Aparna Lakshmi - Academia.edu (original) (raw)
Uploads
Papers by Aparna Lakshmi
Aim: To compare the effects of captopril and Allylmercaptocaptopril (CPSSA) on antioxidant status... more Aim: To compare the effects of captopril and Allylmercaptocaptopril (CPSSA) on antioxidant status in Streptozotocin induced diabetic rats. Method: In this study we determined the effect of captopril and CPSSA on Total antioxidant status (TAS), Total oxidative status (TOS) and Total oxidative stress index (TOSI). The body weight measurement and blood glucose levels were checked for every week until the end of the study by using the GOD/POD method. The parameters are found by using the eral method, by observing the absorbance at 560nm for TOS, 444nm for TAS. The TOSI was found by taking the percentage ratio of TOS and TAS. Results: The TOS value of Allylmercaptocaptopril was less (15.18 ± 2.16) when compared to Captopril (18.03 ± 3.14) which indicate that the level of free radicals was low in case of Allylmercaptocaptopril treated group than Captopril. In contrast the TAS value of Allylmercaptocaptopril was more (2.57 ± 0.16) when compared to Captopril (1.63 ± 0.14). All these values ...
Aim: To compare the effects of captopril and Allylmercaptocaptopril (CPSSA) on antioxidant status... more Aim: To compare the effects of captopril and Allylmercaptocaptopril (CPSSA) on antioxidant status in Streptozotocin induced diabetic rats. Method: In this study we determined the effect of captopril and CPSSA on Total antioxidant status (TAS), Total oxidative status (TOS) and Total oxidative stress index (TOSI). The body weight measurement and blood glucose levels were checked for every week until the end of the study by using the GOD/POD method. The parameters are found by using the eral method, by observing the absorbance at 560nm for TOS, 444nm for TAS. The TOSI was found by taking the percentage ratio of TOS and TAS. Results: The TOS value of Allylmercaptocaptopril was less (15.18 ± 2.16) when compared to Captopril (18.03 ± 3.14) which indicate that the level of free radicals was low in case of Allylmercaptocaptopril treated group than Captopril. In contrast the TAS value of Allylmercaptocaptopril was more (2.57 ± 0.16) when compared to Captopril (1.63 ± 0.14). All these values ...