Arto Yuwono Soeroto - Academia.edu (original) (raw)

Papers by Arto Yuwono Soeroto

Research paper thumbnail of Efficacy and safety of tixagevimab‐cilgavimab as pre‐exposure prophylaxis for COVID‐19: A systematic review and meta‐analysis

Reviews in Medical Virology, Jan 8, 2023

Research paper thumbnail of Polymorphisms of SLCO1B1 Gene in Sundanese Ethnic Population of Tuberculosis Patients in Indonesia

Acta medica Indonesiana, Oct 1, 2022

Research paper thumbnail of Distribution of Rifampicin-Resistant Tuberculosis Patients based on Presumptive Drug-Resistant Tuberculosis Criteria at Dr. Hasan Sadikin Hospital 2016–2019

Althea Medical Journal

Background: Diagnosis of drug-resistant tuberculosis (DR-TB) begins with identifying presumptive ... more Background: Diagnosis of drug-resistant tuberculosis (DR-TB) begins with identifying presumptive DR-TB patients using Xpert MTB/RIF, as a diagnostic test to detect resistance to rifampicin. The study aimed to identify the distribution of rifampicin-resistant tuberculosis (RR-TB) patients based on presumptive DR-TB criteria at Dr. Hasan Sadikin General Hospital Bandung. Moreover, this study also explored the Xpert MTB/RIF Ct values.Methods: This was a descriptive-retrospective study from 570 medical records of DR-TB patients collected at the Multidrug-resistant tuberculosis (MDR-TB) clinic of Dr. Hasan Sadikin General Hospital from 2016 to 2019. The inclusion criteria were suspected patients with the Xpert MTB/RIF Ct values in the very low-low and medium-high categories. Data were analyzed using frequency distribution. Results: The most common presumptive DR-TB criteria among DR-TB patients were relapse cases (52.3%). Presumptive DR-TB criteria, with a high percentage result of mediu...

Research paper thumbnail of Effectiveness and Safety of Normoxic Allogenic Umbilical Cord Mesenchymal Stem Cells Administered as Adjunctive Treatment in Patients with Severe COVID-19

Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells... more Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells (MSCs) have the potential to alleviate inflammation and reduce mortality and length of stay in COVID-19 patients. We investigated the safety and effectiveness of normoxic-allogenic umbilical cord (NA-UC)-MSCs as an adjunctive treatment in severe COVID-19 patients. A double-blind, multicentric, randomized, placebo-controlled trial involving severe COVID-19 patients was performed from January–June 2021 in three major hospitals across Java, Indonesia. Eligible participants (n = 42) were randomly assigned to two groups (1:1), namely the intervention (n = 21) and control (n = 21) groups. Either NA-UC-MSCs or NaCl placebo were administered daily. The primary outcome was the duration of hospitalization. Meanwhile, the secondary outcomes were radiographical progression (Brixia score), respiratory and oxygenation parameters, and inflammatory markers, in addition to the safety profile of NA-UC-MS...

Research paper thumbnail of Supplementary_Table – Supplemental material for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis

Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney I... more Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis by Michael Anthonius Lim, Raymond Pranata, Ian Huang, Emir Yonas, Arto Yuwono Soeroto and Rudi Supriyadi in Canadian Journal of Kidney Health and Disease

Research paper thumbnail of Risk factors of COVID-19 clinical worsening: A retrospective cohort study in COVID-19 referral hospital in west Java, Indonesia

F1000Research

Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is marked as one of the ... more Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is marked as one of the highly pathogenic viruses, resulting in millions of deaths worldwide. Management of COVID-19 in limited resources requires appropriate decisions. Clinical considerations along with simple laboratory parameters that can predict the worsening are needed to determine which patients should be treated more intensively. Methods: This is a retrospective cohort study based on the Research Electronic Data Capture (REDCap) registry of COVID-19 patients in Hasan Sadikin General Hospital from April to December 2020. Patients were divided into worsening and non-worsening groups within a 14-day follow-up. Factors affecting these conditions were analyzed. Results: A total of 537 patients were included in this study, of which 72 patients suffered deterioration. Multivariate analysis showed the significant factors affecting the worsening of COVID-19 patients were age > 60 years (aOR 4.207, 95% CI 2.1...

Research paper thumbnail of The role of 99mTc-ethambutol scintigraphy to diagnose pulmonary tuberculosis

Journal of infection in developing countries, 2022

Tuberculosis is a significant health problem in many parts of the world. According to the Global ... more Tuberculosis is a significant health problem in many parts of the world. According to the Global Tuberculosis Report 2020, 10 million new tuberculosis cases were reported worldwide in 2019, with only 57% of these cases being bacteriologically confirmed. Current tuberculosis diagnostic tests depend on the quality of the sputum, leaving many diagnostic uncertainties. Diagnostic delays result in ongoing transmission and more severe, progressive disease in the affected person. This shows that current diagnostic tests are not sufficient to establish all tuberculosis cases accurately, and there is a need for a new diagnostic technique. 99mTc-ethambutol scintigraphy was recently reported as a new diagnostic test for tuberculosis, with a sensitivity and specificity of 93.9% and 85.7%, respectively. Here, we report a case of the importance of this new technique for diagnosing tuberculosis when the existing bacteriological and molecular tests failed to confirm the diagnosis.

Research paper thumbnail of Supplementary_Table – Supplemental material for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis

Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney I... more Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis by Michael Anthonius Lim, Raymond Pranata, Ian Huang, Emir Yonas, Arto Yuwono Soeroto and Rudi Supriyadi in Canadian Journal of Kidney Health and Disease

Research paper thumbnail of Supplementary Data for "Effect of Chronic Obstructive Pulmonary Disease and Smoking on the Outcome of COVID-19 – A Meta-analysis" (International Journal of Tuberculosis and Lung Disease)

<b>Effect of Chronic Obstructive Pulmonary Disease and Smoking on the Outcome of COVID-19 –... more <b>Effect of Chronic Obstructive Pulmonary Disease and Smoking on the Outcome of COVID-19 – A Meta-analysis </b>

Research paper thumbnail of Nursing knowledge, attitude, and practice to influenza vaccination at suburban hospital in West Java, Indonesia

Journal of Preventive Medicine and Hygiene, 2020

Summary Background High epidemiology of influenza in the world and Indonesia causes some groups t... more Summary Background High epidemiology of influenza in the world and Indonesia causes some groups to have high risk for getting infected with influenza, one of which is healthcare workers. The low rates of influenza vaccination among healthcare workers, especially in nurses, raise the need for an educational strategy to prevent influenza. This study aimed to measure the level of knowledge, attitude and practice among nurses in suburban hospital in West Java. Method This was a cross-sectional study with a random sampling method which started on July-August 2018 at Annisa Medical Center General Hospital. Knowledge, attitude, and practice of research subjects were measured using questionnaire containing 37 items. The questionnaire was the result of adaptation of several questionnaires and a validity test has been was conducted. The data obtained was then analyzed descriptively by the proportion of the score of knowledge, attitude, and practice. Results Of 104 respondents, 19% respondents...

Research paper thumbnail of Cutaneous Vasculitis and Generalized Lymphadenopathy Associated with Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Endocarditis: A Rare Case Report

Infectious Diseases and Therapy, 2020

Introduction: Infective endocarditis (IE) has been known as the great imitator due to variable cl... more Introduction: Infective endocarditis (IE) has been known as the great imitator due to variable clinical manifestation, making its diagnosis challenging. A missed diagnosis could lead to inappropriate therapy. We presented a rare case of blood culture-negative infective endocarditis (BCNIE) due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli manifest with cutaneous vasculitis and generalized lymphadenopathy. We highlighted its diagnostic challenge and management. Case Illustration and Discussion: A 36-year-old male with known asymptomatic ruptured sinus of

Research paper thumbnail of Improving Diagnostic of Pulmonary Tuberculosis in HIV Patients by Bronchoscopy: A Cross Sectional Study

Acta medica Indonesiana, 2017

diagnostic of pulmonary TB in HIV patients is a problem due to non specific clinical features, or... more diagnostic of pulmonary TB in HIV patients is a problem due to non specific clinical features, or radiological appearance. HIV patients with CD4≤200 cells/mL infected with M. tuberculosis have less capacity in containing M. tuberculosis, developing granulomas, casseous necrosis, or cavities. This condition is caused by weakend inflammatory which later reduced sputum production and may cause false negative result. This study aimed to assess differences in the positivity level of acid fast bacilli (AFB) and cultures of M. tuberculosis from non-bronchoscopic sputum (spontaneous and induced sputum) compared to bronchoscopic sputum (bronchoalveolar lavage) in HIV positive patients suspected pulmonary tuberculosis with CD4<200 cells/μL. this cross sectional study was conducted in adult HIV patients treated in Hasan Sadikin Hospital with CD4≤200 cells/μL suspected with pulmonary tuberculosis by using paired comparative analytic test. All patients expelled sputum spontaneously or with sp...

Research paper thumbnail of MDR Pathogens Organisms as Risk Factor of Mortality in Secondary Pulmonary Bacterial Infections Among COVID-19 Patients: Observational Studies in Two Referral Hospitals in West Java, Indonesia

International Journal of General Medicine, May 1, 2022

The coronavirus disease (COVID-19) outbreak has created a global health crisis. Secondary pulmona... more The coronavirus disease (COVID-19) outbreak has created a global health crisis. Secondary pulmonary bacterial infection is a COVID-19 complication, increasing morbidity and mortality. This study aimed to determine the pathogens, antibiotic susceptibility patterns, and risk factors for mortality in hospitalized COVID-19 patients. Patients and Methods: This retrospective study used secondary data from patients' electronic medical records at Hasan Sadikin General Hospital and Santo Borromeus Hospital between March 2020 and March 2021. Overall, 2230 hospitalized COVID-19 patients were screened, and 182 of them who were hospitalized ≥48 hours with a procalcitonin level of ≥0.25 ng/mL were enrolled. Culture examination was performed on sputum samples to determine pathogen and antibiotic susceptibilities. Univariate and multivariate analyses were used to determine mortality-related risk factors in hospitalized COVID-19 patients. Results: The prevalence of secondary pulmonary bacterial infections in COVID-19 patients was 8.2%, with 161/182 pathogen growth from sputum samples. Mainly gram-negative bacteria (64.8%) were present, including Acinetobacter baumannii (31.9%), Klebsiella pneumoniae (19.8%), and Pseudomonas aeruginosa (8.8%). High rate of multidrug-resistant (MDR) pathogens was found among isolate (45.9%), ie carbapenem-resistance A.baumannii (CR-Ab) was 84.2%, extended-spectrum β-lactamase (ESBL) among K. pneumoniae was 61.1%. Secondary infection of MDR pathogens was associated with a higher risk of mortality (AOR 5.63, p = 0.001). Other associated factors were age ≥60 years, ventilator use, and female gender. Conclusion: Gram-negative bacteria are the predominant pathogens causing secondary pulmonary bacterial infection in COVID-19 patients, implying nosocomial infection. High resistance to first-line antimicrobial drugs was observed in Gram-negative bacteria and Gram-positive bacteria. High rate of MDR pathogens was found among isolate and was associated with a significant risk of mortality.

Research paper thumbnail of COVID-19: Implementing a New Healthy Lifestyle and Tackle Vaccination Hesitancy

Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan

Coronavirus disease 2019 (COVID-19), which caused by SARS-COV-2, has spread globally. Pre-existi... more Coronavirus disease 2019 (COVID-19), which caused by SARS-COV-2, has spread globally. Pre-existing comorbidities such as diabetes, hypertension, cardiovascular disease, obesity, and malignancy may increase susceptibility to infection and the worsening of COVID-19. An unhealthy lifestyle in people with pre-existing comorbidities can worsen the condition and increase the risk of mortality and morbidity. During the 5M policy implementation, people tend to adopt unhealthy lifestyles, which lead to weight gain, dysregulated immune systems, increased cardiometabolic risk, and death. Therefore, implement a new healthy lifestyle to achieve health, good mental status, and prevent the worsening of pre-existing comorbidities. Given the importance of comorbidities control, we advised people with pre-existing diseases to monitor their condition using easy devices. Simple home aerobic exercise with minimal equipment is recommended to achieve adequate physical exercise. Vaccination also plays an ...

Research paper thumbnail of Factors associated with treatment outcome of MDR/RR-TB patients treated with shorter injectable based regimen in West Java Indonesia

PLOS ONE

Background and aims Multi drug or rifampicin resistant tuberculosis (MDR/RR-TB) is a major burden... more Background and aims Multi drug or rifampicin resistant tuberculosis (MDR/RR-TB) is a major burden to TB prevention and eradication globally. Since 2016, WHO guidelines have included options for treating MDR/RR-TB with a standard regimen of 9 to 11 months duration (the ’shorter regimen’) rather than an individual regimen of at least 20 months. This regimen has been introduced in Indonesia since September 2017. Therefore, we aimed to determine the success rate and factors associated with the treatment outcome of shorter injectable based regimen in West Java province, Indonesia. Methods This was a retrospective cohort study of MDR/RR-TB patients aged over 18 years old who received the shorter injectable based regimen between September 2017 and December 2020. We defined successful outcomes as the combined proportion of patients who were cured or had complete treatment. While, unsuccessful outcomes were defined as the combined proportion of patients who died from any causes, failure, and...

Research paper thumbnail of Association of BMI and Obesity with Composite poor outcome in COVID-19 adult patients: A Systematic Review and Meta-Analysis

AimThis study aimed to evaluate the association between obesity and composite poor outcome in cor... more AimThis study aimed to evaluate the association between obesity and composite poor outcome in coronavirus disease 2019 (COVID-19) patients.MethodsWe conducted a systematic literature search from PubMed and Embase database. We included all original research articles in COVID-19 adult patients and obesity based on classification of Body Mass Index (BMI) and composite poor outcome which consist of mortality, morbidity, admission of Intensive Care Unit (ICU), mechanical ventilation, Acute Respiratory Distress Syndrome (ARDS), and severe COVID-19.ResultsNine studies were included in meta-analysis with 6 studies presented BMI as continuous outcome and 3 studies presented BMI as dichotomous outcome (obese and non-obese). Most studies were conducted in China (55.5%) with remaining studies from French, Germany, and United States (US). COVID-19 patients with composite poor outcome had higher BMI with mean difference 0.55 kg/m2 (95% CI 0.07–1.03, P=0.02). BMI ≥30 (obese) was associated with co...

Research paper thumbnail of Comparative Study of Kanamycin and Capreomycin on Serum Potassium Level of Multidrug Resistance Tuberculosis Patientsat a Hospital in Bandung, Indonesia

International Journal of Pharmacy and Pharmaceutical Sciences, 2015

Objective: Kanamycin and capreomycin are the second lines injectable ant tuberculosis used in the... more Objective: Kanamycin and capreomycin are the second lines injectable ant tuberculosis used in therapy regimen of multidrug resistance tuberculosis (MDR TB) in Indonesia. Both have effects on serum potassium levels and cause hypokalemia. The aim of this study is to compare and evaluate the effects of kanamycin and capreomycin on serum potassium levels of MDR TB patient. Methods: This was a retrospective and concurrent cohort study with intention-to-treat analysis on MDR TB patients during 2014 at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. The patients were divided into two groups, one group received kanamycin regimen. Meanwhile, the other group received capreomycin regimen. Serum potassium level, the incidence of hypokalemia and the classification of its severity were compared monthly for five months of the therapy. Results: In the first two months, capreomycin significantly decreased serum potassium level stronger than kanamycin (2.95 mEq/l vs. 3.82 mEq/l, P<0.001 in ...

Research paper thumbnail of Antioxidant effect of ethanolic extract of Pleurotus Ostreatus on 4-hydroxy-2-nonenal (HNE) and glutathione (GSH) level in lung rats exposed to cigarette smoke

F1000Research

Background: Cigarette smoke can trigger oxidative stress. An alternative to overcome the harmful ... more Background: Cigarette smoke can trigger oxidative stress. An alternative to overcome the harmful effects of cigarette smoke is through antioxidants. White oyster mushrooms (Pleurotus Ostreatus) are a source of exogenous antioxidants because many contain active compounds for potential antioxidants such as phenol and flavonoid compounds. The purpose of this study was to analyze the effect of ethanolic extract of Pleurotus ostreatus on 4-hydroxy-2-nonenal (HNE) and glutathione (GSH), as well as to analyze their correlation in the lung of Wistar male rats exposed to cigarette smoke. Methods: The study was a preclinical experiment conducted on 24 rats divided into four groups. The treatment was carried out for 42 days and antioxidant effects were assessed through levels of HNE and GSH in rat lungs. Groups were divided as follows: I- normal control, II- negative control, III and IV exposed to cigarette smoke for 60 minutes/day. Group III (treatment group) was treated with ethanolic extrac...

Research paper thumbnail of Knowledge, Attitude, and Practice Survey among Nurses in Dr. Hasan Sadikin General Hospital toward Tuberculosis-Human Immunodeficiency Virus Collaboration Program

Althea Medical Journal, 2016

Background : One of the barriers on implementation of Tuberculosis-Human Immunodeficiency Virus (... more Background : One of the barriers on implementation of Tuberculosis-Human Immunodeficiency Virus (TB-HIV) collaboration is lack of health care workers’ knowledge to this program. This study aimed to measure level of knowledge, attitude, and practice among inpatient nurses in Dr. Hasan Sadikin General Hospital toward TB-HIV collaboration program and to measure their correlation. Methods : This was a cross-sectional study with total sampling method which started on May–October 2013 at Internal Medicine Department ward in Dr. Hasan Sadikin General Hospital. Knowledge, attitude, and practice of research subjects were measured using modified questionnaire about TB-HIV collaboration program, based on guidelines from WHO and National Ministry of Health. Results : Of 88 respondents, there were no respondent had high level, 33 respondents (38%) had moderate level, and 55 respondents (63%) had low level of knowledge toward collaboration. For attitude, 53 respondents (60%) had positive attitude...

Research paper thumbnail of Validity of Mycobacterium Tuberculosis Antigens Cocktail (ESAT-6, CFP-10, MPT 64) Serum Test in Diagnosing Adult and Pediatric Tuberculosis

Background: The diagnosis of tuberculosis relies on the isolation of Mycobacterium tuberculosis (... more Background: The diagnosis of tuberculosis relies on the isolation of Mycobacterium tuberculosis (M. tuberculosis) from sputum culture but in pediatric patient it is difficult to take the sputum. For individuals such as children who are unable to produce sputum, invasive procedures may become necessary when noninvasive methods do not permit a diagnosis. The aim of this study was to determine the validity of M. tuberculosis antigens cocktail ESAT-6, CFP-10 and MPT64 (TB Antigens Cocktail) from serum specimens in Adult TB with Ogawa culture as a gold standard, and from serum specimen of pediatric TB patients with TB Scoring system as a gold standard. Subject and method: This is a cross sectional descriptive observational study. This study was held in Dr Hasan Sadikin General Hospital Bandung, Indonesia. Subjects were divided into two groups: adult TB and Pediatric TB. The sputum specimens from the first group were obtained Ziehl-Neelsen (ZN) stain and M. tuberculosis culture (Ogawa). T...

Research paper thumbnail of Efficacy and safety of tixagevimab‐cilgavimab as pre‐exposure prophylaxis for COVID‐19: A systematic review and meta‐analysis

Reviews in Medical Virology, Jan 8, 2023

Research paper thumbnail of Polymorphisms of SLCO1B1 Gene in Sundanese Ethnic Population of Tuberculosis Patients in Indonesia

Acta medica Indonesiana, Oct 1, 2022

Research paper thumbnail of Distribution of Rifampicin-Resistant Tuberculosis Patients based on Presumptive Drug-Resistant Tuberculosis Criteria at Dr. Hasan Sadikin Hospital 2016–2019

Althea Medical Journal

Background: Diagnosis of drug-resistant tuberculosis (DR-TB) begins with identifying presumptive ... more Background: Diagnosis of drug-resistant tuberculosis (DR-TB) begins with identifying presumptive DR-TB patients using Xpert MTB/RIF, as a diagnostic test to detect resistance to rifampicin. The study aimed to identify the distribution of rifampicin-resistant tuberculosis (RR-TB) patients based on presumptive DR-TB criteria at Dr. Hasan Sadikin General Hospital Bandung. Moreover, this study also explored the Xpert MTB/RIF Ct values.Methods: This was a descriptive-retrospective study from 570 medical records of DR-TB patients collected at the Multidrug-resistant tuberculosis (MDR-TB) clinic of Dr. Hasan Sadikin General Hospital from 2016 to 2019. The inclusion criteria were suspected patients with the Xpert MTB/RIF Ct values in the very low-low and medium-high categories. Data were analyzed using frequency distribution. Results: The most common presumptive DR-TB criteria among DR-TB patients were relapse cases (52.3%). Presumptive DR-TB criteria, with a high percentage result of mediu...

Research paper thumbnail of Effectiveness and Safety of Normoxic Allogenic Umbilical Cord Mesenchymal Stem Cells Administered as Adjunctive Treatment in Patients with Severe COVID-19

Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells... more Inflammatory response in COVID-19 contributes greatly to disease severity. Mesenchymal Stem Cells (MSCs) have the potential to alleviate inflammation and reduce mortality and length of stay in COVID-19 patients. We investigated the safety and effectiveness of normoxic-allogenic umbilical cord (NA-UC)-MSCs as an adjunctive treatment in severe COVID-19 patients. A double-blind, multicentric, randomized, placebo-controlled trial involving severe COVID-19 patients was performed from January–June 2021 in three major hospitals across Java, Indonesia. Eligible participants (n = 42) were randomly assigned to two groups (1:1), namely the intervention (n = 21) and control (n = 21) groups. Either NA-UC-MSCs or NaCl placebo were administered daily. The primary outcome was the duration of hospitalization. Meanwhile, the secondary outcomes were radiographical progression (Brixia score), respiratory and oxygenation parameters, and inflammatory markers, in addition to the safety profile of NA-UC-MS...

Research paper thumbnail of Supplementary_Table – Supplemental material for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis

Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney I... more Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis by Michael Anthonius Lim, Raymond Pranata, Ian Huang, Emir Yonas, Arto Yuwono Soeroto and Rudi Supriyadi in Canadian Journal of Kidney Health and Disease

Research paper thumbnail of Risk factors of COVID-19 clinical worsening: A retrospective cohort study in COVID-19 referral hospital in west Java, Indonesia

F1000Research

Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is marked as one of the ... more Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is marked as one of the highly pathogenic viruses, resulting in millions of deaths worldwide. Management of COVID-19 in limited resources requires appropriate decisions. Clinical considerations along with simple laboratory parameters that can predict the worsening are needed to determine which patients should be treated more intensively. Methods: This is a retrospective cohort study based on the Research Electronic Data Capture (REDCap) registry of COVID-19 patients in Hasan Sadikin General Hospital from April to December 2020. Patients were divided into worsening and non-worsening groups within a 14-day follow-up. Factors affecting these conditions were analyzed. Results: A total of 537 patients were included in this study, of which 72 patients suffered deterioration. Multivariate analysis showed the significant factors affecting the worsening of COVID-19 patients were age > 60 years (aOR 4.207, 95% CI 2.1...

Research paper thumbnail of The role of 99mTc-ethambutol scintigraphy to diagnose pulmonary tuberculosis

Journal of infection in developing countries, 2022

Tuberculosis is a significant health problem in many parts of the world. According to the Global ... more Tuberculosis is a significant health problem in many parts of the world. According to the Global Tuberculosis Report 2020, 10 million new tuberculosis cases were reported worldwide in 2019, with only 57% of these cases being bacteriologically confirmed. Current tuberculosis diagnostic tests depend on the quality of the sputum, leaving many diagnostic uncertainties. Diagnostic delays result in ongoing transmission and more severe, progressive disease in the affected person. This shows that current diagnostic tests are not sufficient to establish all tuberculosis cases accurately, and there is a need for a new diagnostic technique. 99mTc-ethambutol scintigraphy was recently reported as a new diagnostic test for tuberculosis, with a sensitivity and specificity of 93.9% and 85.7%, respectively. Here, we report a case of the importance of this new technique for diagnosing tuberculosis when the existing bacteriological and molecular tests failed to confirm the diagnosis.

Research paper thumbnail of Supplementary_Table – Supplemental material for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis

Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney I... more Supplemental material, Supplementary_Table for Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis by Michael Anthonius Lim, Raymond Pranata, Ian Huang, Emir Yonas, Arto Yuwono Soeroto and Rudi Supriyadi in Canadian Journal of Kidney Health and Disease

Research paper thumbnail of Supplementary Data for "Effect of Chronic Obstructive Pulmonary Disease and Smoking on the Outcome of COVID-19 – A Meta-analysis" (International Journal of Tuberculosis and Lung Disease)

<b>Effect of Chronic Obstructive Pulmonary Disease and Smoking on the Outcome of COVID-19 –... more <b>Effect of Chronic Obstructive Pulmonary Disease and Smoking on the Outcome of COVID-19 – A Meta-analysis </b>

Research paper thumbnail of Nursing knowledge, attitude, and practice to influenza vaccination at suburban hospital in West Java, Indonesia

Journal of Preventive Medicine and Hygiene, 2020

Summary Background High epidemiology of influenza in the world and Indonesia causes some groups t... more Summary Background High epidemiology of influenza in the world and Indonesia causes some groups to have high risk for getting infected with influenza, one of which is healthcare workers. The low rates of influenza vaccination among healthcare workers, especially in nurses, raise the need for an educational strategy to prevent influenza. This study aimed to measure the level of knowledge, attitude and practice among nurses in suburban hospital in West Java. Method This was a cross-sectional study with a random sampling method which started on July-August 2018 at Annisa Medical Center General Hospital. Knowledge, attitude, and practice of research subjects were measured using questionnaire containing 37 items. The questionnaire was the result of adaptation of several questionnaires and a validity test has been was conducted. The data obtained was then analyzed descriptively by the proportion of the score of knowledge, attitude, and practice. Results Of 104 respondents, 19% respondents...

Research paper thumbnail of Cutaneous Vasculitis and Generalized Lymphadenopathy Associated with Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Endocarditis: A Rare Case Report

Infectious Diseases and Therapy, 2020

Introduction: Infective endocarditis (IE) has been known as the great imitator due to variable cl... more Introduction: Infective endocarditis (IE) has been known as the great imitator due to variable clinical manifestation, making its diagnosis challenging. A missed diagnosis could lead to inappropriate therapy. We presented a rare case of blood culture-negative infective endocarditis (BCNIE) due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli manifest with cutaneous vasculitis and generalized lymphadenopathy. We highlighted its diagnostic challenge and management. Case Illustration and Discussion: A 36-year-old male with known asymptomatic ruptured sinus of

Research paper thumbnail of Improving Diagnostic of Pulmonary Tuberculosis in HIV Patients by Bronchoscopy: A Cross Sectional Study

Acta medica Indonesiana, 2017

diagnostic of pulmonary TB in HIV patients is a problem due to non specific clinical features, or... more diagnostic of pulmonary TB in HIV patients is a problem due to non specific clinical features, or radiological appearance. HIV patients with CD4≤200 cells/mL infected with M. tuberculosis have less capacity in containing M. tuberculosis, developing granulomas, casseous necrosis, or cavities. This condition is caused by weakend inflammatory which later reduced sputum production and may cause false negative result. This study aimed to assess differences in the positivity level of acid fast bacilli (AFB) and cultures of M. tuberculosis from non-bronchoscopic sputum (spontaneous and induced sputum) compared to bronchoscopic sputum (bronchoalveolar lavage) in HIV positive patients suspected pulmonary tuberculosis with CD4<200 cells/μL. this cross sectional study was conducted in adult HIV patients treated in Hasan Sadikin Hospital with CD4≤200 cells/μL suspected with pulmonary tuberculosis by using paired comparative analytic test. All patients expelled sputum spontaneously or with sp...

Research paper thumbnail of MDR Pathogens Organisms as Risk Factor of Mortality in Secondary Pulmonary Bacterial Infections Among COVID-19 Patients: Observational Studies in Two Referral Hospitals in West Java, Indonesia

International Journal of General Medicine, May 1, 2022

The coronavirus disease (COVID-19) outbreak has created a global health crisis. Secondary pulmona... more The coronavirus disease (COVID-19) outbreak has created a global health crisis. Secondary pulmonary bacterial infection is a COVID-19 complication, increasing morbidity and mortality. This study aimed to determine the pathogens, antibiotic susceptibility patterns, and risk factors for mortality in hospitalized COVID-19 patients. Patients and Methods: This retrospective study used secondary data from patients' electronic medical records at Hasan Sadikin General Hospital and Santo Borromeus Hospital between March 2020 and March 2021. Overall, 2230 hospitalized COVID-19 patients were screened, and 182 of them who were hospitalized ≥48 hours with a procalcitonin level of ≥0.25 ng/mL were enrolled. Culture examination was performed on sputum samples to determine pathogen and antibiotic susceptibilities. Univariate and multivariate analyses were used to determine mortality-related risk factors in hospitalized COVID-19 patients. Results: The prevalence of secondary pulmonary bacterial infections in COVID-19 patients was 8.2%, with 161/182 pathogen growth from sputum samples. Mainly gram-negative bacteria (64.8%) were present, including Acinetobacter baumannii (31.9%), Klebsiella pneumoniae (19.8%), and Pseudomonas aeruginosa (8.8%). High rate of multidrug-resistant (MDR) pathogens was found among isolate (45.9%), ie carbapenem-resistance A.baumannii (CR-Ab) was 84.2%, extended-spectrum β-lactamase (ESBL) among K. pneumoniae was 61.1%. Secondary infection of MDR pathogens was associated with a higher risk of mortality (AOR 5.63, p = 0.001). Other associated factors were age ≥60 years, ventilator use, and female gender. Conclusion: Gram-negative bacteria are the predominant pathogens causing secondary pulmonary bacterial infection in COVID-19 patients, implying nosocomial infection. High resistance to first-line antimicrobial drugs was observed in Gram-negative bacteria and Gram-positive bacteria. High rate of MDR pathogens was found among isolate and was associated with a significant risk of mortality.

Research paper thumbnail of COVID-19: Implementing a New Healthy Lifestyle and Tackle Vaccination Hesitancy

Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan

Coronavirus disease 2019 (COVID-19), which caused by SARS-COV-2, has spread globally. Pre-existi... more Coronavirus disease 2019 (COVID-19), which caused by SARS-COV-2, has spread globally. Pre-existing comorbidities such as diabetes, hypertension, cardiovascular disease, obesity, and malignancy may increase susceptibility to infection and the worsening of COVID-19. An unhealthy lifestyle in people with pre-existing comorbidities can worsen the condition and increase the risk of mortality and morbidity. During the 5M policy implementation, people tend to adopt unhealthy lifestyles, which lead to weight gain, dysregulated immune systems, increased cardiometabolic risk, and death. Therefore, implement a new healthy lifestyle to achieve health, good mental status, and prevent the worsening of pre-existing comorbidities. Given the importance of comorbidities control, we advised people with pre-existing diseases to monitor their condition using easy devices. Simple home aerobic exercise with minimal equipment is recommended to achieve adequate physical exercise. Vaccination also plays an ...

Research paper thumbnail of Factors associated with treatment outcome of MDR/RR-TB patients treated with shorter injectable based regimen in West Java Indonesia

PLOS ONE

Background and aims Multi drug or rifampicin resistant tuberculosis (MDR/RR-TB) is a major burden... more Background and aims Multi drug or rifampicin resistant tuberculosis (MDR/RR-TB) is a major burden to TB prevention and eradication globally. Since 2016, WHO guidelines have included options for treating MDR/RR-TB with a standard regimen of 9 to 11 months duration (the ’shorter regimen’) rather than an individual regimen of at least 20 months. This regimen has been introduced in Indonesia since September 2017. Therefore, we aimed to determine the success rate and factors associated with the treatment outcome of shorter injectable based regimen in West Java province, Indonesia. Methods This was a retrospective cohort study of MDR/RR-TB patients aged over 18 years old who received the shorter injectable based regimen between September 2017 and December 2020. We defined successful outcomes as the combined proportion of patients who were cured or had complete treatment. While, unsuccessful outcomes were defined as the combined proportion of patients who died from any causes, failure, and...

Research paper thumbnail of Association of BMI and Obesity with Composite poor outcome in COVID-19 adult patients: A Systematic Review and Meta-Analysis

AimThis study aimed to evaluate the association between obesity and composite poor outcome in cor... more AimThis study aimed to evaluate the association between obesity and composite poor outcome in coronavirus disease 2019 (COVID-19) patients.MethodsWe conducted a systematic literature search from PubMed and Embase database. We included all original research articles in COVID-19 adult patients and obesity based on classification of Body Mass Index (BMI) and composite poor outcome which consist of mortality, morbidity, admission of Intensive Care Unit (ICU), mechanical ventilation, Acute Respiratory Distress Syndrome (ARDS), and severe COVID-19.ResultsNine studies were included in meta-analysis with 6 studies presented BMI as continuous outcome and 3 studies presented BMI as dichotomous outcome (obese and non-obese). Most studies were conducted in China (55.5%) with remaining studies from French, Germany, and United States (US). COVID-19 patients with composite poor outcome had higher BMI with mean difference 0.55 kg/m2 (95% CI 0.07–1.03, P=0.02). BMI ≥30 (obese) was associated with co...

Research paper thumbnail of Comparative Study of Kanamycin and Capreomycin on Serum Potassium Level of Multidrug Resistance Tuberculosis Patientsat a Hospital in Bandung, Indonesia

International Journal of Pharmacy and Pharmaceutical Sciences, 2015

Objective: Kanamycin and capreomycin are the second lines injectable ant tuberculosis used in the... more Objective: Kanamycin and capreomycin are the second lines injectable ant tuberculosis used in therapy regimen of multidrug resistance tuberculosis (MDR TB) in Indonesia. Both have effects on serum potassium levels and cause hypokalemia. The aim of this study is to compare and evaluate the effects of kanamycin and capreomycin on serum potassium levels of MDR TB patient. Methods: This was a retrospective and concurrent cohort study with intention-to-treat analysis on MDR TB patients during 2014 at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. The patients were divided into two groups, one group received kanamycin regimen. Meanwhile, the other group received capreomycin regimen. Serum potassium level, the incidence of hypokalemia and the classification of its severity were compared monthly for five months of the therapy. Results: In the first two months, capreomycin significantly decreased serum potassium level stronger than kanamycin (2.95 mEq/l vs. 3.82 mEq/l, P<0.001 in ...

Research paper thumbnail of Antioxidant effect of ethanolic extract of Pleurotus Ostreatus on 4-hydroxy-2-nonenal (HNE) and glutathione (GSH) level in lung rats exposed to cigarette smoke

F1000Research

Background: Cigarette smoke can trigger oxidative stress. An alternative to overcome the harmful ... more Background: Cigarette smoke can trigger oxidative stress. An alternative to overcome the harmful effects of cigarette smoke is through antioxidants. White oyster mushrooms (Pleurotus Ostreatus) are a source of exogenous antioxidants because many contain active compounds for potential antioxidants such as phenol and flavonoid compounds. The purpose of this study was to analyze the effect of ethanolic extract of Pleurotus ostreatus on 4-hydroxy-2-nonenal (HNE) and glutathione (GSH), as well as to analyze their correlation in the lung of Wistar male rats exposed to cigarette smoke. Methods: The study was a preclinical experiment conducted on 24 rats divided into four groups. The treatment was carried out for 42 days and antioxidant effects were assessed through levels of HNE and GSH in rat lungs. Groups were divided as follows: I- normal control, II- negative control, III and IV exposed to cigarette smoke for 60 minutes/day. Group III (treatment group) was treated with ethanolic extrac...

Research paper thumbnail of Knowledge, Attitude, and Practice Survey among Nurses in Dr. Hasan Sadikin General Hospital toward Tuberculosis-Human Immunodeficiency Virus Collaboration Program

Althea Medical Journal, 2016

Background : One of the barriers on implementation of Tuberculosis-Human Immunodeficiency Virus (... more Background : One of the barriers on implementation of Tuberculosis-Human Immunodeficiency Virus (TB-HIV) collaboration is lack of health care workers’ knowledge to this program. This study aimed to measure level of knowledge, attitude, and practice among inpatient nurses in Dr. Hasan Sadikin General Hospital toward TB-HIV collaboration program and to measure their correlation. Methods : This was a cross-sectional study with total sampling method which started on May–October 2013 at Internal Medicine Department ward in Dr. Hasan Sadikin General Hospital. Knowledge, attitude, and practice of research subjects were measured using modified questionnaire about TB-HIV collaboration program, based on guidelines from WHO and National Ministry of Health. Results : Of 88 respondents, there were no respondent had high level, 33 respondents (38%) had moderate level, and 55 respondents (63%) had low level of knowledge toward collaboration. For attitude, 53 respondents (60%) had positive attitude...

Research paper thumbnail of Validity of Mycobacterium Tuberculosis Antigens Cocktail (ESAT-6, CFP-10, MPT 64) Serum Test in Diagnosing Adult and Pediatric Tuberculosis

Background: The diagnosis of tuberculosis relies on the isolation of Mycobacterium tuberculosis (... more Background: The diagnosis of tuberculosis relies on the isolation of Mycobacterium tuberculosis (M. tuberculosis) from sputum culture but in pediatric patient it is difficult to take the sputum. For individuals such as children who are unable to produce sputum, invasive procedures may become necessary when noninvasive methods do not permit a diagnosis. The aim of this study was to determine the validity of M. tuberculosis antigens cocktail ESAT-6, CFP-10 and MPT64 (TB Antigens Cocktail) from serum specimens in Adult TB with Ogawa culture as a gold standard, and from serum specimen of pediatric TB patients with TB Scoring system as a gold standard. Subject and method: This is a cross sectional descriptive observational study. This study was held in Dr Hasan Sadikin General Hospital Bandung, Indonesia. Subjects were divided into two groups: adult TB and Pediatric TB. The sputum specimens from the first group were obtained Ziehl-Neelsen (ZN) stain and M. tuberculosis culture (Ogawa). T...