Arbab Khan - Academia.edu (original) (raw)

Papers by Arbab Khan

CLSM images of E. coli BL21 transformants harbouring bla<... more CLSM images of E. coli BL21 transformants harbouring blaKPC-2 4 hours after treatment with sub-MIC concentration of (B) Meropenem (C) Meropenem + tazobactam (D) Meropenem + ZINC01807204 (E) Meropenem + ZIC02318494 (A) Control, no treatment.</p

Department of Chemistry, University of Allahabad, Allahabad-211 002 Manuscrip... more Department of Chemistry, University of Allahabad, Allahabad-211 002 Manuscript received 13 September 1993, accepted 2 November 1993 Quantitative Structure- Activity Relationship on some 2-Hydroxy-1H-isoindole-diones as Cytostatic Agents

Multinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant... more Multinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant MGC suggests a specific condition and may even signify associated diseases. These cells are problematic when associated with osteoporosis, arthritis, and implant rejection. Some of the important multinucleated giant cells are explained below. Osteoclasts are cells that dissolve bone. They are very active in normal bone growth phases, where they give proper shape to the bone along with osteoblasts, which are the bone forming cells. Osteoclasts are responsible for bone degradation and the subsequent reduction of bone density. These cells are very active in diseases that cause reduced bone density. Foreign body giant cells (FBGC) are found at foreign body sites including stitches and various implants such as oral, breast and bone implants. Furthermore, these giant cells form around organ transplant sites and in some pathological diseases including tumours.

The use of three classical b-lactamase inhibitors (Clavulanic acid, tazobactam and sulbactam) in ... more The use of three classical b-lactamase inhibitors (Clavulanic acid, tazobactam and sulbactam) in combination with b-lactam antibiotics is presently the mainstay of antibiotic therapy against Gram-negative bacterial infections. However these inhibitors are unable to inhibit carbapenemase KPC-2 effectively. They being b-lactam derivatives behave as substrates for this enzyme instead of inactivating it. We have initiated our study to check the in vitro inhibition activity of the two novel screened inhibitors (ZINC01807204 and ZINC02318494) in combination with carbapenems against KPC-2 expressing bacterial strain and their effect on purified enzyme KPC-2. The MIC values of meropenem and ertapenem showed maximum reduction (8 folds) in combination with screened compounds (ZINC01807204 and ZINC02318494). CLSM images also depicted their strong antibacterial activity in comparison to conventional b-lactamase inhibitors. Moreover no toxic effect has been shown on HeLa cell line. Though the IC...

2020 First International Conference of Smart Systems and Emerging Technologies (SMARTTECH), 2020

A dual-band high-performance circular patch microstrip antenna for future 5th generation (5G) of ... more A dual-band high-performance circular patch microstrip antenna for future 5th generation (5G) of mobile communication is proposed. The designed antenna has a ring-shaped Defected Ground Structure (DGS) in the ground plane. The proposed antenna operates at 28GHz (27.68GHz – 28.55GHz, 3.10%), which is a proposed frequency for 5G. A ring-shaped Defected Ground Structure is suitably inserted in the ground plane resulting in an additional frequency band at 38GHz (37.13GHz – 38.20GHz, 2.81%). The gain of the antenna at 28GHz is 6.87dBi and 4.17dBi at 38GHz. The size of the proposed antenna is 7.23mm x 7.23mm. The introduction of Defected Ground Structure also improved the antenna performance. Furthermore, different parameters of the proposed antenna are varied, studied and discussed in detail to observe its effects on the antenna performance.

International Journal of Biological Macromolecules, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Nuclear Physics B - Proceedings Supplements, 1995

The lowest zeros of the lattice partition function for non-compact QED are found in the complex f... more The lowest zeros of the lattice partition function for non-compact QED are found in the complex fermion mass plane on 6 4 , 8 4 and 10 4 lattices at intermediate values of the coupling. The scaling of the low lying zeros with lattice size is analysed.

Journal of Physics E: Scientific Instruments, 1984

For original paper see ibid., vol.16, p.261-4 (1983). Sundqvist (1983) has proposed a technique f... more For original paper see ibid., vol.16, p.261-4 (1983). Sundqvist (1983) has proposed a technique for linear temperature-to-frequency conversion using standard thermistors over a 75K range with an error of less than 0.5K. It has been observed by the authors that a simple circuit based on a similar principle may be designed which exhibits linear conversion over the entire range of

Journal of global antimicrobial resistance, Mar 20, 2017

Antibiotic resistance has become a major problem in treating bacterial infections. The aim of thi... more Antibiotic resistance has become a major problem in treating bacterial infections. The aim of this study was to elucidate the effects of meropenem on a blaKPC-2-harbouring multidrug-resistant clinical strain of Klebsiella pneumoniae through a proteomics approach in order to attain a deeper understanding of bacterial resistance strategies. Analysis was performed by two-dimensional gel electrophoresis of whole-cell extracts of bacteria exposed to a sublethal concentration of meropenem compared with the untreated control. Differentially expressed proteins were identified by matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF). Based on Quantity One(®) software and MALDI-TOF analysis, 16 overexpressed proteins were identified in meropenem-treated bacteria. These proteins were primarily enzymes involved in defence against oxidative stress as well as glycolytic enzymes. LysM domain/BON superfamily protein was found overexpressed by >12-fold. STRING-10 was used to dete...

Indian Journal of Science and Technology, 2016

Inverted pendulum is the single input multi output systems, which is highly unstable and nonlinea... more Inverted pendulum is the single input multi output systems, which is highly unstable and nonlinear. The model of the inverted pendulum is designed and control strategies are applied to stabilize the system efficiently and robustly.

2015 International Conference on Information and Communication Technologies (ICICT), 2015

Energy Efficiency has been categorized as one of the major challenges for Body Area Networks (BAN... more Energy Efficiency has been categorized as one of the major challenges for Body Area Networks (BAN) due to the limited power supply and expected long life of nodes and networks. This work proposes to reduce the energy consumption of BAN through monitoring and eliminating the spatial correlated contention in the BAN nodes. The issues of spatial correlation contention have been studied for traditional WSN's, but not in the BAN's. Since there could be cases in the BAN where multiple nodes make attempt to transmit the same data, the contention may take place resulting in the collisions and retransmissions. Avoiding this contention shall help prolonging the node and network lifetime. Two approaches have been proposed to solve the issue of correlation contention: only master transmitting the unique data and all the sensor nodes transmitting the unique data when compared with that of the neighbors. Simulations have been performed to observe the difference in energy consumption for both the proposed cases. It was found that the energy consumption for BAN comes out to be better when all the sensor nodes monitor the neighbor traffic and send the unique data only avoiding the redundant transmissions; hence the contention and collision reduces. The proposed approach can be integrated with any established MAC protocol for BAN in order to optimize the energy performance.

2006 Portland, Oregon, July 9-12, 2006, 2006

Page 1. The authors are solely responsible for the content of this technical presentation. The te... more Page 1. The authors are solely responsible for the content of this technical presentation. The technical presentation does not necessarily reflect the official position of the American Society of Agricultural and Biological Engineers ...

PloS one, 2014

The use of three classical β-lactamase inhibitors (Clavulanic acid, tazobactam and sulbactam) in ... more The use of three classical β-lactamase inhibitors (Clavulanic acid, tazobactam and sulbactam) in combination with β-lactam antibiotics is presently the mainstay of antibiotic therapy against Gram-negative bacterial infections. However these inhibitors are unable to inhibit carbapenemase KPC-2 effectively. They being β-lactam derivatives behave as substrates for this enzyme instead of inactivating it. We have initiated our study to check the in vitro inhibition activity of the two novel screened inhibitors (ZINC01807204 and ZINC02318494) in combination with carbapenems against KPC-2 expressing bacterial strain and their effect on purified enzyme KPC-2. The MIC values of meropenem and ertapenem showed maximum reduction (8 folds) in combination with screened compounds (ZINC01807204 and ZINC02318494). CLSM images also depicted their strong antibacterial activity in comparison to conventional β-lactamase inhibitors. Moreover no toxic effect has been shown on HeLa cell line. Though the IC...

Nuclear Instruments and Methods, 1980

... BY SOLID STATE NUCLEAR TRACK DETECTORS Asghar A. KHAN, Naeem A. KHAN, Mohammad FAROOQ and Moh... more ... BY SOLID STATE NUCLEAR TRACK DETECTORS Asghar A. KHAN, Naeem A. KHAN, Mohammad FAROOQ and Mohammad MUKHTAR Pakistan Institute of ... The light output from the screens may be seen either directly or through a television camera assisted by an image ...

Journal of Proteomics & Bioinformatics, 2012

Journal of Russian Laser Research, 2009

Abstract We study the resonant interaction of a beam of mono-velocity two-level atoms with a stan... more Abstract We study the resonant interaction of a beam of mono-velocity two-level atoms with a standing-wave light field in the Bragg regime. The atomic beam consists of two different isotopes, and the density is sufficiently small so that at most one atom is inside the cavity ...

Radiology Case Reports, 2009

We report the case of an 84yearold woman with histiocytic sarcoma arising in the terminal ileum. ... more We report the case of an 84yearold woman with histiocytic sarcoma arising in the terminal ileum. The lesion was identified on CT of the abdomen as a 10 cm segment of terminal ileum with mild circumferential wall thickening, isoattenuation, and diffuse homogeneous enhancement. The patient was treated with surgery and adjuvant chemotherapy. This case provides an example of when imaging may be useful for the detection of this rare malignancy and its complications.