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Papers by Anupama Vasudevan

Research paper thumbnail of Association between irritable bowel syndrome and asthma: a meta-analysis and systematic review

Annals of Gastroenterology, 2019

Research paper thumbnail of Urinary Metabolites in Patients Undergoing Coronary Catheterization Via the Radial Versus Femoral Artery Approach

Baylor University Medical Center Proceedings, 2017

Research paper thumbnail of Frequency of atrial arrhythmias after atrial flutter ablation and the effect of presenting rhythm on the day of ablation

Baylor University Medical Center Proceedings, 2018

Research paper thumbnail of The CatLet score: a new coronary angiographic scoring tool accommodating the variable coronary anatomy for the first time

Journal of Thoracic Disease, 2019

Research paper thumbnail of Management of Patients with Severe Aortic Stenosis and Concomitant Tricuspid Regurgitation Undergoing Tavr or Savr

Journal of the American College of Cardiology, 2019

Research paper thumbnail of Personalized Treatment of Heart Failure with Biomarker Guidance Using a Novel Disease Severity Score

Baylor University Medical Center Proceedings, 2017

Research paper thumbnail of Analysis of electrocardiographic intervals before and after transcatheter aortic valve implantation to predict the need for permanent pacing

Baylor University Medical Center Proceedings, 2018

Research paper thumbnail of Time to discharge following diagnostic coronary procedures via transradial artery approach: A comparison of Terumo band and StatSeal hemostasis

Cardiovascular Revascularization Medicine, 2018

Research paper thumbnail of Spinal Implants can be Retained in Patients with Deep Spine Infection: A Cohort Study

Journal of Orthopaedics, Trauma and Rehabilitation, 2018

Background/Purpose It is unclear whether implant removal is necessary when deep spine infection o... more Background/Purpose It is unclear whether implant removal is necessary when deep spine infection of spinal instrumentation occurs. This study compares mortality, relapse, and reoperation rates between such patients with and without removal of spine implants. Methods A total of 20 patients were retrospectively reviewed. Baseline characteristics of the implant removal and nonremoval groups were compared. Outcome measures between groups were compared using multivariable logistic regression and predictors of each outcome identified. Results There were no significant differences in mortality, relapse, or reoperation rates between groups. Multiple vertebral level involvement was common (85%), and the L4 (30%) and L5 (35%) levels were most commonly involved. The majority of patients had osteomyelitis/spondylodiscitis (50%) and Staphylococcus aureus infections (60%). Thoracic spine infection was associated with relapse (odds ratio = 1.26) and reoperation (odds ratio = 1.101). Conclusion Impl...

Research paper thumbnail of Response to the Letter: Spinal Implants Can be Inserted in Patients With Deep Spine Infection-Results from a Large Cohort Study

Spine, Jun 18, 2017

Gabriel Popescu is an assistant professor in the Department of Electrical and Computer Engineerin... more Gabriel Popescu is an assistant professor in the Department of Electrical and Computer Engineering and a full-time faculty member with the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana–Champaign. He and his colleagues started the Nanobiophotonics Summer School at the Beckman Institute in 2009. The school was sponsored by the Network for Computational Nanotechnology (NCN), which is funded by the National Science Foundation.

Research paper thumbnail of Computation of a cardiac severity score with left-censored biomarkers for patients with heart failure

Pathology and Laboratory Medicine International, 2017

Research paper thumbnail of Use of erythrocyte sedimentation rate and C-reactive protein to predict osteomyelitis recurrence

Journal of orthopaedic surgery (Hong Kong), 2016

To determine the association between both erythrocyte sedimentation rate (ESR) and C-reactive pro... more To determine the association between both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and osteomyelitis recurrence. Records of 81 males and 27 females aged 10 to 87 (median, 54) years who underwent antibiotic/ surgical treatment for primary (n=68) or recurrent (n=40) osteomyelitis that was related (n=26) or unrelated (n=82) to a prosthesis were reviewed. Of the 40 cases of osteomyelitis recurrence followed up for a median of 23.4 (range, 0.6-74.0) months, 7 and 33 were related and unrelated to a prosthesis, respectively. The cutoff points of lowest ESR and CRP for osteomyelitis recurrence were calculated. Risk factors for osteomyelitis recurrence were determined. Osteomyelitis recurrence was associated with diabetes mellitus, ischaemic heart disease, non-healing wound, infection in the lower limb, and infection with methicillin-resistant Staphylococcus aureus. The cutoff points of CRP ≥5 mg/l and ESR ≥20 mm/h were used for osteomyelitis recurrence. Risk factors...

Research paper thumbnail of A targeted methicillin-resistant Staphylococcus aureus (MRSA) control program did not affect total nosocomial Staphylococcus aureus (SA) bloodstream infections (BSI) despite reducing MRSA BSI

Research paper thumbnail of The costs of nosocomial resistant gram negative intensive care unit infections among patients with the systemic inflammatory response syndrome- a propensity matched case control study

Antimicrobial Resistance and Infection Control, 2015

Research paper thumbnail of Comparison of analgesic efficacy of transversus abdominis plane block with direct infiltration of local anesthetic into surgical incision in lower abdominal gynecological surgeries

Journal of Anaesthesiology Clinical Pharmacology, 2013

Research paper thumbnail of Effectiveness of Trivalent and Quadrivalent Inactivated Vaccines Against Influenza B in the United States, 2011–2012 to 2016–2017

Clinical Infectious Diseases, 2020

Background Since 2013, quadrivalent influenza vaccines containing 2 B viruses gradually replaced ... more Background Since 2013, quadrivalent influenza vaccines containing 2 B viruses gradually replaced trivalent vaccines in the United States. We compared the vaccine effectiveness of quadrivalent to trivalent inactivated vaccines (IIV4 to IIV3, respectively) against illness due to influenza B during the transition, when IIV4 use increased rapidly. Methods The US Influenza Vaccine Effectiveness (Flu VE) Network analyzed 25 019 of 42 600 outpatients aged ≥6 months who enrolled within 7 days of illness onset during 6 seasons from 2011–2012. Upper respiratory specimens were tested for the influenza virus type and B lineage. Using logistic regression, we estimated IIV4 or IIV3 effectiveness by comparing the odds of an influenza B infection overall and the odds of B lineage among vaccinated versus unvaccinated participants. Over 4 seasons from 2013–2014, we compared the relative odds of an influenza B infection among IIV4 versus IIV3 recipients. Results Trivalent vaccines included the predomi...

Research paper thumbnail of A prediction tool for nosocomial multi-drug resistant gram-negative bacilli infections in critically ill patients - prospective observational study

BMC Infectious Diseases, 2014

Background: The widespread use of empiric broad spectrum antibiotics has contributed to the globa... more Background: The widespread use of empiric broad spectrum antibiotics has contributed to the global increase of Resistant Gram-Negative Bacilli (RGNB) infections in intensive care units (ICU). The aim of this study was to develop a tool to predict nosocomial RGNB infections among ICU patients for targeted therapy. Methods: We conducted a prospective observational study from August'07 to December'11. All adult patients who were admitted and stayed for more than 24 hours at the medical and surgical ICU's were included. All patients who developed nosocomial RGNB infections 48 hours after ICU admission were identified. A prediction score was formulated by using independent risk factors obtained from logistic regression analysis. This was prospectively validated with a subsequent cohort of patients admitted to the ICUs during the following time period of January-September 2012. Results: Seventy-six patients with nosocomial RGNB Infection (31bacteremia) were compared with 1398 patients with Systemic Inflammatory Response Syndrome (SIRS) without any gram negative bacterial infection/colonization admitted to the ICUs during the study period. The following independent risk factors were obtained by a multivariable logistic regression analysis-prior isolation of Gram negative organism (coeff: 1.1, 95% CI 0.5-1.7); Surgery during current admission (coeff: 0.69, 95% CI 0.2-1.2); prior Dialysis with end stage renal disease (coeff: 0.7, 95% CI 0.1-1.1); prior use of Carbapenems (coeff: 1.3, 95% CI 0.3-2.3) and Stay in the ICU for more than 5 days (coeff: 2.4, 95% CI 1.6-3.2). It was validated prospectively in a subsequent cohort (n = 408) and the area-under-the-curve (AUC) of the GSDCS score for predicting nosocomial ICU acquired RGNB infection and bacteremia was 0.77 (95% CI 0.68-0.89 and 0.78 (95% CI 0.69-0.89) respectively. The GSDCS (0-4.3) score clearly differentiated the low (0-1.3), medium (1.4-2.3) and high (2.4-4.3) risk patients, both for RGNB infection (p:0.003) and bacteremia (p:0.009). Conclusion: GSDCS is a simple bedside clinical score which predicts RGNB infection and bacteremia with high predictive value and differentiates low versus high risk patients. This score will help clinicians to choose appropriate, timely targeted antibiotic therapy and avoid exposure to unnecessary treatment for patients at low risk of nosocomial RGNB infection. This will reduce the selection pressure and help to contain antibiotic resistance in ICUs.

Research paper thumbnail of Association between irritable bowel syndrome and asthma: a meta-analysis and systematic review

Annals of Gastroenterology, 2019

Research paper thumbnail of Urinary Metabolites in Patients Undergoing Coronary Catheterization Via the Radial Versus Femoral Artery Approach

Baylor University Medical Center Proceedings, 2017

Research paper thumbnail of Frequency of atrial arrhythmias after atrial flutter ablation and the effect of presenting rhythm on the day of ablation

Baylor University Medical Center Proceedings, 2018

Research paper thumbnail of The CatLet score: a new coronary angiographic scoring tool accommodating the variable coronary anatomy for the first time

Journal of Thoracic Disease, 2019

Research paper thumbnail of Management of Patients with Severe Aortic Stenosis and Concomitant Tricuspid Regurgitation Undergoing Tavr or Savr

Journal of the American College of Cardiology, 2019

Research paper thumbnail of Personalized Treatment of Heart Failure with Biomarker Guidance Using a Novel Disease Severity Score

Baylor University Medical Center Proceedings, 2017

Research paper thumbnail of Analysis of electrocardiographic intervals before and after transcatheter aortic valve implantation to predict the need for permanent pacing

Baylor University Medical Center Proceedings, 2018

Research paper thumbnail of Time to discharge following diagnostic coronary procedures via transradial artery approach: A comparison of Terumo band and StatSeal hemostasis

Cardiovascular Revascularization Medicine, 2018

Research paper thumbnail of Spinal Implants can be Retained in Patients with Deep Spine Infection: A Cohort Study

Journal of Orthopaedics, Trauma and Rehabilitation, 2018

Background/Purpose It is unclear whether implant removal is necessary when deep spine infection o... more Background/Purpose It is unclear whether implant removal is necessary when deep spine infection of spinal instrumentation occurs. This study compares mortality, relapse, and reoperation rates between such patients with and without removal of spine implants. Methods A total of 20 patients were retrospectively reviewed. Baseline characteristics of the implant removal and nonremoval groups were compared. Outcome measures between groups were compared using multivariable logistic regression and predictors of each outcome identified. Results There were no significant differences in mortality, relapse, or reoperation rates between groups. Multiple vertebral level involvement was common (85%), and the L4 (30%) and L5 (35%) levels were most commonly involved. The majority of patients had osteomyelitis/spondylodiscitis (50%) and Staphylococcus aureus infections (60%). Thoracic spine infection was associated with relapse (odds ratio = 1.26) and reoperation (odds ratio = 1.101). Conclusion Impl...

Research paper thumbnail of Response to the Letter: Spinal Implants Can be Inserted in Patients With Deep Spine Infection-Results from a Large Cohort Study

Spine, Jun 18, 2017

Gabriel Popescu is an assistant professor in the Department of Electrical and Computer Engineerin... more Gabriel Popescu is an assistant professor in the Department of Electrical and Computer Engineering and a full-time faculty member with the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana–Champaign. He and his colleagues started the Nanobiophotonics Summer School at the Beckman Institute in 2009. The school was sponsored by the Network for Computational Nanotechnology (NCN), which is funded by the National Science Foundation.

Research paper thumbnail of Computation of a cardiac severity score with left-censored biomarkers for patients with heart failure

Pathology and Laboratory Medicine International, 2017

Research paper thumbnail of Use of erythrocyte sedimentation rate and C-reactive protein to predict osteomyelitis recurrence

Journal of orthopaedic surgery (Hong Kong), 2016

To determine the association between both erythrocyte sedimentation rate (ESR) and C-reactive pro... more To determine the association between both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and osteomyelitis recurrence. Records of 81 males and 27 females aged 10 to 87 (median, 54) years who underwent antibiotic/ surgical treatment for primary (n=68) or recurrent (n=40) osteomyelitis that was related (n=26) or unrelated (n=82) to a prosthesis were reviewed. Of the 40 cases of osteomyelitis recurrence followed up for a median of 23.4 (range, 0.6-74.0) months, 7 and 33 were related and unrelated to a prosthesis, respectively. The cutoff points of lowest ESR and CRP for osteomyelitis recurrence were calculated. Risk factors for osteomyelitis recurrence were determined. Osteomyelitis recurrence was associated with diabetes mellitus, ischaemic heart disease, non-healing wound, infection in the lower limb, and infection with methicillin-resistant Staphylococcus aureus. The cutoff points of CRP ≥5 mg/l and ESR ≥20 mm/h were used for osteomyelitis recurrence. Risk factors...

Research paper thumbnail of A targeted methicillin-resistant Staphylococcus aureus (MRSA) control program did not affect total nosocomial Staphylococcus aureus (SA) bloodstream infections (BSI) despite reducing MRSA BSI

Research paper thumbnail of The costs of nosocomial resistant gram negative intensive care unit infections among patients with the systemic inflammatory response syndrome- a propensity matched case control study

Antimicrobial Resistance and Infection Control, 2015

Research paper thumbnail of Comparison of analgesic efficacy of transversus abdominis plane block with direct infiltration of local anesthetic into surgical incision in lower abdominal gynecological surgeries

Journal of Anaesthesiology Clinical Pharmacology, 2013

Research paper thumbnail of Effectiveness of Trivalent and Quadrivalent Inactivated Vaccines Against Influenza B in the United States, 2011–2012 to 2016–2017

Clinical Infectious Diseases, 2020

Background Since 2013, quadrivalent influenza vaccines containing 2 B viruses gradually replaced ... more Background Since 2013, quadrivalent influenza vaccines containing 2 B viruses gradually replaced trivalent vaccines in the United States. We compared the vaccine effectiveness of quadrivalent to trivalent inactivated vaccines (IIV4 to IIV3, respectively) against illness due to influenza B during the transition, when IIV4 use increased rapidly. Methods The US Influenza Vaccine Effectiveness (Flu VE) Network analyzed 25 019 of 42 600 outpatients aged ≥6 months who enrolled within 7 days of illness onset during 6 seasons from 2011–2012. Upper respiratory specimens were tested for the influenza virus type and B lineage. Using logistic regression, we estimated IIV4 or IIV3 effectiveness by comparing the odds of an influenza B infection overall and the odds of B lineage among vaccinated versus unvaccinated participants. Over 4 seasons from 2013–2014, we compared the relative odds of an influenza B infection among IIV4 versus IIV3 recipients. Results Trivalent vaccines included the predomi...

Research paper thumbnail of A prediction tool for nosocomial multi-drug resistant gram-negative bacilli infections in critically ill patients - prospective observational study

BMC Infectious Diseases, 2014

Background: The widespread use of empiric broad spectrum antibiotics has contributed to the globa... more Background: The widespread use of empiric broad spectrum antibiotics has contributed to the global increase of Resistant Gram-Negative Bacilli (RGNB) infections in intensive care units (ICU). The aim of this study was to develop a tool to predict nosocomial RGNB infections among ICU patients for targeted therapy. Methods: We conducted a prospective observational study from August'07 to December'11. All adult patients who were admitted and stayed for more than 24 hours at the medical and surgical ICU's were included. All patients who developed nosocomial RGNB infections 48 hours after ICU admission were identified. A prediction score was formulated by using independent risk factors obtained from logistic regression analysis. This was prospectively validated with a subsequent cohort of patients admitted to the ICUs during the following time period of January-September 2012. Results: Seventy-six patients with nosocomial RGNB Infection (31bacteremia) were compared with 1398 patients with Systemic Inflammatory Response Syndrome (SIRS) without any gram negative bacterial infection/colonization admitted to the ICUs during the study period. The following independent risk factors were obtained by a multivariable logistic regression analysis-prior isolation of Gram negative organism (coeff: 1.1, 95% CI 0.5-1.7); Surgery during current admission (coeff: 0.69, 95% CI 0.2-1.2); prior Dialysis with end stage renal disease (coeff: 0.7, 95% CI 0.1-1.1); prior use of Carbapenems (coeff: 1.3, 95% CI 0.3-2.3) and Stay in the ICU for more than 5 days (coeff: 2.4, 95% CI 1.6-3.2). It was validated prospectively in a subsequent cohort (n = 408) and the area-under-the-curve (AUC) of the GSDCS score for predicting nosocomial ICU acquired RGNB infection and bacteremia was 0.77 (95% CI 0.68-0.89 and 0.78 (95% CI 0.69-0.89) respectively. The GSDCS (0-4.3) score clearly differentiated the low (0-1.3), medium (1.4-2.3) and high (2.4-4.3) risk patients, both for RGNB infection (p:0.003) and bacteremia (p:0.009). Conclusion: GSDCS is a simple bedside clinical score which predicts RGNB infection and bacteremia with high predictive value and differentiates low versus high risk patients. This score will help clinicians to choose appropriate, timely targeted antibiotic therapy and avoid exposure to unnecessary treatment for patients at low risk of nosocomial RGNB infection. This will reduce the selection pressure and help to contain antibiotic resistance in ICUs.