Athanasia Varvaresou - Academia.edu (original) (raw)

Papers by Athanasia Varvaresou

Anticancer Research

A new series of imidazothioxanthones has recently been synthesized as potential anticancer agents... more A new series of imidazothioxanthones has recently been synthesized as potential anticancer agents with the aim of overcoming drug resistance. The route of synthesis and DNA-binding properties of the compounds were reported previously. This paper describes the general structure-activity relationships for the class of imidazothioxanthones in panels of human and murine tumor cell lines in vitro, and the in vivo activity against human and murine solid tumors of the most potent compound, N-[3-(Dimethylamino)propylo]-11-oxo-11H-benzothiopyrano [3',2':2,3]pyrido[1,2-a]imidazo-2-carboxamide (10a). In addition, the interaction between compound 10a and DNA is also considered in terms of molecular mechanics methods and flexible docking techniques. The cytotoxicity of compounds 10a, 11-oxo-N-[2-(pyrrolidino)ethylo]-11H-benzothiopyrano [3',2':2,3]pyrido[1,2-a]imidazo-2-carboxamide, 11-oxo-N-[2-(piperidino)ethylo]-11H-benzothiopyrano [3',2':2,3]pyrido[1,2-a]imidazo-2-carbo...

Aluminium salts, such as aluminium chlorohydrate that has been introduced in the market since 194... more Aluminium salts, such as aluminium chlorohydrate that has been introduced in the market since 1947, are the active ingre-dients of antiperspirant in underarm and bodycare cosmetics applied to the underarm and breast area [1]. The effects of

Separations

Bioactive peptides are gaining more and more popularity in the research and development of cosmet... more Bioactive peptides are gaining more and more popularity in the research and development of cosmetic products with anti-aging effect. Acetyl hexapeptide-8 is a hydrophilic peptide incorporated in cosmetics to reduce the under-eye wrinkles and the forehead furrows. Hydrophilic interaction liquid chromatography (HILIC) is the separation technique of choice for analyzing peptides. In this work, a rapid HILIC method coupled to photodiode array detection operated at 214 nm was developed, validated and used to determine acetyl-hexapeptide-8 in cosmetics. Chromatography was performed on a Xbridge® HILIC BEH analytical column using as mobile phase a 40 mM ammonium formate water solution (pH 6.5)-acetonitrile mixture 30:70, v/v at flow rate 0.25 mL min−1. The assay was linear over the concentration range 20 to 30 μg mL−1 for the cosmetic formulations and 0.004 to 0.007% (w/w) for the cosmetic cream. The limits of quantitation for acetyl hexapeptide-8 were 1.5 μg mL−1 and 0.002% (w/w) for the ...

Cosmetics

Skin care formulations have evolved as the interaction of health and beauty products for the skin... more Skin care formulations have evolved as the interaction of health and beauty products for the skin. Their benefits are based on the combination of cosmetic active ingredients and targeted application. Cosmetic actives have been used in novel formulations for decades (sunscreens, anti-aging treatments, etc.), but the problems with their low solubility, low penetration, and physicochemical instability when applied to the skin have yet to be solved. One way to circumvent these shortcomings is to use lipid carriers, which are known to play an important role in the solubility of poorly soluble compounds by facilitating skin permeation and improving stability. This review addresses recent advances in skin care products that use novel nanotechnology-based lipid systems (liposomes, solid lipid nanoparticles, etc.) to deliver moisturizing cosmetic actives and improve product efficacy.

Marine Pollution Bulletin

International Journal of Cosmetic Science

According to Cosmetics Europe-The Personal Care Association, 450 million of Europeans daily use a... more According to Cosmetics Europe-The Personal Care Association, 450 million of Europeans daily use a variety of cosmetic products, such as soap, shampoo, hair conditioner, toothpaste, deodorant, shaving cream, skin care, perfume, and make-up [1]. A great part of the environmental impact of cosmetic products ranged from unsustainable sourcing of raw materials, pollution both in the manufacturing stage and disposal of packaging and products [2]. Companies in response to the increasing eco-consumerism are trying to incorporate in cosmetic formulations agents of natural origin and improve the use of sustainable raw materials/ingredients. Cosmetic application could be a solution to reuse by-products discarded by several agro industries. These ingredients especially when raw materials used are classified as natural or possibly obtained from the waste and by-products are concerned to be in general not harmful, not expensive, biodegradable or at least compostable under Accepted Article This article is protected by copyright. All rights reserved. specific environmental conditions, biocompatible and suitable to be used in a wide range of topical preparations. Every year about 300 billion tons of industrial and agricultural waste are generated, deriving from processing of plant raw materials into intermediates or final products [3]. There are cases that the waste materials can cause problems when discarded [4]. The recycling and reuse of waste using green technologies will reduce water consumption, greenhouse gas emissions and worldwide pollution without impoverishing of the environment with precious and fundamental materials whilst saving the biodiversity of the Earth [5]. Effort has been given in recent years for the application of methodologies for the development of formulations with low grey water footprint adapted for eco-design (GWFE) [6]. It is necessary to be underlined that the safety assessment is the key issue for the incorporation of ingredients of non conventional natural origin in cosmetic products. Adverse dermal effects of natural ingredients include irritation, sensitization, phototoxicity and immediate-type allergy, showing that being natural is not equivalent to being safe. Even further, in the case of compounds coming from renewable sources a variety of approaches for quality and safety standards are needed. Consumer safety should be the first objective of these ingredients. The guidelines used for cosmetics can be employed to test the safety of these ingredients according to the Scientific Committee on Consumer Safety (SCCS), as well [7]. Changes in legislation, specifically in the European Union, have encouraged the creation of in vitro tests so as to evaluate the safety of cosmetic ingredients, since the use of animal tests was prohibited in Europe in 2004 for cosmetics and in 2009 for cosmetic ingredients [8].

Journal of Cosmetic Dermatology, 2017

Bioactive peptides have beneficial effects on the skin. We investigated to evaluate the effect of... more Bioactive peptides have beneficial effects on the skin. We investigated to evaluate the effect of acetyl hexapeptide-3 and tripeptide-10 citrulline and the possible synergism between these two peptides. Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days. Skin properties evaluated included skin microtopography, parameters cR2 and cR3, and transepidermal water loss (TEWL) using a skin visioscan and a tewameter, respectively. After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044), G2 and G3 groups (cR2 P=.017, cR3 P=.017), G3 and G4 groups (CR2 P=.022), and G2 and G4 groups (cR3 P=.028) from baseline were significant. After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant. After 20 days, changes in TEWL between groups G1 and G3 (P=.03), groups G2 and G3 (P=.045), and groups G3 and G4 (P=.025) were significant. After 40 days, changes between groups G2 and G3 (P=.028) and groups G3 and G4 (P=.01) from baseline were significant. Our results confirm the antiwrinkle activity of acetyl hexapeptide-3. A significant decrease in TEWL with acetyl hexapeptide-3 treatment is observed. We provided clinical evidence for the antiwrinkle efficacy of tripeptide-10 citrulline and possibly TEWL. The underlying mechanism by which these two peptides can act synergistically was not clear in this study.

Journal of Pharmacy and Pharmacology, 2002

Journal of Pharmacy and Pharmacology

Epitheorese Klinikes Farmakologias kai Farmakokinetikes

Review of Clinical Pharmacology and Pharmacokinetics, International Edition

Among the retinoids, which are important in modern therapy for dermatological treatment of wrinkl... more Among the retinoids, which are important in modern therapy for dermatological treatment of wrinkled skin, retinol and retinyl palmitate are regarded desirable because of their lower irritating activity compared to retinoic acid. Since retinol is unstable in cosmetic preparations, retinyl palmitate and liposomal retinol are used to a great extent in modern cosmetology. The chemical nature of retinoids, consisting of polyunsaturated polar lipids, makes them able to interact with oxygen and UV or visible light to produce reactive oxygen species and free radicals. The great interest in evaluating the stability of retinyl palmitate and liposomal retinol under UV irradiation is due to the loss of potency and enhancement of toxicity of their degradation products. This study aims to evaluate the stability of O/W formulated retinol in the liposomal or palmitate ester form under long term UV irradiation and moreover to investigate, the protection that aluminum lacquered containers could offer...

Pharmaceutical Chemistry Journal

Molecular Modeling and Prediction of Bioactivity, 2000

The accumulation of several heteroatoms in hybrid molecules may affect the safe prediction of lip... more The accumulation of several heteroatoms in hybrid molecules may affect the safe prediction of lipophilicity, while such compounds may differentiate in their hydrogen bonding capability, also important in the manifestation of drug action. The title compounds, which belong to the general types 1,2,3,4 (Figure 1) have shown CNS and antimicrobial activities.1,2 In this study their lipophilicity was investigated and compared to the values obtained by different calculative procedures. Their hydrogen bonding capability was also assessed through the ΔlogP approach.3

Quantitative Structure-Activity Relationships, 1999

Letters in Applied Microbiology, 2015

Biosurfactants are surface‐active biomolecules that are produced by various micro‐organisms. They... more Biosurfactants are surface‐active biomolecules that are produced by various micro‐organisms. They show unique properties i.e. lower toxicity, higher biodegradability and environmental compatibility compared to their chemical counterparts. Glycolipids and lipopeptides have prompted application in biotechnology and cosmetics due to their multi‐functional profile i.e. detergency, emulsifying, foaming and skin hydrating properties. Additionally, some of them can be served as antimicrobials. In this study the current status of research and development on rhamnolipids, sophorolipids, mannosyloerythritol lipids, trehalipids, xylolipids and lipopeptides particularly their commercial application in cosmetics and biopharmaceuticals, is described.

Anticancer research

ChemInform, 1997

ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.