Armen Galstyan - Academia.edu (original) (raw)
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Papers by Armen Galstyan
Proceedings of the YSU B: Chemical and Biological Sciences
The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been stud... more The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been studied by means of potentiometric titration and amperometric titration methods. It has been shown that the given interaction possesses an oxidation-reduction character with further complex formation. The ratio of interacting substances (oxidizer : reducing agent) is 1:1. A possible scheme of interaction has been also suggested.
Journal of Pharmacovigilance, Oct 20, 2016
European journal of organic chemistry, Mar 19, 2024
Proceedings of the YSU B: Chemical and Biological Sciences
A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by... more A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by the interaction of various representatives of cyclic esters with 85% hydrazine hydrate has been elaborated. It has been established that the introduction of a gamma-hydroxypropyl residue into the hydrazides composition results in new biological properties.
ChemBioChem, Mar 13, 2024
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Proceedings of the YSU B: Chemical and Biological Sciences
On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has bee... more On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has been elaborated. The antioxidant properties of hydrazides were researched by the method of competitive reactions and it was established that they have antioxidant activity.
Proceedings of the YSU B: Chemical and Biological Sciences
Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemic... more Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemicarbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․
Molecules
Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl... more Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone. Subsequent CuAAC click reaction with propargylated derivatives provided an efficient synthetic route to a set of terpenyl-derived conjugates with increased solubility in water. All investigated compounds exhibit high antioxidant activity, which is comparable with that of vitamin C. It was also found that serum albumin and the terpenyl-1,2,3-triazoles hybrids spontaneously undergo reversible binding driven by hydrophobic interactions, suggesting that serum albumin can transport the target triazoles.
Mendeleev Communications, 2016
Russian Journal of Organic Chemistry, 2013
ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)di... more ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)dimethanethiol, biphenyl-4,4′-diyldimethanethiol with 1-(oxiran-2-ylmethyl)piperidine and N-(oxiran-2-ylmethyl)-N-ethylaniline afforded the corresponding sulfur-containing vicinal aminoalcohols resulting from the opening of the oxirane ring in keeping with Krasusky rule.
Proceedings of the YSU B: Chemical and Biological Sciences
The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been stud... more The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been studied by means of potentiometric titration and amperometric titration methods. It has been shown that the given interaction possesses an oxidation-reduction character with further complex formation. The ratio of interacting substances (oxidizer : reducing agent) is 1:1. A possible scheme of interaction has been also suggested.
Journal of Pharmacovigilance, Oct 20, 2016
European journal of organic chemistry, Mar 19, 2024
Proceedings of the YSU B: Chemical and Biological Sciences
A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by... more A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by the interaction of various representatives of cyclic esters with 85% hydrazine hydrate has been elaborated. It has been established that the introduction of a gamma-hydroxypropyl residue into the hydrazides composition results in new biological properties.
ChemBioChem, Mar 13, 2024
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Proceedings of the YSU B: Chemical and Biological Sciences
On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has bee... more On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has been elaborated. The antioxidant properties of hydrazides were researched by the method of competitive reactions and it was established that they have antioxidant activity.
Proceedings of the YSU B: Chemical and Biological Sciences
Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemic... more Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemicarbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․
Molecules
Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl... more Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone. Subsequent CuAAC click reaction with propargylated derivatives provided an efficient synthetic route to a set of terpenyl-derived conjugates with increased solubility in water. All investigated compounds exhibit high antioxidant activity, which is comparable with that of vitamin C. It was also found that serum albumin and the terpenyl-1,2,3-triazoles hybrids spontaneously undergo reversible binding driven by hydrophobic interactions, suggesting that serum albumin can transport the target triazoles.
Mendeleev Communications, 2016
Russian Journal of Organic Chemistry, 2013
ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)di... more ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)dimethanethiol, biphenyl-4,4′-diyldimethanethiol with 1-(oxiran-2-ylmethyl)piperidine and N-(oxiran-2-ylmethyl)-N-ethylaniline afforded the corresponding sulfur-containing vicinal aminoalcohols resulting from the opening of the oxirane ring in keeping with Krasusky rule.