Emine Arik - Academia.edu (original) (raw)

Papers by Emine Arik

Trends in Anaesthesia and Critical Care, Oct 1, 2017

Türkiye Klinikleri Journal of Case Reports, 2015

Anaesthesist, Mar 12, 2020

Objective: The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spin... more Objective: The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spinal nerves that innervate the abdominal wall from T6 to L1 dermatomes and provide effective postoperative analgesia after abdominal surgery. Several applications of TAP catheters are described for both acute and chronic abdominal wall pain, but there are no reported cases of TAP catheters used during pregnancy. Case Report: We present the case of a 23-year-old primigravida admitted to the hospital on multiple occasions during her pregnancy for right lower quadrant abdominal "stabbing" pain, with a visual analog scale score intensity of 8/10 abdominal pain. The diagnosis was unclear despite the presence of prominent ileocolic lymph nodes visualized on magnetic resonance imaging. The abdominal pain persisted despite escalating doses of intravenous opioids (up to 30 mg of intravenous hydromorphone daily). At 34 weeks' gestation, a right-sided TAP block with 0.25% bupivacaine was inserted under ultrasound guidance, and this relieved all of her pain (visual analog scale score,0). The patient was managed with repeated boluses of 0.5% ropivacaine via a TAP catheter, which resulted in complete resolution of her pain within 3 days and allowed for complete discontinuation of opioid medications. The patient was discharged home, with no recurrence of pain. She had an uneventful cesarean delivery at term. Conclusions: A TAP catheter inserted under ultrasound guidance can be effective for the treatment of chronic abdominal pain during pregnancy and may provide an alternative analgesic modality when intravenous opioids are not providing relief or when neuraxial analgesia techniques are not feasible or contraindicated.

Turkiye Klinikleri Journal of Anesthesiology Reanimation, 2022

ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in ... more ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in terms of intubation conditions, during elective tracheal intubation in patients with diabetes mellitus (DM) who have a high risk for difficult airway. Material and Methods: One hundred and ten American Society of Anesthesiologist physical class II-III patients with DM undergoing elective surgery were randomized to be intubated using C-MAC video laryngoscope or Macintosh laryngoscope. Glottic view Cormack Lehane (CL) score, intubation time, intubation difficulty scale (IDS) score, and first attempt intubation success were compared. Results: Similar intubation times were detected [Macintosh laryngoscope: 39.6±30.1 seconds; C-MAC: 46.7±35.4 seconds (p=0.098). C-MAC provided significantly better CL scores]. Grade 1 CL laryngeal view was observed in 37 (68%) C-MAC vs. 26 (47.3%) Macintosh laryngoscope intubations (p=0.04). An IDS score of >5 was determined in 11 (20.4%) patients with C-MAC and in 10 (18.2%) with Macintosh laryngoscope (p=0.04), indicating an overall 20.1% moderate-to-severe intubation difficulty (p=0.536). The mean IDS score was 3.2±2.9 and 2.4±3.3 with C-MAC and Macintosh laryngoscopes, (p=0.04). First-attempt intubation success was 83.3% vs. 87.0% with C-MAC vs. Macintosh laryngoscope (p=0.786). Conclusion: In patients with DM, C-MAC provided improved glottis visualization, similar intubation time and first-attempt intubation success as a first-attempt intubation device compared with the Macintosh laryngoscope. However IDS scores were higher with the C-MAC. The incidence of actual intubation difficulty was found 20.1% in this diabetic study population.

Transplantation, 2020

Fatih Sandikci, Sanem Cimen, Sertac Cimen, Ebru Gok Oguz, Emine Ince Arik, Abdurrahim Imamoglu, A... more Fatih Sandikci, Sanem Cimen, Sertac Cimen, Ebru Gok Oguz, Emine Ince Arik, Abdurrahim Imamoglu, Alihan Kokurcan Diskapi Research and Training Hospital Department of Urology and Transplantation, Health Sciences University, Ankara, Turkey; Diskapi Research and Training Hospital Department of Anesthesiology, Health Sciences University, Ankara, Turkey; Diskapi Research and Training Hospital Department of Nephrology, Health Sciences University, Ankara, Turkey.

Regional anesthesia and pain medicine, Jan 22, 2015

The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spinal nerves t... more The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spinal nerves that innervate the abdominal wall from T6 to L1 dermatomes and provide effective postoperative analgesia after abdominal surgery. Several applications of TAP catheters are described for both acute and chronic abdominal wall pain, but there are no reported cases of TAP catheters used during pregnancy. We present the case of a 23-year-old primigravida admitted to the hospital on multiple occasions during her pregnancy for right lower quadrant abdominal "stabbing" pain, with a visual analog scale score intensity of 8/10 abdominal pain. The diagnosis was unclear despite the presence of prominent ileocolic lymph nodes visualized on magnetic resonance imaging. The abdominal pain persisted despite escalating doses of intravenous opioids (up to 30 mg of intravenous hydromorphone daily). At 34 weeks' gestation, a right-sided TAP block with 0.25% bupivacaine was inserted under ultraso...

Anestezi dergisi, 2019

seviyesine sahip bireylerde daha sık anksiyete görülmekteydi. Üniversite mezunlarında da diğer eğ... more seviyesine sahip bireylerde daha sık anksiyete görülmekteydi. Üniversite mezunlarında da diğer eğitim düzeylerine göre anksiyete daha düşük bulundu (p<0.05). Sonuç: Hastaların yaş ve medeni durumunun anksiyete ile ilişkili olmadığını; kadınlarda özellikle çalışmayan ev hanımlarında ve emeklilerde anksiyetenin en yüksek oranda gözlendiğini belirledik. Üniversite mezunu, iyi gelir seviyesine sahip, öğrenci ve memurlarda ise aksine daha az anksiyete mevcuttu. Bu durumun kişilerin eğitim düzeyleri arttıkça, daha rahat bilgilenmesi ve çekincelerinin azalması ile ilişkili olduğunu düşünmekteyiz.

Turkiye Klinikleri Journal of Anesthesiology Reanimation, 2022

ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in ... more ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in terms of intubation conditions, during elective tracheal intubation in patients with diabetes mellitus (DM) who have a high risk for difficult airway. Material and Methods: One hundred and ten American Society of Anesthesiologist physical class II-III patients with DM undergoing elective surgery were randomized to be intubated using C-MAC video laryngoscope or Macintosh laryngoscope. Glottic view Cormack Lehane (CL) score, intubation time, intubation difficulty scale (IDS) score, and first attempt intubation success were compared. Results: Similar intubation times were detected [Macintosh laryngoscope: 39.6±30.1 seconds; C-MAC: 46.7±35.4 seconds (p=0.098). C-MAC provided significantly better CL scores]. Grade 1 CL laryngeal view was observed in 37 (68%) C-MAC vs. 26 (47.3%) Macintosh laryngoscope intubations (p=0.04). An IDS score of >5 was determined in 11 (20.4%) patients with C-MAC and in 10 (18.2%) with Macintosh laryngoscope (p=0.04), indicating an overall 20.1% moderate-to-severe intubation difficulty (p=0.536). The mean IDS score was 3.2±2.9 and 2.4±3.3 with C-MAC and Macintosh laryngoscopes, (p=0.04). First-attempt intubation success was 83.3% vs. 87.0% with C-MAC vs. Macintosh laryngoscope (p=0.786). Conclusion: In patients with DM, C-MAC provided improved glottis visualization, similar intubation time and first-attempt intubation success as a first-attempt intubation device compared with the Macintosh laryngoscope. However IDS scores were higher with the C-MAC. The incidence of actual intubation difficulty was found 20.1% in this diabetic study population.

ÖZET Amaç: Bu çal›flmada amaç, spinal anestezi alt›nda turnike kullan›lan total diz artroplastisi... more ÖZET Amaç: Bu çal›flmada amaç, spinal anestezi alt›nda turnike kullan›lan total diz artroplastisi cerrahisi geçirecek hastalarda verilen %0.9 NaCl ve ringer laktat solüsyonlar›n›n; turnike fliflirilmesi ve indirilmesi s›ras›nda asit-baz dengelerine olan etkilerini karfl›laflt›rmakt›r. Yöntem: Spinal anestezi ile turnike kullan›larak yap›lan total diz artroplastisi uygulanan yafl>40, ASA I-II 60 hasta çal›flmaya dahil edildi. Grup 1’e 10 ml kg % 0.9 NaCl, Grup 2’ye 10 ml kg ringer laktat›n iv infüzyonu sonras› spinal anestezi uyguland›. ‹damede her iki gruba 10 ml kg sa s›v› verildi. Tüm hastalar›n bazal (T0), spinal anestezi sonras› 5. dakika (T1), turnike fliflirilmesi sonras› 15. dk (T2), turnike indirilmesinden sonraki 1. (T3), 15. (T4) ve 30. (T5) dakikalarda OAB ve kalp h›zlar› kaydedildi. Ayr›ca hastalar›n T0, T2, T3, T4, T5 ölçüm zamanlar›nda arteriyel ve venöz kan gazlar›nda pH, PO2, PCO2, laktat, HCO3, klorür (Cl) düzeyleri kaydedildi. Bulgular: Grup 1’de grup 2’ye göre ...

Turkish Journal of Anaesthesiology and Reanimation, 2020

Radiofrequency ablation (RFA) is a minimal invasive approach for treating solid tumors. A compute... more Radiofrequency ablation (RFA) is a minimal invasive approach for treating solid tumors. A computed tomography (CT)-guided needle electrode is inserted percutaneously into the tumor. The electromagnetic current generated by the radiofrequency generator causes coagulation and necrosis in the tumor. In this procedure, the local temperature rises above 90°C, especially in large and close to the chest wall, serious pain occurs during and after the intervention (1). Although RFA procedures can be performed with local anaesthesia–sedation or general anaesthesia, local anaesthesia can lead to simple and fewer postoperative complications and has the advantage of short hospital stay (2).

Gulhane Medical Journal, 2020

The aim of this study was to assess the effectiveness of warming in perioperative hypothermia, he... more The aim of this study was to assess the effectiveness of warming in perioperative hypothermia, hemodynamic variables, post-anesthesia care unit discharge time, shivering, patient comfort and patient satisfaction in elderly patients undergoing transurethral resection of prostate (TURP) surgery under general anesthesia. Methods: Patients aged between 50 and 85 years, scheduled for TURP surgery of 30-90 min under general anesthesia, were enrolled into the study. Patients were randomly allocated to either the warming (Group P) or standard care (Group C) group. Core body temperatures and hemodynamic parameters were assessed. Additionally, patient satisfaction, thermal comfort, and shivering were compared using scales. Results: Overall, 33 patients (Group P; n=16, Group C; n=17) completed the study. Core body temperature was higher in Group P after anesthesia induction than in Group C (37.01±0.29 vs 36.61±0.21) (p=0.001). In addition, at the end of surgery, the core temperature was significantly higher in Group P (36.03±0.33) than in Group C (35.31±0.45) (p=0.001). Hypothermia was observed in four warmed and 17 unwarmed patients at the end of surgery (p=0.001). Following anesthesia induction, one warmed patient and nine unwarmed patients developed hypotension (p=0.004). Thermal comfort and patient satisfaction scores were significantly higher in warmed patients than in unwarmed patients (p<0.05), but shivering scores displayed a similar pattern between the groups (p>0.05). Conclusions: This study demonstrated that perioperative forced-air warming helped preserve perioperative core body temperature, reduced the incidence of hypotension during the induction period, increased thermal comfort, improved patient satisfaction, but did not affect shivering in patients undergoing TURP surgery.

Journal of Ankara University Faculty of Medicine, 2020

Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative ... more Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative stress and apoptosis causing cellular damage. Several animal models have shown paeonol to be a powerful antioxidant, antiapoptotic, and neuroprotective substance. This study aimed to investigate possible neuroprotective effects of paeonol in a rat TBI model. Materials and Methods: Thirty-two male rats were divided into four groups: control, trauma, vehicle, and paeonol groups. Trauma, vehicle, and paeonol groups were subjected to closed-head, contusive weight-drop injuries. The vehicle (saline) or paeonol (50 mg/kg) was orally administered as premedication for 15 days. Brain samples were obtained 24 hours after trauma. Histomorphological evaluation of the cerebral cortex was performed using electron and light microscopy. Results: Histopathological examination revealed that the TBI-induced cerebral cortex damage was less in the paeonol group. Conclusion: Paeonol exhibited neuroprotective and anti-edematous effects against TBI.

Acta Chirurgica Belgica, 2013

Background : Several researchers have investigated how wound healing is effected by supplementati... more Background : Several researchers have investigated how wound healing is effected by supplementation with each of the following amino acids : arginine (Arg), glutamine (Glu), and β-hydroxy β-methylbutyrate (HMB). This research investigates how a combination of these amino acids improves the wound healing associated with anastomoses. Methods : We tested the effects of a combination of Arg, Glu, and HMB on the healing of colon anastomoses in 50 male rats. We randomly divided the animals into two equal groups. In each animal, the cecum was transected from its midpoint to create an end-to end anastomosis. During the first postoperative week, Group 1 (G1) animals were fed standard chow, and Group 2 (G2) animals were fed standard chow plus a ready-to-use supplement that contained a mixture of Arg, Glu, and HMB. At the end of the week, all of the rats were sacrificed, and a cecum segment containing the anastomosis line was resected. Bursting pressure and tissue hydroxyproline were measured for all animals. Results : The mean values for hydroxyproline were 0.0013 ng/mg protein/ml (SD ± 0.00075) and 0.034 ng/mg protein/ ml (SD ± 0.022) for G1 and G2, respectively (p < 0.0001). The mean values for bursting pressure measurements were 122.8 mmHg (SD ± 9.4) and 192.8 mmHg (SD ± 31) for G1 and G2, respectively (p < 0.0001). Statistically significant differences between the groups in terms of both bursting pressure levels and tissue hydroxyproline levels were observed. Conclusion : In an animal model of colon surgery, supplementation with a combination of three amino acids seemingly benefits anastomosis healing.

Turkiye Klinikleri Journal of Anesthesiology Reanimation, 2007

perasyon süresince anestezi derinliğinin izlenmesi büyük önem taşımaktadır. Bu amaçla kullanılabi... more perasyon süresince anestezi derinliğinin izlenmesi büyük önem taşımaktadır. Bu amaçla kullanılabilecek en objektif değerlendirme yöntemi elektroensefalografi (EEG) parametreleridir. 1 Bispektral İndex (BİS) anestezik ve O ORİJİNAL ARAŞTIRMA / ORIGINAL RESEARCH.

Trends in Anaesthesia and Critical Care, Oct 1, 2017

Türkiye Klinikleri Journal of Case Reports, 2015

Anaesthesist, Mar 12, 2020

Objective: The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spin... more Objective: The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spinal nerves that innervate the abdominal wall from T6 to L1 dermatomes and provide effective postoperative analgesia after abdominal surgery. Several applications of TAP catheters are described for both acute and chronic abdominal wall pain, but there are no reported cases of TAP catheters used during pregnancy. Case Report: We present the case of a 23-year-old primigravida admitted to the hospital on multiple occasions during her pregnancy for right lower quadrant abdominal "stabbing" pain, with a visual analog scale score intensity of 8/10 abdominal pain. The diagnosis was unclear despite the presence of prominent ileocolic lymph nodes visualized on magnetic resonance imaging. The abdominal pain persisted despite escalating doses of intravenous opioids (up to 30 mg of intravenous hydromorphone daily). At 34 weeks' gestation, a right-sided TAP block with 0.25% bupivacaine was inserted under ultrasound guidance, and this relieved all of her pain (visual analog scale score,0). The patient was managed with repeated boluses of 0.5% ropivacaine via a TAP catheter, which resulted in complete resolution of her pain within 3 days and allowed for complete discontinuation of opioid medications. The patient was discharged home, with no recurrence of pain. She had an uneventful cesarean delivery at term. Conclusions: A TAP catheter inserted under ultrasound guidance can be effective for the treatment of chronic abdominal pain during pregnancy and may provide an alternative analgesic modality when intravenous opioids are not providing relief or when neuraxial analgesia techniques are not feasible or contraindicated.

Turkiye Klinikleri Journal of Anesthesiology Reanimation, 2022

ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in ... more ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in terms of intubation conditions, during elective tracheal intubation in patients with diabetes mellitus (DM) who have a high risk for difficult airway. Material and Methods: One hundred and ten American Society of Anesthesiologist physical class II-III patients with DM undergoing elective surgery were randomized to be intubated using C-MAC video laryngoscope or Macintosh laryngoscope. Glottic view Cormack Lehane (CL) score, intubation time, intubation difficulty scale (IDS) score, and first attempt intubation success were compared. Results: Similar intubation times were detected [Macintosh laryngoscope: 39.6±30.1 seconds; C-MAC: 46.7±35.4 seconds (p=0.098). C-MAC provided significantly better CL scores]. Grade 1 CL laryngeal view was observed in 37 (68%) C-MAC vs. 26 (47.3%) Macintosh laryngoscope intubations (p=0.04). An IDS score of >5 was determined in 11 (20.4%) patients with C-MAC and in 10 (18.2%) with Macintosh laryngoscope (p=0.04), indicating an overall 20.1% moderate-to-severe intubation difficulty (p=0.536). The mean IDS score was 3.2±2.9 and 2.4±3.3 with C-MAC and Macintosh laryngoscopes, (p=0.04). First-attempt intubation success was 83.3% vs. 87.0% with C-MAC vs. Macintosh laryngoscope (p=0.786). Conclusion: In patients with DM, C-MAC provided improved glottis visualization, similar intubation time and first-attempt intubation success as a first-attempt intubation device compared with the Macintosh laryngoscope. However IDS scores were higher with the C-MAC. The incidence of actual intubation difficulty was found 20.1% in this diabetic study population.

Transplantation, 2020

Fatih Sandikci, Sanem Cimen, Sertac Cimen, Ebru Gok Oguz, Emine Ince Arik, Abdurrahim Imamoglu, A... more Fatih Sandikci, Sanem Cimen, Sertac Cimen, Ebru Gok Oguz, Emine Ince Arik, Abdurrahim Imamoglu, Alihan Kokurcan Diskapi Research and Training Hospital Department of Urology and Transplantation, Health Sciences University, Ankara, Turkey; Diskapi Research and Training Hospital Department of Anesthesiology, Health Sciences University, Ankara, Turkey; Diskapi Research and Training Hospital Department of Nephrology, Health Sciences University, Ankara, Turkey.

Regional anesthesia and pain medicine, Jan 22, 2015

The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spinal nerves t... more The transversus abdominis plane (TAP) block anesthetizes the anterior branches of spinal nerves that innervate the abdominal wall from T6 to L1 dermatomes and provide effective postoperative analgesia after abdominal surgery. Several applications of TAP catheters are described for both acute and chronic abdominal wall pain, but there are no reported cases of TAP catheters used during pregnancy. We present the case of a 23-year-old primigravida admitted to the hospital on multiple occasions during her pregnancy for right lower quadrant abdominal "stabbing" pain, with a visual analog scale score intensity of 8/10 abdominal pain. The diagnosis was unclear despite the presence of prominent ileocolic lymph nodes visualized on magnetic resonance imaging. The abdominal pain persisted despite escalating doses of intravenous opioids (up to 30 mg of intravenous hydromorphone daily). At 34 weeks' gestation, a right-sided TAP block with 0.25% bupivacaine was inserted under ultraso...

Anestezi dergisi, 2019

seviyesine sahip bireylerde daha sık anksiyete görülmekteydi. Üniversite mezunlarında da diğer eğ... more seviyesine sahip bireylerde daha sık anksiyete görülmekteydi. Üniversite mezunlarında da diğer eğitim düzeylerine göre anksiyete daha düşük bulundu (p<0.05). Sonuç: Hastaların yaş ve medeni durumunun anksiyete ile ilişkili olmadığını; kadınlarda özellikle çalışmayan ev hanımlarında ve emeklilerde anksiyetenin en yüksek oranda gözlendiğini belirledik. Üniversite mezunu, iyi gelir seviyesine sahip, öğrenci ve memurlarda ise aksine daha az anksiyete mevcuttu. Bu durumun kişilerin eğitim düzeyleri arttıkça, daha rahat bilgilenmesi ve çekincelerinin azalması ile ilişkili olduğunu düşünmekteyiz.

Turkiye Klinikleri Journal of Anesthesiology Reanimation, 2022

ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in ... more ABS TRACT Objective: C-MAC video laryngoscope and Macintosh direct laryngoscope were compared in terms of intubation conditions, during elective tracheal intubation in patients with diabetes mellitus (DM) who have a high risk for difficult airway. Material and Methods: One hundred and ten American Society of Anesthesiologist physical class II-III patients with DM undergoing elective surgery were randomized to be intubated using C-MAC video laryngoscope or Macintosh laryngoscope. Glottic view Cormack Lehane (CL) score, intubation time, intubation difficulty scale (IDS) score, and first attempt intubation success were compared. Results: Similar intubation times were detected [Macintosh laryngoscope: 39.6±30.1 seconds; C-MAC: 46.7±35.4 seconds (p=0.098). C-MAC provided significantly better CL scores]. Grade 1 CL laryngeal view was observed in 37 (68%) C-MAC vs. 26 (47.3%) Macintosh laryngoscope intubations (p=0.04). An IDS score of >5 was determined in 11 (20.4%) patients with C-MAC and in 10 (18.2%) with Macintosh laryngoscope (p=0.04), indicating an overall 20.1% moderate-to-severe intubation difficulty (p=0.536). The mean IDS score was 3.2±2.9 and 2.4±3.3 with C-MAC and Macintosh laryngoscopes, (p=0.04). First-attempt intubation success was 83.3% vs. 87.0% with C-MAC vs. Macintosh laryngoscope (p=0.786). Conclusion: In patients with DM, C-MAC provided improved glottis visualization, similar intubation time and first-attempt intubation success as a first-attempt intubation device compared with the Macintosh laryngoscope. However IDS scores were higher with the C-MAC. The incidence of actual intubation difficulty was found 20.1% in this diabetic study population.

ÖZET Amaç: Bu çal›flmada amaç, spinal anestezi alt›nda turnike kullan›lan total diz artroplastisi... more ÖZET Amaç: Bu çal›flmada amaç, spinal anestezi alt›nda turnike kullan›lan total diz artroplastisi cerrahisi geçirecek hastalarda verilen %0.9 NaCl ve ringer laktat solüsyonlar›n›n; turnike fliflirilmesi ve indirilmesi s›ras›nda asit-baz dengelerine olan etkilerini karfl›laflt›rmakt›r. Yöntem: Spinal anestezi ile turnike kullan›larak yap›lan total diz artroplastisi uygulanan yafl>40, ASA I-II 60 hasta çal›flmaya dahil edildi. Grup 1’e 10 ml kg % 0.9 NaCl, Grup 2’ye 10 ml kg ringer laktat›n iv infüzyonu sonras› spinal anestezi uyguland›. ‹damede her iki gruba 10 ml kg sa s›v› verildi. Tüm hastalar›n bazal (T0), spinal anestezi sonras› 5. dakika (T1), turnike fliflirilmesi sonras› 15. dk (T2), turnike indirilmesinden sonraki 1. (T3), 15. (T4) ve 30. (T5) dakikalarda OAB ve kalp h›zlar› kaydedildi. Ayr›ca hastalar›n T0, T2, T3, T4, T5 ölçüm zamanlar›nda arteriyel ve venöz kan gazlar›nda pH, PO2, PCO2, laktat, HCO3, klorür (Cl) düzeyleri kaydedildi. Bulgular: Grup 1’de grup 2’ye göre ...

Turkish Journal of Anaesthesiology and Reanimation, 2020

Radiofrequency ablation (RFA) is a minimal invasive approach for treating solid tumors. A compute... more Radiofrequency ablation (RFA) is a minimal invasive approach for treating solid tumors. A computed tomography (CT)-guided needle electrode is inserted percutaneously into the tumor. The electromagnetic current generated by the radiofrequency generator causes coagulation and necrosis in the tumor. In this procedure, the local temperature rises above 90°C, especially in large and close to the chest wall, serious pain occurs during and after the intervention (1). Although RFA procedures can be performed with local anaesthesia–sedation or general anaesthesia, local anaesthesia can lead to simple and fewer postoperative complications and has the advantage of short hospital stay (2).

Gulhane Medical Journal, 2020

The aim of this study was to assess the effectiveness of warming in perioperative hypothermia, he... more The aim of this study was to assess the effectiveness of warming in perioperative hypothermia, hemodynamic variables, post-anesthesia care unit discharge time, shivering, patient comfort and patient satisfaction in elderly patients undergoing transurethral resection of prostate (TURP) surgery under general anesthesia. Methods: Patients aged between 50 and 85 years, scheduled for TURP surgery of 30-90 min under general anesthesia, were enrolled into the study. Patients were randomly allocated to either the warming (Group P) or standard care (Group C) group. Core body temperatures and hemodynamic parameters were assessed. Additionally, patient satisfaction, thermal comfort, and shivering were compared using scales. Results: Overall, 33 patients (Group P; n=16, Group C; n=17) completed the study. Core body temperature was higher in Group P after anesthesia induction than in Group C (37.01±0.29 vs 36.61±0.21) (p=0.001). In addition, at the end of surgery, the core temperature was significantly higher in Group P (36.03±0.33) than in Group C (35.31±0.45) (p=0.001). Hypothermia was observed in four warmed and 17 unwarmed patients at the end of surgery (p=0.001). Following anesthesia induction, one warmed patient and nine unwarmed patients developed hypotension (p=0.004). Thermal comfort and patient satisfaction scores were significantly higher in warmed patients than in unwarmed patients (p<0.05), but shivering scores displayed a similar pattern between the groups (p>0.05). Conclusions: This study demonstrated that perioperative forced-air warming helped preserve perioperative core body temperature, reduced the incidence of hypotension during the induction period, increased thermal comfort, improved patient satisfaction, but did not affect shivering in patients undergoing TURP surgery.

Journal of Ankara University Faculty of Medicine, 2020

Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative ... more Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative stress and apoptosis causing cellular damage. Several animal models have shown paeonol to be a powerful antioxidant, antiapoptotic, and neuroprotective substance. This study aimed to investigate possible neuroprotective effects of paeonol in a rat TBI model. Materials and Methods: Thirty-two male rats were divided into four groups: control, trauma, vehicle, and paeonol groups. Trauma, vehicle, and paeonol groups were subjected to closed-head, contusive weight-drop injuries. The vehicle (saline) or paeonol (50 mg/kg) was orally administered as premedication for 15 days. Brain samples were obtained 24 hours after trauma. Histomorphological evaluation of the cerebral cortex was performed using electron and light microscopy. Results: Histopathological examination revealed that the TBI-induced cerebral cortex damage was less in the paeonol group. Conclusion: Paeonol exhibited neuroprotective and anti-edematous effects against TBI.

Acta Chirurgica Belgica, 2013

Background : Several researchers have investigated how wound healing is effected by supplementati... more Background : Several researchers have investigated how wound healing is effected by supplementation with each of the following amino acids : arginine (Arg), glutamine (Glu), and β-hydroxy β-methylbutyrate (HMB). This research investigates how a combination of these amino acids improves the wound healing associated with anastomoses. Methods : We tested the effects of a combination of Arg, Glu, and HMB on the healing of colon anastomoses in 50 male rats. We randomly divided the animals into two equal groups. In each animal, the cecum was transected from its midpoint to create an end-to end anastomosis. During the first postoperative week, Group 1 (G1) animals were fed standard chow, and Group 2 (G2) animals were fed standard chow plus a ready-to-use supplement that contained a mixture of Arg, Glu, and HMB. At the end of the week, all of the rats were sacrificed, and a cecum segment containing the anastomosis line was resected. Bursting pressure and tissue hydroxyproline were measured for all animals. Results : The mean values for hydroxyproline were 0.0013 ng/mg protein/ml (SD ± 0.00075) and 0.034 ng/mg protein/ ml (SD ± 0.022) for G1 and G2, respectively (p < 0.0001). The mean values for bursting pressure measurements were 122.8 mmHg (SD ± 9.4) and 192.8 mmHg (SD ± 31) for G1 and G2, respectively (p < 0.0001). Statistically significant differences between the groups in terms of both bursting pressure levels and tissue hydroxyproline levels were observed. Conclusion : In an animal model of colon surgery, supplementation with a combination of three amino acids seemingly benefits anastomosis healing.

Turkiye Klinikleri Journal of Anesthesiology Reanimation, 2007

perasyon süresince anestezi derinliğinin izlenmesi büyük önem taşımaktadır. Bu amaçla kullanılabi... more perasyon süresince anestezi derinliğinin izlenmesi büyük önem taşımaktadır. Bu amaçla kullanılabilecek en objektif değerlendirme yöntemi elektroensefalografi (EEG) parametreleridir. 1 Bispektral İndex (BİS) anestezik ve O ORİJİNAL ARAŞTIRMA / ORIGINAL RESEARCH.