Ashley Fogle - Academia.edu (original) (raw)
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Papers by Ashley Fogle
BioEssays, 1995
Members of the Ras superfamily of proteins function as regulated GDP/GTP switches that cycle betw... more Members of the Ras superfamily of proteins function as regulated GDP/GTP switches that cycle between active GTP-complexed and inactive GDP-complexed states. Guanine nucleotide exchange factors (GEFs) stimulate formation of the GTP-bound state, whereas GTPase activating proteins (GAPs) catalyze the formation of the GDP-bound state. We describe three studies that evaluate the mechanism of action of GEFs for Ras (SOS1 and RasGRF/ CDC25) or Ras-related Rho (Dbl and Vav) proteins. Growth factor-mediated activation of Ras is believed to be MEMBRANE TRANSLOCATION MECHANISM OF RAS GEF ACTIVATION? Quite a diverse collection of extracellular ligands can stimulate Ras by activating their cognate receptors (Satoh et al., 1992; Khosravi-Far and Der, 1994). All of these factors, including neurotransmitters, hormones, growth factors, and cytokines cause transient increases in Ras-GTP levels. In resting, unstimulated cells, the level of Ras-GTP is approximately 1-5% of the total Ras protein pool. Upon stimulation by extracellular
SIMILE: Studies In Media & Information Literacy Education, 2001
This article suggests that "The Simpsons" is a sophisticated media text about media that forces e... more This article suggests that "The Simpsons" is a sophisticated media text about media that forces educators who teach media literacy into an encounter with postmodern theory. The meaning of postmodern theory for media education is explored through a focus on two ongoing themes in "The Simpsons": the changing conception of personal identity and the consequences of a relentlessly ironic worldview. Icons of popular culture can be used to teach about philosophical constructs. From its inception "The Simpsons" has posed a significant challenge to educators. The program, which ridiculed all forms of authority and turned Bart Simpson into a wildly popular anti-hero, initially provoked an intense reaction from the education community, in some schools leading to the banning of paraphernalia bearing Bart's images and regular denunciations of the series. As the series grew in popularity-and eventually was joined by other cartoon series that were seen to be even more educationally offensive, such as "Beavis and Butthead" and "South Park"-the furor died down to a ongoing but passive hostility toward the program, at least in the classroom.
SIMILE: Studies In Media & Information Literacy Education, 2004
This article asks "What lessons does commercially produced news teach young people about the mean... more This article asks "What lessons does commercially produced news teach young people about the meaning of democracy and of citizenship?" Three competing models of democracy are introduced: Neoliberalism; Communitarianism; and Participatory. With these three models as reference points, one week of Primedia's Channel One video news program-the week of the 1999 World Trade Organization (WTO) protests in Seattle, Washington-is analyzed. While the concept of "democracy" is never directly taken up in this programming, it is argued that the stories, advertisements, and formal structure construct a compelling vision of neo-liberalism as the normative standard for democracy in the United States. News stories, popular magazine articles, and academic studies have been pointing to a rising tide of political apathy among young people for nearly a decade. And the indicators include everything from: low and declining rates of voter turnout for young adults (
BioEssays, 1995
Members of the Ras superfamily of proteins function as regulated GDP/GTP switches that cycle betw... more Members of the Ras superfamily of proteins function as regulated GDP/GTP switches that cycle between active GTP-complexed and inactive GDP-complexed states. Guanine nucleotide exchange factors (GEFs) stimulate formation of the GTP-bound state, whereas GTPase activating proteins (GAPs) catalyze the formation of the GDP-bound state. We describe three studies that evaluate the mechanism of action of GEFs for Ras (SOS1 and RasGRF/ CDC25) or Ras-related Rho (Dbl and Vav) proteins. Growth factor-mediated activation of Ras is believed to be MEMBRANE TRANSLOCATION MECHANISM OF RAS GEF ACTIVATION? Quite a diverse collection of extracellular ligands can stimulate Ras by activating their cognate receptors (Satoh et al., 1992; Khosravi-Far and Der, 1994). All of these factors, including neurotransmitters, hormones, growth factors, and cytokines cause transient increases in Ras-GTP levels. In resting, unstimulated cells, the level of Ras-GTP is approximately 1-5% of the total Ras protein pool. Upon stimulation by extracellular
SIMILE: Studies In Media & Information Literacy Education, 2001
This article suggests that "The Simpsons" is a sophisticated media text about media that forces e... more This article suggests that "The Simpsons" is a sophisticated media text about media that forces educators who teach media literacy into an encounter with postmodern theory. The meaning of postmodern theory for media education is explored through a focus on two ongoing themes in "The Simpsons": the changing conception of personal identity and the consequences of a relentlessly ironic worldview. Icons of popular culture can be used to teach about philosophical constructs. From its inception "The Simpsons" has posed a significant challenge to educators. The program, which ridiculed all forms of authority and turned Bart Simpson into a wildly popular anti-hero, initially provoked an intense reaction from the education community, in some schools leading to the banning of paraphernalia bearing Bart's images and regular denunciations of the series. As the series grew in popularity-and eventually was joined by other cartoon series that were seen to be even more educationally offensive, such as "Beavis and Butthead" and "South Park"-the furor died down to a ongoing but passive hostility toward the program, at least in the classroom.
SIMILE: Studies In Media & Information Literacy Education, 2004
This article asks "What lessons does commercially produced news teach young people about the mean... more This article asks "What lessons does commercially produced news teach young people about the meaning of democracy and of citizenship?" Three competing models of democracy are introduced: Neoliberalism; Communitarianism; and Participatory. With these three models as reference points, one week of Primedia's Channel One video news program-the week of the 1999 World Trade Organization (WTO) protests in Seattle, Washington-is analyzed. While the concept of "democracy" is never directly taken up in this programming, it is argued that the stories, advertisements, and formal structure construct a compelling vision of neo-liberalism as the normative standard for democracy in the United States. News stories, popular magazine articles, and academic studies have been pointing to a rising tide of political apathy among young people for nearly a decade. And the indicators include everything from: low and declining rates of voter turnout for young adults (