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Papers by Archana Awasthi

Research paper thumbnail of Design, Synthesis, in vitro Anti‐inflammatory Activity and in silico Studies of Imidazole‐Based 1,2,3‐Triazole Hybrids Targeting p38 MAP Kinase

ChemistrySelect, Jan 24, 2024

Research paper thumbnail of Synthesis, In Silico Studies, and In Vitro Anti-Inflammatory Activity of Novel Imidazole Derivatives Targeting p38 MAP Kinase

Research paper thumbnail of Microwave-assisted extraction, in vitro antioxidant and anticancer activity of Curcuma longa L. and Manilkara zapota L

Journal of Phytonanotechnology and Pharmaceutical Sciences

Research paper thumbnail of Spirulina: A panacea for all human ailments

Annals of Phytomedicine An International Journal

In recent years, the idea of "superfoods" has interested people worldwide as most of them provide... more In recent years, the idea of "superfoods" has interested people worldwide as most of them provide benefits irrespective of it being palliative or therapeutic. Spirulina is a cynobacterium of genus Arthrospira. Although unicellular, it is a storehouse of a great number of proteins, carbohydrates, vitamins, and essential nutrients. Spirulina is relatively easy to propagate considering it can be grown in both fresh water and wastewater, but only the former is implied for human use. Spirulina basically steals the spotlight as it exerts antioxidant and anti-inflammatory properties due to phycocyanin, antiproliferative property due to phycocyanobilin (PCB), chlorophyllin, carotenoids, and polysaccharides, antianemic due to positive hematologic properties, immunomodulatory traits due to phenolics and phycocyanin, antihyperlipidemic potential due to polyunsaturated fatty acids (PUFA), and antihypertensive action due to phycobiloproteins in addition to low sodium value. Apart from these, it is also antimicrobial and aids in reversing the toxicity of some elements as well.The objective of this article is to present the efficacy of Spirulina in treating various human ailments and to project it as protecting agent of the human body. This review presents Spirulina's great significance in treating various diseases. It can greatly affect the food, chemical, and pharmaceutical industries, provided its capacity is realized and popularized further in the near future.

Research paper thumbnail of Synthesis, In Silico Studies, and In Vitro Anti-Inflammatory Activity of Novel Imidazole Derivatives Targeting p38 MAP Kinase

Research paper thumbnail of Avant-Garde: P38 Mitogen Activated Protein Kinase Inhibitors

Social Science Research Network, Feb 4, 2020

Research paper thumbnail of Assessment of in vitro antiarthritic activity of Manilkara hexandra (Roxb.) Dubard leaf extract

The rationale of the current study was to assess the in vitro antiarthritic activity of methanoli... more The rationale of the current study was to assess the in vitro antiarthritic activity of methanolic (MEMH) and hydroalcoholic (HAMH) leaf extracts of Manilkara hexandra (Roxb.) Dubard. The in vitro models adopted for the study includes protein denaturation method and proteinase inhibition method.The culmination revealed the dose dependent increase in the antiarthritic activity of both the extracts. At concentrations 50,100, 200, 250 and 500 μg/ml, methanolic and hydro alcoholic leaf extracts of M. hexandra exhibited significant inhibition of protein denaturation and proteinase inhibition which were comparable to the standard diclofenac sodium. Hydroalcoholic extract exhibited significant protein denaturation and proteinase inhibition with IC50 values of 305 and 312 μg/ml which are comparable with standard IC50 values of 235 and 230 μg/ml, respectively.

Research paper thumbnail of Pre-Clinical Evaluation of Manilkara hexandra (Roxb.) Dubard Extract for Anti-Arthritic Activity

The instigation of the prevailing study was to explore the in-vivo anti-arthritic activity of hyd... more The instigation of the prevailing study was to explore the in-vivo anti-arthritic activity of hydro alcoholic extract of Manilkara hexandra against formaldehyde and Complete Freund's adjuvant induced arthritis. Formaldehyde induced arthritis, an acute model and Complete Freund's adjuvant induced arthritis, a chronic model were induced by administering 0.1ml of formaldehyde and Complete Freund's adjuvant into the sub plantar regions of hind paw respectively. Hydro alcoholic leaf extract of Manilkara hexandra was administered in varying doses for its evaluation of anti-arthritic activity. The parameters employed for evaluation are paw volume; paw diameter, body weight, arthritic index and hematological parameters. Hydro alcoholic extract of Manilkara hexandra at a concentration of 250mg/kg elicited potent rebate in the measured parameters associated with both the models. The percentage inhibition of paw diameter (80.4%) and paw volume (84.5%) were more potent as compared t...

Research paper thumbnail of Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Medicinal Chemistry

Background:: Inflammatory process is one of the mechanisms by which our body upholds us from path... more Background:: Inflammatory process is one of the mechanisms by which our body upholds us from pathogens such as parasites, bacteria, viruses, and other harmful microorganisms. Inflammatory stimuli activate many intracellular signaling pathways such as nuclear factor-kB (NF-kB) pathway and three mitogen-activated protein kinase (MAPK) pathways which are mediated through extracellular-signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. The p38 has evolved as an enticing target in treating many persistent inflammatory diseases. Hence, designing novel p38 inhibitors targeting MAPK pathways has acquired significance. Objective: Peruse to identify the lead target to discover novel p38MAPK inhibitors with different scaffolds having improved selectivity over the prototype drugs. Methods: Structure and the binding sites of p38MAPK were focused. Various scaffolds designed for inhibition and the molecules which have entered the clinical trials are discussed. Results: This revi...

Research paper thumbnail of Synthesis and evaluation of some novel heterocyclic compounds containing an oxadiazole moiety Primary tabs

GSC Biological and Pharmaceutical Sciences, Feb 28, 2019

Heterocyclic compounds analog have attracted wide attention due to their useful biological proper... more Heterocyclic compounds analog have attracted wide attention due to their useful biological properties. Among them, 1,3,4-oxadiazoles have exhibited a wide range of biological properties including anti-bacterial, anti-viral, anti-fungal, anti-cancer, anti-tumor, anti-inflammatory, anti-hypertensive, anti-convulsant and anti-diabetic properties. The purpose of this study was to collect the literature work reported by researchers on oxadiazole derivatives for their various pharmacological activities and also efforts made on this moiety. This study covers the work reported on various biological activities of oxadiazole derivatives.

Research paper thumbnail of Design, Synthesis, in vitro Anti‐inflammatory Activity and in silico Studies of Imidazole‐Based 1,2,3‐Triazole Hybrids Targeting p38 MAP Kinase

ChemistrySelect, Jan 24, 2024

Research paper thumbnail of Synthesis, In Silico Studies, and In Vitro Anti-Inflammatory Activity of Novel Imidazole Derivatives Targeting p38 MAP Kinase

Research paper thumbnail of Microwave-assisted extraction, in vitro antioxidant and anticancer activity of Curcuma longa L. and Manilkara zapota L

Journal of Phytonanotechnology and Pharmaceutical Sciences

Research paper thumbnail of Spirulina: A panacea for all human ailments

Annals of Phytomedicine An International Journal

In recent years, the idea of "superfoods" has interested people worldwide as most of them provide... more In recent years, the idea of "superfoods" has interested people worldwide as most of them provide benefits irrespective of it being palliative or therapeutic. Spirulina is a cynobacterium of genus Arthrospira. Although unicellular, it is a storehouse of a great number of proteins, carbohydrates, vitamins, and essential nutrients. Spirulina is relatively easy to propagate considering it can be grown in both fresh water and wastewater, but only the former is implied for human use. Spirulina basically steals the spotlight as it exerts antioxidant and anti-inflammatory properties due to phycocyanin, antiproliferative property due to phycocyanobilin (PCB), chlorophyllin, carotenoids, and polysaccharides, antianemic due to positive hematologic properties, immunomodulatory traits due to phenolics and phycocyanin, antihyperlipidemic potential due to polyunsaturated fatty acids (PUFA), and antihypertensive action due to phycobiloproteins in addition to low sodium value. Apart from these, it is also antimicrobial and aids in reversing the toxicity of some elements as well.The objective of this article is to present the efficacy of Spirulina in treating various human ailments and to project it as protecting agent of the human body. This review presents Spirulina's great significance in treating various diseases. It can greatly affect the food, chemical, and pharmaceutical industries, provided its capacity is realized and popularized further in the near future.

Research paper thumbnail of Synthesis, In Silico Studies, and In Vitro Anti-Inflammatory Activity of Novel Imidazole Derivatives Targeting p38 MAP Kinase

Research paper thumbnail of Avant-Garde: P38 Mitogen Activated Protein Kinase Inhibitors

Social Science Research Network, Feb 4, 2020

Research paper thumbnail of Assessment of in vitro antiarthritic activity of Manilkara hexandra (Roxb.) Dubard leaf extract

The rationale of the current study was to assess the in vitro antiarthritic activity of methanoli... more The rationale of the current study was to assess the in vitro antiarthritic activity of methanolic (MEMH) and hydroalcoholic (HAMH) leaf extracts of Manilkara hexandra (Roxb.) Dubard. The in vitro models adopted for the study includes protein denaturation method and proteinase inhibition method.The culmination revealed the dose dependent increase in the antiarthritic activity of both the extracts. At concentrations 50,100, 200, 250 and 500 μg/ml, methanolic and hydro alcoholic leaf extracts of M. hexandra exhibited significant inhibition of protein denaturation and proteinase inhibition which were comparable to the standard diclofenac sodium. Hydroalcoholic extract exhibited significant protein denaturation and proteinase inhibition with IC50 values of 305 and 312 μg/ml which are comparable with standard IC50 values of 235 and 230 μg/ml, respectively.

Research paper thumbnail of Pre-Clinical Evaluation of Manilkara hexandra (Roxb.) Dubard Extract for Anti-Arthritic Activity

The instigation of the prevailing study was to explore the in-vivo anti-arthritic activity of hyd... more The instigation of the prevailing study was to explore the in-vivo anti-arthritic activity of hydro alcoholic extract of Manilkara hexandra against formaldehyde and Complete Freund's adjuvant induced arthritis. Formaldehyde induced arthritis, an acute model and Complete Freund's adjuvant induced arthritis, a chronic model were induced by administering 0.1ml of formaldehyde and Complete Freund's adjuvant into the sub plantar regions of hind paw respectively. Hydro alcoholic leaf extract of Manilkara hexandra was administered in varying doses for its evaluation of anti-arthritic activity. The parameters employed for evaluation are paw volume; paw diameter, body weight, arthritic index and hematological parameters. Hydro alcoholic extract of Manilkara hexandra at a concentration of 250mg/kg elicited potent rebate in the measured parameters associated with both the models. The percentage inhibition of paw diameter (80.4%) and paw volume (84.5%) were more potent as compared t...

Research paper thumbnail of Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Medicinal Chemistry

Background:: Inflammatory process is one of the mechanisms by which our body upholds us from path... more Background:: Inflammatory process is one of the mechanisms by which our body upholds us from pathogens such as parasites, bacteria, viruses, and other harmful microorganisms. Inflammatory stimuli activate many intracellular signaling pathways such as nuclear factor-kB (NF-kB) pathway and three mitogen-activated protein kinase (MAPK) pathways which are mediated through extracellular-signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. The p38 has evolved as an enticing target in treating many persistent inflammatory diseases. Hence, designing novel p38 inhibitors targeting MAPK pathways has acquired significance. Objective: Peruse to identify the lead target to discover novel p38MAPK inhibitors with different scaffolds having improved selectivity over the prototype drugs. Methods: Structure and the binding sites of p38MAPK were focused. Various scaffolds designed for inhibition and the molecules which have entered the clinical trials are discussed. Results: This revi...

Research paper thumbnail of Synthesis and evaluation of some novel heterocyclic compounds containing an oxadiazole moiety Primary tabs

GSC Biological and Pharmaceutical Sciences, Feb 28, 2019

Heterocyclic compounds analog have attracted wide attention due to their useful biological proper... more Heterocyclic compounds analog have attracted wide attention due to their useful biological properties. Among them, 1,3,4-oxadiazoles have exhibited a wide range of biological properties including anti-bacterial, anti-viral, anti-fungal, anti-cancer, anti-tumor, anti-inflammatory, anti-hypertensive, anti-convulsant and anti-diabetic properties. The purpose of this study was to collect the literature work reported by researchers on oxadiazole derivatives for their various pharmacological activities and also efforts made on this moiety. This study covers the work reported on various biological activities of oxadiazole derivatives.