Asim Mushtaq - Academia.edu (original) (raw)
Papers by Asim Mushtaq
Nanomaterials
Significant attention is paid to the design of magnetoplasmonic nanohybrids, which exploit synerg... more Significant attention is paid to the design of magnetoplasmonic nanohybrids, which exploit synergistic properties for biomedical applications. Here, a facile method was employed to prepare plasmonic magnetic Au-MnO heterostructured hybrid nanoparticles for imaging-guided photothermal therapy of cancers in vitro, with the view to reducing the serious drawbacks of chemotherapy and gadolinium-based contrast agents. The biocompatibility of the prepared Au-MnO nanocomposites was further enhanced by Food and Drug Administration (FDA)-approved triblock copolymers Pluronic® F-127 and chitosan oligosaccharide (COS), with complementary support to enhance the absorption in the near-infrared (NIR) region. In addition, synthesized COS-PF127@Au-MnO nanocomposites exhibited promising contrast enhancement in T1 MR imaging with a good r1 relaxivity value (1.2 mM−1 s−1), demonstrating a capable substitute to Gd-based toxic contrast agents. In addition, prepared COS-PF127@Au-MnO hybrid nanoparticles (...
Beilstein Journal of Nanotechnology, 2020
The control over contagious diseases caused by pathogenic organisms has become a serious health i... more The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag–TiO2 nanocomposites (NCs) were synthesized on the gram scale and the enhanced antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag–TiO2 NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO2 NCs exhibited promising and superior antibacterial prop...
Materials Innovations
Janus nanopar cles are a aining profound interest due to their exci ng and mul func onal proper e... more Janus nanopar cles are a aining profound interest due to their exci ng and mul func onal proper es generated from their asymmetric structures. However, control over synthesis, especially in solu ons with small sizes, is a challenging concern. Herein, a simple hydrothermal method was applied to integrate the two highly biocompa ble materials to design a Fe 3 O 4-TiO 2 Janus structure. The structural characteriza on techniques were jus fied the asymmetric nature of the prepared nanocomposites. The average size of the JNPs was~30 ± 2 nm, whereas the hydrodynamic size of Pluronic ® F-127-coated JNPs was 120 nm. The PF-127 modified Fe 3 O 4-TiO 2 JNPs showed good biocompa bility, cancer cell targe ng, and reac ve oxygen species (ROS) genera on ability. The designed nanocomposites yielded excellent r 2 relaxivity 18.2 mM −1 s −1 and MRimage enchantment, sugges ng their capability as a T 2-weighted contrast agent. Moreover, the PF127@Fe 3 O 4-TiO 2 JNCs probe caused efficient photo-toxicity efficiency in vitro on 4T1 breast cancer cells under low-intensity UV light without any adverse effects to the control group. The present research provides a simple synthesis method and possesses an excellent imaging-guided therapeu c pla orm for future cancer treatment and biomedical applica ons.
Biocompatible magnetic hydroxyapatite Fe3O4-HAp nanocomposites for T1-magnetic resonance imaging guided photothermal therapy of breast cancer
Materials Today Communications
ROS-responsive Ag-TiO2 hybrid nanorods for enhanced photodynamic therapy of breast cancer and antimicrobial applications
Journal of Science: Advanced Materials and Devices, 2022
Calcium Carbonate-Based Nanoparticles for Gene Delivery
Biomaterial Engineering, 2021
Materials & Design, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Nanomaterials
Significant attention is paid to the design of magnetoplasmonic nanohybrids, which exploit synerg... more Significant attention is paid to the design of magnetoplasmonic nanohybrids, which exploit synergistic properties for biomedical applications. Here, a facile method was employed to prepare plasmonic magnetic Au-MnO heterostructured hybrid nanoparticles for imaging-guided photothermal therapy of cancers in vitro, with the view to reducing the serious drawbacks of chemotherapy and gadolinium-based contrast agents. The biocompatibility of the prepared Au-MnO nanocomposites was further enhanced by Food and Drug Administration (FDA)-approved triblock copolymers Pluronic® F-127 and chitosan oligosaccharide (COS), with complementary support to enhance the absorption in the near-infrared (NIR) region. In addition, synthesized COS-PF127@Au-MnO nanocomposites exhibited promising contrast enhancement in T1 MR imaging with a good r1 relaxivity value (1.2 mM−1 s−1), demonstrating a capable substitute to Gd-based toxic contrast agents. In addition, prepared COS-PF127@Au-MnO hybrid nanoparticles (...
Beilstein Journal of Nanotechnology, 2020
The control over contagious diseases caused by pathogenic organisms has become a serious health i... more The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag–TiO2 nanocomposites (NCs) were synthesized on the gram scale and the enhanced antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag–TiO2 NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO2 NCs exhibited promising and superior antibacterial prop...
Materials Innovations
Janus nanopar cles are a aining profound interest due to their exci ng and mul func onal proper e... more Janus nanopar cles are a aining profound interest due to their exci ng and mul func onal proper es generated from their asymmetric structures. However, control over synthesis, especially in solu ons with small sizes, is a challenging concern. Herein, a simple hydrothermal method was applied to integrate the two highly biocompa ble materials to design a Fe 3 O 4-TiO 2 Janus structure. The structural characteriza on techniques were jus fied the asymmetric nature of the prepared nanocomposites. The average size of the JNPs was~30 ± 2 nm, whereas the hydrodynamic size of Pluronic ® F-127-coated JNPs was 120 nm. The PF-127 modified Fe 3 O 4-TiO 2 JNPs showed good biocompa bility, cancer cell targe ng, and reac ve oxygen species (ROS) genera on ability. The designed nanocomposites yielded excellent r 2 relaxivity 18.2 mM −1 s −1 and MRimage enchantment, sugges ng their capability as a T 2-weighted contrast agent. Moreover, the PF127@Fe 3 O 4-TiO 2 JNCs probe caused efficient photo-toxicity efficiency in vitro on 4T1 breast cancer cells under low-intensity UV light without any adverse effects to the control group. The present research provides a simple synthesis method and possesses an excellent imaging-guided therapeu c pla orm for future cancer treatment and biomedical applica ons.
Biocompatible magnetic hydroxyapatite Fe3O4-HAp nanocomposites for T1-magnetic resonance imaging guided photothermal therapy of breast cancer
Materials Today Communications
ROS-responsive Ag-TiO2 hybrid nanorods for enhanced photodynamic therapy of breast cancer and antimicrobial applications
Journal of Science: Advanced Materials and Devices, 2022
Calcium Carbonate-Based Nanoparticles for Gene Delivery
Biomaterial Engineering, 2021
Materials & Design, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.