Astawus Alemayehu - Academia.edu (original) (raw)

Papers by Astawus Alemayehu

Frontiers in Medicine, May 31, 2023

Clinical medicine insights. Pediatrics, 2024

Women's Health, 2021

Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues t... more Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues to have countries with the highest maternal mortality rates. Family planning is one of the most effective techniques for lowering mother and child mortality, in addition to limiting rapid population expansion. Objective: The aim of this study was to assess level and determinants of long-acting family planning method among reproductive age women in Harar, Eastern Ethiopia, 2021 Method: Community-based cross-sectional study was conducted among 845 randomly selected reproductive age women. Data were collected by trained data collector using pretested structured questionnaire. Data were coded and entered into Epidata v.3 and analyzed using SPSS v.26 software. Descriptive statistics, bivariate and multivariate logistic regression analysis was used. Variable with p-value less than 0.05 was declared as statistically significant. Result: The prevalence of long-acting family planning method was 74.7%, while 53.6% and 46.4% was from rural and urban, respectively. The mean age of participants was 28.5 (± 5.6) years. Married women four times (AOR: 4.1; 95% CI: 1.6, 10.4) more likely to use long-acting family planning method than single women. Women with educated husband four times (AOR: 4.4; 95% CI: 1.8, 10.6) more likely to use long-acting family planning method than women with illiterate husband. Conclusion: There is high level of utilization of long-acting family planning. The women’s marital status, increased education level of husbands, increasing in age of women, intention to spacing birth, and having less than five children were found to significantly increase the utilization of long-acting family planning.

The Lancet Haematology

Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are cr... more Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories. Methods We estimated population-level distributions of haemoglobin concentration by age and sex for each location from 1990 to 2021. We then calculated anaemia burden by severity and associated years lived with disability (YLDs). With data on prevalence of the causes of anaemia and associated cause-specific shifts in haemoglobin concentrations, we modelled the proportion of anaemia attributed to 37 underlying causes for all locations, years, and demographics in the Global Burden of Disease Study 2021. Findings In 2021, the global prevalence of anaemia across all ages was 24•3% (95% uncertainty interval [UI] 23•9-24•7), corresponding to 1•92 billion (1•89-1•95) prevalent cases, compared with a prevalence of 28•2% (27•8-28•5) and 1•50 billion (1•48-1•52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52•0 million (35•1-75•1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic Index. The most common causes of anaemia YLDs in 2021 were dietary iron deficiency (cause-specific anaemia YLD rate per 100 000 population: 422•4 [95% UI 286•1-612•9]), haemoglobinopathies and haemolytic anaemias (89•0 [58•2-123•7]), and other neglected tropical diseases (36•3 [24•4-52•8]), collectively accounting for 84•7% (84•1-85•2) of anaemia YLDs. Interpretation Anaemia remains a substantial global health challenge, with persistent disparities according to age, sex, and geography. Estimates of cause-specific anaemia burden can be used to design locally relevant health interventions aimed at improving anaemia management and prevention. Funding Bill & Melinda Gates Foundation.

PLOS ONE

Background The novel coronavirus disease has emerged as the most pressing global health issue. In... more Background The novel coronavirus disease has emerged as the most pressing global health issue. In women with COVID-19 disease, pregnancy confers a substantial additional risk of morbidity and mortality. Objective This study aimed to assess WHO-recommended COVID-19 prevention practices and determinant factors among pregnant women attending antenatal care during the third wave of COVID-19 in eastern Ethiopia. Methods An Institutional-based cross-sectional study was conducted among 422 pregnant women attending antenatal care in Harar, from October 10 to November 10, 2021. The sample size was proportionally allocated to all healthcare facilities, then the study participants were selected using systematic random sampling. Descriptive summary statistics were done. Logistic regression analyses were computed to identify associations between dependent and independent variables. Variables with a p-value < 0.05 were declared statistically significant. Result Out of 422 pregnant women, 61.6%...

The New England journal of medicine, Aug 24, 2017

Rheumatic heart disease remains an important preventable cause of cardiovascular death and disabi... more Rheumatic heart disease remains an important preventable cause of cardiovascular death and disability, particularly in low-income and middle-income countries. We estimated global, regional, and national trends in the prevalence of and mortality due to rheumatic heart disease as part of the 2015 Global Burden of Disease study. We systematically reviewed data on fatal and nonfatal rheumatic heart disease for the period from 1990 through 2015. Two Global Burden of Disease analytic tools, the Cause of Death Ensemble model and DisMod-MR 2.1, were used to produce estimates of mortality and prevalence, including estimates of uncertainty. We estimated that there were 319,400 (95% uncertainty interval, 297,300 to 337,300) deaths due to rheumatic heart disease in 2015. Global age-standardized mortality due to rheumatic heart disease decreased by 47.8% (95% uncertainty interval, 44.7 to 50.9) from 1990 to 2015, but large differences were observed across regions. In 2015, the highest age-standa...

IntroductionNeonatal sepsis is a serious blood bacterial infection in neonates at the age of equa... more IntroductionNeonatal sepsis is a serious blood bacterial infection in neonates at the age of equal to or less than 28 days of life, and it’s still the major significant cause of death and long-term morbidity in developing countries. Therefore, this study has assessed the prevalence and related factors with neonatal sepsis among new born admitted to the neonatal intensive care unit at Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia.MethodsAn institutional based retrospective cross-sectional study design was conducted among 386 neonates admitted to NICU from September 2017 to August 2019 G.C. A systematic random sampling method was used. Data was analyzed using SPSS V.26. Descriptive summary statistics was done. Bivariate analysis was computed to identify association between dependent and independent variables. Multivariate analysis was used to control possible confounder variables and variables with p-value <0.05 were declared as having statistically sign...

SAGE Open Medicine

Background: Adolescence is a transition period of advancement from a state of immature sexual cha... more Background: Adolescence is a transition period of advancement from a state of immature sexual characteristics to sexual and reproductive maturity; an improvement in the mental form progressing to the mental maturity of a grown-up adult; and a period of transition from total socioeconomic dependence to relative independence. An adolescent is defined as a person aged between 10 and 19 years. This study assessed the level and determinant factors of knowledge, attitude, and practice of risky sexual behavior among secondary school adolescents in Harar, Eastern Ethiopia, 2022. Methods: A school-based cross-sectional study design was employed. From the total population of adolescents, 387 respondents were sampled. A simple random sampling method was used to select study participants. The data was collected by using a self-administered questionnaire and analyzed using SPSS version 26. Result: Among the participants, 47.3% had good knowledge of risky sexual behavior. 41.9% had a positive att...

SAGE Open Medicine

Objective: The pandemic of coronavirus disease 2019 (COVID-19) is a major threat to community hea... more Objective: The pandemic of coronavirus disease 2019 (COVID-19) is a major threat to community health, and vaccinations are a safe and effective way to reduce disease loads around the world. This study aimed to assess the age and gender disparity in adverse effects following the first dose of the AstraZeneca COVID-19 vaccine among the vaccinated population in Eastern Ethiopia. Methods: A community-based cross-sectional study design was conducted among 832 randomly selected individuals from December 1st to 20th, 2021, in eastern Ethiopia. Data were collected by face-to-face interviews using a pretested structured questionnaire. Data were analyzed using the SPSS V26. Descriptive summary statistics were done. A chi-square test statistic was computed to assess the difference in adverse effects between age groups and both genders. Result: Out of 832 study participants who had taken the first dose of AstraZeneca vaccine, 96.3% of them felt at least one adverse effect. The magnitude of adve...

The Lancet Public Health

Background Globally, transport and unintentional injuries persist as leading preventable causes o... more Background Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10-24 years during the past three decades. Methods Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10-14, 15-19, and 20-24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31•1 million DALYs (of which 16•2 million [52%] were transport related) among adolescents aged 10-24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34•4% (from 17•5 to 11•5 per 100 000) for transport injuries, and by 47•7% (from 15•9 to 8•3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80•5% to 42 774 for transport injuries and by 39•4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010-19, the rate per 100 000 of transport injury DALYs was reduced by 16•7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48•5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0•2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010-19. Interpretation As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low-middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Funding Bill & Melinda Gates Foundation.

Health Services Research and Managerial Epidemiology

Background Vaccines are an effective and ideal solution that can reduce the burden of disease wor... more Background Vaccines are an effective and ideal solution that can reduce the burden of disease worldwide. Although vaccines are the most effective way to prevent infectious diseases. Anti-vaccine conspiracy theories impair vaccination acceptance intentions. Several studies were conducted in East Africa. However, these studies had reported inconsistent findings. Therefore, this systematic review aimed to pool the prevalence of COVID-19 vaccine acceptance and identify its determinants. Methods PubMed, Google Scholar, and GLOBAL HEALTH databases were used to retrieve previously published studies. All papers published in the English language up to February 28, 2022 were included. The result was written and reported according to the PRISMA updated guideline. A random-effect model was used to estimate the pooled prevalence and effect sizes. Heterogeneity was assessed using I2 test statistics. Publication bias was assessed using funnel plot and egger’s test statistics. Statistical tests res...

Rapid Antigen tests can help rapid detection, effective isolation of symptomatic cases, and syste... more Rapid Antigen tests can help rapid detection, effective isolation of symptomatic cases, and systematic tracing of close contacts. However, the reliability of rapid antigen tests must be validated before they can be used widely. A cross-sectional study was conducted among 236 COVID-19 suspected patients visiting four health institutions in Harari Regional state, Harar, Eastern Ethiopia from June-July, 2021. Two Nasopharyngeal samples were also collected and processed by the Panbio™ Ag-RDT kit directly and RT-PCR. Data were analyzed using SPSS version 25.0. The Panbio tests has sensitivity of 77.5% (95% CI: 61.6% − 89.2%), specificity of 98.5% (95% CI: 95.6%- 99.7%), Positive Predictive Value of 91.2% (95% CI : 76.9% − 96.9%), negative Predictive Value of 95.5%(95%CI: 92.3%-,97.4%) and Kappa = 0.81, (95% CI: 0.7–0.9.).The test has sensitivity of 94.4% ,100%, 100% and 90% in sample collected from patients with in the 1–5 days duration of COVID post on set symptoms, age group < = 18 ...

Women's Health, 2021

Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues t... more Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues to have countries with the highest maternal mortality rates. Family planning is one of the most effective techniques for lowering mother and child mortality, in addition to limiting rapid population expansion. Objective: The aim of this study was to assess level and determinants of long-acting family planning method among reproductive age women in Harar, Eastern Ethiopia, 2021 Method: Community-based cross-sectional study was conducted among 845 randomly selected reproductive age women. Data were collected by trained data collector using pretested structured questionnaire. Data were coded and entered into Epidata v.3 and analyzed using SPSS v.26 software. Descriptive statistics, bivariate and multivariate logistic regression analysis was used. Variable with p-value less than 0.05 was declared as statistically significant. Result: The prevalence of long-acting family planning method was 74...

Journal of Clinical Images & Reports

Background: COVID-19 is not well studied in Ethiopia, especially in the eastern parts of the coun... more Background: COVID-19 is not well studied in Ethiopia, especially in the eastern parts of the country. Determining the clinical profile and treatment outcome of COVID-19 cases will help to plan better prevention and treatment strategies considering the local context. So, this study attempted to investigate and describe the Clinical characteristics and outcomes among hospitalized COVID-19 patients. Methodology: Institutional based retrospective study design was used. The data extraction tool was prepared by using the COVID-19 log-book template and data was collected from 2091 COVID-19 confirmed patients using RT-PCR (real-time polymerase chain reaction) testing method who were admitted at three COVID-19 treatment centers from 21-May-2020 to 02-Aug-2021. Data was entered in Epi-data version 3.2 and analysis was done by SPSS version 25.0. Descriptive statistics proportions, percentages, ratios, frequency distributions, measures of central tendency, and dispersion were used. The result w...

BackgroundMenstruation is a visible manifestation of cyclic uterine bleeding as a result of the i... more BackgroundMenstruation is a visible manifestation of cyclic uterine bleeding as a result of the interaction of different hormones. During menstruation, girls face gender problems. These are, early marriage, premature childbirth, higher infant mortality and potential vaginal infections resulting in infertility.ObjectiveTo assess the level of menstrual hygiene practice and associated factors among high school female students in Harari Region Eastern, Ethiopia, 2019.Study Design and MethodA cross-sectional quantitative study was employed from April 02-05/2019. A minimum sample size of 301 Data was collected using a self-administered structured questionnaire. Descriptive and analytical facts were applied. Bivariate analysis and multivariate regression model were used. P-value <= 0.05 was declared as statistical significanceResultAccording to study 168(55.8%) had good practiced the rest had no. students who have no pocket money from family(AOR 0.36:95% CI,0.309,0.989) was 64% less lik...

Result In this study, 75.1%, 44.7%, and 52.8% of participants had a good knowledge, positive atti... more Result In this study, 75.1%, 44.7%, and 52.8% of participants had a good knowledge, positive attitude and good practice toward COVID-19 prevention, respectively. Occupation and educational status were found to have significant strong association with level of knowledge. Occupation, educational status, monthly income and family size were found to have significant strong association with level of attitude. Marital status, educational status and family size were found to have significant strong association with level of practice toward Covid-19 recommended prevention measures. Conclusion Overall, there is high level of knowledge and medium level of attitude and practice toward Covid-19 recommended prevention measures. Repeated tailored information using different media should be provided to the community regarding Covid-19 prevention methods. Existing Covid-19 prevention efforts should be strengthened and evaluated to improve community preventive practices.

SAGE Open Medicine, 2022

Objective: Coronavirus disease is a deadly virus that continues to afflict many countries worldwi... more Objective: Coronavirus disease is a deadly virus that continues to afflict many countries worldwide. Ethiopia has planned to give vaccines to 20% of the population by March 2022. This study aimed to assess determinants of vaccine uptake and barriers to being vaccinated among first-round eligibles for coronavirus disease vaccination in Harar, eastern Ethiopia. Methods: A community-based cross-sectional study design was conducted among 820 randomly selected coronavirus disease first-round eligible groups in Harar from August 20 to September 15, 2021. Descriptive summary statistics were done. Logistic regression analyses were computed to identify associations between dependent and independent variables. Variables with a p value of <0.05 were declared statistically significant. Result: Out of 820, only 39.4% of participants took the coronavirus disease vaccine. The main barriers to being vaccinated were, belief vaccine has no use (24%), and belief vaccine causes blood clots (17.9%). ...

Frontiers in Medicine, May 31, 2023

Clinical medicine insights. Pediatrics, 2024

Women's Health, 2021

Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues t... more Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues to have countries with the highest maternal mortality rates. Family planning is one of the most effective techniques for lowering mother and child mortality, in addition to limiting rapid population expansion. Objective: The aim of this study was to assess level and determinants of long-acting family planning method among reproductive age women in Harar, Eastern Ethiopia, 2021 Method: Community-based cross-sectional study was conducted among 845 randomly selected reproductive age women. Data were collected by trained data collector using pretested structured questionnaire. Data were coded and entered into Epidata v.3 and analyzed using SPSS v.26 software. Descriptive statistics, bivariate and multivariate logistic regression analysis was used. Variable with p-value less than 0.05 was declared as statistically significant. Result: The prevalence of long-acting family planning method was 74.7%, while 53.6% and 46.4% was from rural and urban, respectively. The mean age of participants was 28.5 (± 5.6) years. Married women four times (AOR: 4.1; 95% CI: 1.6, 10.4) more likely to use long-acting family planning method than single women. Women with educated husband four times (AOR: 4.4; 95% CI: 1.8, 10.6) more likely to use long-acting family planning method than women with illiterate husband. Conclusion: There is high level of utilization of long-acting family planning. The women’s marital status, increased education level of husbands, increasing in age of women, intention to spacing birth, and having less than five children were found to significantly increase the utilization of long-acting family planning.

The Lancet Haematology

Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are cr... more Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories. Methods We estimated population-level distributions of haemoglobin concentration by age and sex for each location from 1990 to 2021. We then calculated anaemia burden by severity and associated years lived with disability (YLDs). With data on prevalence of the causes of anaemia and associated cause-specific shifts in haemoglobin concentrations, we modelled the proportion of anaemia attributed to 37 underlying causes for all locations, years, and demographics in the Global Burden of Disease Study 2021. Findings In 2021, the global prevalence of anaemia across all ages was 24•3% (95% uncertainty interval [UI] 23•9-24•7), corresponding to 1•92 billion (1•89-1•95) prevalent cases, compared with a prevalence of 28•2% (27•8-28•5) and 1•50 billion (1•48-1•52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52•0 million (35•1-75•1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic Index. The most common causes of anaemia YLDs in 2021 were dietary iron deficiency (cause-specific anaemia YLD rate per 100 000 population: 422•4 [95% UI 286•1-612•9]), haemoglobinopathies and haemolytic anaemias (89•0 [58•2-123•7]), and other neglected tropical diseases (36•3 [24•4-52•8]), collectively accounting for 84•7% (84•1-85•2) of anaemia YLDs. Interpretation Anaemia remains a substantial global health challenge, with persistent disparities according to age, sex, and geography. Estimates of cause-specific anaemia burden can be used to design locally relevant health interventions aimed at improving anaemia management and prevention. Funding Bill &amp; Melinda Gates Foundation.

PLOS ONE

Background The novel coronavirus disease has emerged as the most pressing global health issue. In... more Background The novel coronavirus disease has emerged as the most pressing global health issue. In women with COVID-19 disease, pregnancy confers a substantial additional risk of morbidity and mortality. Objective This study aimed to assess WHO-recommended COVID-19 prevention practices and determinant factors among pregnant women attending antenatal care during the third wave of COVID-19 in eastern Ethiopia. Methods An Institutional-based cross-sectional study was conducted among 422 pregnant women attending antenatal care in Harar, from October 10 to November 10, 2021. The sample size was proportionally allocated to all healthcare facilities, then the study participants were selected using systematic random sampling. Descriptive summary statistics were done. Logistic regression analyses were computed to identify associations between dependent and independent variables. Variables with a p-value < 0.05 were declared statistically significant. Result Out of 422 pregnant women, 61.6%...

The New England journal of medicine, Aug 24, 2017

Rheumatic heart disease remains an important preventable cause of cardiovascular death and disabi... more Rheumatic heart disease remains an important preventable cause of cardiovascular death and disability, particularly in low-income and middle-income countries. We estimated global, regional, and national trends in the prevalence of and mortality due to rheumatic heart disease as part of the 2015 Global Burden of Disease study. We systematically reviewed data on fatal and nonfatal rheumatic heart disease for the period from 1990 through 2015. Two Global Burden of Disease analytic tools, the Cause of Death Ensemble model and DisMod-MR 2.1, were used to produce estimates of mortality and prevalence, including estimates of uncertainty. We estimated that there were 319,400 (95% uncertainty interval, 297,300 to 337,300) deaths due to rheumatic heart disease in 2015. Global age-standardized mortality due to rheumatic heart disease decreased by 47.8% (95% uncertainty interval, 44.7 to 50.9) from 1990 to 2015, but large differences were observed across regions. In 2015, the highest age-standa...

IntroductionNeonatal sepsis is a serious blood bacterial infection in neonates at the age of equa... more IntroductionNeonatal sepsis is a serious blood bacterial infection in neonates at the age of equal to or less than 28 days of life, and it’s still the major significant cause of death and long-term morbidity in developing countries. Therefore, this study has assessed the prevalence and related factors with neonatal sepsis among new born admitted to the neonatal intensive care unit at Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia.MethodsAn institutional based retrospective cross-sectional study design was conducted among 386 neonates admitted to NICU from September 2017 to August 2019 G.C. A systematic random sampling method was used. Data was analyzed using SPSS V.26. Descriptive summary statistics was done. Bivariate analysis was computed to identify association between dependent and independent variables. Multivariate analysis was used to control possible confounder variables and variables with p-value <0.05 were declared as having statistically sign...

SAGE Open Medicine

Background: Adolescence is a transition period of advancement from a state of immature sexual cha... more Background: Adolescence is a transition period of advancement from a state of immature sexual characteristics to sexual and reproductive maturity; an improvement in the mental form progressing to the mental maturity of a grown-up adult; and a period of transition from total socioeconomic dependence to relative independence. An adolescent is defined as a person aged between 10 and 19 years. This study assessed the level and determinant factors of knowledge, attitude, and practice of risky sexual behavior among secondary school adolescents in Harar, Eastern Ethiopia, 2022. Methods: A school-based cross-sectional study design was employed. From the total population of adolescents, 387 respondents were sampled. A simple random sampling method was used to select study participants. The data was collected by using a self-administered questionnaire and analyzed using SPSS version 26. Result: Among the participants, 47.3% had good knowledge of risky sexual behavior. 41.9% had a positive att...

SAGE Open Medicine

Objective: The pandemic of coronavirus disease 2019 (COVID-19) is a major threat to community hea... more Objective: The pandemic of coronavirus disease 2019 (COVID-19) is a major threat to community health, and vaccinations are a safe and effective way to reduce disease loads around the world. This study aimed to assess the age and gender disparity in adverse effects following the first dose of the AstraZeneca COVID-19 vaccine among the vaccinated population in Eastern Ethiopia. Methods: A community-based cross-sectional study design was conducted among 832 randomly selected individuals from December 1st to 20th, 2021, in eastern Ethiopia. Data were collected by face-to-face interviews using a pretested structured questionnaire. Data were analyzed using the SPSS V26. Descriptive summary statistics were done. A chi-square test statistic was computed to assess the difference in adverse effects between age groups and both genders. Result: Out of 832 study participants who had taken the first dose of AstraZeneca vaccine, 96.3% of them felt at least one adverse effect. The magnitude of adve...

The Lancet Public Health

Background Globally, transport and unintentional injuries persist as leading preventable causes o... more Background Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10-24 years during the past three decades. Methods Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10-14, 15-19, and 20-24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31•1 million DALYs (of which 16•2 million [52%] were transport related) among adolescents aged 10-24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34•4% (from 17•5 to 11•5 per 100 000) for transport injuries, and by 47•7% (from 15•9 to 8•3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80•5% to 42 774 for transport injuries and by 39•4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010-19, the rate per 100 000 of transport injury DALYs was reduced by 16•7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48•5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0•2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010-19. Interpretation As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low-middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Funding Bill & Melinda Gates Foundation.

Health Services Research and Managerial Epidemiology

Background Vaccines are an effective and ideal solution that can reduce the burden of disease wor... more Background Vaccines are an effective and ideal solution that can reduce the burden of disease worldwide. Although vaccines are the most effective way to prevent infectious diseases. Anti-vaccine conspiracy theories impair vaccination acceptance intentions. Several studies were conducted in East Africa. However, these studies had reported inconsistent findings. Therefore, this systematic review aimed to pool the prevalence of COVID-19 vaccine acceptance and identify its determinants. Methods PubMed, Google Scholar, and GLOBAL HEALTH databases were used to retrieve previously published studies. All papers published in the English language up to February 28, 2022 were included. The result was written and reported according to the PRISMA updated guideline. A random-effect model was used to estimate the pooled prevalence and effect sizes. Heterogeneity was assessed using I2 test statistics. Publication bias was assessed using funnel plot and egger’s test statistics. Statistical tests res...

Rapid Antigen tests can help rapid detection, effective isolation of symptomatic cases, and syste... more Rapid Antigen tests can help rapid detection, effective isolation of symptomatic cases, and systematic tracing of close contacts. However, the reliability of rapid antigen tests must be validated before they can be used widely. A cross-sectional study was conducted among 236 COVID-19 suspected patients visiting four health institutions in Harari Regional state, Harar, Eastern Ethiopia from June-July, 2021. Two Nasopharyngeal samples were also collected and processed by the Panbio™ Ag-RDT kit directly and RT-PCR. Data were analyzed using SPSS version 25.0. The Panbio tests has sensitivity of 77.5% (95% CI: 61.6% − 89.2%), specificity of 98.5% (95% CI: 95.6%- 99.7%), Positive Predictive Value of 91.2% (95% CI : 76.9% − 96.9%), negative Predictive Value of 95.5%(95%CI: 92.3%-,97.4%) and Kappa = 0.81, (95% CI: 0.7–0.9.).The test has sensitivity of 94.4% ,100%, 100% and 90% in sample collected from patients with in the 1–5 days duration of COVID post on set symptoms, age group < = 18 ...

Women's Health, 2021

Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues t... more Background: Ethiopia’s population is currently estimated to be 117,814,659 people and continues to have countries with the highest maternal mortality rates. Family planning is one of the most effective techniques for lowering mother and child mortality, in addition to limiting rapid population expansion. Objective: The aim of this study was to assess level and determinants of long-acting family planning method among reproductive age women in Harar, Eastern Ethiopia, 2021 Method: Community-based cross-sectional study was conducted among 845 randomly selected reproductive age women. Data were collected by trained data collector using pretested structured questionnaire. Data were coded and entered into Epidata v.3 and analyzed using SPSS v.26 software. Descriptive statistics, bivariate and multivariate logistic regression analysis was used. Variable with p-value less than 0.05 was declared as statistically significant. Result: The prevalence of long-acting family planning method was 74...

Journal of Clinical Images & Reports

Background: COVID-19 is not well studied in Ethiopia, especially in the eastern parts of the coun... more Background: COVID-19 is not well studied in Ethiopia, especially in the eastern parts of the country. Determining the clinical profile and treatment outcome of COVID-19 cases will help to plan better prevention and treatment strategies considering the local context. So, this study attempted to investigate and describe the Clinical characteristics and outcomes among hospitalized COVID-19 patients. Methodology: Institutional based retrospective study design was used. The data extraction tool was prepared by using the COVID-19 log-book template and data was collected from 2091 COVID-19 confirmed patients using RT-PCR (real-time polymerase chain reaction) testing method who were admitted at three COVID-19 treatment centers from 21-May-2020 to 02-Aug-2021. Data was entered in Epi-data version 3.2 and analysis was done by SPSS version 25.0. Descriptive statistics proportions, percentages, ratios, frequency distributions, measures of central tendency, and dispersion were used. The result w...

BackgroundMenstruation is a visible manifestation of cyclic uterine bleeding as a result of the i... more BackgroundMenstruation is a visible manifestation of cyclic uterine bleeding as a result of the interaction of different hormones. During menstruation, girls face gender problems. These are, early marriage, premature childbirth, higher infant mortality and potential vaginal infections resulting in infertility.ObjectiveTo assess the level of menstrual hygiene practice and associated factors among high school female students in Harari Region Eastern, Ethiopia, 2019.Study Design and MethodA cross-sectional quantitative study was employed from April 02-05/2019. A minimum sample size of 301 Data was collected using a self-administered structured questionnaire. Descriptive and analytical facts were applied. Bivariate analysis and multivariate regression model were used. P-value <= 0.05 was declared as statistical significanceResultAccording to study 168(55.8%) had good practiced the rest had no. students who have no pocket money from family(AOR 0.36:95% CI,0.309,0.989) was 64% less lik...

Result In this study, 75.1%, 44.7%, and 52.8% of participants had a good knowledge, positive atti... more Result In this study, 75.1%, 44.7%, and 52.8% of participants had a good knowledge, positive attitude and good practice toward COVID-19 prevention, respectively. Occupation and educational status were found to have significant strong association with level of knowledge. Occupation, educational status, monthly income and family size were found to have significant strong association with level of attitude. Marital status, educational status and family size were found to have significant strong association with level of practice toward Covid-19 recommended prevention measures. Conclusion Overall, there is high level of knowledge and medium level of attitude and practice toward Covid-19 recommended prevention measures. Repeated tailored information using different media should be provided to the community regarding Covid-19 prevention methods. Existing Covid-19 prevention efforts should be strengthened and evaluated to improve community preventive practices.

SAGE Open Medicine, 2022

Objective: Coronavirus disease is a deadly virus that continues to afflict many countries worldwi... more Objective: Coronavirus disease is a deadly virus that continues to afflict many countries worldwide. Ethiopia has planned to give vaccines to 20% of the population by March 2022. This study aimed to assess determinants of vaccine uptake and barriers to being vaccinated among first-round eligibles for coronavirus disease vaccination in Harar, eastern Ethiopia. Methods: A community-based cross-sectional study design was conducted among 820 randomly selected coronavirus disease first-round eligible groups in Harar from August 20 to September 15, 2021. Descriptive summary statistics were done. Logistic regression analyses were computed to identify associations between dependent and independent variables. Variables with a p value of <0.05 were declared statistically significant. Result: Out of 820, only 39.4% of participants took the coronavirus disease vaccine. The main barriers to being vaccinated were, belief vaccine has no use (24%), and belief vaccine causes blood clots (17.9%). ...