Asha Baxi - Academia.edu (original) (raw)

Papers by Asha Baxi

Background: The purpose of the study was to evaluate menstrual and reproductive outcome in patien... more Background: The purpose of the study was to evaluate menstrual and reproductive outcome in patients diagnosed with Asherman’s syndrome on hysteroscopy and to assess the role of hysteroscopic adhesiolysis. Methods: A prospective study was performed for patients having intrauterine adhe-sion at a tertiary care teaching hospital, Indore, India for a period of 2 years. Find-ings at hysteroscopy, details of adhesiolysis, changes in menstrual pattern following adhesiolysis, need for repeat procedure and fertility outcome were prospectively col-lected. Data was analysed using SPSS software. A p-value of <0.05 was considered significant. Results: A total of 60 patients with a mean age of 30.1±5.5 years with Asherman’s syndrome were included. In 53.3 % of them, no factors like post-partum curettage, uterine surgery or history of tuberculosis could be found in which the present intrau-terine adhesions could be attributed to. Hypomenorrhoea was the most common (53.3%) menstrual pattern in p...

The Journal of Obstetrics and Gynecology of India, 2021

The physical characteristics which are known to affect the ovarian reserve are age, body mass ind... more The physical characteristics which are known to affect the ovarian reserve are age, body mass index (BMI), occupational exposures, age at menarche and menstrual cycle length. A correlation between different physical characteristics and the ovarian reserve will help to identify areas which need to be tackled to increase the chances of fertility of women in India. In this retrospective, observational study, namely the MOTHER Study, data of women between 18 and 45 years of age, attending the selected fertility centers across different states in India were taken for evaluation. Demographic information along with information on factors potentially related to fertility like age of menarche, menstrual cycle length and occupational factors were collected by review of medical records at screening visit. Most recent AMH assay and antral follicle count (AFC) where the subject has not taken any contraceptives 12 months prior to the test were collected. Age of woman, years of marriage, years of infertility and smoking have shown effect on ovarian reserve testing like AMH and AFC. The other physical characteristics which were evaluated and considered to affect the ovarian reserve like body mass index BMI, occupational exposures, age at menarche and menstrual cycle length have not shown statistically significant correlation. Age of woman and years of infertility are inversely proportional to ovarian reserve markers, namely AMH and AFC. Addictions like smoking and alcohol affect ovarian reserve.

Decoding Polycystic Ovarian Syndrome (PCOS), 2018

Journal of SAFOG, 2016

Objectives To study the prevalence of male and female genital tuberculosis in Indian infertile co... more Objectives To study the prevalence of male and female genital tuberculosis in Indian infertile couples as detected by semen polymerase chain reaction (PCR) and endometrial PCR and to study the correlation of semen TB PCR with endometrial TB PCR of sexual partner. Design Noncomparative retrospective observational series. Patients A total of 100 couples presenting with infertility at clinic were enrolled after obtaining informed consent. Interventions All couples were tested for mycobacterium tuberculosis (MTB) by nested PCR on the semen and the endometrial sample. The results of PCR of sexual partners were mutually correlated. Results Out of 108 couples, 56 males and 52 females had positive PCR in the sample of semen and the endometrium. Also, 30 couples simultaneously had both semen PCR and endometrial PCR positive. Conclusion Addition of PCR tests to the routine clinical and laboratory assessments may add to the detection of subclinical urogenital infection and the timely evaluatio...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2015

Heavy menstrual bleeding or menorrhagia is a common menstrual disorder. Currently, both medical a... more Heavy menstrual bleeding or menorrhagia is a common menstrual disorder. Currently, both medical and surgical treatment options are available for the management of heavy menstrual bleeding. Hysterectomy, one of the surgical treatment options is associated with risks and is a costly procedure. Medical treatment may be preferred for the management of heavy menstrual bleeding. Oral medical treatments have various limitations for their use. For instance, cost is a limiting factor for tranexamic acid. Limited data is available to support the effectiveness of oral contraceptives. Poor patient compliance and intolerable adverse events are some other limitations especially in long term use. Levonorgestrel intrauterine system (LNG-IUS) is one of the common medical modalities in the management of heavy menstrual bleeding. LNG-IUS has been compared with other medical options like tranexamic acid, mefenamic acid, combined estrogen-progestogen, or progesterone alone, cyclic oral medroxyprogesterone acetate (MPA) oral norethisterone and low-dose combined oral contraceptive. LNG-IUS is more effective than usual medical treatment and also reduces the effect of heavy menstrual bleeding on quality of life. Similarly, it has shown similar therapeutic effects compared to endometrial ablation. Based on its efficacy, convenience and cost of therapy, it can be considered as the first line medical therapy for the management of heavy menstrual bleeding.

The Internet Journal of Gynecology and Obstetrics, 2007

Objective: This study was undertaken to determine in a cross-sectional survey whether rubella vir... more Objective: This study was undertaken to determine in a cross-sectional survey whether rubella virus circulation in the Indian population induces detectable immunoglobulin G (IgG) antibodies with a protective level, in a random group of pregnant & nonpregnant women. Methods: Rubella-IgG antibody status was assessed in 1182 Indian women comprising of 617 pregnant women, 497 nonpregnant women of childbearing age group and 68 women who suffered from miscarriage. Results: Rubella IgG was detected in 91.73% of pregnant women, 88.93% of non-pregnant women of childbearing age and 92.65% of women who had miscarriage. Rubella IgG antibody titers amongst the Indian women studied ranged between 15-272 IU/ml. Conclusion: Majority of the Indian women appeared to possess protective level of Rubella IgG antibodies. However there is a significant group that does not posses the immunity. Screening to pick up such women is necessary so that rubella vaccine can be offered to such women for the protection of offspring's born in subsequent pregnancy.

Journal of Gynecologic Surgery, 2010

... The adductor magnus and brevis, which share lumbar innervation with quadriceps and iliopsoas,... more ... The adductor magnus and brevis, which share lumbar innervation with quadriceps and iliopsoas, are spared since they are innervated primarily ... Control of Uterine Cavity Following Manual Removal of Placenta or Early Postpartum Curettage. Selcuk Ayas, Erdal Eskicirak, Bahar ...

Manual of Endometriosis, 2013

International Journal of Infertility and Fetal Medicine, 2010

A 25 years old woman with Down syndrome (DS) presented at 9 weeks gestational age. She belonged t... more A 25 years old woman with Down syndrome (DS) presented at 9 weeks gestational age. She belonged to a very supportive family. She was married to a person with normal karyotype and conceived within 3 months of marriage. Her antenatal period was uneventful, except for mild IUGR and oligohydroamnios 32 weeks onwards. At 38 weeks, she underwent induction of labor. She tolerated labor pains well but because of failure to progress, cesarean section was performed. She delivered a 2 kg male baby, who was phenotypically and genotypically normal. Screening for trisomy 21 should be offered to all women as part of routine antenatal care. This offer should include detailed counseling about the implications and limitations of the test used in the screening program. The available second trimester screening tests are the double, triple and quadruple tests. Children with Down syndrome may benefit from speech therapy, physical therapy and occupational therapy. They may receive special education and as...

The Journal of Obstetrics and Gynecology of India, 2011

has profound implications for the asymptomatic women seeking fertility because the multidrug ther... more has profound implications for the asymptomatic women seeking fertility because the multidrug therapy required for ≥6 months is not very promising in terms of pregnancy outcome and TB is associated with social stigma as well in the country. Moreover, this silent invader of genital tract tends to create diagnostic dilemmas because of varied clinical presentations, diverse results on imaging and laparoscopy, and limitations of histopathologic, serologic, bacteriologic, and culture methods. This is so because although the histopathologic evidence of mycobacterial infection is highly indicative of genital TB, its absence fails to exclude the infection and suggestive lesions may be seen in fungal

Journal of Human Reproductive Sciences, 2010

Fertility and Sterility, 2007

Fertility and Sterility, 2008

Journal of reproduction & infertility

The purpose of the study was to evaluate menstrual and reproductive outcome in patients diagnosed... more The purpose of the study was to evaluate menstrual and reproductive outcome in patients diagnosed with Asherman's syndrome on hysteroscopy and to assess the role of hysteroscopic adhesiolysis. A prospective study was performed for patients having intrauterine adhesion at a tertiary care teaching hospital, Indore, India for a period of 2 years. Findings at hysteroscopy, details of adhesiolysis, changes in menstrual pattern following adhesiolysis, need for repeat procedure and fertility outcome were prospectively collected. Data was analysed using SPSS software. A p-value of <0.05 was considered significant. A total of 60 patients with a mean age of 30.1±5.5 years with Asherman's syndrome were included. In 53.3% of them, no factors like post-partum curettage, uterine surgery or history of tuberculosis could be found in which the present intrauterine adhesions could be attributed to. Hypomenorrhoea was the most common (53.3%) menstrual pattern in patients diagnosed with Ashe...

Journal of human …, 2010

Expectant management for tubal heterotopic pregnancy could be considered as a successful option i... more Expectant management for tubal heterotopic pregnancy could be considered as a successful option in a symptom-free patient where the ectopic embryo has a limited craniocaudal length with no cardiac activity. We report the obstetric outcome after expectant management for a right tubal heterotopic pregnancy. Heterotopic pregnancy was first recognized at 6 weeks gestation in a 32-year-old salpingectomized woman with an 8-year history of subfertility who conceived after in utero transfer of three embryos obtained by in vitro fertilization. Expectant management and close ultrasonographic and clinical monitoring were done. The intrauterine pregnancy proceeded unremarkably. A cesarean section was performed for breech presentation, and it allowed the delivery of a healthy 2260-g male infant. The examination of the adnexa showed a pre-rupture of the right fallopian tube.

Indian Journal of Hematology and Blood Transfusion

To study the prevalence of β thalassemia trait in pregnancy in urban population screening for β t... more To study the prevalence of β thalassemia trait in pregnancy in urban population screening for β thalassemia in pregnant women at a single center in Indore (MP) has been conducted for a period of 2 year. Blood samples were tested for complete blood count and hemoglobin electrophoresis. During the 2 year period a total of 1,006 women were screened; 28 women who carried abnormal pattern were detected. The mean gestational age for screening was 13 ± 4 weeks. The prevalence of carriers was 2.78 %. As much as 99 % of pregnant women undergoing screening were willing for prenatal diagnosis if required. The economic burden to the society for treating thalassemic patients is huge. The institution of prevention programs like carrier screening has proven costeffective in populations with a high frequency of carriers. Screening of pregnant women early in pregnancy followed by prenatal diagnosis is acceptable and effective strategy for control of thalassemia in developing countries like India.

The Art and Science of Assisted Reproductive Technique (ART), 2003

Journal of Human Reproductive Sciences, 2010

Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease, although rare in young patie... more Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease, although rare in young patients, may be encountered in the reproductive age group. We report a rare combination of this disease with infertility, which has not been previously reported. The case record of a 29-year-old woman with infertility and Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease are retrospectively reviewed. An IVF indicated for tubal factor infertility resulted in a successful singleton pregnancy. She delivered a healthy male baby without experiencing any worsening of her Parkinsonism. The course of pregnancy remained unaffected by the Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease and anti-Parkinsonian drugs. The details of the infertility management, antenatal and postnatal course, and medications are described. With careful evaluation, counseling, and monitoring, IVF may be safely used in women with Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease.

Background: The purpose of the study was to evaluate menstrual and reproductive outcome in patien... more Background: The purpose of the study was to evaluate menstrual and reproductive outcome in patients diagnosed with Asherman’s syndrome on hysteroscopy and to assess the role of hysteroscopic adhesiolysis. Methods: A prospective study was performed for patients having intrauterine adhe-sion at a tertiary care teaching hospital, Indore, India for a period of 2 years. Find-ings at hysteroscopy, details of adhesiolysis, changes in menstrual pattern following adhesiolysis, need for repeat procedure and fertility outcome were prospectively col-lected. Data was analysed using SPSS software. A p-value of <0.05 was considered significant. Results: A total of 60 patients with a mean age of 30.1±5.5 years with Asherman’s syndrome were included. In 53.3 % of them, no factors like post-partum curettage, uterine surgery or history of tuberculosis could be found in which the present intrau-terine adhesions could be attributed to. Hypomenorrhoea was the most common (53.3%) menstrual pattern in p...

The Journal of Obstetrics and Gynecology of India, 2021

The physical characteristics which are known to affect the ovarian reserve are age, body mass ind... more The physical characteristics which are known to affect the ovarian reserve are age, body mass index (BMI), occupational exposures, age at menarche and menstrual cycle length. A correlation between different physical characteristics and the ovarian reserve will help to identify areas which need to be tackled to increase the chances of fertility of women in India. In this retrospective, observational study, namely the MOTHER Study, data of women between 18 and 45 years of age, attending the selected fertility centers across different states in India were taken for evaluation. Demographic information along with information on factors potentially related to fertility like age of menarche, menstrual cycle length and occupational factors were collected by review of medical records at screening visit. Most recent AMH assay and antral follicle count (AFC) where the subject has not taken any contraceptives 12 months prior to the test were collected. Age of woman, years of marriage, years of infertility and smoking have shown effect on ovarian reserve testing like AMH and AFC. The other physical characteristics which were evaluated and considered to affect the ovarian reserve like body mass index BMI, occupational exposures, age at menarche and menstrual cycle length have not shown statistically significant correlation. Age of woman and years of infertility are inversely proportional to ovarian reserve markers, namely AMH and AFC. Addictions like smoking and alcohol affect ovarian reserve.

Decoding Polycystic Ovarian Syndrome (PCOS), 2018

Journal of SAFOG, 2016

Objectives To study the prevalence of male and female genital tuberculosis in Indian infertile co... more Objectives To study the prevalence of male and female genital tuberculosis in Indian infertile couples as detected by semen polymerase chain reaction (PCR) and endometrial PCR and to study the correlation of semen TB PCR with endometrial TB PCR of sexual partner. Design Noncomparative retrospective observational series. Patients A total of 100 couples presenting with infertility at clinic were enrolled after obtaining informed consent. Interventions All couples were tested for mycobacterium tuberculosis (MTB) by nested PCR on the semen and the endometrial sample. The results of PCR of sexual partners were mutually correlated. Results Out of 108 couples, 56 males and 52 females had positive PCR in the sample of semen and the endometrium. Also, 30 couples simultaneously had both semen PCR and endometrial PCR positive. Conclusion Addition of PCR tests to the routine clinical and laboratory assessments may add to the detection of subclinical urogenital infection and the timely evaluatio...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2015

Heavy menstrual bleeding or menorrhagia is a common menstrual disorder. Currently, both medical a... more Heavy menstrual bleeding or menorrhagia is a common menstrual disorder. Currently, both medical and surgical treatment options are available for the management of heavy menstrual bleeding. Hysterectomy, one of the surgical treatment options is associated with risks and is a costly procedure. Medical treatment may be preferred for the management of heavy menstrual bleeding. Oral medical treatments have various limitations for their use. For instance, cost is a limiting factor for tranexamic acid. Limited data is available to support the effectiveness of oral contraceptives. Poor patient compliance and intolerable adverse events are some other limitations especially in long term use. Levonorgestrel intrauterine system (LNG-IUS) is one of the common medical modalities in the management of heavy menstrual bleeding. LNG-IUS has been compared with other medical options like tranexamic acid, mefenamic acid, combined estrogen-progestogen, or progesterone alone, cyclic oral medroxyprogesterone acetate (MPA) oral norethisterone and low-dose combined oral contraceptive. LNG-IUS is more effective than usual medical treatment and also reduces the effect of heavy menstrual bleeding on quality of life. Similarly, it has shown similar therapeutic effects compared to endometrial ablation. Based on its efficacy, convenience and cost of therapy, it can be considered as the first line medical therapy for the management of heavy menstrual bleeding.

The Internet Journal of Gynecology and Obstetrics, 2007

Objective: This study was undertaken to determine in a cross-sectional survey whether rubella vir... more Objective: This study was undertaken to determine in a cross-sectional survey whether rubella virus circulation in the Indian population induces detectable immunoglobulin G (IgG) antibodies with a protective level, in a random group of pregnant & nonpregnant women. Methods: Rubella-IgG antibody status was assessed in 1182 Indian women comprising of 617 pregnant women, 497 nonpregnant women of childbearing age group and 68 women who suffered from miscarriage. Results: Rubella IgG was detected in 91.73% of pregnant women, 88.93% of non-pregnant women of childbearing age and 92.65% of women who had miscarriage. Rubella IgG antibody titers amongst the Indian women studied ranged between 15-272 IU/ml. Conclusion: Majority of the Indian women appeared to possess protective level of Rubella IgG antibodies. However there is a significant group that does not posses the immunity. Screening to pick up such women is necessary so that rubella vaccine can be offered to such women for the protection of offspring's born in subsequent pregnancy.

Journal of Gynecologic Surgery, 2010

... The adductor magnus and brevis, which share lumbar innervation with quadriceps and iliopsoas,... more ... The adductor magnus and brevis, which share lumbar innervation with quadriceps and iliopsoas, are spared since they are innervated primarily ... Control of Uterine Cavity Following Manual Removal of Placenta or Early Postpartum Curettage. Selcuk Ayas, Erdal Eskicirak, Bahar ...

Manual of Endometriosis, 2013

International Journal of Infertility and Fetal Medicine, 2010

A 25 years old woman with Down syndrome (DS) presented at 9 weeks gestational age. She belonged t... more A 25 years old woman with Down syndrome (DS) presented at 9 weeks gestational age. She belonged to a very supportive family. She was married to a person with normal karyotype and conceived within 3 months of marriage. Her antenatal period was uneventful, except for mild IUGR and oligohydroamnios 32 weeks onwards. At 38 weeks, she underwent induction of labor. She tolerated labor pains well but because of failure to progress, cesarean section was performed. She delivered a 2 kg male baby, who was phenotypically and genotypically normal. Screening for trisomy 21 should be offered to all women as part of routine antenatal care. This offer should include detailed counseling about the implications and limitations of the test used in the screening program. The available second trimester screening tests are the double, triple and quadruple tests. Children with Down syndrome may benefit from speech therapy, physical therapy and occupational therapy. They may receive special education and as...

The Journal of Obstetrics and Gynecology of India, 2011

has profound implications for the asymptomatic women seeking fertility because the multidrug ther... more has profound implications for the asymptomatic women seeking fertility because the multidrug therapy required for ≥6 months is not very promising in terms of pregnancy outcome and TB is associated with social stigma as well in the country. Moreover, this silent invader of genital tract tends to create diagnostic dilemmas because of varied clinical presentations, diverse results on imaging and laparoscopy, and limitations of histopathologic, serologic, bacteriologic, and culture methods. This is so because although the histopathologic evidence of mycobacterial infection is highly indicative of genital TB, its absence fails to exclude the infection and suggestive lesions may be seen in fungal

Journal of Human Reproductive Sciences, 2010

Fertility and Sterility, 2007

Fertility and Sterility, 2008

Journal of reproduction & infertility

The purpose of the study was to evaluate menstrual and reproductive outcome in patients diagnosed... more The purpose of the study was to evaluate menstrual and reproductive outcome in patients diagnosed with Asherman's syndrome on hysteroscopy and to assess the role of hysteroscopic adhesiolysis. A prospective study was performed for patients having intrauterine adhesion at a tertiary care teaching hospital, Indore, India for a period of 2 years. Findings at hysteroscopy, details of adhesiolysis, changes in menstrual pattern following adhesiolysis, need for repeat procedure and fertility outcome were prospectively collected. Data was analysed using SPSS software. A p-value of <0.05 was considered significant. A total of 60 patients with a mean age of 30.1±5.5 years with Asherman's syndrome were included. In 53.3% of them, no factors like post-partum curettage, uterine surgery or history of tuberculosis could be found in which the present intrauterine adhesions could be attributed to. Hypomenorrhoea was the most common (53.3%) menstrual pattern in patients diagnosed with Ashe...

Journal of human …, 2010

Expectant management for tubal heterotopic pregnancy could be considered as a successful option i... more Expectant management for tubal heterotopic pregnancy could be considered as a successful option in a symptom-free patient where the ectopic embryo has a limited craniocaudal length with no cardiac activity. We report the obstetric outcome after expectant management for a right tubal heterotopic pregnancy. Heterotopic pregnancy was first recognized at 6 weeks gestation in a 32-year-old salpingectomized woman with an 8-year history of subfertility who conceived after in utero transfer of three embryos obtained by in vitro fertilization. Expectant management and close ultrasonographic and clinical monitoring were done. The intrauterine pregnancy proceeded unremarkably. A cesarean section was performed for breech presentation, and it allowed the delivery of a healthy 2260-g male infant. The examination of the adnexa showed a pre-rupture of the right fallopian tube.

Indian Journal of Hematology and Blood Transfusion

To study the prevalence of β thalassemia trait in pregnancy in urban population screening for β t... more To study the prevalence of β thalassemia trait in pregnancy in urban population screening for β thalassemia in pregnant women at a single center in Indore (MP) has been conducted for a period of 2 year. Blood samples were tested for complete blood count and hemoglobin electrophoresis. During the 2 year period a total of 1,006 women were screened; 28 women who carried abnormal pattern were detected. The mean gestational age for screening was 13 ± 4 weeks. The prevalence of carriers was 2.78 %. As much as 99 % of pregnant women undergoing screening were willing for prenatal diagnosis if required. The economic burden to the society for treating thalassemic patients is huge. The institution of prevention programs like carrier screening has proven costeffective in populations with a high frequency of carriers. Screening of pregnant women early in pregnancy followed by prenatal diagnosis is acceptable and effective strategy for control of thalassemia in developing countries like India.

The Art and Science of Assisted Reproductive Technique (ART), 2003

Journal of Human Reproductive Sciences, 2010

Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease, although rare in young patie... more Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease, although rare in young patients, may be encountered in the reproductive age group. We report a rare combination of this disease with infertility, which has not been previously reported. The case record of a 29-year-old woman with infertility and Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease are retrospectively reviewed. An IVF indicated for tubal factor infertility resulted in a successful singleton pregnancy. She delivered a healthy male baby without experiencing any worsening of her Parkinsonism. The course of pregnancy remained unaffected by the Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease and anti-Parkinsonian drugs. The details of the infertility management, antenatal and postnatal course, and medications are described. With careful evaluation, counseling, and monitoring, IVF may be safely used in women with Parkinson&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease.