Asterios Gagalis - Academia.edu (original) (raw)
Papers by Asterios Gagalis
![Research paper thumbnail of [690] Expression of Hepatic Leptin Receptors in Patients with Nafld](https://attachments.academia-assets.com/115329435/thumbnails/1.jpg)
](Journal of Hepatology, Apr 1, 2007
Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a ... more Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a congenital abnormal portal anatomy. This syndrome is charactenzed by noncirrhotic portal hypertension, absence of intrahepatic portal venules or fibrosis on liver biopsy, and abnormal extrahepatic portal venous anatomy on imaging Severe pulmonary hypertension may also be associated with this syndrome
Annals of Gastroenterology, Apr 27, 2009
Hp eradication improves acid reflux and esophageal motility in patients with GrD and antral gastr... more Hp eradication improves acid reflux and esophageal motility in patients with GrD and antral gastritis xx xx x xx x
World Journal of Gastroenterology, 2015
AIM: To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship ... more AIM: To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship with esophageal cancer in Greece.
Annals of Gastroenterology, 2009
Introduction: The relationship between Ηelicobacter pylori (Hp) gastritis, the most common infect... more Introduction: The relationship between Ηelicobacter pylori (Hp) gastritis, the most common infection worldwide and Gastroesophageal Reflux Disease (GERD), a major health problem in Western Countries, remains controversial. AIM: To investigate the association between Hp infection and GERD and the impact of Hp eradication on esophageal acid exposure and esophageal motility in Hp-positive patients with GERD. Methods: Twenty seven Hp-positive (group I) and 20 Hp-negative (group II) patients with GERD underwent endoscopy- biopsy, esophageal manometry and 24-hour pH-metry. All group I patients received eradication treatment and six months later they were re-evaluated with 24-hour pHmetry, esophageal manometry and endoscopy-biopsy. Results: There were no significant differences between the two groups regarding sex, age, grade of esophagitis, manometric and pH-metry findings. All Hp-positive patients had antrum predominant gastritis. In all group I patients’ eradication of Hp was successful...
Case Reports in Gastroenterology, 2021
Herpes esophagitis (HE) is a rare condition in immunocompetent adolescents. However, it commonly ... more Herpes esophagitis (HE) is a rare condition in immunocompetent adolescents. However, it commonly occurs as a primary infection in younger individuals. Herein, we report a 16-year-old female patient who had a history of fever for 5 days, odynophagia, and orolabial herpes infection for 7 days. Clusters of painful vesicles on an erythematous base on the lips, gingiva, and palate were observed on physical examination. Further, esophagogastroduodenoscopy revealed diffuse linear ulcerations in the distal esophagus. The patient then received the following treatment: intravenous (I.V.) acyclovir 5 mg/kg three times a day, I.V. omeprazole 40 mg two times a day, and acyclovir 5% cream four times a day. After 8 days of admission, the patient was discharged. A follow-up esophagogastroduodenoscopy was performed 7 weeks after discharge, and the results revealed that the esophageal mucosa had a normal appearance. The effect of antiviral treatment against HE remains unknown in these patients. Never...
Journal of Hepatology, 2015
Crizotinib was the first clinically available inhibitor of the tyrosine kinase ALK, and next-gene... more Crizotinib was the first clinically available inhibitor of the tyrosine kinase ALK, and next-generation ALK inhibitors, such as alectinib, are now under development. Although crizotinib is generally well tolerated, severe esophageal injury has been reported as a rare but serious adverse event of crizotinib therapy. We now describe the successful treatment with alectinib of a patient who developed crizotinib-induced esophageal ulceration.
Gastrointestinal Endoscopy, 2006
![Research paper thumbnail of [690] Expression of Hepatic Leptin Receptors in Patients with Nafld](https://attachments.academia-assets.com/115329411/thumbnails/1.jpg)
](Journal of Hepatology, 2007
Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a ... more Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a congenital abnormal portal anatomy. This syndrome is charactenzed by noncirrhotic portal hypertension, absence of intrahepatic portal venules or fibrosis on liver biopsy, and abnormal extrahepatic portal venous anatomy on imaging Severe pulmonary hypertension may also be associated with this syndrome
Data Revues 22107401 Unassign S2210740114000114, Feb 10, 2014
Diabetes research and clinical practice, Jan 9, 2016
Diabetes mellitus type 2 (DMT2) and non-alcoholic fatty liver disease (NAFLD) are both characteri... more Diabetes mellitus type 2 (DMT2) and non-alcoholic fatty liver disease (NAFLD) are both characterized by decreased circulating adiponectin. Recently, glucagon-like peptide-1 receptor agonists have been shown to induce adiponectin's expression. However, their interaction on clinical grounds needs to be further elucidated. DMT2 patients with abnormal aminotransferases were screened for NAFLD and subjected to liver biopsy (group A, n=17). A subgroup of patients (n=110), after assessed for eligibility criteria, was blindly randomized to receive either 6-month exenatide supplementation on glargine insulin (group B) or intense, self-regulated, insulin therapy alone (group C). Baseline patient characteristics: 49(38.6%) males, aged 63.1±7.5 years-old, BMI 32.9±4.9kg/m(2), HbA1c 8.1±1.2% (65±14mmol/mol), median ALT 23U/L (range 5-126), AST 20U/L (7-72). Group A had biopsy-proven NAFLD with a median Activity Score of 5 and fibrosis stage 3. Presence of NAFLD was accompanied by a significa...
World journal of gastroenterology : WJG, Jan 28, 2015
To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship with ... more To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship with esophageal cancer in Greece. Forty-nine patients underwent esophagogastroduodenoscopy (EGD) and esophageal biopsy at a university hospital that acts as a referral center for Northern Greece. Nineteen of these patients (14 male and 5 female) had esophageal squamous cell carcinoma (ESCC) and 30 (15 male and 15 female) did not have any reported esophageal malignancy. Histopathological assessment was followed by polymerase chain reaction analysis of all the samples. Patient demographic data (age, sex, and place of birth) and information regarding smoking habits, alcohol consumption or sexual habits were collected. A method of statistical interference, verification of hypotheses based on homogeneity and independent χ(2) test, was used. From the 49 patients that underwent EGD and biopsy, 19 had ESCC and 30 had normal esophageal mucosa, with a mean age of 65.2 years. Regarding the prevalence of...
Atherosclerosis Supplements, 2010
Atherosclerosis Supplements, 2010
Atherosclerosis Supplements, 2010
Journal of Interdisciplinary Histopathology, 2014
Clinics and Research in Hepatology and Gastroenterology, 2014
Pathology International, 2010
Possible correlations among clinical data, serum aminotransferase levels and histological feature... more Possible correlations among clinical data, serum aminotransferase levels and histological features were assessed in a series of 37 adult patients with non-alcoholic fatty liver disease (NAFLD), consisting of nine patients with fatty liver (FL) and 28 with non-alcoholic steatohepatitis (NASH). In each liver biopsy, the NAFLD activity score (NAS) and the stage of fibrosis were determined. Additionally, the number of Kupffer cell aggregates (microgranulomas) per centimeter of biopsy length (MG/cm ratio) was assessed on immunohistochemical stains for CD68 antigen. Definite NASH (NAS >or= 5) was strongly correlated with serum aspartate aminotransferase (AST) level (P= 0.003), stage of fibrosis (P= 0.003) and age (P= 0.014). On multivariate analysis, age >46 years and AST level above normal values were found to be independent clinical predictors of established NASH. The MG/cm ratio increased from control liver to FL to NASH (P < 0.001), and was correlated with the NAS (P= 0.003) and with the stage of fibrosis (P= 0.004), but not with the serum aminotransferase levels. In conclusion, persistent AST elevation in patients with suspected NAFLD should be an indication for liver biopsy, in order to determine the severity of necroinflammatory activity and the stage of fibrosis. Microgranuloma counting may represent a useful complementary marker of necroinflammatory activity in patients with NAFLD.
Journal of Clinical Gastroenterology, 2006
Gastrointestinal Endoscopy, 2006
Journal of Hepatology, Apr 1, 2007
Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a ... more Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a congenital abnormal portal anatomy. This syndrome is charactenzed by noncirrhotic portal hypertension, absence of intrahepatic portal venules or fibrosis on liver biopsy, and abnormal extrahepatic portal venous anatomy on imaging Severe pulmonary hypertension may also be associated with this syndrome
Annals of Gastroenterology, Apr 27, 2009
Hp eradication improves acid reflux and esophageal motility in patients with GrD and antral gastr... more Hp eradication improves acid reflux and esophageal motility in patients with GrD and antral gastritis xx xx x xx x
World Journal of Gastroenterology, 2015
AIM: To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship ... more AIM: To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship with esophageal cancer in Greece.
Annals of Gastroenterology, 2009
Introduction: The relationship between Ηelicobacter pylori (Hp) gastritis, the most common infect... more Introduction: The relationship between Ηelicobacter pylori (Hp) gastritis, the most common infection worldwide and Gastroesophageal Reflux Disease (GERD), a major health problem in Western Countries, remains controversial. AIM: To investigate the association between Hp infection and GERD and the impact of Hp eradication on esophageal acid exposure and esophageal motility in Hp-positive patients with GERD. Methods: Twenty seven Hp-positive (group I) and 20 Hp-negative (group II) patients with GERD underwent endoscopy- biopsy, esophageal manometry and 24-hour pH-metry. All group I patients received eradication treatment and six months later they were re-evaluated with 24-hour pHmetry, esophageal manometry and endoscopy-biopsy. Results: There were no significant differences between the two groups regarding sex, age, grade of esophagitis, manometric and pH-metry findings. All Hp-positive patients had antrum predominant gastritis. In all group I patients’ eradication of Hp was successful...
Case Reports in Gastroenterology, 2021
Herpes esophagitis (HE) is a rare condition in immunocompetent adolescents. However, it commonly ... more Herpes esophagitis (HE) is a rare condition in immunocompetent adolescents. However, it commonly occurs as a primary infection in younger individuals. Herein, we report a 16-year-old female patient who had a history of fever for 5 days, odynophagia, and orolabial herpes infection for 7 days. Clusters of painful vesicles on an erythematous base on the lips, gingiva, and palate were observed on physical examination. Further, esophagogastroduodenoscopy revealed diffuse linear ulcerations in the distal esophagus. The patient then received the following treatment: intravenous (I.V.) acyclovir 5 mg/kg three times a day, I.V. omeprazole 40 mg two times a day, and acyclovir 5% cream four times a day. After 8 days of admission, the patient was discharged. A follow-up esophagogastroduodenoscopy was performed 7 weeks after discharge, and the results revealed that the esophageal mucosa had a normal appearance. The effect of antiviral treatment against HE remains unknown in these patients. Never...
Journal of Hepatology, 2015
Crizotinib was the first clinically available inhibitor of the tyrosine kinase ALK, and next-gene... more Crizotinib was the first clinically available inhibitor of the tyrosine kinase ALK, and next-generation ALK inhibitors, such as alectinib, are now under development. Although crizotinib is generally well tolerated, severe esophageal injury has been reported as a rare but serious adverse event of crizotinib therapy. We now describe the successful treatment with alectinib of a patient who developed crizotinib-induced esophageal ulceration.
Gastrointestinal Endoscopy, 2006
Journal of Hepatology, 2007
Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a ... more Conclusion: We describe a new familial syndrome of noncirrhotic portal hypertension related to a congenital abnormal portal anatomy. This syndrome is charactenzed by noncirrhotic portal hypertension, absence of intrahepatic portal venules or fibrosis on liver biopsy, and abnormal extrahepatic portal venous anatomy on imaging Severe pulmonary hypertension may also be associated with this syndrome
Data Revues 22107401 Unassign S2210740114000114, Feb 10, 2014
Diabetes research and clinical practice, Jan 9, 2016
Diabetes mellitus type 2 (DMT2) and non-alcoholic fatty liver disease (NAFLD) are both characteri... more Diabetes mellitus type 2 (DMT2) and non-alcoholic fatty liver disease (NAFLD) are both characterized by decreased circulating adiponectin. Recently, glucagon-like peptide-1 receptor agonists have been shown to induce adiponectin's expression. However, their interaction on clinical grounds needs to be further elucidated. DMT2 patients with abnormal aminotransferases were screened for NAFLD and subjected to liver biopsy (group A, n=17). A subgroup of patients (n=110), after assessed for eligibility criteria, was blindly randomized to receive either 6-month exenatide supplementation on glargine insulin (group B) or intense, self-regulated, insulin therapy alone (group C). Baseline patient characteristics: 49(38.6%) males, aged 63.1±7.5 years-old, BMI 32.9±4.9kg/m(2), HbA1c 8.1±1.2% (65±14mmol/mol), median ALT 23U/L (range 5-126), AST 20U/L (7-72). Group A had biopsy-proven NAFLD with a median Activity Score of 5 and fibrosis stage 3. Presence of NAFLD was accompanied by a significa...
World journal of gastroenterology : WJG, Jan 28, 2015
To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship with ... more To detect human papillomavirus (HPV) in the esophageal mucosa and the possible relationship with esophageal cancer in Greece. Forty-nine patients underwent esophagogastroduodenoscopy (EGD) and esophageal biopsy at a university hospital that acts as a referral center for Northern Greece. Nineteen of these patients (14 male and 5 female) had esophageal squamous cell carcinoma (ESCC) and 30 (15 male and 15 female) did not have any reported esophageal malignancy. Histopathological assessment was followed by polymerase chain reaction analysis of all the samples. Patient demographic data (age, sex, and place of birth) and information regarding smoking habits, alcohol consumption or sexual habits were collected. A method of statistical interference, verification of hypotheses based on homogeneity and independent χ(2) test, was used. From the 49 patients that underwent EGD and biopsy, 19 had ESCC and 30 had normal esophageal mucosa, with a mean age of 65.2 years. Regarding the prevalence of...
Atherosclerosis Supplements, 2010
Atherosclerosis Supplements, 2010
Atherosclerosis Supplements, 2010
Journal of Interdisciplinary Histopathology, 2014
Clinics and Research in Hepatology and Gastroenterology, 2014
Pathology International, 2010
Possible correlations among clinical data, serum aminotransferase levels and histological feature... more Possible correlations among clinical data, serum aminotransferase levels and histological features were assessed in a series of 37 adult patients with non-alcoholic fatty liver disease (NAFLD), consisting of nine patients with fatty liver (FL) and 28 with non-alcoholic steatohepatitis (NASH). In each liver biopsy, the NAFLD activity score (NAS) and the stage of fibrosis were determined. Additionally, the number of Kupffer cell aggregates (microgranulomas) per centimeter of biopsy length (MG/cm ratio) was assessed on immunohistochemical stains for CD68 antigen. Definite NASH (NAS >or= 5) was strongly correlated with serum aspartate aminotransferase (AST) level (P= 0.003), stage of fibrosis (P= 0.003) and age (P= 0.014). On multivariate analysis, age >46 years and AST level above normal values were found to be independent clinical predictors of established NASH. The MG/cm ratio increased from control liver to FL to NASH (P < 0.001), and was correlated with the NAS (P= 0.003) and with the stage of fibrosis (P= 0.004), but not with the serum aminotransferase levels. In conclusion, persistent AST elevation in patients with suspected NAFLD should be an indication for liver biopsy, in order to determine the severity of necroinflammatory activity and the stage of fibrosis. Microgranuloma counting may represent a useful complementary marker of necroinflammatory activity in patients with NAFLD.
Journal of Clinical Gastroenterology, 2006
Gastrointestinal Endoscopy, 2006