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Armen Galstyan

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Papers by Armen Galstyan

Research paper thumbnail of The Study of the Interaction Between Gold (III) and 2-(3-AZEPAN-1-YL)-2-HYDROXYPROPYLTHIOACETIC Acid by Means of Potentiometric and Amperometric Titration Methods

Proceedings of the YSU B: Chemical and Biological Sciences

The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been stud... more The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been studied by means of potentiometric titration and amperometric titration methods. It has been shown that the given interaction possesses an oxidation-reduction character with further complex formation. The ratio of interacting substances (oxidizer : reducing agent) is 1:1. A possible scheme of interaction has been also suggested.

Research paper thumbnail of Derivatives of 1,2,4-triazoles: Synthesis and study of biological activity

Journal of Pharmacovigilance, Oct 20, 2016

Research paper thumbnail of Ligand‐Free Cu(0) Catalyzed C–S Cross‐Coupling Ullmann‐type Reaction: S‐Arylation of 5,4‐Disubstituted‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones

European journal of organic chemistry, Mar 19, 2024

Research paper thumbnail of A New Method for the Preparation of Hydrazides of Substituted Gamma-Hydroxybutanoic Acids

Proceedings of the YSU B: Chemical and Biological Sciences

A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by... more A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by the interaction of various representatives of cyclic esters with 85% hydrazine hydrate has been elaborated. It has been established that the introduction of a gamma-hydroxypropyl residue into the hydrazides composition results in new biological properties.

Research paper thumbnail of Novel Triazole‐Containing “Dipeptides”: Synthesis, Molecular Docking And Analgesic Activity Studies

ChemBioChem, Mar 13, 2024

Research paper thumbnail of CCDC 1564725: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Synthesis of Γ-Hydroxy Acid Hydrazides of a New Structure and Study of Their Antioxidant Properties

Proceedings of the YSU B: Chemical and Biological Sciences

On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has bee... more On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has been elaborated. The antioxidant properties of hydrazides were researched by the method of competitive reactions and it was established that they have antioxidant activity.

Research paper thumbnail of ChemInform Abstract: Efficient Synthesis of Triazole-Containing Spiro Dilactones

Research paper thumbnail of Synthesis and characteristics of new 1,2,3-triazoles containing fragments of biologically active compounds

Research paper thumbnail of Study of the Biological Properties of Semi- and Thiosemicarbazones of Carbonyl Derivatives of 4-BUTANOLIDES

Proceedings of the YSU B: Chemical and Biological Sciences

Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemic... more Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemi­carbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․

Research paper thumbnail of Synthesis of cinnamyl substituted dihydrofuranones by the Heck cross-coupling reaction

Research paper thumbnail of Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

Research paper thumbnail of Synthesis of Novel Derivatives of 1,2,4-Triazoles

Research paper thumbnail of Copper catalyzed alkyne–azide cycloaddition with 3-propargyl- γ-butyrolactones

Research paper thumbnail of Synthesis of Carvone-Derived 1,2,3-Triazoles Study of Their Antioxidant Properties and Interaction with Bovine Serum Albumin

Molecules

Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl... more Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone. Subsequent CuAAC click reaction with propargylated derivatives provided an efficient synthetic route to a set of terpenyl-derived conjugates with increased solubility in water. All investigated compounds exhibit high antioxidant activity, which is comparable with that of vitamin C. It was also found that serum albumin and the terpenyl-1,2,3-triazoles hybrids spontaneously undergo reversible binding driven by hydrophobic interactions, suggesting that serum albumin can transport the target triazoles.

Research paper thumbnail of Synthesis of Alkynylated Dihydrofuran-2(3H )-ones as Potent and Selective Inhibitors of Tissue Non-Specific Alkaline Phosphatase

Research paper thumbnail of ChemInform Abstract: Efficient Synthesis of Triazole-Containing Spiro Dilactones

Research paper thumbnail of Synthesis of new derivatives of sulfur-containing vicinal amino alcohols on the basis of N-(oxiran-2-ylmethyl)amines

Research paper thumbnail of Efficient synthesis of triazole-containing spiro dilactones

Mendeleev Communications, 2016

Research paper thumbnail of Synthesis of sulfur-containing vicinal amino alcohols on the basis of N-(oxiran-2-ylmethyl)amines

Russian Journal of Organic Chemistry, 2013

ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)di... more ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)dimethanethiol, biphenyl-4,4′-diyldimethanethiol with 1-(oxiran-2-ylmethyl)piperidine and N-(oxiran-2-ylmethyl)-N-ethylaniline afforded the corresponding sulfur-containing vicinal aminoalcohols resulting from the opening of the oxirane ring in keeping with Krasusky rule.

Research paper thumbnail of The Study of the Interaction Between Gold (III) and 2-(3-AZEPAN-1-YL)-2-HYDROXYPROPYLTHIOACETIC Acid by Means of Potentiometric and Amperometric Titration Methods

Proceedings of the YSU B: Chemical and Biological Sciences

The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been stud... more The interaction of gold (III) with 2-(3-azepan-1-yl)-2-hydroxypropylthioacetic acid has been studied by means of potentiometric titration and amperometric titration methods. It has been shown that the given interaction possesses an oxidation-reduction character with further complex formation. The ratio of interacting substances (oxidizer : reducing agent) is 1:1. A possible scheme of interaction has been also suggested.

Research paper thumbnail of Derivatives of 1,2,4-triazoles: Synthesis and study of biological activity

Journal of Pharmacovigilance, Oct 20, 2016

Research paper thumbnail of Ligand‐Free Cu(0) Catalyzed C–S Cross‐Coupling Ullmann‐type Reaction: S‐Arylation of 5,4‐Disubstituted‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones

European journal of organic chemistry, Mar 19, 2024

Research paper thumbnail of A New Method for the Preparation of Hydrazides of Substituted Gamma-Hydroxybutanoic Acids

Proceedings of the YSU B: Chemical and Biological Sciences

A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by... more A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by the interaction of various representatives of cyclic esters with 85% hydrazine hydrate has been elaborated. It has been established that the introduction of a gamma-hydroxypropyl residue into the hydrazides composition results in new biological properties.

Research paper thumbnail of Novel Triazole‐Containing “Dipeptides”: Synthesis, Molecular Docking And Analgesic Activity Studies

ChemBioChem, Mar 13, 2024

Research paper thumbnail of CCDC 1564725: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Synthesis of Γ-Hydroxy Acid Hydrazides of a New Structure and Study of Their Antioxidant Properties

Proceedings of the YSU B: Chemical and Biological Sciences

On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has bee... more On the basis of cyclic esters а method for producing of γ-hydroxybutyric acids hydrazides has been elaborated. The antioxidant properties of hydrazides were researched by the method of competitive reactions and it was established that they have antioxidant activity.

Research paper thumbnail of ChemInform Abstract: Efficient Synthesis of Triazole-Containing Spiro Dilactones

Research paper thumbnail of Synthesis and characteristics of new 1,2,3-triazoles containing fragments of biologically active compounds

Research paper thumbnail of Study of the Biological Properties of Semi- and Thiosemicarbazones of Carbonyl Derivatives of 4-BUTANOLIDES

Proceedings of the YSU B: Chemical and Biological Sciences

Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemic... more Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemi­carbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․

Research paper thumbnail of Synthesis of cinnamyl substituted dihydrofuranones by the Heck cross-coupling reaction

Research paper thumbnail of Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

Research paper thumbnail of Synthesis of Novel Derivatives of 1,2,4-Triazoles

Research paper thumbnail of Copper catalyzed alkyne–azide cycloaddition with 3-propargyl- γ-butyrolactones

Research paper thumbnail of Synthesis of Carvone-Derived 1,2,3-Triazoles Study of Their Antioxidant Properties and Interaction with Bovine Serum Albumin

Molecules

Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl... more Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone. Subsequent CuAAC click reaction with propargylated derivatives provided an efficient synthetic route to a set of terpenyl-derived conjugates with increased solubility in water. All investigated compounds exhibit high antioxidant activity, which is comparable with that of vitamin C. It was also found that serum albumin and the terpenyl-1,2,3-triazoles hybrids spontaneously undergo reversible binding driven by hydrophobic interactions, suggesting that serum albumin can transport the target triazoles.

Research paper thumbnail of Synthesis of Alkynylated Dihydrofuran-2(3H )-ones as Potent and Selective Inhibitors of Tissue Non-Specific Alkaline Phosphatase

Research paper thumbnail of ChemInform Abstract: Efficient Synthesis of Triazole-Containing Spiro Dilactones

Research paper thumbnail of Synthesis of new derivatives of sulfur-containing vicinal amino alcohols on the basis of N-(oxiran-2-ylmethyl)amines

Research paper thumbnail of Efficient synthesis of triazole-containing spiro dilactones

Mendeleev Communications, 2016

Research paper thumbnail of Synthesis of sulfur-containing vicinal amino alcohols on the basis of N-(oxiran-2-ylmethyl)amines

Russian Journal of Organic Chemistry, 2013

ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)di... more ABSTRACT The reaction of (methanediyldibenzene-4,1-diyl)dimethanethiol, (oxydibenzene-4,1-diyl)dimethanethiol, biphenyl-4,4′-diyldimethanethiol with 1-(oxiran-2-ylmethyl)piperidine and N-(oxiran-2-ylmethyl)-N-ethylaniline afforded the corresponding sulfur-containing vicinal aminoalcohols resulting from the opening of the oxirane ring in keeping with Krasusky rule.

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