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Papers by Annu Rani
Archives of current research international, Jun 26, 2024
This study evaluates the tensile properties of various timber species used in agricultural implem... more This study evaluates the tensile properties of various timber species used in agricultural implements, focusing on their tensile strength and elongation characteristics. Understanding these properties is crucial for selecting suitable timber for different applications, ensuring durability and performance under mechanical stress. The species analyzed include Yellow Teak, Red Cedar, Teak, Lebbeck, Java Plum, Eucalyptus, Margosa, Mango, Sal, and North Indian Rosetimber. The tensile properties were determined using the IS 1708 standard on a servo-controlled universal testing machine. Results showed that Sal exhibited the highest tensile strength and elongation, making it the Most Intense and flexible timber with consistent properties. Margosa also demonstrated high tensile strength and moderate elongation with very low variability, indicating
ACS chemical neuroscience, Mar 4, 2024
Frontiers in Immunology, Oct 8, 2023
Background: EBV infection has long been postulated to trigger multiple sclerosis (MS) and anti-EB... more Background: EBV infection has long been postulated to trigger multiple sclerosis (MS) and anti-EBV antibodies showed a consistent presence in MS patients. Previous reports from our group have shown that the EBV infects different brain cells. Entry of the virus in neuronal cells is assisted by several host factors including membrane cholesterol. By using an inhibitor, methyl-b-cyclodextrin (MbCD), we evaluated the role of membrane cholesterol in EBV infection and pathogenesis Methodology: The membrane cholesterol depleted cells were infected with EBV and its latent genes expression were assessed. Further, EBV-mediated downstream signalling molecules namely STAT3, RIP, NF-kB and TNF-a levels was checked at protein level along with spatial (periphery and nucleus) and temporal changes in biomolecular fingerprints with Raman microspectroscopy (RS). Results: Upon treatment with MbCD, lmp1 and lmp2a suggested significant downregulation compared to EBV infection. Downstream molecules like STAT3 and RIP, exhibited a decrease in protein levels temporally upon exposure to MbCD while NF-kB levels were found to be increased. Further, the intensity of the Raman spectra exhibited an increase in triglycerides and fatty acids in the cytoplasm of EBV-infected LN-229 cells compared to MbCD+EBV. Likewise, the Raman peak width of cholesterol, lipid and fatty acids were found to be reduced in EBV-infected samples indicates elevation in the cholesterol specific moieties. In contrast, an opposite pattern was observed in the nucleus. Moreover, the ingenuity pathway analysis revealed protein molecules such as VLDLR, MBP and Frontiers in Immunology frontiersin.org 01
ACS Chemical Neuroscience, Jun 8, 2023
Engineering Failure Analysis, Dec 1, 2022
Microbial Pathogenesis, 2023
Lecture notes in networks and systems, 2023
Lecture notes in networks and systems, 2023
Future Virology
Neurotropic viruses target the central nervous system through various mechanisms: they have the p... more Neurotropic viruses target the central nervous system through various mechanisms: they have the potential to modulate synaptic plasticity, causing cognitive impairments by blocking N-methyl d-aspartate receptors; they alter the Ca2+ ion-signaling pathways modulating long-term potentiation, leading to a severe inflammatory response in brain cells, increased reactive oxygen species and lipid peroxidation through mitochondria and peroxisomes. Inflammatory pathways have a key role in modulating the plasticity of neurons, linked to numerous neurological disorders. Advanced neuroimaging techniques facilitate the early diagnosis of impaired synaptic function in viral infections and neurodegenerative disorders. Here we discuss the understanding of the interplay between neurotropic viral infections and their effects on synaptic plasticity and diagnosis through neuroimaging techniques.
ACS Chemical Neuroscience
ACS Chemical Neuroscience
International Journal of Current Microbiology and Applied Sciences
Social Science Research Network, 2023
Engineering Failure Analysis
International Journal of Current Microbiology and Applied Sciences, 2020
Archives of current research international, Jun 26, 2024
This study evaluates the tensile properties of various timber species used in agricultural implem... more This study evaluates the tensile properties of various timber species used in agricultural implements, focusing on their tensile strength and elongation characteristics. Understanding these properties is crucial for selecting suitable timber for different applications, ensuring durability and performance under mechanical stress. The species analyzed include Yellow Teak, Red Cedar, Teak, Lebbeck, Java Plum, Eucalyptus, Margosa, Mango, Sal, and North Indian Rosetimber. The tensile properties were determined using the IS 1708 standard on a servo-controlled universal testing machine. Results showed that Sal exhibited the highest tensile strength and elongation, making it the Most Intense and flexible timber with consistent properties. Margosa also demonstrated high tensile strength and moderate elongation with very low variability, indicating
ACS chemical neuroscience, Mar 4, 2024
Frontiers in Immunology, Oct 8, 2023
Background: EBV infection has long been postulated to trigger multiple sclerosis (MS) and anti-EB... more Background: EBV infection has long been postulated to trigger multiple sclerosis (MS) and anti-EBV antibodies showed a consistent presence in MS patients. Previous reports from our group have shown that the EBV infects different brain cells. Entry of the virus in neuronal cells is assisted by several host factors including membrane cholesterol. By using an inhibitor, methyl-b-cyclodextrin (MbCD), we evaluated the role of membrane cholesterol in EBV infection and pathogenesis Methodology: The membrane cholesterol depleted cells were infected with EBV and its latent genes expression were assessed. Further, EBV-mediated downstream signalling molecules namely STAT3, RIP, NF-kB and TNF-a levels was checked at protein level along with spatial (periphery and nucleus) and temporal changes in biomolecular fingerprints with Raman microspectroscopy (RS). Results: Upon treatment with MbCD, lmp1 and lmp2a suggested significant downregulation compared to EBV infection. Downstream molecules like STAT3 and RIP, exhibited a decrease in protein levels temporally upon exposure to MbCD while NF-kB levels were found to be increased. Further, the intensity of the Raman spectra exhibited an increase in triglycerides and fatty acids in the cytoplasm of EBV-infected LN-229 cells compared to MbCD+EBV. Likewise, the Raman peak width of cholesterol, lipid and fatty acids were found to be reduced in EBV-infected samples indicates elevation in the cholesterol specific moieties. In contrast, an opposite pattern was observed in the nucleus. Moreover, the ingenuity pathway analysis revealed protein molecules such as VLDLR, MBP and Frontiers in Immunology frontiersin.org 01
ACS Chemical Neuroscience, Jun 8, 2023
Engineering Failure Analysis, Dec 1, 2022
Microbial Pathogenesis, 2023
Lecture notes in networks and systems, 2023
Lecture notes in networks and systems, 2023
Future Virology
Neurotropic viruses target the central nervous system through various mechanisms: they have the p... more Neurotropic viruses target the central nervous system through various mechanisms: they have the potential to modulate synaptic plasticity, causing cognitive impairments by blocking N-methyl d-aspartate receptors; they alter the Ca2+ ion-signaling pathways modulating long-term potentiation, leading to a severe inflammatory response in brain cells, increased reactive oxygen species and lipid peroxidation through mitochondria and peroxisomes. Inflammatory pathways have a key role in modulating the plasticity of neurons, linked to numerous neurological disorders. Advanced neuroimaging techniques facilitate the early diagnosis of impaired synaptic function in viral infections and neurodegenerative disorders. Here we discuss the understanding of the interplay between neurotropic viral infections and their effects on synaptic plasticity and diagnosis through neuroimaging techniques.
ACS Chemical Neuroscience
ACS Chemical Neuroscience
International Journal of Current Microbiology and Applied Sciences
Social Science Research Network, 2023
Engineering Failure Analysis
International Journal of Current Microbiology and Applied Sciences, 2020