Arash Pourhabibi - Academia.edu (original) (raw)
Papers by Arash Pourhabibi
Journal of Ophthalmic & Vision Research, 2009
Purpose To compare the incidence of adverse reactions following rapid versus slow fluorescein inj... more Purpose To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. Methods This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15–25 seconds) versus the usual rapid injection (in 5–8 seconds), and were compared for adverse effects. Results Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nau...
Proceedings of the Twenty-Fifth International Conference on Architectural Support for Programming Languages and Operating Systems
Modern online services are shifting away from monolithic applications to loosely-coupled microser... more Modern online services are shifting away from monolithic applications to loosely-coupled microservices because of their improved scalability, reliability, programmability and development velocity. Microservices communicating over the datacenter network require data transformation (DT) to convert messages back and forth between their internal formats. This work identifies DT as a bottleneck due to reductions in latency of the surrounding system components, namely application runtimes, protocol stacks, and network hardware. We therefore propose Optimus Prime (OP), a programmable DT accelerator that uses a novel abstraction, an in-memory schema, to represent DT operations. The schema is compatible with today's DT frameworks and enables any compliant accelerator to perform the transformations comprising a request in parallel. Our evaluation shows that OP's DT throughput matches the line rate of today's NICs and has ~60x higher throughput compared to software, at a tiny fraction of the CPU's silicon area and power. We also evaluate a set of microservices running on Thrift, and show up to 30% reduction in service latency.
Journal of Ophthalmic & …, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with slow infusion of fluorescein (P=0.02), however no statistically significant difference was observed in the frequency of vertigo and vasovagal reactions between the study groups. Slow fluorescein injection during fundus angiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance.
Journal of Ophthalmic & …, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with slow infusion of fluorescein (P=0.02), however no statistically significant difference was observed in the frequency of vertigo and vasovagal reactions between the study groups. Slow fluorescein injection during fundus angiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance.
Journal of ophthalmic & vision research, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with sl...
Current eye research, Jan 12, 2016
Granulocyte colony-stimulating factor (G-CSF) has potential ocular neuroprotective effects. The a... more Granulocyte colony-stimulating factor (G-CSF) has potential ocular neuroprotective effects. The aim of this study was to evaluate the retinal toxicity of intravitreal G-CSF in rabbit eye. Eight New Zealand albino rabbits, weighing between 2 and 3 kg, were selected for this study. The initial concentration of G-CSF (300 µg/0.5 ml) was titrated to obtain different concentrations of 45 μg, 30 μg, 15 μg, and 7.5 μg in 0.1 ml. Each concentration was injected into two rabbit eyes. For each dose, dextrose was injected in one contralateral eye and the other fellow eye remained non-injected. Electroretinographic (ERG) testing was performed before and 4 weeks after injections. The rabbits were euthanized and the eyes were enucleated 4 weeks after injections and examined using light microscopy and immunohistochemistry. One rabbit with the injected dosage of 7.5 µg died at the first post-injection day. No sign of intraocular toxicity was found in clinical examination in other rabbits. A signifi...
Ocular Immunology and Inflammation, 2016
To report the clinical characteristics, antibiotic susceptibilities, and visual outcomes for eyes... more To report the clinical characteristics, antibiotic susceptibilities, and visual outcomes for eyes with endophthalmitis caused by Pseudomonas aeruginosa. In this retrospective, non-comparative case series, medical records of eyes with culture-proven Pseudomonas aeruginosa endophthalmitis, who were treated from April 2005 to April 2015 at a referral center in Tehran were reviewed. Clinical features, antibiotic susceptibilities, and visual outcomes were assessed. In total, 20 eyes of 19 patients were identified. The clinical settings included cataract surgery (85%), pars plana vitrectomy (5%), endogenous source (5%), and intravitreal bevacizumab injection (5%). Presenting visual acuity ranged from 20/120 to no light perception. Pars plana vitrectomy with intravitreal antibiotic injection was performed as the initial treatment in 16 eyes (80%). The organisms were sensitive to ciprofloxacin and imipenem in 100%; amikacin in 88.3%; ceftazidime in 83.4%; and tobramycin in 83.4% of isolates tested. Final visual acuity was hand motions or worse in 18 eyes (90%). Evisceration was performed in five eyes (20%). Susceptibility to ciprofloxacin and imipenem was found in all isolates tested. Despite appropriate treatment, visual and anatomic outcomes were generally poor.
Medical science monitor: international medical journal of experimental and clinical research
This study was carried out to defi ne the major clinical presentation and laboratory fi ndings of... more This study was carried out to defi ne the major clinical presentation and laboratory fi ndings of leptospirosis in Guilan province, an agricultural and fi shery area in the Caspian littoral.
Cutaneous and ocular toxicology, Jan 11, 2015
To evaluate the retinal toxicity of intravitreal minocycline in rabbit eyes. Intravitreal injecti... more To evaluate the retinal toxicity of intravitreal minocycline in rabbit eyes. Intravitreal injection of minocycline with concentrations of 1000, 500, 250, 125 and 62.5 μg in 0.1 ml was performed in 10 New Zealand albino rabbits. Each concentration was injected into two rabbit eyes. For each dose, normal saline was injected in one contralateral eye and the other fellow eye remained non-injected. Electrophysiologic testing was performed before and 4 weeks after injections. The eyes were enucleated 4 weeks after injections and examined using light microscopy. The clinical examination was unremarkable after injections. Electroretinography recordings were significantly affected at all doses in at least one of the a- or b-waves of photopic or scotopic responses. Histopathologic examination revealed marked atrophy and loss of integrity in all retinal layers in all minocycline injected eyes. Contralateral eyes were normal. In our study, intravitreal minocycline was toxic to the retina in alb...
Medical science monitor : international medical journal of experimental and clinical research, 2005
This study was carried out to define the major clinical presentation and laboratory findings of l... more This study was carried out to define the major clinical presentation and laboratory findings of leptospirosis in Guilan province, an agricultural and fishery area in the Caspian littoral. Cases with a clinically compatible illness and positive serology (immunofluorescence antibody method (IFA)), were included. Clinical information and other lab data were collected. Seventy-four cases, with a mean age of 47.3 +/- 12.4 years and of whom 52 (70.3%) were male, were recruited. All had had contact with stagnant water of a farm within the week prior to their admission. Fever and chills were the most frequent chief complaint in 47 (63.5%). Fever, headache, and myalgia were reported by 73 (98.6%), 69 (93.2%), and 57 (77%) cases, respectively. Increased serum creatinine was detected in 18 (27.3%). Only in 27% of patients did CPK rise to 3-fold or more above the Normal Upper Limit, and in 43% of patients its level was within the normal range. Thrombocytopenia was noticed in 87.3%, and 15.5% of...
Background: Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindn... more Background: Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindness worldwide. Different factors have been contributed in the patho- genesis of glaucoma including H. pylori infection. Objective: To determine the levels of anti-H. pylori IgG antibody in the aqueous humor of patients with pseudo- exfoliation and primary open angle glaucoma, in comparison with age
Journal of Ophthalmic Vision Research, Oct 1, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with slow infusion of fluorescein (P=0.02), however no statistically significant difference was observed in the frequency of vertigo and vasovagal reactions between the study groups. Slow fluorescein injection during fundus angiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance.
Journal of Ophthalmic & Vision Research, 2009
Purpose To compare the incidence of adverse reactions following rapid versus slow fluorescein inj... more Purpose To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. Methods This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15–25 seconds) versus the usual rapid injection (in 5–8 seconds), and were compared for adverse effects. Results Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nau...
Proceedings of the Twenty-Fifth International Conference on Architectural Support for Programming Languages and Operating Systems
Modern online services are shifting away from monolithic applications to loosely-coupled microser... more Modern online services are shifting away from monolithic applications to loosely-coupled microservices because of their improved scalability, reliability, programmability and development velocity. Microservices communicating over the datacenter network require data transformation (DT) to convert messages back and forth between their internal formats. This work identifies DT as a bottleneck due to reductions in latency of the surrounding system components, namely application runtimes, protocol stacks, and network hardware. We therefore propose Optimus Prime (OP), a programmable DT accelerator that uses a novel abstraction, an in-memory schema, to represent DT operations. The schema is compatible with today's DT frameworks and enables any compliant accelerator to perform the transformations comprising a request in parallel. Our evaluation shows that OP's DT throughput matches the line rate of today's NICs and has ~60x higher throughput compared to software, at a tiny fraction of the CPU's silicon area and power. We also evaluate a set of microservices running on Thrift, and show up to 30% reduction in service latency.
Journal of Ophthalmic & …, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with slow infusion of fluorescein (P=0.02), however no statistically significant difference was observed in the frequency of vertigo and vasovagal reactions between the study groups. Slow fluorescein injection during fundus angiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance.
Journal of Ophthalmic & …, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with slow infusion of fluorescein (P=0.02), however no statistically significant difference was observed in the frequency of vertigo and vasovagal reactions between the study groups. Slow fluorescein injection during fundus angiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance.
Journal of ophthalmic & vision research, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with sl...
Current eye research, Jan 12, 2016
Granulocyte colony-stimulating factor (G-CSF) has potential ocular neuroprotective effects. The a... more Granulocyte colony-stimulating factor (G-CSF) has potential ocular neuroprotective effects. The aim of this study was to evaluate the retinal toxicity of intravitreal G-CSF in rabbit eye. Eight New Zealand albino rabbits, weighing between 2 and 3 kg, were selected for this study. The initial concentration of G-CSF (300 µg/0.5 ml) was titrated to obtain different concentrations of 45 μg, 30 μg, 15 μg, and 7.5 μg in 0.1 ml. Each concentration was injected into two rabbit eyes. For each dose, dextrose was injected in one contralateral eye and the other fellow eye remained non-injected. Electroretinographic (ERG) testing was performed before and 4 weeks after injections. The rabbits were euthanized and the eyes were enucleated 4 weeks after injections and examined using light microscopy and immunohistochemistry. One rabbit with the injected dosage of 7.5 µg died at the first post-injection day. No sign of intraocular toxicity was found in clinical examination in other rabbits. A signifi...
Ocular Immunology and Inflammation, 2016
To report the clinical characteristics, antibiotic susceptibilities, and visual outcomes for eyes... more To report the clinical characteristics, antibiotic susceptibilities, and visual outcomes for eyes with endophthalmitis caused by Pseudomonas aeruginosa. In this retrospective, non-comparative case series, medical records of eyes with culture-proven Pseudomonas aeruginosa endophthalmitis, who were treated from April 2005 to April 2015 at a referral center in Tehran were reviewed. Clinical features, antibiotic susceptibilities, and visual outcomes were assessed. In total, 20 eyes of 19 patients were identified. The clinical settings included cataract surgery (85%), pars plana vitrectomy (5%), endogenous source (5%), and intravitreal bevacizumab injection (5%). Presenting visual acuity ranged from 20/120 to no light perception. Pars plana vitrectomy with intravitreal antibiotic injection was performed as the initial treatment in 16 eyes (80%). The organisms were sensitive to ciprofloxacin and imipenem in 100%; amikacin in 88.3%; ceftazidime in 83.4%; and tobramycin in 83.4% of isolates tested. Final visual acuity was hand motions or worse in 18 eyes (90%). Evisceration was performed in five eyes (20%). Susceptibility to ciprofloxacin and imipenem was found in all isolates tested. Despite appropriate treatment, visual and anatomic outcomes were generally poor.
Medical science monitor: international medical journal of experimental and clinical research
This study was carried out to defi ne the major clinical presentation and laboratory fi ndings of... more This study was carried out to defi ne the major clinical presentation and laboratory fi ndings of leptospirosis in Guilan province, an agricultural and fi shery area in the Caspian littoral.
Cutaneous and ocular toxicology, Jan 11, 2015
To evaluate the retinal toxicity of intravitreal minocycline in rabbit eyes. Intravitreal injecti... more To evaluate the retinal toxicity of intravitreal minocycline in rabbit eyes. Intravitreal injection of minocycline with concentrations of 1000, 500, 250, 125 and 62.5 μg in 0.1 ml was performed in 10 New Zealand albino rabbits. Each concentration was injected into two rabbit eyes. For each dose, normal saline was injected in one contralateral eye and the other fellow eye remained non-injected. Electrophysiologic testing was performed before and 4 weeks after injections. The eyes were enucleated 4 weeks after injections and examined using light microscopy. The clinical examination was unremarkable after injections. Electroretinography recordings were significantly affected at all doses in at least one of the a- or b-waves of photopic or scotopic responses. Histopathologic examination revealed marked atrophy and loss of integrity in all retinal layers in all minocycline injected eyes. Contralateral eyes were normal. In our study, intravitreal minocycline was toxic to the retina in alb...
Medical science monitor : international medical journal of experimental and clinical research, 2005
This study was carried out to define the major clinical presentation and laboratory findings of l... more This study was carried out to define the major clinical presentation and laboratory findings of leptospirosis in Guilan province, an agricultural and fishery area in the Caspian littoral. Cases with a clinically compatible illness and positive serology (immunofluorescence antibody method (IFA)), were included. Clinical information and other lab data were collected. Seventy-four cases, with a mean age of 47.3 +/- 12.4 years and of whom 52 (70.3%) were male, were recruited. All had had contact with stagnant water of a farm within the week prior to their admission. Fever and chills were the most frequent chief complaint in 47 (63.5%). Fever, headache, and myalgia were reported by 73 (98.6%), 69 (93.2%), and 57 (77%) cases, respectively. Increased serum creatinine was detected in 18 (27.3%). Only in 27% of patients did CPK rise to 3-fold or more above the Normal Upper Limit, and in 43% of patients its level was within the normal range. Thrombocytopenia was noticed in 87.3%, and 15.5% of...
Background: Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindn... more Background: Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindness worldwide. Different factors have been contributed in the patho- genesis of glaucoma including H. pylori infection. Objective: To determine the levels of anti-H. pylori IgG antibody in the aqueous humor of patients with pseudo- exfoliation and primary open angle glaucoma, in comparison with age
Journal of Ophthalmic Vision Research, Oct 1, 2009
To compare the incidence of adverse reactions following rapid versus slow fluorescein injection f... more To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography. This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects. Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with slow infusion of fluorescein (P=0.02), however no statistically significant difference was observed in the frequency of vertigo and vasovagal reactions between the study groups. Slow fluorescein injection during fundus angiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance.