Ashish Kumar - Academia.edu (original) (raw)
Papers by Ashish Kumar
Spectra of Sierpinski graph defined as eigenvalues of graph at different stage of iteration. In t... more Spectra of Sierpinski graph defined as eigenvalues of graph at different stage of iteration. In this is paper it aimed to found that the choice of matrix representation has a large impact, on the suitability of spectrum in a number of pattern recognition tasks, i.e. various stages of iteration. Introduction:
OF DISSERTATION Dust Control Examination using Computational Fluid Dynamics Modeling and Laborato... more OF DISSERTATION Dust Control Examination using Computational Fluid Dynamics Modeling and Laboratory Testing of Vortecone and Impingement Screen Filters Heavy industries, such as mining, generate dust in quantities that present an occupational health hazard. Prolonged exposure to the respirable dust has been found to result in many irreversible occupational ailments in thousands of miners. In underground mining applications, a variety of scrubbing systems are used to remove dust near the zones of generation. However, the wire-mesh type fibrous screens in the flooded-bed dust scrubbers used on continuous miners, are prone to clogging due to the accumulation of dust particles. This clogging results in a reduced capture efficiency and a higher exposure to the personnel. This research establishes the Vortecone, an inertial wet scrubber system, as a suitable alternative to the existing filters. The Vortecone accelerates its inlet fluids into a rapid circulatory motion into a vortex chambe...
Decision Science Letters, 2015
The main aim of the present paper is to analyze the stochastic behavior of a cold standby system ... more The main aim of the present paper is to analyze the stochastic behavior of a cold standby system with concept of preventive maintenance, priority and maximum repair time. For this purpose, a stochastic model is developed in which initially one unit is operative and other is kept as cold standby. There is a single server who visits the system immediately as and when required. The server takes the unit under preventive maintenance after a maximum operation time at normal mode if one standby unit is available for operation. If the repair of the failed unit is not possible up to a maximum repair time, failed unit is replaced by new one. The failure time, maximum operation time and maximum repair time distributions of the unit are considered as exponentially distributed while repair and maintenance time distributions are considered as arbitrary. All random variables are statistically independent and repairs are perfect. Various measures of system effectiveness are obtained by using the technique of semi-Markov process and RPT. To highlight the importance of the study numerical results are also obtained for MTSF, availability and profit function.
International Journal of Computer Applications, 2014
Oral health and dental management, 2012
Complete access to the existing pool of biomedical literature and the ability to "hit" ... more Complete access to the existing pool of biomedical literature and the ability to "hit" upon the exact information of the relevant specialty are becoming essential elements of academic and clinical expertise. With the rapid expansion of the literature database, it is almost impossible to keep up to date with every innovation. Using the Internet, however, most people can freely access this literature at any time, from almost anywhere. This paper highlights the use of the Internet in obtaining valuable biomedical research information, which is mostly available from journals, databases, textbooks and e-journals in the form of web pages, text materials, images, and so on. The authors present an overview of web-based resources for biomedical researchers, providing information about Internet search engines (e.g., Google), web-based bibliographic databases (e.g., PubMed, IndMed) and how to use them, and other online biomedical resources that can assist clinicians in reaching well-...
2011 IEEE International Vacuum Electronics Conference (IVEC), 2011
Abstract In this paper, the design concept of a 460 GHz, 3050 W, CW, second harmonic gyrotron fo... more Abstract In this paper, the design concept of a 460 GHz, 3050 W, CW, second harmonic gyrotron for medical spectroscopy will be presented. Mode selection has been done keeping in view the second harmonic operation, first harmonic competitors, and a probable radial ...
2011 International Conference on Infrared, Millimeter, and Terahertz Waves, 2011
Abstract This paper presents the design studies of the output coupling system of a 460 GHz, 50–10... more Abstract This paper presents the design studies of the output coupling system of a 460 GHz, 50–100 W, CW, second harmonic gyrotron for medical spectroscopy. During this course, the design studies of an advanced dimpled-wall quasi optical launcher (QOL), non-linear ...
2011 International Conference on Infrared, Millimeter, and Terahertz Waves, 2011
Abstract This paper presents the design of a triode-type Magnetron Injection Gun (MIG) for a 460 ... more Abstract This paper presents the design of a triode-type Magnetron Injection Gun (MIG) for a 460 GHz, 50–100 W gyrotron for Medical Spectroscopy operating at 25 KV and 0.1 A. The design is facilitated by determining the initial design following analytical expressions of ...
European Journal of General Dentistry, 2012
ABSTRACT
Parkinsonism & Related Disorders, 2009
Nano Letters, 2006
DNA nanotubes are crystalline self-assemblies of DNA tiles ∼10 nm in diameter that readily grow t... more DNA nanotubes are crystalline self-assemblies of DNA tiles ∼10 nm in diameter that readily grow tens of micrometers in length. Easy assembly, programmability, and stiffness make them interesting for many applications, but DNA nanotubes begin to melt at temperatures below 40°C, break open when deposited on mica or scanned by AFM, and disintegrate in deionized water. These weaknesses can be traced to the presence of discontinuities in the phosphate backbone, called nicks. The nanotubes studied here have five nicks, one in the core of a tile and one at each corner. We report the successful ligation of all four corner nicks by T4 DNA ligase. Although ligation does not change the nanotubes' stiffness, ligated nanotubes withstand temperatures over 70°C, resist breaking during AFM, and are stable in pure water for over a month. Ligated DNA nanotubes are thus physically and chemically sturdy enough to withstand the manipulations necessary for many technological applications.
Journal of the Mechanics and Physics of Solids, 2009
Texturing of polycrystals under slip-dominated plastic deformation is driven by reorientation vel... more Texturing of polycrystals under slip-dominated plastic deformation is driven by reorientation velocity fields that arise from the lattice spin that accompanies restricted slip. Here, the dynamics of reorientation velocity fields are analyzed to isolate mechanisms by which textures develop and dissipate. Two tools are introduced to enable this analysis: linear stability analysis to assess behavior of equilibrium orientations, and a parametrization of lattice spins to enable analysis of fields without equilibria. This toolkit is applied to face-centered cubic (FCC) polycrystals and sheds new insight into texture development under three representative deformation modes: plane strain compression, pure shear and simple shear.
Journal of the American Chemical Society, 2013
Justification: Although the equation for p tube /p helix in the paper is correct, the original Su... more Justification: Although the equation for p tube /p helix in the paper is correct, the original Supporting Information presented an incorrect derivation (invoking mass moment instead of area moment of inertia). Here we provide a correct derivation. We use the letters J and j to emphasize that area moments rather than mass moments are being calculated, the latter of which are commonly designated by the letter I.
Computer Methods in Applied Mechanics and Engineering, 1998
A novel methodology is presented for the modeling of crystallographic texture based on the applic... more A novel methodology is presented for the modeling of crystallographic texture based on the application of finite elements to represent and compute the orientation distribution function (ODF) over explicit discretizations of orientation space. Various orientation spaces are examined for this purpose. The neo-Eulerian axis angle spaces of Frank are preferred over the conventional Euler angle spaces for their superior properties. Properties of the neo-Eulerian spaces required by the modeling are derived. These include the reduction of the spaces under crystal symmetries to fundamental regions, the consequent boundary symmetry relationships, and the various Riemannian metrical properties of the spaces. The structure of crystal flow generated under the uniaxral extension of FCC crystals is examined over the cubic fundamental region of Rodrrgues' space. Stabilized finite element schemes for the ODF conservation equation, developed previously for the texturing of planar polycrystals, are extended to the three-dimensional texturing considered. Properties of the schemes are illustrated by application to the texturing of FCC polycrystals over Rodrigues' space.
Clinical Toxicology, 2010
Context-Poisoning is the second leading cause of injury-related fatality in the United States. An... more Context-Poisoning is the second leading cause of injury-related fatality in the United States. An elevated serum lactate concentration identifies medical and surgical patients at risk for death; however, its utility in predicting death in drug overdose is controversial and unclear. Objective-We aimed to evaluate the prognostic utility of serum lactate concentration for fatality in emergency department (ED) patients with acute drug overdose. Materials and Methods-This was a case-control study at two urban university teaching hospitals affiliated with a regional poison control center. Data were obtained from electronic medical records, poison center data, and the office of the chief medical examiner. Controls were consecutive acute drug overdoses over a 1-year period surviving to hospital discharge. Cases were subjects over a 7-year period with fatality because of drug overdose. Serum lactate concentration was obtained from the initial blood draw in the ED and correlated with fatality. Results-During the study period, 873 subjects were screened with 50 cases and 100 controls included. Drug exposures and baseline characteristics were similar between groups. Mean lactate concentration (mmol/L) was 9.88 ± 6.7 for cases and 2.76 ± 2.9 for controls (p < 0.001). The receiver operating characteristic area under the curve for prediction of fatality was 0.87 (95% CI: 0.81-0.94). The optimal lactate cutpoint was 3.0 mmol/L (84% sensitivity, 75% specificity), which conferred a 15.8-fold increase in odds of fatality (p < 0.001). Conclusion-In this derivation study, serum lactate concentration had excellent prognostic utility to predict drug-overdose fatality. Prospective validation in the ED evaluation of drug overdoses is warranted.
Biochemical and Biophysical Research Communications, 2010
We have studied the functions of the Trichoderma virens TmkB, a homologue of the yeast cell-wall ... more We have studied the functions of the Trichoderma virens TmkB, a homologue of the yeast cell-wall integrity MAP kinase Slt2, using gene knockout. The functions of TmkB were compared to those of the pathogenicity MAP kinase homologue (TmkA). Like the tmkA loss-of-function mutants, tmkB mutants exhibited reduced radial growth and constitutive conidiation in dark as well as in liquid shake cultures. The tmkB mutants, in contrast to tmkA mutants, had cell-wall integrity defects, as shown by autolysis of the mycelia and increased sensitivity to cell-wall degrading enzymes. Interestingly, the tmkB mutants were not autolytic on the synthetic Vogels minimal medium. The tmkB mutants had attenuated ability to overgrow the plant pathogen Sclerotium rolfsii, while retaining the ability to overgrow Rhizoctonia solani and Pythium spp., a phenotype also exhibited by the tmkA mutants. This first functional analysis of a cell-wall integrity MAPK in Trichoderma spp., a group of economically important fungi, shows the importance of this signaling pathway in biocontrol. Common phenotypes of the TmkA and TmkB pathways suggest that the two MAPKs may share some substrates, perhaps subunits of key transcription factors, thus dependent on two phosphorylation events for their activity.
American Journal of Respiratory Cell and Molecular Biology, 1998
In the present study, we characterized surfactant protein (SP)-A messenger RNA (mRNA) in mid-trim... more In the present study, we characterized surfactant protein (SP)-A messenger RNA (mRNA) in mid-trimester human fetal trachea and bronchi. SPA protein was localized by immunocytochemistry to scattered epithelial cells in the airway surface epithelium and in submucosal glands of the fetal trachea and bronchi. SPA mRNA (2.2 kb) was detected by Northern blot analysis in human fetal trachea, as well as in primary and more distal bronchi. The levels of detectable SPA mRNA were highest in the upper airways and were decreased in smaller bronchi in comparison. SPA mRNA was barely detectable in the distal fetal lung tissue. In contrast, SPA mRNA was abundant in cultured explants of distal human fetal lung tissue. SP-A1 and SP-A2 mRNA were detected by primer extension analysis in adult human lung tissue and in cultured human fetal lung explants. Only SP-A2 mRNA was detected in RNA isolated from human fetal trachea and bronchi. SPA mRNA was localized by in situ hybridization in the fetal trachea and bronchi in scattered cells in the surface epithelium and, most prominently, in submucosal glands. Our results suggest that SP-A2, and not SP-A1, is produced in the human fetal tracheal and bronchial epithelium and in submucosal glands.
The American Journal of Cardiology, 2005
The effect of topiramate on weight and blood pressure (BP) was examined in a randomized, placebo-... more The effect of topiramate on weight and blood pressure (BP) was examined in a randomized, placebo-controlled trial in obese subjects who had hypertension. After a 4-week, placebo, run-in period, 531 obese subjects (body mass index 27 to 50 kg/m(2)) who had established hypertension were randomly assigned to placebo or 96 or 192 mg/day of topiramate. All subjects received a standardized diet, exercise advice, and behavioral modification from run-in through study end. Initially scheduled for 60 weeks on medication, the sponsor ended the study early to develop a new controlled-release formulation. As a consequence, efficacy was assessed within a predefined modified intent-to-treat population (subjects who enrolled early enough to potentially complete 28 weeks on medication). The placebo and 96- and 192-mg groups had respective weight losses of 1.9%, 5.9%, and 6.5% from baseline (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 for each comparison with placebo) and decreases in diastolic BP of 2.1, 5.5, and 6.3 mm Hg (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.015 vs placebo). Systolic BP was decreased by 8.6 and 9.7 mm Hg in the 96- and 192-mg groups and 4.9 mm Hg in the placebo group (p = NS). Compared with placebo, the topiramate groups had larger proportions of subjects whose weight decreased by…
Spectra of Sierpinski graph defined as eigenvalues of graph at different stage of iteration. In t... more Spectra of Sierpinski graph defined as eigenvalues of graph at different stage of iteration. In this is paper it aimed to found that the choice of matrix representation has a large impact, on the suitability of spectrum in a number of pattern recognition tasks, i.e. various stages of iteration. Introduction:
OF DISSERTATION Dust Control Examination using Computational Fluid Dynamics Modeling and Laborato... more OF DISSERTATION Dust Control Examination using Computational Fluid Dynamics Modeling and Laboratory Testing of Vortecone and Impingement Screen Filters Heavy industries, such as mining, generate dust in quantities that present an occupational health hazard. Prolonged exposure to the respirable dust has been found to result in many irreversible occupational ailments in thousands of miners. In underground mining applications, a variety of scrubbing systems are used to remove dust near the zones of generation. However, the wire-mesh type fibrous screens in the flooded-bed dust scrubbers used on continuous miners, are prone to clogging due to the accumulation of dust particles. This clogging results in a reduced capture efficiency and a higher exposure to the personnel. This research establishes the Vortecone, an inertial wet scrubber system, as a suitable alternative to the existing filters. The Vortecone accelerates its inlet fluids into a rapid circulatory motion into a vortex chambe...
Decision Science Letters, 2015
The main aim of the present paper is to analyze the stochastic behavior of a cold standby system ... more The main aim of the present paper is to analyze the stochastic behavior of a cold standby system with concept of preventive maintenance, priority and maximum repair time. For this purpose, a stochastic model is developed in which initially one unit is operative and other is kept as cold standby. There is a single server who visits the system immediately as and when required. The server takes the unit under preventive maintenance after a maximum operation time at normal mode if one standby unit is available for operation. If the repair of the failed unit is not possible up to a maximum repair time, failed unit is replaced by new one. The failure time, maximum operation time and maximum repair time distributions of the unit are considered as exponentially distributed while repair and maintenance time distributions are considered as arbitrary. All random variables are statistically independent and repairs are perfect. Various measures of system effectiveness are obtained by using the technique of semi-Markov process and RPT. To highlight the importance of the study numerical results are also obtained for MTSF, availability and profit function.
International Journal of Computer Applications, 2014
Oral health and dental management, 2012
Complete access to the existing pool of biomedical literature and the ability to "hit" ... more Complete access to the existing pool of biomedical literature and the ability to "hit" upon the exact information of the relevant specialty are becoming essential elements of academic and clinical expertise. With the rapid expansion of the literature database, it is almost impossible to keep up to date with every innovation. Using the Internet, however, most people can freely access this literature at any time, from almost anywhere. This paper highlights the use of the Internet in obtaining valuable biomedical research information, which is mostly available from journals, databases, textbooks and e-journals in the form of web pages, text materials, images, and so on. The authors present an overview of web-based resources for biomedical researchers, providing information about Internet search engines (e.g., Google), web-based bibliographic databases (e.g., PubMed, IndMed) and how to use them, and other online biomedical resources that can assist clinicians in reaching well-...
2011 IEEE International Vacuum Electronics Conference (IVEC), 2011
Abstract In this paper, the design concept of a 460 GHz, 3050 W, CW, second harmonic gyrotron fo... more Abstract In this paper, the design concept of a 460 GHz, 3050 W, CW, second harmonic gyrotron for medical spectroscopy will be presented. Mode selection has been done keeping in view the second harmonic operation, first harmonic competitors, and a probable radial ...
2011 International Conference on Infrared, Millimeter, and Terahertz Waves, 2011
Abstract This paper presents the design studies of the output coupling system of a 460 GHz, 50–10... more Abstract This paper presents the design studies of the output coupling system of a 460 GHz, 50–100 W, CW, second harmonic gyrotron for medical spectroscopy. During this course, the design studies of an advanced dimpled-wall quasi optical launcher (QOL), non-linear ...
2011 International Conference on Infrared, Millimeter, and Terahertz Waves, 2011
Abstract This paper presents the design of a triode-type Magnetron Injection Gun (MIG) for a 460 ... more Abstract This paper presents the design of a triode-type Magnetron Injection Gun (MIG) for a 460 GHz, 50–100 W gyrotron for Medical Spectroscopy operating at 25 KV and 0.1 A. The design is facilitated by determining the initial design following analytical expressions of ...
European Journal of General Dentistry, 2012
ABSTRACT
Parkinsonism & Related Disorders, 2009
Nano Letters, 2006
DNA nanotubes are crystalline self-assemblies of DNA tiles ∼10 nm in diameter that readily grow t... more DNA nanotubes are crystalline self-assemblies of DNA tiles ∼10 nm in diameter that readily grow tens of micrometers in length. Easy assembly, programmability, and stiffness make them interesting for many applications, but DNA nanotubes begin to melt at temperatures below 40°C, break open when deposited on mica or scanned by AFM, and disintegrate in deionized water. These weaknesses can be traced to the presence of discontinuities in the phosphate backbone, called nicks. The nanotubes studied here have five nicks, one in the core of a tile and one at each corner. We report the successful ligation of all four corner nicks by T4 DNA ligase. Although ligation does not change the nanotubes' stiffness, ligated nanotubes withstand temperatures over 70°C, resist breaking during AFM, and are stable in pure water for over a month. Ligated DNA nanotubes are thus physically and chemically sturdy enough to withstand the manipulations necessary for many technological applications.
Journal of the Mechanics and Physics of Solids, 2009
Texturing of polycrystals under slip-dominated plastic deformation is driven by reorientation vel... more Texturing of polycrystals under slip-dominated plastic deformation is driven by reorientation velocity fields that arise from the lattice spin that accompanies restricted slip. Here, the dynamics of reorientation velocity fields are analyzed to isolate mechanisms by which textures develop and dissipate. Two tools are introduced to enable this analysis: linear stability analysis to assess behavior of equilibrium orientations, and a parametrization of lattice spins to enable analysis of fields without equilibria. This toolkit is applied to face-centered cubic (FCC) polycrystals and sheds new insight into texture development under three representative deformation modes: plane strain compression, pure shear and simple shear.
Journal of the American Chemical Society, 2013
Justification: Although the equation for p tube /p helix in the paper is correct, the original Su... more Justification: Although the equation for p tube /p helix in the paper is correct, the original Supporting Information presented an incorrect derivation (invoking mass moment instead of area moment of inertia). Here we provide a correct derivation. We use the letters J and j to emphasize that area moments rather than mass moments are being calculated, the latter of which are commonly designated by the letter I.
Computer Methods in Applied Mechanics and Engineering, 1998
A novel methodology is presented for the modeling of crystallographic texture based on the applic... more A novel methodology is presented for the modeling of crystallographic texture based on the application of finite elements to represent and compute the orientation distribution function (ODF) over explicit discretizations of orientation space. Various orientation spaces are examined for this purpose. The neo-Eulerian axis angle spaces of Frank are preferred over the conventional Euler angle spaces for their superior properties. Properties of the neo-Eulerian spaces required by the modeling are derived. These include the reduction of the spaces under crystal symmetries to fundamental regions, the consequent boundary symmetry relationships, and the various Riemannian metrical properties of the spaces. The structure of crystal flow generated under the uniaxral extension of FCC crystals is examined over the cubic fundamental region of Rodrrgues' space. Stabilized finite element schemes for the ODF conservation equation, developed previously for the texturing of planar polycrystals, are extended to the three-dimensional texturing considered. Properties of the schemes are illustrated by application to the texturing of FCC polycrystals over Rodrigues' space.
Clinical Toxicology, 2010
Context-Poisoning is the second leading cause of injury-related fatality in the United States. An... more Context-Poisoning is the second leading cause of injury-related fatality in the United States. An elevated serum lactate concentration identifies medical and surgical patients at risk for death; however, its utility in predicting death in drug overdose is controversial and unclear. Objective-We aimed to evaluate the prognostic utility of serum lactate concentration for fatality in emergency department (ED) patients with acute drug overdose. Materials and Methods-This was a case-control study at two urban university teaching hospitals affiliated with a regional poison control center. Data were obtained from electronic medical records, poison center data, and the office of the chief medical examiner. Controls were consecutive acute drug overdoses over a 1-year period surviving to hospital discharge. Cases were subjects over a 7-year period with fatality because of drug overdose. Serum lactate concentration was obtained from the initial blood draw in the ED and correlated with fatality. Results-During the study period, 873 subjects were screened with 50 cases and 100 controls included. Drug exposures and baseline characteristics were similar between groups. Mean lactate concentration (mmol/L) was 9.88 ± 6.7 for cases and 2.76 ± 2.9 for controls (p < 0.001). The receiver operating characteristic area under the curve for prediction of fatality was 0.87 (95% CI: 0.81-0.94). The optimal lactate cutpoint was 3.0 mmol/L (84% sensitivity, 75% specificity), which conferred a 15.8-fold increase in odds of fatality (p < 0.001). Conclusion-In this derivation study, serum lactate concentration had excellent prognostic utility to predict drug-overdose fatality. Prospective validation in the ED evaluation of drug overdoses is warranted.
Biochemical and Biophysical Research Communications, 2010
We have studied the functions of the Trichoderma virens TmkB, a homologue of the yeast cell-wall ... more We have studied the functions of the Trichoderma virens TmkB, a homologue of the yeast cell-wall integrity MAP kinase Slt2, using gene knockout. The functions of TmkB were compared to those of the pathogenicity MAP kinase homologue (TmkA). Like the tmkA loss-of-function mutants, tmkB mutants exhibited reduced radial growth and constitutive conidiation in dark as well as in liquid shake cultures. The tmkB mutants, in contrast to tmkA mutants, had cell-wall integrity defects, as shown by autolysis of the mycelia and increased sensitivity to cell-wall degrading enzymes. Interestingly, the tmkB mutants were not autolytic on the synthetic Vogels minimal medium. The tmkB mutants had attenuated ability to overgrow the plant pathogen Sclerotium rolfsii, while retaining the ability to overgrow Rhizoctonia solani and Pythium spp., a phenotype also exhibited by the tmkA mutants. This first functional analysis of a cell-wall integrity MAPK in Trichoderma spp., a group of economically important fungi, shows the importance of this signaling pathway in biocontrol. Common phenotypes of the TmkA and TmkB pathways suggest that the two MAPKs may share some substrates, perhaps subunits of key transcription factors, thus dependent on two phosphorylation events for their activity.
American Journal of Respiratory Cell and Molecular Biology, 1998
In the present study, we characterized surfactant protein (SP)-A messenger RNA (mRNA) in mid-trim... more In the present study, we characterized surfactant protein (SP)-A messenger RNA (mRNA) in mid-trimester human fetal trachea and bronchi. SPA protein was localized by immunocytochemistry to scattered epithelial cells in the airway surface epithelium and in submucosal glands of the fetal trachea and bronchi. SPA mRNA (2.2 kb) was detected by Northern blot analysis in human fetal trachea, as well as in primary and more distal bronchi. The levels of detectable SPA mRNA were highest in the upper airways and were decreased in smaller bronchi in comparison. SPA mRNA was barely detectable in the distal fetal lung tissue. In contrast, SPA mRNA was abundant in cultured explants of distal human fetal lung tissue. SP-A1 and SP-A2 mRNA were detected by primer extension analysis in adult human lung tissue and in cultured human fetal lung explants. Only SP-A2 mRNA was detected in RNA isolated from human fetal trachea and bronchi. SPA mRNA was localized by in situ hybridization in the fetal trachea and bronchi in scattered cells in the surface epithelium and, most prominently, in submucosal glands. Our results suggest that SP-A2, and not SP-A1, is produced in the human fetal tracheal and bronchial epithelium and in submucosal glands.
The American Journal of Cardiology, 2005
The effect of topiramate on weight and blood pressure (BP) was examined in a randomized, placebo-... more The effect of topiramate on weight and blood pressure (BP) was examined in a randomized, placebo-controlled trial in obese subjects who had hypertension. After a 4-week, placebo, run-in period, 531 obese subjects (body mass index 27 to 50 kg/m(2)) who had established hypertension were randomly assigned to placebo or 96 or 192 mg/day of topiramate. All subjects received a standardized diet, exercise advice, and behavioral modification from run-in through study end. Initially scheduled for 60 weeks on medication, the sponsor ended the study early to develop a new controlled-release formulation. As a consequence, efficacy was assessed within a predefined modified intent-to-treat population (subjects who enrolled early enough to potentially complete 28 weeks on medication). The placebo and 96- and 192-mg groups had respective weight losses of 1.9%, 5.9%, and 6.5% from baseline (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001 for each comparison with placebo) and decreases in diastolic BP of 2.1, 5.5, and 6.3 mm Hg (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.015 vs placebo). Systolic BP was decreased by 8.6 and 9.7 mm Hg in the 96- and 192-mg groups and 4.9 mm Hg in the placebo group (p = NS). Compared with placebo, the topiramate groups had larger proportions of subjects whose weight decreased by…