Asmaa Mohamed - Academia.edu (original) (raw)

Papers by Asmaa Mohamed

Diatoms: Fundamentals and Applications

Assiut Scientific Nursing Journal (Print), Feb 1, 2022

Współczesna Onkologia

Introduction: Diffuse large B-cell non-Hodgkin lymphoma (DLBCL) is the largest common category of... more Introduction: Diffuse large B-cell non-Hodgkin lymphoma (DLBCL) is the largest common category of adult lymphoma. Recurrence and treatment resistance occurs in one-third of cases, triggering them to the progressive stage of DLBCL after treatment. Detection of novel predictive and prognostic biomarkers leads to improvement of its treatment and prognosis. Aim of the study: To assess the prognostic roles of protein expression of myeloid differentiation factor 88 (MYD88) and transducin (β)-like receptor 1 (TBLR1) in tissues of DLBCL patients. Material and methods: In the current study we included tissues from 100 cases of DLBCL. For immunohistochemistry, tissues were stained with MYD88 and TBLR1. We followed patients for about 3 years, and then we correlated their expression with clinicopathological and prognostic parameters. Results: Higher MYD88 and TBLR1 expressions were associated with presence of B symptoms, fever, night sweat, advanced stage, bone marrow involvement and bulky nodal size, presence of extra-nodal extension, unfavourable relapse-free survival, and unfavourable overall survival rates (p < 0.001). Conclusions: overexpression of MYD88 and TBLR1 expression was present in DLBCL patients and was associated with unfavourable clinicopathological and prognostic parameters.

Tanta Scientific Nursing Journal, 2020

COVID-19 pandemic represents a challenge not only to frontline health professionals, who introduc... more COVID-19 pandemic represents a challenge not only to frontline health professionals, who introducing nursing services but also to nursing academics in nursing education. Clinical simulation is a valuable tool for teaching and learning in nursing education especially in this crisis. Aim: The study aimed to identify the perceived nursing students' satisfaction and selfconfidence towards the elements of clinical simulation design and educational practice during the outbreak of COVID-19 pandemic. Methods: A quantitative descriptive cross-sectional design was utilized. The study was conducted at the nursing department, College of Applied Medical Sciences affiliated to the University of Hafr Al-Batin. This study involved 118 nursing students who were enrolled in different levels of academic years. The questionnaire involved three instruments; the Simulation Design Scale, Educational Practices Questionnaire, and Student Satisfaction / Self-Confidence in Learning Scale. Results: The findings revealed that around half of nursing students had a low level of satisfaction with simulation activity and the highest percent of them had a high level of self-confidence for managing the simulated situations. Conclusion & Recommendations: The study findings reflected that the use of simulation in presence of design elements and educational practices' features is a typical solution for clinical nursing education to promote students' satisfaction and self-confidence in learning. The study recommended incorporating virtual clinical simulation and other adaptive digital learning methods as a teaching strategy in nursing curricula, as well as encouragement the nursing colleges to allocate budget for purchasing equipment and high fidelity patient simulation manikins.

Open Access Macedonian Journal of Medical Sciences, 2021

Background and aim of the study: Sclerostin is produced by osteocytes and has been shown to down-... more Background and aim of the study: Sclerostin is produced by osteocytes and has been shown to down-regulate the synthesis of many markers of bone formation by osteogenic cells. The aim of this study to investigate the relationship between serum sclerostin levels and bone mineral disorders and vascular calcification in hemodialysis patients (HD). Methods:This is a cross-sectional study of 70 patients with ESRD on regular HD for at least six months, Theodor Bilharz Research Institute, Giza, Egypt.Twenty-five subjects who matched the ages, genders, and demographics of the study patients were included as a control group.All patients and control groups included in the study underwent a full through history and clinical examination. Serum calcium, phosphorus, alkaline phosphatase and intact PTH (iPTH) levels were measured. Serum sclerostin was measured by an ELISA. Bone Mineral Densitometry Measurements BMD (g/cm2) was determined by dual-energy X-ray absorptiometry (DXA). CT scan was done t...

Alfarama Journal of Basic & Applied Sciences, 2021

Banach Contraction Principle (BCP) is a fundamental result in metric fixed point theory and it is... more Banach Contraction Principle (BCP) is a fundamental result in metric fixed point theory and it is a very powerful tool in solving the existence problems in pure and applied sciences. Also, the fuzzy set theory has many applications in various branches of engineering, mathematical sciences including artificial intelligence, control engineering, computer science, management science etc., see [1]. The aim of this paper is to study a common fixed point results for fuzzy mappings under implicit relation in a complex-valued metric space. we introduces a new class of an implicit relation to prove a common fixed point theorems for fuzzy mappings in this paper and constructed some examples to illustrate the main theorem. Also, we gave the consequences of our main result. The results have been reached in our current research work that consider applying for an integral0type0contractive0condition, these 0results0are 0extention0 ofnmanyw resultszinz thiszfield.

Ain Shams Medical Journal, 2021

Background: Axillary lymph node (LN) status is one of the most significant prognostic markers in ... more Background: Axillary lymph node (LN) status is one of the most significant prognostic markers in breast cancer, many studies show that LN ratio (LNR) has been shown to outperform N staging in survival prediction. Aim of the Work: To assess the impact of lymph node ratio (LNR) on the disease free survival (DFS), overall survival (OS) and pattern of recurrence among the study group (non metastatic, triple negative patients treated with upfront surgery). Patients and Methods: A retrospective analysis of 42 female patients with non metastatic triple negative breast cancer treated with up front surgery from January 2016 and January 2019 at the breast unit, clinical oncology department, Ain shams university. to evaluate prognostic value of the lymph node ratio (LNR) in these patients. Results: In this analysis there was statistical significant difference in the primary endpoint of DFS between group I with LNR <0.2 and group II with LNR≥0.20 [Mean: 43.843months versus23.781 months; 3year DFS 68% versus 29.4% respectively]. P = 0.0049, although there was no statistical significant difference between these two groups in OS [Mean: 48.664 months versus37.531 months; 3year OS 78.6%versus65.4% respectively] P = 00.2618. Also, there was statistical significant increase risk of recurrence at group II with LNR≥0.20 more than group I with LNR <0.2 [60% versus 40% respectively] P = 0.0152. On the other hand, ypN staging was not associated with PFS or OS where mean OS of N1&N2-3 (46 months versus 42.3 months respectively) p=0.8005 and mean OS of N1&N2-3 (46 months versus 42.3 months respectively) p=0.8005 Conclusion: The lymph node ratio (LNR) is a better prognostic factor of survival than N staging in non metastatic triple breast cancer patients and it may be accurate marker for staging of axillary nodes to evaluate of the prognosis in the clinical setting.

UC Merced Undergraduate Research Journal, 2017

Hematopoiesis is a process in which the Hematopoietic stem cells (HSC's) differentiate to give ri... more Hematopoiesis is a process in which the Hematopoietic stem cells (HSC's) differentiate to give rise to all lineages of blood cells. In normal adults, HSC's reside in the bone marrow (BM) and their cell niche (microenvironment) in the BM is well-studied in the literature. However, when the BM microenvironment is stressed or diseased, Hematopoiesis takes place in other hematopoietic organs. One of the primary hemic organs is the spleen, yet the mechanisms and microenvironments of the spleen that regulate hematopoiesis and HSC's are not well investigated. By synthesizing articles from the literature, and comparing the spleen hematopoiesis niche to the bone marrow niche, this review will shed light on some of the factors and aspects that mediate hematopoiesis in the spleen microenvironments. It is important to understand how hematopoiesis operates in the spleen as it will provide insights into understanding hematological diseases and some prospective treatments.

Mansoura Nursing Journal, 2021

Leukemia is common neoplastic disease accounting 40-55% worldwide. Malnutrition in cancer patient... more Leukemia is common neoplastic disease accounting 40-55% worldwide. Malnutrition in cancer patients has been reported occurrence 36% of patients in USA and in 50 % of patients in Netherlands. Patients' nutritional needs must include energy requirement to support the patient during the disease and its treatment. Aim: To evaluate the impact of applying dietary pattern on the nutritional status of patients with leukemia undergoing chemotherapy. Design: Quasi/experimental research design was utilized in this study. Sample: A purposive sample of 120 patients with leukemia was included in the study. Tools: Data was collected by using two tools. Patients were interviewed to collect socio-demographic data and medical history of the disease. The subjects were undergone a comprehensive nutritional assessment and application of dietary pattern. Data was collected during a period of 6 months. Results: The results showed that impact of dietary pattern during chemotherapy was significantly effective in improving the ` nutritional status, the chemotherapy side effects and their management. It also showed improvement in the leukemic patients` anthropometric measurements and laboratory investigations. Conclusion: Impact of a dietary pattern during chemotherapy was significantly effective in improving the patients 'nutritional status and their knowledge about nutrition and treatment Recommendations: Emphasizing the importance of nutritional assessment and management process in the medical settings are mandatory. Educating and training the nursing staff to be familiar with how and when to apply such process and improving the food services in medical setting are highly recommended.

My gratitude goes first to my family without whom, I would not be in such position or reached thi... more My gratitude goes first to my family without whom, I would not be in such position or reached this stage in my life. Thanks to my mother who taught me how to be an independent and responsible woman who always seek to do the best she can. Thanks to my father who has been a role model for a hard-worker, dedicated and cooperative professor to his students and who always encouraged me to work and improve myself. Thanks as well to my teachers at school and my professors at university whether in the bachelor degree or the master’s degree who contributed to my personality and my knowledge by their continuous help and advice. However, I owe a special debt of gratitude to my supervisor, Dr. Kevin Koehler who was a role model for a dedicated and cooperative professor to his students. Thanks for your patience throughout the way and for your continuous support and guidance which added a lot to my mentality and research capabilities. I would also like to give special thanks to Dr. Oliver Schlumb...

Assiut Journal of Agricultural Sciences, 2021

This investigation was carried out at Agronomy Department Farm, Faculty of Agriculture, Assiut Un... more This investigation was carried out at Agronomy Department Farm, Faculty of Agriculture, Assiut University, Egypt, to study the effect of temperature resulting from different sowing dates, genotypes and their interaction on forage yield and its components of alfalfa. A set of ten genotypes (Ismailia-1, Nubaria-1, Ramah-1, populations from F.R.S., Kharja, El-Dahlia, Farafra, Balady and Aswan and Cuf 101) were sown on five sowing dates (three at autumn, October 10 th (D1), November 10 th (D2), December 10 th (D3), beside two at spring i.e. March 20 th (D4), April 20 th (D5). Two experiments were carried out as experiment I (2017-2019) and experiment II (2018-2020). Each experiment included all autumn and spring sowing dates. The split block design with three replications was used in both experiments. Fifteen cuts were taken in the two years from each sowing date for each experiment. The results showed that the sowing dates and genotypes had highly significant effect on plant height, leaves/stem ratio, total fresh, dry and protein forage yields for the two experiments, except total protein forage yield in experiment I among studied genotypes which was non-significant. While, the interaction between sowing dates x genotypes insignificant for all studied traits in the two experiments. The highest mean values of plant height obtained from the plants sown in fourth (March D4) and fifth sowing dates (April D5) sowing date were in the two experiments. While, sowing at November (D2) and December (D3) gave the highest mean values of leaves/stems ratio. Furthermore, the maximum total fresh, dry, protein forage yields were obtained from sowing at March 20 th (D4) in experiment I and from sowing on October 10 th (D1) in experiment II. It is remarkable results that the Ramah-1 genotype produced the highest total fresh, dry, and protein forage yields in the two experiments. Finally, the correlations between forage yield and its components revealed that total protein forage yield was positive and significant correlated with fresh and dry forage yield, but negatively correlated with leaves/stems ratio in two experiments.

International Journal of Medical Arts, 2020

Background: Morbidity attached placenta [MAP] remain a major surgical problem for obstetricians d... more Background: Morbidity attached placenta [MAP] remain a major surgical problem for obstetricians due to severe hemorrhage and its incidence had been continually increased due to increased rate of cesarean deliveries. Aim of the work: To evaluate the safety and efficacy of a conservative intervention for management of placenta accreta. Patients and Methods: Forty-eight, pregnant females with a confirmed diagnosis of placenta previa accreta had been scheduled for elective cesarean delivery had been included. All females had been screened by full history taking, clinical examination, ultrasound and laboratory investigations. Blood loss, operative time, need for transfusion and need for other surgical interventions represented the main outcome and other complications were documented. Results: The blood loss [ml] ranged between 850 to 1300 ml; the mean values were 1082.29±105.89 ml. The operative time ranged between 60 to 130 minutes; the mean values were 87.92±19.35 minutes. There was significant decrease of post-partum hemoglobin when compared to corresponding pre-partum values [9.29±0.76 vs 10.71±0.54 mg/dl respectively]. Four patients [8.3%] need ICU admission, and nine patients [18.75%] need blood transfusion. However, no patients need further surgical intervention or developed DIC. In addition, no mortality had been reported in the current work. Conclusion: Combined uterine artery ligation, partial segmental myometrial resection and intrauterine balloon as a conservative treatment modality or placenta previa accreta is safe and effective.

Bulletin of Egyptian Society for Physiological Sciences, 2020

Background: postmenopausal women are more susceptible to insulin resistance. Many studies reporte... more Background: postmenopausal women are more susceptible to insulin resistance. Many studies reported that estrogen (E2) contributes in insulin sensitivity improvement. As a result of postmenopausal estrogen replacement therapy (ERT) hazards, tamoxifen (TAM) as an alternative to estrogen are now applicable. There are no published data distinguishing the effects of TAM on insulin sensitivity in non-diabetic post menopause women. Objectives: Test whether TAM acts as E2 in improving insulin sensitivity in post-menopausal period and to what extent the effect would be similar for both, together with exploring the underlying mechanism. Material & method: Forty female albino rats were divided into 4 groups (10 rats each): sham (SH), ovariectomized (OV), ovariectomized E2 (OVE) treated and ovariectomized TAM (OVT) treated groups. At the end of experiment, blood samples were taken for estimation of fasting blood glucose (FBG), serum concentration of insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid parameters and tumour necrosis factor α (TNFα), then adipose tissues were removed for measurement of MDA and SOD. Also, histopathological and immunohistochemical examination of adipose tissue were done. Results: Ovariectomy worsened glycemic state, insulin resistance and lipid profile. TAM was like E2 induced glucose metabolic improvement, decreased insulin resistance alongside with lipid profile improvement. These metabolic changes might assert to oxidative state and inflammatory response improvement accompanying apparent histopathological and immunohistochemical changes on adipose tissue. Conclusion: TAM can counterbalance the metabolic disorders in postmenopausal period and this may improve metabolic disorders as E2 with avoiding the undesired effects of ERT.

Zagazig University Medical Journal, 2020

Journal of Food and Dairy Sciences, 2020

ABSTRACTRomosozumab, a humanized monoclonal antibody specific for sclerostin, has been approved f... more ABSTRACTRomosozumab, a humanized monoclonal antibody specific for sclerostin, has been approved for treatment of post-menopausal women with osteoporosis at high risk for fracture. In several Phase III clinical trials, romosozumab decreased the risk of vertebral fractures up to 73% and increased total hip area bone mineral density by 3.2%. Previous work in 12 to 15-week-old sclerostin-knockout (Sost-/-) mice indicated that changes in immune cell development occur in the bone marrow (BM), which could be a possible side effect to follow in human patients. Our overall goal was to define the mechanisms that guide behavior of long-term hematopoietic stem cells (LT-HSCs) after exposure to an irregular BM microenvironment. SOST plays an important role in maintaining bone homeostasis, as demonstrated by the increased ratio of bone volume to total volume observed in Sost-/- mice. Here, we examined the effects of short-term sclerostin depletion in the BM on hematopoiesis in young (8 week-old) ...

SAGE Open Medicine, 2020

Background and objectives: Achieving vancomycin therapeutic levels is essential for antibacterial... more Background and objectives: Achieving vancomycin therapeutic levels is essential for antibacterial success and resistance prevention. Multiple studies have shown that most of the children fail to reach therapeutic trough levels (10–20 µg/mL). This study aims to determine the frequency of achieving therapeutic vancomycin initial trough levels in children, evaluate the effect of age on that achievement and the mean initial trough levels, and the frequency of supratherapeutic levels. Methods: Children aged 1 month to 12 years who received three or more vancomycin doses 15 mg/kg every 6 h while admitted at our hospital from February 2016 to January 2017, and had a level before the fourth dose were included. Cases with high baseline serum creatinine, acute kidney injury, and congenital heart disease were excluded. Results: Out of 75 included cases, one third, 28/75 (37.3%), achieved goal. The lowest frequency was 6/28 (21.4%) of the 2–5 years group, which were statistically less likely to...

Assiut Scientific Nursing Journal, Mar 1, 2020

Introduction : Typhoid fever is a systemic bacterial illness of public health importance. The dis... more Introduction : Typhoid fever is a systemic bacterial illness of public health importance. The disease is transmitted person to person due to fecal contamination of food and water. Aim: Determine the incidence of typhoid disease for patient and caregiver in hospitals of Assuit governorate. Assess the knowledge, attitude of patient and their caregiver about typhoid fever. Methods: Descriptive cross sectional research design used in the present study. The study was carried out in the fever hospitals of Assuit governorate, which consists from (Assuit fever hospital, Dirout fever hospital, Elshamia fever hospital). Sample was total coverage to all cases attended to the previous setting during six months, the total cases around (400) cases (232) patients and (168) caregiver. Tools of the study was assess the knowledge of patient and caregivers about typhoid fever and their attitude reward typhoid disease. Data collection by direct interview to cases and their caregiver started from first January / 2018 to the end June / 2018, data was analyzed by SPSS version 20.0 Results: It was found that satisfactory knowledge of patient and caregiver related to typhoid disease. It was found that negative attitude of patients and caregivers regarding to typhoid disease. Conclusion and Recommendation: It was conclude that all patients and caregivers knowledge satisfactory while negative attitude were observed that toward typhoid fever. The study recommended that education at programs should be organized for patients and caregivers regarding management and prevention of typhoid fever.

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 2017

Among these nanoscale chemical structures, fullerenes represent an important source of the biocom... more Among these nanoscale chemical structures, fullerenes represent an important source of the biocompatible molecules because of their capacity to be in contact with cells and biological tissues without altering their behaviour (yang et al., 2007). The fullerene family, and especially C 60 , has very appealing photo-electro-chemical and physical properties, which can be exploited in many and different biological fields (Bosi et al., 2003). C 60 is soluble in lipid droplets inside living cells (Garbi et al., 2005) as well as in fats in general. Moreover, C 60 can freely cross membrane barriers as observed experimentally and recently modelled by computer simulations (Wong-Ekkabut et al., 2008).