a functional connectivity approach. Participants were exposed to a new word presented in two successive sentences and needed to derive the meaning of the new word. We observed two neural networks involved in mapping the meaning to the new word. One network connected the left inferior frontal gyrus (LIFG) with the middle frontal gyrus (MFG), medial superior frontal gyrus, caudate nucleus, thalamus, and inferior parietal lobule. The other network connected the left middle temporal gyrus (LMTG) with the MFG, anterior and posterior cingulate cortex. The LIFG network showed stronger interregional interactions for new than real words, whereas the LMTG network showed similar connectivity patterns for new and real words. We proposed that these two networks support different functions during word learning. The LIFG network appears to select the most appropriate meaning from competing candidates and to map the selected meaning onto the new word. The LMTG network may be recruited to integrate the word into sentential context, regardless of whether the word is real or new. The LIFG and the LMTG networks share a common node, the MFG, suggesting that these two networks communicate in working memory. Hum Brain Mapp, 2011. © 2010 Wiley-Liss, Inc.
Cerebral Cortex, 2009
People's sensitivity to reinforcing stimuli such as monetary gains and losses shows a wide interi... more People's sensitivity to reinforcing stimuli such as monetary gains and losses shows a wide interindividual variation that might in part be determined by genetic differences. Because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the Valine or Methionine variant of the catechol-O-methyltransferase (COMT) codon 158 polymorphism as well as homozygous for the C or T variant of the SNP 2521 polymorphism of the dopamine D4 receptor. Participants took part in a gambling paradigm featuring unexpectedly high monetary gains and losses in addition to standard gains/losses of expected magnitude while undergoing functional magnetic resonance imaging at 3 T. Valence-related brain activations were seen in the ventral striatum, the anterior cingulate cortex, and the inferior parietal cortex. These activations were modulated by the COMT polymorphism with greater effects for valine/valine participants but not by the D4 receptor polymorphism. By contrast, magnituderelated effects in the anterior insula and the cingulate cortex were modulated by the D4 receptor polymorphism with larger responses for the CC variant. These findings emphasize the differential contribution of genetic variants in the dopaminergic system to various aspects of reward processing.
Journal of Cognitive Neuroscience, 2008
& An important issue in language learning is how new words are integrated in the brain representa... more & An important issue in language learning is how new words are integrated in the brain representations that sustain language processing. To identify the brain regions involved in meaning acquisition and word learning, we conducted a functional magnetic resonance imaging study. Young participants were required to deduce the meaning of a novel word presented within increasingly constrained sentence contexts that were read silently during the scanning session. Inconsistent contexts were also presented in which no meaning could be assigned to the novel word. Participants showed meaning acquisition in the consistent but not in the inconsistent condition. A distributed brain network was identified comprising the left anterior inferior frontal gyrus (BA 45), the middle temporal gyrus (BA 21), the parahippocampal gyrus, and several subcortical structures (the thalamus and the striatum). Drawing on previous neuroimaging evidence, we tentatively identify the roles of these brain areas in the retrieval, selection, and encoding of the meaning. &
Philosophical Transactions of The Royal Society B: Biological Sciences, 2009
The link between word form and meaning lies in the core of human language. The aim of the present... more The link between word form and meaning lies in the core of human language. The aim of the present investigation is to unravel the neural mechanisms implied in language acquisition and word-learning. More specifically, this project addresses the challenge that young children are facing when learning the meaning of words or similarly adults when learning a foreign language. This ability
& The meaning of a novel word can be acquired by extracting it from linguistic context. Here we s... more & The meaning of a novel word can be acquired by extracting it from linguistic context. Here we simulated word learning of new words associated to concrete and abstract concepts in a variant of the human simulation paradigm that provided linguistic context information in order to characterize the brain systems involved. Native speakers of Spanish read pairs of sentences in order to derive the meaning of a new word that appeared in the terminal position of the sentences. fMRI revealed that learning the meaning associated to concrete and abstract new words was qualitatively different and recruited similar brain regions as the processing of real concrete and abstract words. In particular, learning of new concrete words selectively boosted the activation of the ventral anterior fusiform gyrus, a region driven by imageability, which has previously been implicated in the processing of concrete words. &
Brain and Language, 2009
In natural languages some syntactic structures are simpler than others. Syntactically complex str... more In natural languages some syntactic structures are simpler than others. Syntactically complex structures require further computation that is not required by syntactically simple structures. In particular, canonical, basic word order represents the simplest sentence-structure. Natural languages have different canonical word orders, and they vary in the degree of word order freedom they allow. In the case of free word order, whether canonical word order plays any role in processing is still unclear. In this paper, we present behavioral and electrophysiological evidence that simpler, canonical word order preference is found even in a free word order language.
Journal of Cognitive Neuroscience, 2009
& The meaning of a novel word can be acquired by extracting it from linguistic context. Here we s... more & The meaning of a novel word can be acquired by extracting it from linguistic context. Here we simulated word learning of new words associated to concrete and abstract concepts in a variant of the human simulation paradigm that provided linguistic context information in order to characterize the brain systems involved. Native speakers of Spanish read pairs of sentences in order to derive the meaning of a new word that appeared in the terminal position of the sentences. fMRI revealed that learning the meaning associated to concrete and abstract new words was qualitatively different and recruited similar brain regions as the processing of real concrete and abstract words. In particular, learning of new concrete words selectively boosted the activation of the ventral anterior fusiform gyrus, a region driven by imageability, which has previously been implicated in the processing of concrete words. &
Neuroimage, 2010
A dissociation between noun and verb processing has been found in brain damaged patients leading ... more A dissociation between noun and verb processing has been found in brain damaged patients leading to the proposal that different word classes are supported by different neural representations. This notion is supported by the facts that children acquire nouns faster and adults usually perform better for nouns than verbs in a range of tasks. In the present study, we simulated word learning in a variant of the human simulation paradigm that provided only linguistic context information and required young healthy adults to map noun or verb meanings to novel words. The mapping of a meaning associated with a new-noun and a new-verb recruited different brain regions as revealed by functional magnetic resonance imaging. While new-nouns showed greater activation in the left fusiform gyrus, larger activation was observed for newverbs in the left posterior middle temporal gyrus and left inferior frontal gyrus (opercular part). Furthermore, the activation in several regions of the brain (for example the bilateral hippocampus and bilateral putamen) was positively correlated with the efficiency of new-noun but not new-verb learning. The present results suggest that the same brain regions that have previously been associated with the representation of meaning of nouns and verbs are also associated with the mapping of such meanings to novel words, a process needed in second language learning.
Cerebral Cortex, 2006
Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizi... more Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizing or, similar to meaning acquisition during infancy, by extracting it from context. Little is known about the brain mechanisms involved in word learning. Here we demonstrate, using event-related brain potentials, the rapid development of a brain signature related to lexical and semantic processing during contextual word learning. Healthy volunteers engaged in a simple word-learning task were required to discover the meaning of a novel word from a context during silent reading. After 3 exposures, brain potentials to novel words in meaningful contexts were indistinguishable from real words, although this acquisition effect was not observed for novel words, for which sentence contexts allowed no meaning derivation. Furthermore, when the learned novel words were presented in isolation, an activation of their corresponding meaning was observed, although this process was slower than for real words.
Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizi... more Acquiring the meaning of a new word in a foreign language can be achieved either by rote memorizing or, similar to meaning acquisition during infancy, by extracting it from context. Little is known about the brain mechanisms involved in word learning. Here we demonstrate, using event-related brain potentials, the rapid development of a brain signature related to lexical and semantic processing during contextual word learning. Healthy volunteers engaged in a simple word-learning task were required to discover the meaning of a novel word from a context during silent reading. After 3 exposures, brain potentials to novel words in meaningful contexts were indistinguishable from real words, although this acquisition effect was not observed for novel words, for which sentence contexts allowed no meaning derivation. Furthermore, when the learned novel words were presented in isolation, an activation of their corresponding meaning was observed, although this process was slower than for real words.
Human Brain Mapping, 2010
Children can learn the meaning of a new word from context during normal reading or listening, wit... more Children can learn the meaning of a new word from context during normal reading or listening, without any explicit instruction. It is unclear how such meaning acquisition is supported and achieved in human brain. In this functional magnetic resonance imaging (fMRI) study we investigated neural networks supporting word learning with a functional connectivity approach. Participants were exposed to a new word presented in two successive sentences and needed to derive the meaning of the new word. We observed two neural networks involved in mapping the meaning to the new word. One network connected the left inferior frontal gyrus (LIFG) with the middle frontal gyrus (MFG), medial superior frontal gyrus, caudate nucleus, thalamus, and inferior parietal lobule. The other network connected the left middle temporal gyrus (LMTG) with the MFG, anterior and posterior cingulate cortex. The LIFG network showed stronger interregional interactions for new than real words, whereas the LMTG network showed similar connectivity patterns for new and real words. We proposed that these two networks support different functions during word learning. The LIFG network appears to select the most appropriate meaning from competing candidates and to map the selected meaning onto the new word. The LMTG network may be recruited to integrate the word into sentential context, regardless of whether the word is real or new. The LIFG and the LMTG networks share a common node, the MFG, suggesting that these two networks communicate in working memory. Hum Brain Mapp, 2011. © 2010 Wiley-Liss, Inc.
Cerebral Cortex, 2009
People's sensitivity to reinforcing stimuli such as monetary gains and losses shows a wide interi... more People's sensitivity to reinforcing stimuli such as monetary gains and losses shows a wide interindividual variation that might in part be determined by genetic differences. Because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the Valine or Methionine variant of the catechol-O-methyltransferase (COMT) codon 158 polymorphism as well as homozygous for the C or T variant of the SNP 2521 polymorphism of the dopamine D4 receptor. Participants took part in a gambling paradigm featuring unexpectedly high monetary gains and losses in addition to standard gains/losses of expected magnitude while undergoing functional magnetic resonance imaging at 3 T. Valence-related brain activations were seen in the ventral striatum, the anterior cingulate cortex, and the inferior parietal cortex. These activations were modulated by the COMT polymorphism with greater effects for valine/valine participants but not by the D4 receptor polymorphism. By contrast, magnituderelated effects in the anterior insula and the cingulate cortex were modulated by the D4 receptor polymorphism with larger responses for the CC variant. These findings emphasize the differential contribution of genetic variants in the dopaminergic system to various aspects of reward processing.