Arsida Bajrami - Academia.edu (original) (raw)

Papers by Arsida Bajrami

Research paper thumbnail of Symmetric Corticobasal Degeneration: Case Report

World Academy of Science, Engineering and Technology, International Journal of Medical and Health Sciences, May 25, 2015

Research paper thumbnail of Bilateral Hypertrophic Olivary Degeneration Secondary to Ischemia Following Endovascular Treatment Of Cerebral Aneurysm: A Case Report

Türk Beyin Damar Hastalıkları Dergisi, 2016

Hypertrophic olivary degeneration (HOD) is a degenerative disorder of the inferior olivary nucleu... more Hypertrophic olivary degeneration (HOD) is a degenerative disorder of the inferior olivary nucleus (ION) that occurs after damage to the dentatorubroolivary pathway (DROP). Damage to the DROP causes hypertrophy and enlargement of the inferior olivary nuclei (ION) contrary to the atrophy observed in the other parts of central nervous system. Focal lesions that may lead to HOD include ischemia, hemorrhage, trauma, and cavernous hemangioma and it also may mimic diseases including tumors and demyelinating processes. We here in present our experience with a case of bilateral HOD, which was a result of a thromboembolic complication during endovascular aneurysm embolization.

Research paper thumbnail of MRI findings and cognitive functions in a small cohort of myotonic dystrophy type 1: Retrospective analyses

Rivista Di Neuroradiologia, Nov 11, 2016

Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cognitive defi... more Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cognitive deficits and potential brain involvement in addition to the cardinal muscular and systemic symptoms. Impaired mental function associated with nonspecific pathological findings such as white-matter hyperintense lesions (WMHLs), ventricular enlargement and brain atrophy on brain MRI have been previously reported in DM1 patients. While some studies showed correlation of brain morphological changes with neuropsychological and clinical parameters including CTG repeat sizes and disease severity scales in DM1, others failed. The goal of this study was to retrospectively investigate cranial MR abnormalities, predominantly WMHLs, and their effects on clinical and cognitive deficits in a small, phenotypically or genotypically well-characterized cohort of DM1 patients.

Research paper thumbnail of Abstract Number ‐ 175: First Pass Results of Mechanical Thrombectomy with two‐drop zone NeVaTM Device

Stroke: vascular and interventional neurology, Mar 1, 2023

Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the ... more Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the success of the thrombectomy.The NeVaTM(Vesalio, Nashville, Tennessee) thrombectomy device was originally designed for all types of clot. Our aim was to evaluate the efficacy and safety of the NeVaTMdevice for mechanical thrombectomy. Methods Retrospective review of prospectively collected mechanical thrombectomy database revealed 145 patients who had fullfilled the inclusion criteria.The data collected includes clinical patient characteristics, procedural measures, timestamp at each stage, and patient outcome. IV thrombolytics application, pre and post‐intervention imaging findings, device related adverse event and any type of intracranial hemorrhage were recorded. Results There was female pre‐dominance (54.5%). Median presenting NIHSS was 16 (IQR, 3–32). 88 MCA‐m1 (60,6%), 43 ICA‐tip (29,6%), 11 MCA‐m2 (7,5%), 2 ACA (1,4%) and 1 basilar (0,7%) occlusions were underwent for mechanical thrombectomy. Median procedure time was 25 min (IQR, 7–136). First‐pass reperfusion scores were mTICI 0–2a 22.7%, mTICI 2b 23.4%, mTICI 2c 17.9% andmTICI 3 35.9%.Mean number of pass was1,84±1,14.Final mTICI 2b‐3 score was 97.9% and TICI2c‐3 score was 87.6%. No device related adverse event occurred. The mean 24‐hour NIHS score was 6 (IQR 0–33). Conclusions In conclusion, the NeVa thrombectomy device offers a high rate of first‐pass success along with favorable safety profile. Larger series and multi‐center studies are needed for further investigation

Research paper thumbnail of The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats

Indian Journal of Pharmaceutical Education and Research, Jun 30, 2022

Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits o... more Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits on neurological disorders associated with the effects of reactive oxygen species. Aim: The purpose of this research was to evaluate the protective effects of curcumin and memantine in a cerebral ischemia/reperfusion model in rats. Materials and Methods: This experimental study was conducted at the Bagcilar Training and Research Hospital, Istanbul, Turkey. Rats were separated into five experimental groups (n=8) as follows: Curcumin (Group I), Memantine (Group II), Curcumin+Memantine (Group III), ischemia (Group IV), and sham (Group V). Cerebral ischemia was performed surgically with bilateral common carotid artery occlusion for 30 min, followed by reperfusion for 72 hr. Tissue and serum samples were collected and assessed for tumor necrosis factor-α, interleukin-6, lactate dehydrogenase, catalase, glutathione peroxidase, xanthine dehydrogenase, superoxide dismutase, and malondialdehyde levels. Further, in tissue samples, both neuronal loss and caspase-3 levels were determined. Results: Serum and tissue levels of interleukin-6, tumor necrosis factor-α, malondialdehyde, and lactate dehydrogenase were found significantly lower in the Group I, II, and III compared to Group IV (p<0.001). Glutathione peroxidase, superoxide dismutase, and catalase levels in Group I, II, and III were significantly higher than those of Group IV (p<0.001). Conclusion: Curcumin, Memantine, and Curcumin+Memantine treatment were found to be efficacious in decreasing oxidative damage in cerebral ischemia but failed to prevent tissue damage.

Research paper thumbnail of P349 Assessment of prevalence and risk factors for carpal tunnel syndrome in polio survivors

Clinical Neurophysiology, Sep 1, 2017

MF treatment on signaling systems, AMP-activated kinase (AMPK) and mitochondrial dynamics in hypo... more MF treatment on signaling systems, AMP-activated kinase (AMPK) and mitochondrial dynamics in hypothalamic neurons of agoutimice(Ay/a) with melanocortin type obesity. Methods: Obese agouti-mice were treated with MF during 9 days (200 mg/kg/day), and expression and phosphorylation of AMPK and the signal and mitochondrial proteins were analyzed by Western blotting and RT-PCR. The C57Bl/6J micewere taken as a control. Results: In the hypothalamus of agouti-mice, MF treatment restored expression of pro-opiomelanocortin, increased D2dopamine signaling and the ratio of D2/D1-signaling pathways, activated the leptin signaling, as illustrated by the increase of Ser473phosphorylation of Akt-kinase, and normalized the expression of Mfn1 and Drp1 proteins responsible for mitochondria biogenesis, but it had a little effect on AMPK activity. Discussion: MF-induced improvement of hypothalamic regulation and functions inagouti-mice is associated with the decreased body weight, the improved glucose tolerance and insulin sensitivity, which indicates a close relationship between MF effect on CNS and its peripheral effects. Conclusions: Long-term MF treatment restored the dopamine and leptin signaling, the ratio of anorexigenic and orexigenic factors and mitochondrial dynamics in the hypothalamus of agouti-mice with melanocortin obesity. Significance: The obtained data indicates that the hypothalamus is the most important target for MF, and central effects of MF can make a significant contribution to its therapeutic potential in obesity. This work was supported by RSF (16-15-10388).

Research paper thumbnail of ID 293 – Evaluation of cognitive functions, electrophysiological findings brain mr and in myotonic dystrophy type 1: Retrospective analyses

Clinical Neurophysiology, Mar 1, 2016

Objective Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cogn... more Objective Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cognitive deficits and potential brain involvement beside the cardinal muscular symptoms. In this study, we evaluated the relationship between cognitive functions and cranial MRI findings in DM1 patients. Methods Clinical, electrophysiological and radiological data of 16 DM1 patients were evaluated. A comprehensive analysis of white-matter hyperintense lesions (WMHL) and brain atrophy detected by 3T MRI was performed. Cognitive impairment was assessed by an extensive neuropsychological battery. Results The age range of 16 (11M/5F) patients was 19-55 years. EMG showed myotonia and myopathic MUPs in all patients. Mild cognitive impairment was detected in 72% of the patients. WMHL was present in 55% and mild cognitive impairment was prominent in patients with temporal involvement. The severity of cognitive dysfunction was correlated by early onset of myotonia but not with clinical findings or sex. Conclusions The nature of CNS abnormalities revealed by MRI is still unclear: the ones located at the temporal poles seem to be characteristics of the disease, while small, diffuse WMHLs are similar to the age related alterations. Key message Our results indicate that the white matter abnormalities shown by neuroimaging might have implications for cognitive function.

Research paper thumbnail of Neuroimaging Findings in Hypoglycemia Triggered Syndrome of Acute Bilateral Basal Ganglia Lesions in Patients Treated With Regular Dialysis: Two Case Reports

Journal of Neurology and Neuroscience, 2015

Research paper thumbnail of LDL Subclasses in Ischemic Stroke: A Risk Factor?

Nöropsikiyatri arşivi, Sep 8, 2017

Introduction: Seven low-density lipoprotein (LDL) subclasses are identified, and smaller LDL part... more Introduction: Seven low-density lipoprotein (LDL) subclasses are identified, and smaller LDL particles are associated with an increased risk for cardiovascular events. However, there is limited data about the relationship between the acute ischemic stroke (AIS) subtypes and LDL subclasses. The aim of our study is to investigate the relationship between AIS subtypes and LDL subclasses. Methods: This study consisted of 110 AIS patients and 60 healthy controls. Stroke patients were classified according to the TOAST classification system as cardioembolic infarct (CI), large artery atherosclerosis (LAA), and lacunar infarct (LI). LDL subclasses were distributed as seven bands (LDL-1 and-2 defined as large, and LDL-3 to-7 defined as small-LDL particle), using the LipoPrintª System. Control group and AIS subtypes were compared in terms of LDL subclasses; p<0.05 was considered statistically significant. Results: AIS patients had higher LDL-2, LDL-3 and LDL-4 subclasses compared to the control groups, while LDL-1 was similar in two groups. In addition, LDL-2 and LDL-3 subclasses were significantly higher in each AIS subtype when compared to the control group. LDL-4 subclasses were significantly higher in LAA and LI subtypes than in the control group, but there was no relationship for CI subtypes. Smaller subclasses LDL-5 to LDL-7 were undetectable in both AIS patients and controls. Using regression analysis; age, LDL-2, LDL-3 and LDL-4 were found to be independent predictors of AIS development. Conclusion: Our study showed that examination of LDL subclasses may be important in management of AIS patients. LDL-2, LDL-3, and LDL-4 are independent predictors of AIS development. These findings should be supported by further large studies.

Research paper thumbnail of Abstract WMP87: Primary Results From The CLEAR Study Of The Safety And Effectiveness Of The Neva Stent Retriever For Large Vessel Thrombectomy

Research paper thumbnail of Abstract WMP96: A Prospective Trial Of The Rapidpulse Tm Aspiration System As Frontline Approach For Stroke Thrombectomy (RapidPulseFS)

Stroke

Introduction: First-pass effect (FPE) is associated with improved clinical outcomes and reduced m... more Introduction: First-pass effect (FPE) is associated with improved clinical outcomes and reduced mortality in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). However, FPE is achieved in only 30-40% of patients with the current devices. The RapidPulse TM Cyclic Aspiration System (RP) is a novel technology consisting of a valve box that precisely cycles pressure from full to no vacuum multiple times per second adding kinetic energy to the suction forces. Initial clinical evaluation suggests that the system can achieve FPE rates in the 70% range. We aim to evaluate the RP as a frontline approach in LVOS. Methods: Prospective, multicenter, open-label, core lab adjudicated, two-arm study comparing the safety and efficacy of the RP System with non-randomized retrospective controls who were consecutively treated at the study sites based on similar eligibility criteria. Patients with LVOS involving the anterior or posterior circulations in whom the target lesion could...

Research paper thumbnail of First pass results of mechanical thrombectomy with two-drop zone NeVaTM device

Interventional Neuroradiology

Background Occlusive thrombi in acute ischemic stroke can be in various types which limits the su... more Background Occlusive thrombi in acute ischemic stroke can be in various types which limits the success of the thrombectomy. The NeVaTM (Vesalio, Nashville, Tennessee) thrombectomy device was originally designed for all types of clot. Our aim was to evaluate the efficacy and safety of the NeVaTM device for mechanical thrombectomy. Methods Retrospective review of prospectively collected mechanical thrombectomy database revealed 145 patients who had fullfilled the inclusion criteria. The data collected includes clinical patient characteristics, procedural measures, timestamp at each stage, and patient outcome. IV thrombolytics application, pre and post-intervention imaging findings, device related adverse event and any type of intracranial hemorrhage were recorded. Results There was female pre-dominance (54.5%). Median presenting national institutes of health stroke scale (NIHSS) was 16 (IQR, 3–32). 88 MCA-m1 (60,6%), 43 ICA-tip (29,6%), 11 MCA-m2 (7,5%), 2 ACA (1,4%) and 1 basilar (0,...

Research paper thumbnail of Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events

Neurology

Background and ObjectivesDeclines in stroke admission, IV thrombolysis (IVT), and mechanical thro... more Background and ObjectivesDeclines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).MethodsWe conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by theirICD-10codes or ...

Research paper thumbnail of Poster Presentations: EuroNeuro 2014

Turkısh Journal of Anesthesıa and Reanımatıon, Apr 1, 2014

Research paper thumbnail of Abstract Number ‐ 175: First Pass Results of Mechanical Thrombectomy with two‐drop zone NeVaTM Device

Stroke: Vascular and Interventional Neurology

Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the ... more Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the success of the thrombectomy.The NeVaTM(Vesalio, Nashville, Tennessee) thrombectomy device was originally designed for all types of clot. Our aim was to evaluate the efficacy and safety of the NeVaTMdevice for mechanical thrombectomy. Methods Retrospective review of prospectively collected mechanical thrombectomy database revealed 145 patients who had fullfilled the inclusion criteria.The data collected includes clinical patient characteristics, procedural measures, timestamp at each stage, and patient outcome. IV thrombolytics application, pre and post‐intervention imaging findings, device related adverse event and any type of intracranial hemorrhage were recorded. Results There was female pre‐dominance (54.5%). Median presenting NIHSS was 16 (IQR, 3–32). 88 MCA‐m1 (60,6%), 43 ICA‐tip (29,6%), 11 MCA‐m2 (7,5%), 2 ACA (1,4%) and 1 basilar (0,7%) occlusions were underwent for mechanical th...

Research paper thumbnail of The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats

Indian Journal of Pharmaceutical Education and Research

Research paper thumbnail of Intraserebral Anevrizmanın Endovaskuler Tedavi Sonrası Gelişen İskemiye Ikincil Olarak Gelişen Bilateral Hipertrofik Olivar Dejenerasyon: Olgu Sunumu

Türk Beyin Damar Hastalıkları Dergisi, 2016

Research paper thumbnail of Sekonder Santral Sinir Sistem Vaskülitin İzole Magnetik Rezonans Bulgusu Olarak Leptomeningeal Tutulum: Olgu Sunumu

Türk Beyin Damar Hastalıkları Dergisi, 2016

Research paper thumbnail of Symmetric Corticobasal Degeneration: Case Report

Research paper thumbnail of Leptomeningeal Enhancement As A Sole Magnetic Resonance Imaging Finding of Secondary Central Nervous System Vasculitis: A Case Report

Turkish Journal of Cerebrovascular Diseases, 2016

The main radiological findings of central nervous system (CNS) consist of multiple subcortical in... more The main radiological findings of central nervous system (CNS) consist of multiple subcortical infarcts, parenchymal and leptomeningeal enhancement, petechial hemorrhages on MRI and multifocal caliber changes of the vessels on MRA and DSA. Solely or prominent leptomeningeal enhancement is rarely seen as an isolated manifestation of CNS. We report a case of intracerebral vasculitis secondary to inflammatory bowel disease (IBD) showing leptomeningeal enhancement as a unique finding in routine contrast-enhanced cranial MRI and aimed to emphasize the importance of these finding in diagnosing CNS.

Research paper thumbnail of Symmetric Corticobasal Degeneration: Case Report

World Academy of Science, Engineering and Technology, International Journal of Medical and Health Sciences, May 25, 2015

Research paper thumbnail of Bilateral Hypertrophic Olivary Degeneration Secondary to Ischemia Following Endovascular Treatment Of Cerebral Aneurysm: A Case Report

Türk Beyin Damar Hastalıkları Dergisi, 2016

Hypertrophic olivary degeneration (HOD) is a degenerative disorder of the inferior olivary nucleu... more Hypertrophic olivary degeneration (HOD) is a degenerative disorder of the inferior olivary nucleus (ION) that occurs after damage to the dentatorubroolivary pathway (DROP). Damage to the DROP causes hypertrophy and enlargement of the inferior olivary nuclei (ION) contrary to the atrophy observed in the other parts of central nervous system. Focal lesions that may lead to HOD include ischemia, hemorrhage, trauma, and cavernous hemangioma and it also may mimic diseases including tumors and demyelinating processes. We here in present our experience with a case of bilateral HOD, which was a result of a thromboembolic complication during endovascular aneurysm embolization.

Research paper thumbnail of MRI findings and cognitive functions in a small cohort of myotonic dystrophy type 1: Retrospective analyses

Rivista Di Neuroradiologia, Nov 11, 2016

Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cognitive defi... more Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cognitive deficits and potential brain involvement in addition to the cardinal muscular and systemic symptoms. Impaired mental function associated with nonspecific pathological findings such as white-matter hyperintense lesions (WMHLs), ventricular enlargement and brain atrophy on brain MRI have been previously reported in DM1 patients. While some studies showed correlation of brain morphological changes with neuropsychological and clinical parameters including CTG repeat sizes and disease severity scales in DM1, others failed. The goal of this study was to retrospectively investigate cranial MR abnormalities, predominantly WMHLs, and their effects on clinical and cognitive deficits in a small, phenotypically or genotypically well-characterized cohort of DM1 patients.

Research paper thumbnail of Abstract Number ‐ 175: First Pass Results of Mechanical Thrombectomy with two‐drop zone NeVaTM Device

Stroke: vascular and interventional neurology, Mar 1, 2023

Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the ... more Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the success of the thrombectomy.The NeVaTM(Vesalio, Nashville, Tennessee) thrombectomy device was originally designed for all types of clot. Our aim was to evaluate the efficacy and safety of the NeVaTMdevice for mechanical thrombectomy. Methods Retrospective review of prospectively collected mechanical thrombectomy database revealed 145 patients who had fullfilled the inclusion criteria.The data collected includes clinical patient characteristics, procedural measures, timestamp at each stage, and patient outcome. IV thrombolytics application, pre and post‐intervention imaging findings, device related adverse event and any type of intracranial hemorrhage were recorded. Results There was female pre‐dominance (54.5%). Median presenting NIHSS was 16 (IQR, 3–32). 88 MCA‐m1 (60,6%), 43 ICA‐tip (29,6%), 11 MCA‐m2 (7,5%), 2 ACA (1,4%) and 1 basilar (0,7%) occlusions were underwent for mechanical thrombectomy. Median procedure time was 25 min (IQR, 7–136). First‐pass reperfusion scores were mTICI 0–2a 22.7%, mTICI 2b 23.4%, mTICI 2c 17.9% andmTICI 3 35.9%.Mean number of pass was1,84±1,14.Final mTICI 2b‐3 score was 97.9% and TICI2c‐3 score was 87.6%. No device related adverse event occurred. The mean 24‐hour NIHS score was 6 (IQR 0–33). Conclusions In conclusion, the NeVa thrombectomy device offers a high rate of first‐pass success along with favorable safety profile. Larger series and multi‐center studies are needed for further investigation

Research paper thumbnail of The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats

Indian Journal of Pharmaceutical Education and Research, Jun 30, 2022

Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits o... more Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits on neurological disorders associated with the effects of reactive oxygen species. Aim: The purpose of this research was to evaluate the protective effects of curcumin and memantine in a cerebral ischemia/reperfusion model in rats. Materials and Methods: This experimental study was conducted at the Bagcilar Training and Research Hospital, Istanbul, Turkey. Rats were separated into five experimental groups (n=8) as follows: Curcumin (Group I), Memantine (Group II), Curcumin+Memantine (Group III), ischemia (Group IV), and sham (Group V). Cerebral ischemia was performed surgically with bilateral common carotid artery occlusion for 30 min, followed by reperfusion for 72 hr. Tissue and serum samples were collected and assessed for tumor necrosis factor-α, interleukin-6, lactate dehydrogenase, catalase, glutathione peroxidase, xanthine dehydrogenase, superoxide dismutase, and malondialdehyde levels. Further, in tissue samples, both neuronal loss and caspase-3 levels were determined. Results: Serum and tissue levels of interleukin-6, tumor necrosis factor-α, malondialdehyde, and lactate dehydrogenase were found significantly lower in the Group I, II, and III compared to Group IV (p<0.001). Glutathione peroxidase, superoxide dismutase, and catalase levels in Group I, II, and III were significantly higher than those of Group IV (p<0.001). Conclusion: Curcumin, Memantine, and Curcumin+Memantine treatment were found to be efficacious in decreasing oxidative damage in cerebral ischemia but failed to prevent tissue damage.

Research paper thumbnail of P349 Assessment of prevalence and risk factors for carpal tunnel syndrome in polio survivors

Clinical Neurophysiology, Sep 1, 2017

MF treatment on signaling systems, AMP-activated kinase (AMPK) and mitochondrial dynamics in hypo... more MF treatment on signaling systems, AMP-activated kinase (AMPK) and mitochondrial dynamics in hypothalamic neurons of agoutimice(Ay/a) with melanocortin type obesity. Methods: Obese agouti-mice were treated with MF during 9 days (200 mg/kg/day), and expression and phosphorylation of AMPK and the signal and mitochondrial proteins were analyzed by Western blotting and RT-PCR. The C57Bl/6J micewere taken as a control. Results: In the hypothalamus of agouti-mice, MF treatment restored expression of pro-opiomelanocortin, increased D2dopamine signaling and the ratio of D2/D1-signaling pathways, activated the leptin signaling, as illustrated by the increase of Ser473phosphorylation of Akt-kinase, and normalized the expression of Mfn1 and Drp1 proteins responsible for mitochondria biogenesis, but it had a little effect on AMPK activity. Discussion: MF-induced improvement of hypothalamic regulation and functions inagouti-mice is associated with the decreased body weight, the improved glucose tolerance and insulin sensitivity, which indicates a close relationship between MF effect on CNS and its peripheral effects. Conclusions: Long-term MF treatment restored the dopamine and leptin signaling, the ratio of anorexigenic and orexigenic factors and mitochondrial dynamics in the hypothalamus of agouti-mice with melanocortin obesity. Significance: The obtained data indicates that the hypothalamus is the most important target for MF, and central effects of MF can make a significant contribution to its therapeutic potential in obesity. This work was supported by RSF (16-15-10388).

Research paper thumbnail of ID 293 – Evaluation of cognitive functions, electrophysiological findings brain mr and in myotonic dystrophy type 1: Retrospective analyses

Clinical Neurophysiology, Mar 1, 2016

Objective Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cogn... more Objective Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cognitive deficits and potential brain involvement beside the cardinal muscular symptoms. In this study, we evaluated the relationship between cognitive functions and cranial MRI findings in DM1 patients. Methods Clinical, electrophysiological and radiological data of 16 DM1 patients were evaluated. A comprehensive analysis of white-matter hyperintense lesions (WMHL) and brain atrophy detected by 3T MRI was performed. Cognitive impairment was assessed by an extensive neuropsychological battery. Results The age range of 16 (11M/5F) patients was 19-55 years. EMG showed myotonia and myopathic MUPs in all patients. Mild cognitive impairment was detected in 72% of the patients. WMHL was present in 55% and mild cognitive impairment was prominent in patients with temporal involvement. The severity of cognitive dysfunction was correlated by early onset of myotonia but not with clinical findings or sex. Conclusions The nature of CNS abnormalities revealed by MRI is still unclear: the ones located at the temporal poles seem to be characteristics of the disease, while small, diffuse WMHLs are similar to the age related alterations. Key message Our results indicate that the white matter abnormalities shown by neuroimaging might have implications for cognitive function.

Research paper thumbnail of Neuroimaging Findings in Hypoglycemia Triggered Syndrome of Acute Bilateral Basal Ganglia Lesions in Patients Treated With Regular Dialysis: Two Case Reports

Journal of Neurology and Neuroscience, 2015

Research paper thumbnail of LDL Subclasses in Ischemic Stroke: A Risk Factor?

Nöropsikiyatri arşivi, Sep 8, 2017

Introduction: Seven low-density lipoprotein (LDL) subclasses are identified, and smaller LDL part... more Introduction: Seven low-density lipoprotein (LDL) subclasses are identified, and smaller LDL particles are associated with an increased risk for cardiovascular events. However, there is limited data about the relationship between the acute ischemic stroke (AIS) subtypes and LDL subclasses. The aim of our study is to investigate the relationship between AIS subtypes and LDL subclasses. Methods: This study consisted of 110 AIS patients and 60 healthy controls. Stroke patients were classified according to the TOAST classification system as cardioembolic infarct (CI), large artery atherosclerosis (LAA), and lacunar infarct (LI). LDL subclasses were distributed as seven bands (LDL-1 and-2 defined as large, and LDL-3 to-7 defined as small-LDL particle), using the LipoPrintª System. Control group and AIS subtypes were compared in terms of LDL subclasses; p<0.05 was considered statistically significant. Results: AIS patients had higher LDL-2, LDL-3 and LDL-4 subclasses compared to the control groups, while LDL-1 was similar in two groups. In addition, LDL-2 and LDL-3 subclasses were significantly higher in each AIS subtype when compared to the control group. LDL-4 subclasses were significantly higher in LAA and LI subtypes than in the control group, but there was no relationship for CI subtypes. Smaller subclasses LDL-5 to LDL-7 were undetectable in both AIS patients and controls. Using regression analysis; age, LDL-2, LDL-3 and LDL-4 were found to be independent predictors of AIS development. Conclusion: Our study showed that examination of LDL subclasses may be important in management of AIS patients. LDL-2, LDL-3, and LDL-4 are independent predictors of AIS development. These findings should be supported by further large studies.

Research paper thumbnail of Abstract WMP87: Primary Results From The CLEAR Study Of The Safety And Effectiveness Of The Neva Stent Retriever For Large Vessel Thrombectomy

Research paper thumbnail of Abstract WMP96: A Prospective Trial Of The Rapidpulse Tm Aspiration System As Frontline Approach For Stroke Thrombectomy (RapidPulseFS)

Stroke

Introduction: First-pass effect (FPE) is associated with improved clinical outcomes and reduced m... more Introduction: First-pass effect (FPE) is associated with improved clinical outcomes and reduced mortality in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). However, FPE is achieved in only 30-40% of patients with the current devices. The RapidPulse TM Cyclic Aspiration System (RP) is a novel technology consisting of a valve box that precisely cycles pressure from full to no vacuum multiple times per second adding kinetic energy to the suction forces. Initial clinical evaluation suggests that the system can achieve FPE rates in the 70% range. We aim to evaluate the RP as a frontline approach in LVOS. Methods: Prospective, multicenter, open-label, core lab adjudicated, two-arm study comparing the safety and efficacy of the RP System with non-randomized retrospective controls who were consecutively treated at the study sites based on similar eligibility criteria. Patients with LVOS involving the anterior or posterior circulations in whom the target lesion could...

Research paper thumbnail of First pass results of mechanical thrombectomy with two-drop zone NeVaTM device

Interventional Neuroradiology

Background Occlusive thrombi in acute ischemic stroke can be in various types which limits the su... more Background Occlusive thrombi in acute ischemic stroke can be in various types which limits the success of the thrombectomy. The NeVaTM (Vesalio, Nashville, Tennessee) thrombectomy device was originally designed for all types of clot. Our aim was to evaluate the efficacy and safety of the NeVaTM device for mechanical thrombectomy. Methods Retrospective review of prospectively collected mechanical thrombectomy database revealed 145 patients who had fullfilled the inclusion criteria. The data collected includes clinical patient characteristics, procedural measures, timestamp at each stage, and patient outcome. IV thrombolytics application, pre and post-intervention imaging findings, device related adverse event and any type of intracranial hemorrhage were recorded. Results There was female pre-dominance (54.5%). Median presenting national institutes of health stroke scale (NIHSS) was 16 (IQR, 3–32). 88 MCA-m1 (60,6%), 43 ICA-tip (29,6%), 11 MCA-m2 (7,5%), 2 ACA (1,4%) and 1 basilar (0,...

Research paper thumbnail of Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events

Neurology

Background and ObjectivesDeclines in stroke admission, IV thrombolysis (IVT), and mechanical thro... more Background and ObjectivesDeclines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).MethodsWe conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by theirICD-10codes or ...

Research paper thumbnail of Poster Presentations: EuroNeuro 2014

Turkısh Journal of Anesthesıa and Reanımatıon, Apr 1, 2014

Research paper thumbnail of Abstract Number ‐ 175: First Pass Results of Mechanical Thrombectomy with two‐drop zone NeVaTM Device

Stroke: Vascular and Interventional Neurology

Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the ... more Introduction Occlusive thrombi in acute ischemic stroke can be in various types which limits the success of the thrombectomy.The NeVaTM(Vesalio, Nashville, Tennessee) thrombectomy device was originally designed for all types of clot. Our aim was to evaluate the efficacy and safety of the NeVaTMdevice for mechanical thrombectomy. Methods Retrospective review of prospectively collected mechanical thrombectomy database revealed 145 patients who had fullfilled the inclusion criteria.The data collected includes clinical patient characteristics, procedural measures, timestamp at each stage, and patient outcome. IV thrombolytics application, pre and post‐intervention imaging findings, device related adverse event and any type of intracranial hemorrhage were recorded. Results There was female pre‐dominance (54.5%). Median presenting NIHSS was 16 (IQR, 3–32). 88 MCA‐m1 (60,6%), 43 ICA‐tip (29,6%), 11 MCA‐m2 (7,5%), 2 ACA (1,4%) and 1 basilar (0,7%) occlusions were underwent for mechanical th...

Research paper thumbnail of The Neuroprotective Effects of Memantine, and Curcumin after Cerebral Ischemia-reperfusion Injury in Elderly Rats

Indian Journal of Pharmaceutical Education and Research

Research paper thumbnail of Intraserebral Anevrizmanın Endovaskuler Tedavi Sonrası Gelişen İskemiye Ikincil Olarak Gelişen Bilateral Hipertrofik Olivar Dejenerasyon: Olgu Sunumu

Türk Beyin Damar Hastalıkları Dergisi, 2016

Research paper thumbnail of Sekonder Santral Sinir Sistem Vaskülitin İzole Magnetik Rezonans Bulgusu Olarak Leptomeningeal Tutulum: Olgu Sunumu

Türk Beyin Damar Hastalıkları Dergisi, 2016

Research paper thumbnail of Symmetric Corticobasal Degeneration: Case Report

Research paper thumbnail of Leptomeningeal Enhancement As A Sole Magnetic Resonance Imaging Finding of Secondary Central Nervous System Vasculitis: A Case Report

Turkish Journal of Cerebrovascular Diseases, 2016

The main radiological findings of central nervous system (CNS) consist of multiple subcortical in... more The main radiological findings of central nervous system (CNS) consist of multiple subcortical infarcts, parenchymal and leptomeningeal enhancement, petechial hemorrhages on MRI and multifocal caliber changes of the vessels on MRA and DSA. Solely or prominent leptomeningeal enhancement is rarely seen as an isolated manifestation of CNS. We report a case of intracerebral vasculitis secondary to inflammatory bowel disease (IBD) showing leptomeningeal enhancement as a unique finding in routine contrast-enhanced cranial MRI and aimed to emphasize the importance of these finding in diagnosing CNS.