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Papers by Anthony Lozama

Research paper thumbnail of Synthesis of Neoclerodane Diterpenes and Their Pharmacological Effects

Abstract Salvinorin A is a neoclerodane diterpene that has been shown to be an agonist at kappa o... more Abstract Salvinorin A is a neoclerodane diterpene that has been shown to be an agonist at kappa opioid receptors. Its unique structure makes it an attractive target for synthetic organic chemists due to its seven chiral centers and diterpene scaffold. This molecule is also interesting to pharmacologists because it is a non-serotonergic hallucinogen, and the first opioid ligand discovered that lacks a basic nitrogen. There have been several total synthesis approaches to salvinorin A, and these will be detailed within this chapter. Additionally, research efforts have concentrated on structure modification of the salvinorin A scaffold through semi-synthetic methods. Most modifications have focused on the manipulation of the acetate at C-2 and the furan ring. However, chemistry has also been developed to generate analogs at the C-1 ketone, the C-4 methyl ester, and the C-17 lactone. The synthetic methodologies developed for the salvinorin A scaffold will be described, as well as specific analogs with interesting biological activities. Graphical Abstract

Research paper thumbnail of Synthetic Studies of Neoclerodane Diterpenes from Salvia d ivinorum : Preparation and Opioid Receptor Activity of Salvinicin Analogues

Journal of Medicinal Chemistry, 2007

Research paper thumbnail of ChemInform Abstract: Chemical Methods for the Synthesis and Modification of Neoclerodane Diterpenes

Cheminform, 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Research paper thumbnail of Behavioral Evaluation of Modafinil and the Abuse-Related Effects of Cocaine in Rhesus Monkeys

Experimental and Clinical Psychopharmacology, 2010

Research paper thumbnail of Synthesis of Salvinorin A Analogues as Opioid Receptor Probes

Journal of Natural Products, 2006

Research paper thumbnail of Herkinorin Analogues with Differential β-Arrestin-2 Interactions

Journal of Medicinal Chemistry, 2008

Research paper thumbnail of Chemical methods for the synthesis and modification of neoclerodane diterpenes

Bioorganic & Medicinal Chemistry Letters, 2009

Research paper thumbnail of Synthesis of Neoclerodane Diterpenes and Their Pharmacological Effects

Abstract Salvinorin A is a neoclerodane diterpene that has been shown to be an agonist at kappa o... more Abstract Salvinorin A is a neoclerodane diterpene that has been shown to be an agonist at kappa opioid receptors. Its unique structure makes it an attractive target for synthetic organic chemists due to its seven chiral centers and diterpene scaffold. This molecule is also interesting to pharmacologists because it is a non-serotonergic hallucinogen, and the first opioid ligand discovered that lacks a basic nitrogen. There have been several total synthesis approaches to salvinorin A, and these will be detailed within this chapter. Additionally, research efforts have concentrated on structure modification of the salvinorin A scaffold through semi-synthetic methods. Most modifications have focused on the manipulation of the acetate at C-2 and the furan ring. However, chemistry has also been developed to generate analogs at the C-1 ketone, the C-4 methyl ester, and the C-17 lactone. The synthetic methodologies developed for the salvinorin A scaffold will be described, as well as specific analogs with interesting biological activities. Graphical Abstract

Research paper thumbnail of Synthetic Studies of Neoclerodane Diterpenes from Salvia d ivinorum : Preparation and Opioid Receptor Activity of Salvinicin Analogues

Journal of Medicinal Chemistry, 2007

Research paper thumbnail of ChemInform Abstract: Chemical Methods for the Synthesis and Modification of Neoclerodane Diterpenes

Cheminform, 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Research paper thumbnail of Behavioral Evaluation of Modafinil and the Abuse-Related Effects of Cocaine in Rhesus Monkeys

Experimental and Clinical Psychopharmacology, 2010

Research paper thumbnail of Synthesis of Salvinorin A Analogues as Opioid Receptor Probes

Journal of Natural Products, 2006

Research paper thumbnail of Herkinorin Analogues with Differential β-Arrestin-2 Interactions

Journal of Medicinal Chemistry, 2008

Research paper thumbnail of Chemical methods for the synthesis and modification of neoclerodane diterpenes

Bioorganic & Medicinal Chemistry Letters, 2009

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