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Papers by Asmaa Mostafa

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

omen in low-and middle-income nations face major public health issues related to micronutrient de... more omen in low-and middle-income nations face major public health issues related to micronutrient deficiencies. From every region of Egypt, samples of women of fertile age who were neither pregnant nor lactating were chosen at random in several governorates. 4694 women between the ages of 18 and less than 50 years old participated in this study from 2015-2020. Using data from the participant's social relationships, daily consumption, and anthropometric measures, the micronutrient nutritional status was assessed. The results showed that most of the sample participants were between the ages of 25 and 35. In upper Egypt districts women made up 75.1% of university graduates. The frontier regions had the highest numbers of illiteracies, whereas Lower Egypt had the lowest. The highest percentages of professionals working were found in urban areas (37.1%) and upper Egypt (32.4%). Female unemployment was the highest in frontier areas (58.2%). The sample was overweight (29.1%) and obese (49.0%). Females consumed more minerals than they needed, such as sodium and copper. While intake of potassium, calcium, and magnesium fell below 50% of the reference daily intake (RDI). Furthermore, the utilization of phosphorus, iron, and zinc fell within the permissible ranges of 77-81%, 77-84%, and 92-105%, respectively. Upper Egypt regions were found to have the lowest vitamin A intake (51%) while the frontier region had the highest rate (122%). All water-soluble vitamins, with the exception of vitamin B1, were above 75% of RDI. This study indicated present poor dietary practices among women and their need for additional nutrition education.

Mansoura Nursing Journal

Background: Nurses are responsible for ensuring safety and quality of patient care at all times. ... more Background: Nurses are responsible for ensuring safety and quality of patient care at all times. Many nursing tasks involve a degree of risk such as medication administration procedures carries the greatest risk for patients if staff nurses not follow five rights of medication administration (patient, drug, route, time and dose). Aim: the study aimed to evaluate nurses' knowledge and performance about safety measures in medication administration among staff nurses. Method: A descriptive correlational research design was utilized; the study was conducted on 350 staff nurses working at Al-Mahalla general hospital. Data was collected by using two tool, Medication Safety Measures Knowledge Assessment Questionnaire. Safe Medication Administration Observation Checklist. Results: The study results showed that total nurses' knowledge of safety measures related to medication administration was high level as well as their total performance related to medication administration. Conclusion: There was statistically significant correlation between staff nurses' knowledge and their performance of safety measures related to medication administration. Recommendation: Provision of adequate supervision and guidance for nurses. Establishing a standard of reward or promotion for nurses who follow the hospital policies related to dealing with medication administration.

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

iscuits are a favorite snack among the younger generation. Biscuits fortified with zinc (Zn) or s... more iscuits are a favorite snack among the younger generation. Biscuits fortified with zinc (Zn) or selenium (Se) may help to avoid several diseases that are common in developing countries. The goals of this research were to determine the chemical makeup of reinforced biscuits and to see how different fortified biscuit samples affected feed intake, body weight, feed efficiency ratio, serum lipids profile, liver, kidney functions, immunity, and liver histopathology. Forty male albino rats have been separated into eight groups: group (1) was a negative control; group (2) was fed a diet containing control biscuits without fortified; and the other groups have been fed biscuits fortified with 10, 15, and 20 mg of zinc or selenium for 28 days. The results showed that rats fed on selenium or zinc biscuits had a higher feed efficiency ratio (FER) (P ≤0.05) than the control groups. Adding zinc or selenium led to significantly improved serum liver, kidney functions, and lipid profile especially at the levels of 10 and 15% when compared with a control group. Biochemical indicators were affected more by selenium levels than zinc levels. As a result, zinc and selenium are essential minerals that must be added to food or taken as dietary supplements to fulfill their crucial functions.

ACS Omega

Based on the "canonical" view of reactive oxygen species' (ROS) contribution to carcinogenesis, R... more Based on the "canonical" view of reactive oxygen species' (ROS) contribution to carcinogenesis, ROS induce oxidative stress and promote various tumor progression events. However, tumor cells also need to defend themselves against oxidative damage. This "heresy" was supported by several recent studies underlining the role of cellular antioxidant capacity in promoting metastasis and resistance to chemotherapy. Accordingly, harnessing the ROS-induced oxidative stress via selective suppression of the cancer antioxidant defense machinery has been launched as an innovative anticancer strategy. Within this approach, pharmacological inhibition of superoxide dismutases (SODs), the first-line defense antioxidant enzymes for cancer cells, selectively kills tumor cells and circumvents their acquired resistance. Various SOD inhibitors have been introduced, of which some were tolerated in clinical trials. However, the hit SOD inhibitors belong to diverse chemical classes and lack comprehensive structure−activity relationships (SAR). Herein, we probe the potential of newly synthesized benzylidene thiazolidinedione derivatives to inhibit SOD in colorectal cancer with special emphasis on their effects on correlated antioxidant enzymes aldehyde dehydrogenase 1 (ALDH1) and glutathione peroxidase (GPx). This may possibly bring a new dawn for utilizing thiazolidinediones (TZDs) in cancer therapy through SOD inhibition mechanisms. The preliminary 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that all of the evaluated TZDs exhibited excellent safety profiles on normal human cells, recording an EC100 of up to 47.5-folds higher than that of doxorubicin. Compounds 3c, 6a, and 6e (IC50 = 4.4−4.7 μM) were superior to doxorubicin and other derivatives against Caco-2 colorectal cancer cells within their safe doses. The hit anticancer agents inhibited SOD (IC50 = 97.2−228.8 μM). Then, they were selected for further in-depth evaluation on the cellular level. The anticancer IC50 doses of 3c, 6a, and 6e diminished the antioxidant activities of SOD (by 29.7, 70.1, and 33.3%, respectively), ALDH1A (by 85.92, 95.84, and 86.48%, respectively), and GPX (by 50.17, 87.03, and 53.28%, respectively) in the treated Caco-2 cells, elevating the Caco-2 cellular content of ROS by 21.42, 7.863, and 8.986-folds, respectively. Docking simulations were conducted to display their possible binding modes and essential structural features. Also, their physicochemical parameters and pharmacokinetic profiles formulating drug-likeness were computed.

Effect of Single and Multiple Injections of Adipose Stem Cells and Ascorbic Acid on the Cerebral Cortex: Histological Study in Experimentally Induced Type I Diabetes

Egyptian Journal of Histology, 2021

Journal of Research in Curriculum Instruction and Educational Technology, 2019

ocabulary has been considered as the building block of language. EFL teachers almost always apply... more ocabulary has been considered as the building block of language. EFL teachers almost always apply traditional techniques for teaching new vocabulary. The present study aimed to discover the effects of a fairly new vocabulary learning technique that is, teaching vocabulary through activities based on the lexical approach learning. This experiment utilized a Pre-post-test. Fifty students at the preparatory stage were selected through convenient sampling. They were divided into two groups of 25. The present study adopted the quasi-experimental design, using one experimental group and one control group. The experimental group was taught through the treatment i.e., studying vocabulary through collocations, whereas the control group was taught vocabulary through the traditional methods of presenting vocabulary that is suggested in the Teacher's Guide. The two groups were tested before and after the experiment. The results demonstrated that vocabulary learning through collocations eventuated in a better learning of the words than teaching them by means of classical techniques and improves learning of new words.

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt, 2020

on-communicable diseases (NCDs) come via (unhealthy diet, /physical inactivity, tobacco use and h... more on-communicable diseases (NCDs) come via (unhealthy diet, /physical inactivity, tobacco use and harmful use of alcohol); all increase the risk of dying from NCDs. Children consume approximately half of their total daily amount of energy at school. This work designed to get a baseline data on the condition with reference to school canteen and physical activities between primary and preparatory schools. The study was conducted among 1361 school children age (6 y-13 y) randomly selected from schools in four governorates: Cairo, Qalyobia, Menofia and Giza. Two types of questionnaire were done during the study; which interview was conducted to the school children, and qualitative type (focus group discussion) for school children and teachers responsible for nutrition in the school. Results revealed that the majority of the sample used to buy from school canteens (1294). Food from canteen was Low nutritious value high energy. However, these recommendations were achieved by only (37.1%) of study sample, nearly two thirds (63.9%) of the sample didn't practice any physical activities, while 14% and 10.7% of them practice physical activity once and twice weekly respectively. One quarter of the sample (25.4%) stay in front of TV or computer less than 1 hour daily, and 58% of them stay 2 hours daily. Conclusion: The present study shows that low nutritious value high energy density food items represent the commonly consumed food brought from school canteens. The practice of physical activity is very little, and in case of practicing, it is practiced infrequently.

Toxicology and Applied Pharmacology, 2020

augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran... more augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats, Toxicology and Applied Pharmacology (2020),

Macromolecular Bioscience, 2019

Zanco Journal of Medical Sciences, 2014

Background and objective: Nurses have major role in prevention and management of hepatitis B. Aim... more Background and objective: Nurses have major role in prevention and management of hepatitis B. Aim of the study was to find out the effect of an educational program on nurse' knowledge and practices concerning hepatitis B virus. Methods: A quasi-experimental study was conducted in emergency hospitals, Erbil city, Iraq from 15th of January to 15th of June 2012 involving 50 nurses. Assessment of the knowledge and practices of nurses was carried out by using a questionnaire developed by the researchers. An educational program was designed, constructed and oriented in order to improve the nurses' knowledge and practices towards hepatitis B virus. Post-test was carried out after the educational program using the same (pre program) questionnaire. Results: The mean (±SD) score of pre test knowledge was 6.96±1.6, while the mean (±SD) score of post test knowledge was 8.4±1.5 (P<0.001). The educational program has significant effects on nurses' knowledge about main function of liver (P<0.001), complications of renal failure (P=0.002), and avoiding sharing needles and syringes (P=0.013). The post test means (±SD) scores for practices (47±2.46) were significantly higher than the pretest mean score (43.7±5.16). The educational program had effects on advising practice of hand washing before and after using gloves (P=0.01), using solution for hand washing (P=0.003), risk of contamination with patients' bloods and fluids (P=0.04), removing of gown and washing hands (P=0.012). Conclusion: The educational program played a significant role in some items which could raise the level of knowledge and practices toward prevention of hepatitis B virus.

Disease Markers, 2013

Introduction. Hepatitis C virus (HCV) infection affects almost 3% of the world's population w... more Introduction. Hepatitis C virus (HCV) infection affects almost 3% of the world's population with the highest prevalence in Egypt (15%). The standard therapy; pegylated interferon (PEG-IFN) and ribavirin, is effective in only 60% of Egyptian patients; moreover it is costly, prolonged, and has severe side effects, so prediction of response is essential to reduce burden of unfavorable treatment. Several viral and host factors have been proved to affect response to the treatment PEG-IFN and ribavirin; the strongest of them is polymorphisms near IL28B; nonetheless, nonresponse in patients with favorable IL28B is still unexplained, which implies the importance of studying other immunological factors that may correlate with response. Interleukin 12 (IL-12) is one of the most important proinflammatory cytokine presented with the initiation of immune response, determining Th1 and Th2 differentiation. A functional single nucleotide polymorphism (A/C) at the 3′ untranslated region (3′UTR) ...

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

omen in low-and middle-income nations face major public health issues related to micronutrient de... more omen in low-and middle-income nations face major public health issues related to micronutrient deficiencies. From every region of Egypt, samples of women of fertile age who were neither pregnant nor lactating were chosen at random in several governorates. 4694 women between the ages of 18 and less than 50 years old participated in this study from 2015-2020. Using data from the participant's social relationships, daily consumption, and anthropometric measures, the micronutrient nutritional status was assessed. The results showed that most of the sample participants were between the ages of 25 and 35. In upper Egypt districts women made up 75.1% of university graduates. The frontier regions had the highest numbers of illiteracies, whereas Lower Egypt had the lowest. The highest percentages of professionals working were found in urban areas (37.1%) and upper Egypt (32.4%). Female unemployment was the highest in frontier areas (58.2%). The sample was overweight (29.1%) and obese (49.0%). Females consumed more minerals than they needed, such as sodium and copper. While intake of potassium, calcium, and magnesium fell below 50% of the reference daily intake (RDI). Furthermore, the utilization of phosphorus, iron, and zinc fell within the permissible ranges of 77-81%, 77-84%, and 92-105%, respectively. Upper Egypt regions were found to have the lowest vitamin A intake (51%) while the frontier region had the highest rate (122%). All water-soluble vitamins, with the exception of vitamin B1, were above 75% of RDI. This study indicated present poor dietary practices among women and their need for additional nutrition education.

Mansoura Nursing Journal

Background: Nurses are responsible for ensuring safety and quality of patient care at all times. ... more Background: Nurses are responsible for ensuring safety and quality of patient care at all times. Many nursing tasks involve a degree of risk such as medication administration procedures carries the greatest risk for patients if staff nurses not follow five rights of medication administration (patient, drug, route, time and dose). Aim: the study aimed to evaluate nurses' knowledge and performance about safety measures in medication administration among staff nurses. Method: A descriptive correlational research design was utilized; the study was conducted on 350 staff nurses working at Al-Mahalla general hospital. Data was collected by using two tool, Medication Safety Measures Knowledge Assessment Questionnaire. Safe Medication Administration Observation Checklist. Results: The study results showed that total nurses' knowledge of safety measures related to medication administration was high level as well as their total performance related to medication administration. Conclusion: There was statistically significant correlation between staff nurses' knowledge and their performance of safety measures related to medication administration. Recommendation: Provision of adequate supervision and guidance for nurses. Establishing a standard of reward or promotion for nurses who follow the hospital policies related to dealing with medication administration.

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

iscuits are a favorite snack among the younger generation. Biscuits fortified with zinc (Zn) or s... more iscuits are a favorite snack among the younger generation. Biscuits fortified with zinc (Zn) or selenium (Se) may help to avoid several diseases that are common in developing countries. The goals of this research were to determine the chemical makeup of reinforced biscuits and to see how different fortified biscuit samples affected feed intake, body weight, feed efficiency ratio, serum lipids profile, liver, kidney functions, immunity, and liver histopathology. Forty male albino rats have been separated into eight groups: group (1) was a negative control; group (2) was fed a diet containing control biscuits without fortified; and the other groups have been fed biscuits fortified with 10, 15, and 20 mg of zinc or selenium for 28 days. The results showed that rats fed on selenium or zinc biscuits had a higher feed efficiency ratio (FER) (P ≤0.05) than the control groups. Adding zinc or selenium led to significantly improved serum liver, kidney functions, and lipid profile especially at the levels of 10 and 15% when compared with a control group. Biochemical indicators were affected more by selenium levels than zinc levels. As a result, zinc and selenium are essential minerals that must be added to food or taken as dietary supplements to fulfill their crucial functions.

ACS Omega

Based on the "canonical" view of reactive oxygen species' (ROS) contribution to carcinogenesis, R... more Based on the "canonical" view of reactive oxygen species' (ROS) contribution to carcinogenesis, ROS induce oxidative stress and promote various tumor progression events. However, tumor cells also need to defend themselves against oxidative damage. This "heresy" was supported by several recent studies underlining the role of cellular antioxidant capacity in promoting metastasis and resistance to chemotherapy. Accordingly, harnessing the ROS-induced oxidative stress via selective suppression of the cancer antioxidant defense machinery has been launched as an innovative anticancer strategy. Within this approach, pharmacological inhibition of superoxide dismutases (SODs), the first-line defense antioxidant enzymes for cancer cells, selectively kills tumor cells and circumvents their acquired resistance. Various SOD inhibitors have been introduced, of which some were tolerated in clinical trials. However, the hit SOD inhibitors belong to diverse chemical classes and lack comprehensive structure−activity relationships (SAR). Herein, we probe the potential of newly synthesized benzylidene thiazolidinedione derivatives to inhibit SOD in colorectal cancer with special emphasis on their effects on correlated antioxidant enzymes aldehyde dehydrogenase 1 (ALDH1) and glutathione peroxidase (GPx). This may possibly bring a new dawn for utilizing thiazolidinediones (TZDs) in cancer therapy through SOD inhibition mechanisms. The preliminary 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that all of the evaluated TZDs exhibited excellent safety profiles on normal human cells, recording an EC100 of up to 47.5-folds higher than that of doxorubicin. Compounds 3c, 6a, and 6e (IC50 = 4.4−4.7 μM) were superior to doxorubicin and other derivatives against Caco-2 colorectal cancer cells within their safe doses. The hit anticancer agents inhibited SOD (IC50 = 97.2−228.8 μM). Then, they were selected for further in-depth evaluation on the cellular level. The anticancer IC50 doses of 3c, 6a, and 6e diminished the antioxidant activities of SOD (by 29.7, 70.1, and 33.3%, respectively), ALDH1A (by 85.92, 95.84, and 86.48%, respectively), and GPX (by 50.17, 87.03, and 53.28%, respectively) in the treated Caco-2 cells, elevating the Caco-2 cellular content of ROS by 21.42, 7.863, and 8.986-folds, respectively. Docking simulations were conducted to display their possible binding modes and essential structural features. Also, their physicochemical parameters and pharmacokinetic profiles formulating drug-likeness were computed.

Effect of Single and Multiple Injections of Adipose Stem Cells and Ascorbic Acid on the Cerebral Cortex: Histological Study in Experimentally Induced Type I Diabetes

Egyptian Journal of Histology, 2021

Journal of Research in Curriculum Instruction and Educational Technology, 2019

ocabulary has been considered as the building block of language. EFL teachers almost always apply... more ocabulary has been considered as the building block of language. EFL teachers almost always apply traditional techniques for teaching new vocabulary. The present study aimed to discover the effects of a fairly new vocabulary learning technique that is, teaching vocabulary through activities based on the lexical approach learning. This experiment utilized a Pre-post-test. Fifty students at the preparatory stage were selected through convenient sampling. They were divided into two groups of 25. The present study adopted the quasi-experimental design, using one experimental group and one control group. The experimental group was taught through the treatment i.e., studying vocabulary through collocations, whereas the control group was taught vocabulary through the traditional methods of presenting vocabulary that is suggested in the Teacher's Guide. The two groups were tested before and after the experiment. The results demonstrated that vocabulary learning through collocations eventuated in a better learning of the words than teaching them by means of classical techniques and improves learning of new words.

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt, 2020

on-communicable diseases (NCDs) come via (unhealthy diet, /physical inactivity, tobacco use and h... more on-communicable diseases (NCDs) come via (unhealthy diet, /physical inactivity, tobacco use and harmful use of alcohol); all increase the risk of dying from NCDs. Children consume approximately half of their total daily amount of energy at school. This work designed to get a baseline data on the condition with reference to school canteen and physical activities between primary and preparatory schools. The study was conducted among 1361 school children age (6 y-13 y) randomly selected from schools in four governorates: Cairo, Qalyobia, Menofia and Giza. Two types of questionnaire were done during the study; which interview was conducted to the school children, and qualitative type (focus group discussion) for school children and teachers responsible for nutrition in the school. Results revealed that the majority of the sample used to buy from school canteens (1294). Food from canteen was Low nutritious value high energy. However, these recommendations were achieved by only (37.1%) of study sample, nearly two thirds (63.9%) of the sample didn't practice any physical activities, while 14% and 10.7% of them practice physical activity once and twice weekly respectively. One quarter of the sample (25.4%) stay in front of TV or computer less than 1 hour daily, and 58% of them stay 2 hours daily. Conclusion: The present study shows that low nutritious value high energy density food items represent the commonly consumed food brought from school canteens. The practice of physical activity is very little, and in case of practicing, it is practiced infrequently.

Toxicology and Applied Pharmacology, 2020

augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran... more augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats, Toxicology and Applied Pharmacology (2020),

Macromolecular Bioscience, 2019

Zanco Journal of Medical Sciences, 2014

Background and objective: Nurses have major role in prevention and management of hepatitis B. Aim... more Background and objective: Nurses have major role in prevention and management of hepatitis B. Aim of the study was to find out the effect of an educational program on nurse' knowledge and practices concerning hepatitis B virus. Methods: A quasi-experimental study was conducted in emergency hospitals, Erbil city, Iraq from 15th of January to 15th of June 2012 involving 50 nurses. Assessment of the knowledge and practices of nurses was carried out by using a questionnaire developed by the researchers. An educational program was designed, constructed and oriented in order to improve the nurses' knowledge and practices towards hepatitis B virus. Post-test was carried out after the educational program using the same (pre program) questionnaire. Results: The mean (±SD) score of pre test knowledge was 6.96±1.6, while the mean (±SD) score of post test knowledge was 8.4±1.5 (P<0.001). The educational program has significant effects on nurses' knowledge about main function of liver (P<0.001), complications of renal failure (P=0.002), and avoiding sharing needles and syringes (P=0.013). The post test means (±SD) scores for practices (47±2.46) were significantly higher than the pretest mean score (43.7±5.16). The educational program had effects on advising practice of hand washing before and after using gloves (P=0.01), using solution for hand washing (P=0.003), risk of contamination with patients' bloods and fluids (P=0.04), removing of gown and washing hands (P=0.012). Conclusion: The educational program played a significant role in some items which could raise the level of knowledge and practices toward prevention of hepatitis B virus.

Disease Markers, 2013

Introduction. Hepatitis C virus (HCV) infection affects almost 3% of the world's population w... more Introduction. Hepatitis C virus (HCV) infection affects almost 3% of the world's population with the highest prevalence in Egypt (15%). The standard therapy; pegylated interferon (PEG-IFN) and ribavirin, is effective in only 60% of Egyptian patients; moreover it is costly, prolonged, and has severe side effects, so prediction of response is essential to reduce burden of unfavorable treatment. Several viral and host factors have been proved to affect response to the treatment PEG-IFN and ribavirin; the strongest of them is polymorphisms near IL28B; nonetheless, nonresponse in patients with favorable IL28B is still unexplained, which implies the importance of studying other immunological factors that may correlate with response. Interleukin 12 (IL-12) is one of the most important proinflammatory cytokine presented with the initiation of immune response, determining Th1 and Th2 differentiation. A functional single nucleotide polymorphism (A/C) at the 3′ untranslated region (3′UTR) ...