Aparna Varma - Academia.edu (original) (raw)
Papers by Aparna Varma
International journal of reproduction, contraception, obstetrics and gynecology, 2015
Background: Hypertensive disorders are the most common in pregnancy. Several studies showed a pos... more Background: Hypertensive disorders are the most common in pregnancy. Several studies showed a positive correlation between elevated maternal serum uric acid (UA), serum creatinine and adverse maternal and fetal outcomes, but only a few studies are available on serum cystatin C and maternal and fetal outcomes. The present study was undertaken to study the association of serum UA, creatinine and cystatin C with maternal and fetal outcomes. Methods: Out of 116 pregnant women 69 women had no hypertension and 47 had hypertension with or without proteinuria. Serum UA, creatinine and cystatin C was measured by modified Uricase method, modified kinetic Jaffe's reaction and particle-enhanced immunonephelometric assay respectively. Multivariate logistic regression was performed to determine the independent effects of serum UA, creatinine and cystatin C on maternal and fetal outcomes using stata 13.1. Results: The adjusted odds ratio (OR) was 3.73 (95% CI: 1.18-11.75; P=0.024) for UA; 15.79 (95% CI: 3.04-81.94; P=0.001) for creatinine and 2.03 (95% CI: 0.70-5.87; P=0.192) for cystatin C in hypertensive disorders of pregnancy. All the three renal parameters were not significantly associated with birth weight, gestational age of delivery and mode of delivery after adjusting for the confounding factors. Conclusions: Serum creatinine and uric acid are independent risk factors for hypertensive disorders of pregnancy. High serum uric acid is associated with low birth weight and delivery by caesarian section whereas high serum creatinine with preterm delivery only before adjustment for confounding factors and not after adjustment. Serum cystatin C was not significantly associated with the maternal and fetal outcomes.
Journal of Clinical and Diagnostic Research, 2015
Background: The concentration of total proteins in urine is a good index of renal function, but i... more Background: The concentration of total proteins in urine is a good index of renal function, but its determination is found to be unreliable. The pyrogallol red molybdate (PRM) method for urine total proteins is being widely used in most of the hospitals because of its high sensitivity, better precision and its practicability. Bicinchoninic acid method (BCA) is also used for protein estimation and there have been no studies comparing this method with the PRM method in human urine samples. BCA method overestimates the urinary protein concentration in the presence of interfering substances. After removing the interfering substances present in the human urine samples the results of BCA method were compared with the PRM method. Aim: The purpose of the study is to identify whether the results of urine total proteins by BCA method are comparable to PRM method and can be used as an alternative to the PRM method. setting and design: This is a cross-sectional study done on fresh urine specimens from the hospital laboratory, covering a wide range of protein concentrations. Material and Methods: Fresh urine specimens covering a wide range of protein concentrations (urine dipstick: nil, trace, 1+, 2+ and ≥ 3+) of 36 patients were analysed by both the methods. statistical Analysis: Imprecision was determined by repeated analysis study and Inaccuracy was assessed by comparing the results of the patient's urine samples by both the methods using correlation plots, Bland and Altman, and Passing and Bablok regression analyses. results: The coefficient of variation and mean (SD) for the BCA method were 4.6% and 799.1 (882.5) mg/L and for the PRM method were 5.1% and 802.1 (911.9) mg/L. The Pearson correlation coefficient, r was 0.93 (p < 0.0001). Method agreement studies showed no significant constant and proportional bias between both the methods. conclusion: In urine which is subjected to removal of interfering substances, the BCA results are comparable to PRM method.
Indian Journal of Medical Biochemistry, 2018
Aim: The aim of the study is to see the difference between high-sensitivity C-reactive protein (h... more Aim: The aim of the study is to see the difference between high-sensitivity C-reactive protein (hsCRP) in subclinical hypothyroidism (SCH) and controls and find an association between hsCRP and thyroid-stimulating hormone (TSH) in SCH. Materials and methods: Totally, 60 subjects were selected for the study, which included 30 cases of SCH and 30 controls with normal thyroid status. Results: The mean TSH levels were significantly elevated in SCH when compared with controls (9.20 ± 2.12 mU/mL; 2.26 ± 0.78 mU/mL; p-value: <0.0001 respectively). Significantly elevated hsCRP was observed in SCH when compared with controls (3.05 ± 1.78 mg/L; 0.62 ± 0.39 mg/L; p < 0.0001 respectively). As per stratification of cardiovascular disease (CVD) risk by hsCRP, 23% of SCH had high risk of developing CVD. Multivariate linear regression suggested that hsCRP is significantly and positively associated with SCH after adjusting for age and body mass index (BMI). Conclusion: Elevated levels of hsCRP in SCH suggest inflammation as a possible factor for linking SCH and CVD. Clinical significance: Progression to overt hypothyroidism and cardiovascular risk are the major implications of SCH. The hsCRP is not only an inflammatory marker, but also a stimulator of inflammation and predictor of CVD. The hsCRP indicates the cardiovascular risk associated with SCH. Hence, it can be used to screen SCH patients who are at a risk of developing CVD.
Anais Brasileiros De Dermatologia, Nov 1, 2021
Anais Brasileiros De Dermatologia, 2021
PALAVRAS-CHAVE Metanálise; Vitamina D; Vitiligo; 25-hidroxivitamina D2 Resumo Fundamentos: Dados ... more PALAVRAS-CHAVE Metanálise; Vitamina D; Vitiligo; 25-hidroxivitamina D2 Resumo Fundamentos: Dados sobre nível sérico de vitamina D em pacientes com vitiligo são ambíguos quando comparado aos controles. Foram conduzidas uma revisão sistemática e uma metanálise atualizada para avaliar a associação entre vitamina D e vitiligo. Métodos: Estudos relevantes foram identificados por meio de pesquisa na PubMed e outras bases de dados. O modelo de efeitos aleatórios foi usado para obter as diferenças médias padronizadas e coeficientes de correlação agrupados. Metarregressão e análises de subgrupos foram realizadas para explorar a heterogeneidade. A presença de viés de publicação e a robustez do estudo foram testados utilizando o gráfico de funil e análises de sensibilidade, respectivamente. Resultados: Ao final, esta metanálise incluiu 31 estudos. Em comparação com os controles, os pacientes com vitiligo apresentaram níveis circulatórios de vitamina D significativamente diminuídos (diferença m...
Asian Pacific Journal of Cancer Prevention
squamous cell carcinoma (5%) and adenocarcinoma (<2%) (Kaufman et al., 2009). Among the diagnosed... more squamous cell carcinoma (5%) and adenocarcinoma (<2%) (Kaufman et al., 2009). Among the diagnosed BC cases, approximately 70%-80% present with non-muscleinvasive carcinoma, 50%-70% will recur, and 10%-30% progress to muscle-invasive disease (Saad et al., 2002).
Anais Brasileiros de Dermatologia, 2021
Background The serum Vitamin D status in patients with vitiligo is ambiguous when compared to con... more Background The serum Vitamin D status in patients with vitiligo is ambiguous when compared to controls. A systematic review and updated meta-analysis were conducted to evaluate the association between Vitamin D and vitiligo. Methods Relevant studies were identified by searching PubMed and other databases. The random effects model was used to obtain standardized mean differences and pooled correlation coefficients. Meta-regression and sub-group analyses were conducted to explore heterogeneity. The presence of publication bias and the study robustness were tested using funnel plot and sensitivity analyses, respectively. Results This meta-analysis finally included 31 studies. Compared with controls, vitiligo patients showed significantly decreased serum Vitamin D levels (standardized mean difference = −1.03; p < 0.0001). The sub-group analysis showed that vitiligo patients with indoor/urban work had a significantly lower Vitamin D level when compared to their outdoor/rural counterpa...
Anais Brasileiros de Dermatologia (Portuguese), Nov 1, 2021
International Journal of Science and Research (IJSR), 2016
Introduction: Systemic inflammatory activity plays a key role in the pathogenesis and progression... more Introduction: Systemic inflammatory activity plays a key role in the pathogenesis and progression of atherosclerosis in subjects with type 2 diabetes. Hence evaluation of inflammatory novel biomarkers like high-sensitivity C-reactive protein and ferritin serves as tools for cardiovascular risk prediction. Objectives: to evaluate the levels of high-sensitivity C-reactive protein (hs-CRP), ferritin& glycated haemoglobin in controls and type 2 diabetic subjects and to assess the correlations if any, between fasting serum glucose, hs-CRP, ferritin& glycated haemoglobin. Materials and Methods: A total number of 100 subjects were studied, comprising of 50 controls and 50 type 2 diabetic subjects. Diabetic subjects were further divided depending upon treatment modalities. Serum levels of hs-CRP, ferritin were measured by Chemiluminescense Immunoassay. Glycated haemoglobin was measured by Nephelometry. The statistical analysis was carried out using student't' test and Karl Pearson's coefficient of correlation. Results: hs-CRP, ferritin & glycated haemoglobin levels were found to be significantly increased (p<0.01) in type 2 diabetic subjects compared to controls. There was highly significant (P<0.01) positive correlations existed between fasting serum glucose, hs-CRP and HbA1c. Discussion & Conclusion: Elevated levels of hs-CRP and ferritin predict the future cardiovascular complications in type 2 diabetic subjects. Glycated haemoglobin serves as a simple and rapid biomarker to assess glycemic control in type 2 diabetic subjects. The current study demonstrates that higher HbA1c levels are significantly associated with elevation of hs-CRP. These results imply a significant relation between glycemic control, inflammation and cardiovascular risk.
BACKGROUND Thyroid hormones influences glucose homeostasis. The association of insulin resistance... more BACKGROUND Thyroid hormones influences glucose homeostasis. The association of insulin resistance in overt hypothyroidism is well proven, but very less information is available about insulin action on subclinical hypothyroidism. OBJECTIVE This study was done to evaluate the association between thyroid hormones and insulin resistance in subclinical hypothyroidism (SCH). MATERIALS AND METHODS Thirty subjects diagnosed as SCH and 30 age matched euthyroids were included. Serum TSH, FT3, FT4, fasting plasma glucose and insulin were estimated. Homeostasis Model Assessment was used to assess insulin resistance (HOMA- IR). RESULTS AND CONCLUSION Serum TSH levels were significantly increased in SCH (14.20 ± 5.23 μU/ml) when compared with euthyroids (2.24 ±1.43μU/ml; P< 0.0001). Serum FT3, FT4 levels in SCH (2.96±0.80 pg/ml & 1.15 ± 0.52 ng/dl) were within the normal range. The mean insulin levels were significantly elevated in SCH (9.07±3.41 μU/ml) when compared with euthyroids (5.28± 2.1...
njirm.pbworks.com
Abstracts: Background: In fluorosis endemic area, the amount of fluoride transferred to the fetus... more Abstracts: Background: In fluorosis endemic area, the amount of fluoride transferred to the fetus is significant in determining the early onset of fluorosis. The role played by placenta in transporting fluoride and other ions which are present in high concentrations in the local ...
The Journal of the Association of Physicians of India, 2011
OBJECTIVES Massive urbanization in developing nations like India is predicted to cause epidemiolo... more OBJECTIVES Massive urbanization in developing nations like India is predicted to cause epidemiologic transition to increased Coronary Artery Disease (CAD). To evaluate the rural-urban epidemiologic transition, risk factors for CAD were measured in two groups of subjects; Rural and Urban college students. METHODS Subjects included 232 college students (58 men and 58 women in each group) aged between 18-22 years (mean 19.2 +/- 1.0). Since the age of urban youth was significantly higher (19.9 vs 18.4 years), age-adjusted analysis was performed. RESULTS Age-adjusted BMI was significantly higher in urban (21.8 vs 17.8); 69.8% of rural and 13.8% of urban were underweight whereas 3.5% of rural and 31.9% of urban were either overweight or obese. Waist circumference (73.2 vs 61.9 cm), waist: hip circumference ratio (0.80 vs 0.75), diastolic BP (72.7 vs 67.9 mmHg), fasting blood glucose (82.4 vs 79.0 mg/dl), total cholesterol (147.9 vs 129.2 mg/dl), and LDL (89.3 vs 71.9 mg/dl) were significa...
Journal of Evidence Based Medicine and Healthcare
BACKGROUND Face is the index of mind. All human beings tend to express various emotions through d... more BACKGROUND Face is the index of mind. All human beings tend to express various emotions through different facial expressions. Parents of children who are critically ill, experience both positive and negative emotions simultaneously as they may feel love, affection and sometimes sad, angry, and helpless. METHODS We observed facial expressions of mothers of children and recorded vital data of these children in our Paediatric Intensive Care Unit (PICU). 107 children were observed, and vitals recorded simultaneously by two different observers from time of admission to 72 hours at fixed time intervals, using Hamilton’s scoring system. RESULTS 107 critically ill children were observed. Glasgow Coma Scale (GCS), AVPU scale, peripheral temperature, capillary filling time (CFT), seizures at admission, were corelated with facial expressions of the mother at the time of admission, at 12 hours, at 24 hours, at 48 hours and at 72 hours. We found that facial expressions of the mothers changed fro...
Journal of Artificial Organs
This meta-analysis was conducted to compare skin autofluorescence (SAF) levels as a measure of ad... more This meta-analysis was conducted to compare skin autofluorescence (SAF) levels as a measure of advanced glycation end products (AGEs) accumulation between diabetic and non-diabetic dialysis patients. Relevant studies were identified primarily by searching PubMed/MEDLINE and other online databases and manual searching of cross-references. Random-effects model was used to obtain standardized mean differences (SMD) as a summary statistic. Heterogeneity was tested with meta-regression and sub-group analyses. Publication bias and robustness of this meta-analysis were tested using funnel plot and sensitivity analyses. A total of 11 reports comparing SAF between diabetic and non-diabetic dialysis patients were finally included in this meta-analysis. Dialysis patients with diabetes showed significantly higher circulatory SAF levels than their non-diabetic counterparts (SMD = 0.39; P < 0.0001). The difference was more evident in hemodialysis modality (SMD = 0.40; P < 0.0001). A one-study leave-out sensitivity analysis validated the robustness of this meta-analysis. The presence of diabetes in dialysis patients is associated with increased AGEs accumulation reflected through SAF measurements using a novel and non-invasive AGE-Reader™ technology. Our findings are in support of considering anti-AGE therapeutic strategies in addition to standard glycemic management in dialysis patients with diabetes.
Indian Journal of Clinical Biochemistry
European journal pharmaceutical and medical research, 2015
To assess the urinary uric acid/creatinine ratio (UA/Cr) in relation to Apgar score and cord bloo... more To assess the urinary uric acid/creatinine ratio (UA/Cr) in relation to Apgar score and cord blood gas analysis in identification of perinatal asphyxia and to define the cutoff values. case control study. The newborns admitted in the department of pediatrics and NICU of Mediciti Institute of Medical Science, Ghanpur, Medchal mandal, Telangana from May-July 2011 were enrolled. The study was conducted on 31 (18 males, 13 females) controls and 18 (12males, 6 females) asphyxiated neonates. 5ml of arterial cord blood of newborn collected at the time of birth and spot urine samples were collected within 24-72 hours of life. Cord blood gas analysis were done immediately and Urinary uric acid was measured by modified Uricase method, urinary creatinine by modified kinetic Jaffe's reaction. The mean urinary uric acid and creatinine ratio (2.58± 0.48 vs 1.89 ± 0.59) is significantly higher in Asphyxiated group than in the control group. The umbilical cord blood pH had significant positive ...
Indian Journal of Clinical Biochemistry, 2016
The Journal of the Association of Physicians of India, 2011
Massive urbanization in developing nations like India is predicted to cause epidemiologic transit... more Massive urbanization in developing nations like India is predicted to cause epidemiologic transition to increased Coronary Artery Disease (CAD). To evaluate the rural-urban epidemiologic transition, risk factors for CAD were measured in two groups of subjects; Rural and Urban college students. Subjects included 232 college students (58 men and 58 women in each group) aged between 18-22 years (mean 19.2 +/- 1.0). Since the age of urban youth was significantly higher (19.9 vs 18.4 years), age-adjusted analysis was performed. Age-adjusted BMI was significantly higher in urban (21.8 vs 17.8); 69.8% of rural and 13.8% of urban were underweight whereas 3.5% of rural and 31.9% of urban were either overweight or obese. Waist circumference (73.2 vs 61.9 cm), waist: hip circumference ratio (0.80 vs 0.75), diastolic BP (72.7 vs 67.9 mmHg), fasting blood glucose (82.4 vs 79.0 mg/dl), total cholesterol (147.9 vs 129.2 mg/dl), and LDL (89.3 vs 71.9 mg/dl) were significantly higher in the urban gr...
International journal of reproduction, contraception, obstetrics and gynecology, 2015
Background: Hypertensive disorders are the most common in pregnancy. Several studies showed a pos... more Background: Hypertensive disorders are the most common in pregnancy. Several studies showed a positive correlation between elevated maternal serum uric acid (UA), serum creatinine and adverse maternal and fetal outcomes, but only a few studies are available on serum cystatin C and maternal and fetal outcomes. The present study was undertaken to study the association of serum UA, creatinine and cystatin C with maternal and fetal outcomes. Methods: Out of 116 pregnant women 69 women had no hypertension and 47 had hypertension with or without proteinuria. Serum UA, creatinine and cystatin C was measured by modified Uricase method, modified kinetic Jaffe's reaction and particle-enhanced immunonephelometric assay respectively. Multivariate logistic regression was performed to determine the independent effects of serum UA, creatinine and cystatin C on maternal and fetal outcomes using stata 13.1. Results: The adjusted odds ratio (OR) was 3.73 (95% CI: 1.18-11.75; P=0.024) for UA; 15.79 (95% CI: 3.04-81.94; P=0.001) for creatinine and 2.03 (95% CI: 0.70-5.87; P=0.192) for cystatin C in hypertensive disorders of pregnancy. All the three renal parameters were not significantly associated with birth weight, gestational age of delivery and mode of delivery after adjusting for the confounding factors. Conclusions: Serum creatinine and uric acid are independent risk factors for hypertensive disorders of pregnancy. High serum uric acid is associated with low birth weight and delivery by caesarian section whereas high serum creatinine with preterm delivery only before adjustment for confounding factors and not after adjustment. Serum cystatin C was not significantly associated with the maternal and fetal outcomes.
Journal of Clinical and Diagnostic Research, 2015
Background: The concentration of total proteins in urine is a good index of renal function, but i... more Background: The concentration of total proteins in urine is a good index of renal function, but its determination is found to be unreliable. The pyrogallol red molybdate (PRM) method for urine total proteins is being widely used in most of the hospitals because of its high sensitivity, better precision and its practicability. Bicinchoninic acid method (BCA) is also used for protein estimation and there have been no studies comparing this method with the PRM method in human urine samples. BCA method overestimates the urinary protein concentration in the presence of interfering substances. After removing the interfering substances present in the human urine samples the results of BCA method were compared with the PRM method. Aim: The purpose of the study is to identify whether the results of urine total proteins by BCA method are comparable to PRM method and can be used as an alternative to the PRM method. setting and design: This is a cross-sectional study done on fresh urine specimens from the hospital laboratory, covering a wide range of protein concentrations. Material and Methods: Fresh urine specimens covering a wide range of protein concentrations (urine dipstick: nil, trace, 1+, 2+ and ≥ 3+) of 36 patients were analysed by both the methods. statistical Analysis: Imprecision was determined by repeated analysis study and Inaccuracy was assessed by comparing the results of the patient's urine samples by both the methods using correlation plots, Bland and Altman, and Passing and Bablok regression analyses. results: The coefficient of variation and mean (SD) for the BCA method were 4.6% and 799.1 (882.5) mg/L and for the PRM method were 5.1% and 802.1 (911.9) mg/L. The Pearson correlation coefficient, r was 0.93 (p < 0.0001). Method agreement studies showed no significant constant and proportional bias between both the methods. conclusion: In urine which is subjected to removal of interfering substances, the BCA results are comparable to PRM method.
Indian Journal of Medical Biochemistry, 2018
Aim: The aim of the study is to see the difference between high-sensitivity C-reactive protein (h... more Aim: The aim of the study is to see the difference between high-sensitivity C-reactive protein (hsCRP) in subclinical hypothyroidism (SCH) and controls and find an association between hsCRP and thyroid-stimulating hormone (TSH) in SCH. Materials and methods: Totally, 60 subjects were selected for the study, which included 30 cases of SCH and 30 controls with normal thyroid status. Results: The mean TSH levels were significantly elevated in SCH when compared with controls (9.20 ± 2.12 mU/mL; 2.26 ± 0.78 mU/mL; p-value: <0.0001 respectively). Significantly elevated hsCRP was observed in SCH when compared with controls (3.05 ± 1.78 mg/L; 0.62 ± 0.39 mg/L; p < 0.0001 respectively). As per stratification of cardiovascular disease (CVD) risk by hsCRP, 23% of SCH had high risk of developing CVD. Multivariate linear regression suggested that hsCRP is significantly and positively associated with SCH after adjusting for age and body mass index (BMI). Conclusion: Elevated levels of hsCRP in SCH suggest inflammation as a possible factor for linking SCH and CVD. Clinical significance: Progression to overt hypothyroidism and cardiovascular risk are the major implications of SCH. The hsCRP is not only an inflammatory marker, but also a stimulator of inflammation and predictor of CVD. The hsCRP indicates the cardiovascular risk associated with SCH. Hence, it can be used to screen SCH patients who are at a risk of developing CVD.
Anais Brasileiros De Dermatologia, Nov 1, 2021
Anais Brasileiros De Dermatologia, 2021
PALAVRAS-CHAVE Metanálise; Vitamina D; Vitiligo; 25-hidroxivitamina D2 Resumo Fundamentos: Dados ... more PALAVRAS-CHAVE Metanálise; Vitamina D; Vitiligo; 25-hidroxivitamina D2 Resumo Fundamentos: Dados sobre nível sérico de vitamina D em pacientes com vitiligo são ambíguos quando comparado aos controles. Foram conduzidas uma revisão sistemática e uma metanálise atualizada para avaliar a associação entre vitamina D e vitiligo. Métodos: Estudos relevantes foram identificados por meio de pesquisa na PubMed e outras bases de dados. O modelo de efeitos aleatórios foi usado para obter as diferenças médias padronizadas e coeficientes de correlação agrupados. Metarregressão e análises de subgrupos foram realizadas para explorar a heterogeneidade. A presença de viés de publicação e a robustez do estudo foram testados utilizando o gráfico de funil e análises de sensibilidade, respectivamente. Resultados: Ao final, esta metanálise incluiu 31 estudos. Em comparação com os controles, os pacientes com vitiligo apresentaram níveis circulatórios de vitamina D significativamente diminuídos (diferença m...
Asian Pacific Journal of Cancer Prevention
squamous cell carcinoma (5%) and adenocarcinoma (<2%) (Kaufman et al., 2009). Among the diagnosed... more squamous cell carcinoma (5%) and adenocarcinoma (<2%) (Kaufman et al., 2009). Among the diagnosed BC cases, approximately 70%-80% present with non-muscleinvasive carcinoma, 50%-70% will recur, and 10%-30% progress to muscle-invasive disease (Saad et al., 2002).
Anais Brasileiros de Dermatologia, 2021
Background The serum Vitamin D status in patients with vitiligo is ambiguous when compared to con... more Background The serum Vitamin D status in patients with vitiligo is ambiguous when compared to controls. A systematic review and updated meta-analysis were conducted to evaluate the association between Vitamin D and vitiligo. Methods Relevant studies were identified by searching PubMed and other databases. The random effects model was used to obtain standardized mean differences and pooled correlation coefficients. Meta-regression and sub-group analyses were conducted to explore heterogeneity. The presence of publication bias and the study robustness were tested using funnel plot and sensitivity analyses, respectively. Results This meta-analysis finally included 31 studies. Compared with controls, vitiligo patients showed significantly decreased serum Vitamin D levels (standardized mean difference = −1.03; p < 0.0001). The sub-group analysis showed that vitiligo patients with indoor/urban work had a significantly lower Vitamin D level when compared to their outdoor/rural counterpa...
Anais Brasileiros de Dermatologia (Portuguese), Nov 1, 2021
International Journal of Science and Research (IJSR), 2016
Introduction: Systemic inflammatory activity plays a key role in the pathogenesis and progression... more Introduction: Systemic inflammatory activity plays a key role in the pathogenesis and progression of atherosclerosis in subjects with type 2 diabetes. Hence evaluation of inflammatory novel biomarkers like high-sensitivity C-reactive protein and ferritin serves as tools for cardiovascular risk prediction. Objectives: to evaluate the levels of high-sensitivity C-reactive protein (hs-CRP), ferritin& glycated haemoglobin in controls and type 2 diabetic subjects and to assess the correlations if any, between fasting serum glucose, hs-CRP, ferritin& glycated haemoglobin. Materials and Methods: A total number of 100 subjects were studied, comprising of 50 controls and 50 type 2 diabetic subjects. Diabetic subjects were further divided depending upon treatment modalities. Serum levels of hs-CRP, ferritin were measured by Chemiluminescense Immunoassay. Glycated haemoglobin was measured by Nephelometry. The statistical analysis was carried out using student't' test and Karl Pearson's coefficient of correlation. Results: hs-CRP, ferritin & glycated haemoglobin levels were found to be significantly increased (p<0.01) in type 2 diabetic subjects compared to controls. There was highly significant (P<0.01) positive correlations existed between fasting serum glucose, hs-CRP and HbA1c. Discussion & Conclusion: Elevated levels of hs-CRP and ferritin predict the future cardiovascular complications in type 2 diabetic subjects. Glycated haemoglobin serves as a simple and rapid biomarker to assess glycemic control in type 2 diabetic subjects. The current study demonstrates that higher HbA1c levels are significantly associated with elevation of hs-CRP. These results imply a significant relation between glycemic control, inflammation and cardiovascular risk.
BACKGROUND Thyroid hormones influences glucose homeostasis. The association of insulin resistance... more BACKGROUND Thyroid hormones influences glucose homeostasis. The association of insulin resistance in overt hypothyroidism is well proven, but very less information is available about insulin action on subclinical hypothyroidism. OBJECTIVE This study was done to evaluate the association between thyroid hormones and insulin resistance in subclinical hypothyroidism (SCH). MATERIALS AND METHODS Thirty subjects diagnosed as SCH and 30 age matched euthyroids were included. Serum TSH, FT3, FT4, fasting plasma glucose and insulin were estimated. Homeostasis Model Assessment was used to assess insulin resistance (HOMA- IR). RESULTS AND CONCLUSION Serum TSH levels were significantly increased in SCH (14.20 ± 5.23 μU/ml) when compared with euthyroids (2.24 ±1.43μU/ml; P< 0.0001). Serum FT3, FT4 levels in SCH (2.96±0.80 pg/ml & 1.15 ± 0.52 ng/dl) were within the normal range. The mean insulin levels were significantly elevated in SCH (9.07±3.41 μU/ml) when compared with euthyroids (5.28± 2.1...
njirm.pbworks.com
Abstracts: Background: In fluorosis endemic area, the amount of fluoride transferred to the fetus... more Abstracts: Background: In fluorosis endemic area, the amount of fluoride transferred to the fetus is significant in determining the early onset of fluorosis. The role played by placenta in transporting fluoride and other ions which are present in high concentrations in the local ...
The Journal of the Association of Physicians of India, 2011
OBJECTIVES Massive urbanization in developing nations like India is predicted to cause epidemiolo... more OBJECTIVES Massive urbanization in developing nations like India is predicted to cause epidemiologic transition to increased Coronary Artery Disease (CAD). To evaluate the rural-urban epidemiologic transition, risk factors for CAD were measured in two groups of subjects; Rural and Urban college students. METHODS Subjects included 232 college students (58 men and 58 women in each group) aged between 18-22 years (mean 19.2 +/- 1.0). Since the age of urban youth was significantly higher (19.9 vs 18.4 years), age-adjusted analysis was performed. RESULTS Age-adjusted BMI was significantly higher in urban (21.8 vs 17.8); 69.8% of rural and 13.8% of urban were underweight whereas 3.5% of rural and 31.9% of urban were either overweight or obese. Waist circumference (73.2 vs 61.9 cm), waist: hip circumference ratio (0.80 vs 0.75), diastolic BP (72.7 vs 67.9 mmHg), fasting blood glucose (82.4 vs 79.0 mg/dl), total cholesterol (147.9 vs 129.2 mg/dl), and LDL (89.3 vs 71.9 mg/dl) were significa...
Journal of Evidence Based Medicine and Healthcare
BACKGROUND Face is the index of mind. All human beings tend to express various emotions through d... more BACKGROUND Face is the index of mind. All human beings tend to express various emotions through different facial expressions. Parents of children who are critically ill, experience both positive and negative emotions simultaneously as they may feel love, affection and sometimes sad, angry, and helpless. METHODS We observed facial expressions of mothers of children and recorded vital data of these children in our Paediatric Intensive Care Unit (PICU). 107 children were observed, and vitals recorded simultaneously by two different observers from time of admission to 72 hours at fixed time intervals, using Hamilton’s scoring system. RESULTS 107 critically ill children were observed. Glasgow Coma Scale (GCS), AVPU scale, peripheral temperature, capillary filling time (CFT), seizures at admission, were corelated with facial expressions of the mother at the time of admission, at 12 hours, at 24 hours, at 48 hours and at 72 hours. We found that facial expressions of the mothers changed fro...
Journal of Artificial Organs
This meta-analysis was conducted to compare skin autofluorescence (SAF) levels as a measure of ad... more This meta-analysis was conducted to compare skin autofluorescence (SAF) levels as a measure of advanced glycation end products (AGEs) accumulation between diabetic and non-diabetic dialysis patients. Relevant studies were identified primarily by searching PubMed/MEDLINE and other online databases and manual searching of cross-references. Random-effects model was used to obtain standardized mean differences (SMD) as a summary statistic. Heterogeneity was tested with meta-regression and sub-group analyses. Publication bias and robustness of this meta-analysis were tested using funnel plot and sensitivity analyses. A total of 11 reports comparing SAF between diabetic and non-diabetic dialysis patients were finally included in this meta-analysis. Dialysis patients with diabetes showed significantly higher circulatory SAF levels than their non-diabetic counterparts (SMD = 0.39; P < 0.0001). The difference was more evident in hemodialysis modality (SMD = 0.40; P < 0.0001). A one-study leave-out sensitivity analysis validated the robustness of this meta-analysis. The presence of diabetes in dialysis patients is associated with increased AGEs accumulation reflected through SAF measurements using a novel and non-invasive AGE-Reader™ technology. Our findings are in support of considering anti-AGE therapeutic strategies in addition to standard glycemic management in dialysis patients with diabetes.
Indian Journal of Clinical Biochemistry
European journal pharmaceutical and medical research, 2015
To assess the urinary uric acid/creatinine ratio (UA/Cr) in relation to Apgar score and cord bloo... more To assess the urinary uric acid/creatinine ratio (UA/Cr) in relation to Apgar score and cord blood gas analysis in identification of perinatal asphyxia and to define the cutoff values. case control study. The newborns admitted in the department of pediatrics and NICU of Mediciti Institute of Medical Science, Ghanpur, Medchal mandal, Telangana from May-July 2011 were enrolled. The study was conducted on 31 (18 males, 13 females) controls and 18 (12males, 6 females) asphyxiated neonates. 5ml of arterial cord blood of newborn collected at the time of birth and spot urine samples were collected within 24-72 hours of life. Cord blood gas analysis were done immediately and Urinary uric acid was measured by modified Uricase method, urinary creatinine by modified kinetic Jaffe's reaction. The mean urinary uric acid and creatinine ratio (2.58± 0.48 vs 1.89 ± 0.59) is significantly higher in Asphyxiated group than in the control group. The umbilical cord blood pH had significant positive ...
Indian Journal of Clinical Biochemistry, 2016
The Journal of the Association of Physicians of India, 2011
Massive urbanization in developing nations like India is predicted to cause epidemiologic transit... more Massive urbanization in developing nations like India is predicted to cause epidemiologic transition to increased Coronary Artery Disease (CAD). To evaluate the rural-urban epidemiologic transition, risk factors for CAD were measured in two groups of subjects; Rural and Urban college students. Subjects included 232 college students (58 men and 58 women in each group) aged between 18-22 years (mean 19.2 +/- 1.0). Since the age of urban youth was significantly higher (19.9 vs 18.4 years), age-adjusted analysis was performed. Age-adjusted BMI was significantly higher in urban (21.8 vs 17.8); 69.8% of rural and 13.8% of urban were underweight whereas 3.5% of rural and 31.9% of urban were either overweight or obese. Waist circumference (73.2 vs 61.9 cm), waist: hip circumference ratio (0.80 vs 0.75), diastolic BP (72.7 vs 67.9 mmHg), fasting blood glucose (82.4 vs 79.0 mg/dl), total cholesterol (147.9 vs 129.2 mg/dl), and LDL (89.3 vs 71.9 mg/dl) were significantly higher in the urban gr...