Atif Malik - Academia.edu (original) (raw)
Papers by Atif Malik
Journal of Perioperative Practice, 2014
Pre-existing cardiac disease contributes significantly to morbidity and mortality amongst patient... more Pre-existing cardiac disease contributes significantly to morbidity and mortality amongst patients undergoing non cardiac surgery. Patients with pre-existing cardiac disease or with risk factors for it, have as much as a 3.9% risk of suffering a major perioperative cardiac event (Lee et al 1999, Devereaux 2005). Furthermore, the incidence of perioperative myocardial infarction (MI) is increased 10 to 50 fold in patients with previous coronary events (Jassal 2008).
The Open Orthopaedics Journal, 2017
Background: Whiplash has been suggested to cause chronic symptoms and long term disability. This ... more Background: Whiplash has been suggested to cause chronic symptoms and long term disability. This study was designed to assess long term function after whiplash injury. Material & Methods: A random sample of patients in the outpatient clinic was interviewed, questionnaire completed and clinical examination performed. Assessment was made of passive cervical range of movement and Visual Analogue Scale pain scores. One hundred and sixty-four patients were divided into four different groups including patients with no whiplash injury but long-standing neck pain (Group A), previous symptomatic whiplash injury and long-standing neck pain (Group B), previous symptomatic whiplash injury and no neck symptoms (Group C), and a control group of patients with no history of whiplash injury or neck symptoms (Group D). Results: Data was analyzed by performing an Independent samples t-test and ANOVA, with level of significance taken as p<0.05. Comparing the four groups using a one-way ANOVA showed ...
Current Rheumatology Reviews, 2015
Rheumatoid arthritis affects around 1% of the global population with a predilection for Western s... more Rheumatoid arthritis affects around 1% of the global population with a predilection for Western societies. The treatment of the rheumatoid hip has gone through significant changes in recent years. Although osteotomies and synovectomies were previously commonplace, advances in arthroplasty technique and technology has seen these former procedures being performed less commonly. This article tackles some of the key issues with regard to the rheumatoid hip, namely the increased risk and methods of dealing with protrusio acetabuli, the risk of dislocation, infection and rates of aseptic loosening.
Shoulder & Elbow, 2014
Background Nerve injury is an acknowledged complication of total shoulder arthroplasty (TSA). Alt... more Background Nerve injury is an acknowledged complication of total shoulder arthroplasty (TSA). Although the incidence of postoperative neurological deficit has been reported to be between 1% and 16%, the true incidence of nerve damage is considered to be higher. The present study aimed to identify the rate of intraoperative nerve injury during total shoulder arthroplasty and to determine potential risk factors. Methods A prospective study of nerve conduction in 21 patients who underwent primary or revision TSA was carried out over a 12-month period. Nerve conduction was monitored by measuring intraoperative sensory evoked potentials (SEP). A significant neurophysiological signal change was defined as either a unilateral or bilateral decrease in SEP signal of ≥50%, a latency increase of ≥10% or a change in waveform morphology, not caused by operative or anaesthetic technique. Results Seven (33%) patients had a SEP signal change. The only significant risk factor identified for signal c...
Current Stem Cell Research & Therapy, 2014
Current Stem Cell Research & Therapy, 2013
Spinal pathologies are a major burden on society and individuals. Recent years have seen a large ... more Spinal pathologies are a major burden on society and individuals. Recent years have seen a large number of studies dedicated to the use of stem cells in spinal surgery. This review focuses on recent advances and controversies regarding the applications of stem cells in spinal fusion surgery, spinal cord injury and intervertebral disc degeneration. There are significant concerns regarding the ethics and risks of stem cell use. Animal models do not always accurately depict the human condition. While a great deal has been achieved, successful translation into clinical practice is needed. However there is no doubt that stem cells have a major role to play in the future management of spinal conditions.
Journal of perioperative practice, 2009
The fractured neck of femur is the classically described fracture in osteoporotic elderly patient... more The fractured neck of femur is the classically described fracture in osteoporotic elderly patients. Further, the fracture has a strong predominance in post-menopausal women and, although relatively uncommon in both children and young adults, where present in this age group it is usually the result of significant trauma. In elderly patients, with an already weakened bone, even minimal trauma may be sufficient to cause fracture and as such a fractured neck of femur is often referred to as a fragility fracture.
Journal of perioperative practice, 2010
Members can search all issues of the BJPN/JPP published since 1998 and download articles free of ... more Members can search all issues of the BJPN/JPP published since 1998 and download articles free of charge at www.afpp.org.uk. Access is also available to non-members who pay a small fee for each article download.
Journal of perioperative practice, 2012
Respiratory disease contributes significantly to the perioperative challenges of surgery. Preexis... more Respiratory disease contributes significantly to the perioperative challenges of surgery. Preexisting pulmonary co-morbidities and respiratory complications can have profound effects on patient outcomes. Knowledge of these conditions and the potentially deleterious effects of anaesthesia and surgery can enable clinicians to optimise lung function, reduce complications and improve results.
The Open Orthopaedics Journal, 2014
Soft tissue injuries include a wide and heterogeneous range of injuries. In this issue we cover a... more Soft tissue injuries include a wide and heterogeneous range of injuries. In this issue we cover a range of these topics including negative pressure wound therapy and the evidence-based principles behind its use, multiligamentous knee injuries, knee dislocations, compartment syndrome, and nerve injuries and principles of repair. There are a number of papers on bite injuries ranging from a literature review, their microbiology and virology, and mammalian bites. We also include a research paper on the management of knee osteochondritis dissecans. No issue on soft tissues in an orthopaedic journal would be completed without a review on fractures, and that too is included.
![Research paper thumbnail of Editorial [Stem Cell Applications and Tissue Engineering Approaches in Orthopaedic Surgery and Musculoskeletal Medicine (Guest Editor: Wasim S. Khan)]](https://attachments.academia-assets.com/110142237/thumbnails/1.jpg)
](Current Stem Cell Research & Therapy, 2012
Musculoskeletal tissue is frequently damaged or lost in injury and disease. Orthopaedic surgery h... more Musculoskeletal tissue is frequently damaged or lost in injury and disease. Orthopaedic surgery has been highly successful in repairing, realigning and replacing damaged musculoskeletal structures. The coming years will establish whether a paradigm shift from fixation towards regeneration of tissue is possible, clinically feasible and financially viable. There has been an increasing interest in stem cell applications and tissue engineering approaches in surgical practice to deal with damaged or lost tissue [1-3]. Tissue engineering is an exciting strategy being explored to deal with damaged or lost tissue. It is the science of generating tissue using molecular and cellular techniques, combined with material engineering principles, to replace tissue. This could be in the form of cells with or without matrices. Although there have been developments in almost all surgical disciplines [1], the greatest advances are being made in orthopaedics, especially in bone repair [3]. This is due to many factors including the familiarity with bone marrow derived mesenchymal stem cells and bone grafting. STEM CELLS Stem cells are a self-renewing, slow-cycling cell population that exhibits a high proliferation potential and the ability to undergo multilineage differentiation. They can be isolated from tissues of individuals of various ages and maintain capacity for multilineage differentiation. Protocols for the culture [4] and, chondrogenic, osteogenic and adipogenic differentiation of bone marrow derived mesenchymal stem cells have been described [5, 6]. The rationale behind these protocols is discussed in this issue as well as highlighting the different regulators which determine the lineage a particular mesenchymal stem cell will differentiate into. By the end of last century, there was considerable interest in the use of mesenchymal stem cells for clinical tissue engineering applications. Unlike embryonic stem cells, the use of autologous postnatal mesenchymal stem cells is generally well accepted by society. Mesenchymal stem cells are less tumourogenic than their embryonic counterparts [7] and provide an autologous source of cells eliminating concerns regarding rejection and disease transmission. Cells with mesenchymal stem cell characteristics have been isolated from many different adult tissues including bone marrow, liver, dental pulp, periosteum, skin, retina, adipose tissue, skeletal muscle, synovial tissue, the infrapatellar fat pad, and more recently, cartilage [8-14].
Current Stem Cell Research & Therapy, 2013
Cartilage disorders and injuries range from acute injuries to chronic, debilitating diseases and ... more Cartilage disorders and injuries range from acute injuries to chronic, debilitating diseases and significantly affect an individual's well-being. This results in a significant disease burden on society as a whole. In recent years there has been great interest in the cell-based treatment strategies and the potential of stem cell-based treatment options for the repair of cartilage. Being an avascular, aneural and alymphatic tissue, it is well suited to stem cell and tissue engineering applications. In this issue, we look at stem cells from various sources and discuss their isolation, proliferation and differentiation. We also consider the associated use of bioreactors, biomaterials, scaffolds and growth factors. We cover the use of stem cell applications for cartilage, and discuss the basic sciences, pre-clinical and clinical studies in the field.
Archives of Physical Medicine and Rehabilitation, 2003
Objective: To investigate whether gabitril (Tiagabine) is effective in the prophylaxis of chronic... more Objective: To investigate whether gabitril (Tiagabine) is effective in the prophylaxis of chronic daily headaches and migraine headaches. Design: Retrospective chart review analyzing the reports of headache before and after the administration of Tiagabine. Setting: Outpatient pain clinic. Participants: 5 patients with chronic daily headache with migrainous features. Intervention: Patients were treated with an initial dose of Tiagabine at 2mg/d
Journal of Perioperative Practice, 2014
Pre-existing cardiac disease contributes significantly to morbidity and mortality amongst patient... more Pre-existing cardiac disease contributes significantly to morbidity and mortality amongst patients undergoing non cardiac surgery. Patients with pre-existing cardiac disease or with risk factors for it, have as much as a 3.9% risk of suffering a major perioperative cardiac event (Lee et al 1999, Devereaux 2005). Furthermore, the incidence of perioperative myocardial infarction (MI) is increased 10 to 50 fold in patients with previous coronary events (Jassal 2008).
The Open Orthopaedics Journal, 2017
Background: Whiplash has been suggested to cause chronic symptoms and long term disability. This ... more Background: Whiplash has been suggested to cause chronic symptoms and long term disability. This study was designed to assess long term function after whiplash injury. Material & Methods: A random sample of patients in the outpatient clinic was interviewed, questionnaire completed and clinical examination performed. Assessment was made of passive cervical range of movement and Visual Analogue Scale pain scores. One hundred and sixty-four patients were divided into four different groups including patients with no whiplash injury but long-standing neck pain (Group A), previous symptomatic whiplash injury and long-standing neck pain (Group B), previous symptomatic whiplash injury and no neck symptoms (Group C), and a control group of patients with no history of whiplash injury or neck symptoms (Group D). Results: Data was analyzed by performing an Independent samples t-test and ANOVA, with level of significance taken as p<0.05. Comparing the four groups using a one-way ANOVA showed ...
Current Rheumatology Reviews, 2015
Rheumatoid arthritis affects around 1% of the global population with a predilection for Western s... more Rheumatoid arthritis affects around 1% of the global population with a predilection for Western societies. The treatment of the rheumatoid hip has gone through significant changes in recent years. Although osteotomies and synovectomies were previously commonplace, advances in arthroplasty technique and technology has seen these former procedures being performed less commonly. This article tackles some of the key issues with regard to the rheumatoid hip, namely the increased risk and methods of dealing with protrusio acetabuli, the risk of dislocation, infection and rates of aseptic loosening.
Shoulder & Elbow, 2014
Background Nerve injury is an acknowledged complication of total shoulder arthroplasty (TSA). Alt... more Background Nerve injury is an acknowledged complication of total shoulder arthroplasty (TSA). Although the incidence of postoperative neurological deficit has been reported to be between 1% and 16%, the true incidence of nerve damage is considered to be higher. The present study aimed to identify the rate of intraoperative nerve injury during total shoulder arthroplasty and to determine potential risk factors. Methods A prospective study of nerve conduction in 21 patients who underwent primary or revision TSA was carried out over a 12-month period. Nerve conduction was monitored by measuring intraoperative sensory evoked potentials (SEP). A significant neurophysiological signal change was defined as either a unilateral or bilateral decrease in SEP signal of ≥50%, a latency increase of ≥10% or a change in waveform morphology, not caused by operative or anaesthetic technique. Results Seven (33%) patients had a SEP signal change. The only significant risk factor identified for signal c...
Current Stem Cell Research & Therapy, 2014
Current Stem Cell Research & Therapy, 2013
Spinal pathologies are a major burden on society and individuals. Recent years have seen a large ... more Spinal pathologies are a major burden on society and individuals. Recent years have seen a large number of studies dedicated to the use of stem cells in spinal surgery. This review focuses on recent advances and controversies regarding the applications of stem cells in spinal fusion surgery, spinal cord injury and intervertebral disc degeneration. There are significant concerns regarding the ethics and risks of stem cell use. Animal models do not always accurately depict the human condition. While a great deal has been achieved, successful translation into clinical practice is needed. However there is no doubt that stem cells have a major role to play in the future management of spinal conditions.
Journal of perioperative practice, 2009
The fractured neck of femur is the classically described fracture in osteoporotic elderly patient... more The fractured neck of femur is the classically described fracture in osteoporotic elderly patients. Further, the fracture has a strong predominance in post-menopausal women and, although relatively uncommon in both children and young adults, where present in this age group it is usually the result of significant trauma. In elderly patients, with an already weakened bone, even minimal trauma may be sufficient to cause fracture and as such a fractured neck of femur is often referred to as a fragility fracture.
Journal of perioperative practice, 2010
Members can search all issues of the BJPN/JPP published since 1998 and download articles free of ... more Members can search all issues of the BJPN/JPP published since 1998 and download articles free of charge at www.afpp.org.uk. Access is also available to non-members who pay a small fee for each article download.
Journal of perioperative practice, 2012
Respiratory disease contributes significantly to the perioperative challenges of surgery. Preexis... more Respiratory disease contributes significantly to the perioperative challenges of surgery. Preexisting pulmonary co-morbidities and respiratory complications can have profound effects on patient outcomes. Knowledge of these conditions and the potentially deleterious effects of anaesthesia and surgery can enable clinicians to optimise lung function, reduce complications and improve results.
The Open Orthopaedics Journal, 2014
Soft tissue injuries include a wide and heterogeneous range of injuries. In this issue we cover a... more Soft tissue injuries include a wide and heterogeneous range of injuries. In this issue we cover a range of these topics including negative pressure wound therapy and the evidence-based principles behind its use, multiligamentous knee injuries, knee dislocations, compartment syndrome, and nerve injuries and principles of repair. There are a number of papers on bite injuries ranging from a literature review, their microbiology and virology, and mammalian bites. We also include a research paper on the management of knee osteochondritis dissecans. No issue on soft tissues in an orthopaedic journal would be completed without a review on fractures, and that too is included.
Current Stem Cell Research & Therapy, 2012
Musculoskeletal tissue is frequently damaged or lost in injury and disease. Orthopaedic surgery h... more Musculoskeletal tissue is frequently damaged or lost in injury and disease. Orthopaedic surgery has been highly successful in repairing, realigning and replacing damaged musculoskeletal structures. The coming years will establish whether a paradigm shift from fixation towards regeneration of tissue is possible, clinically feasible and financially viable. There has been an increasing interest in stem cell applications and tissue engineering approaches in surgical practice to deal with damaged or lost tissue [1-3]. Tissue engineering is an exciting strategy being explored to deal with damaged or lost tissue. It is the science of generating tissue using molecular and cellular techniques, combined with material engineering principles, to replace tissue. This could be in the form of cells with or without matrices. Although there have been developments in almost all surgical disciplines [1], the greatest advances are being made in orthopaedics, especially in bone repair [3]. This is due to many factors including the familiarity with bone marrow derived mesenchymal stem cells and bone grafting. STEM CELLS Stem cells are a self-renewing, slow-cycling cell population that exhibits a high proliferation potential and the ability to undergo multilineage differentiation. They can be isolated from tissues of individuals of various ages and maintain capacity for multilineage differentiation. Protocols for the culture [4] and, chondrogenic, osteogenic and adipogenic differentiation of bone marrow derived mesenchymal stem cells have been described [5, 6]. The rationale behind these protocols is discussed in this issue as well as highlighting the different regulators which determine the lineage a particular mesenchymal stem cell will differentiate into. By the end of last century, there was considerable interest in the use of mesenchymal stem cells for clinical tissue engineering applications. Unlike embryonic stem cells, the use of autologous postnatal mesenchymal stem cells is generally well accepted by society. Mesenchymal stem cells are less tumourogenic than their embryonic counterparts [7] and provide an autologous source of cells eliminating concerns regarding rejection and disease transmission. Cells with mesenchymal stem cell characteristics have been isolated from many different adult tissues including bone marrow, liver, dental pulp, periosteum, skin, retina, adipose tissue, skeletal muscle, synovial tissue, the infrapatellar fat pad, and more recently, cartilage [8-14].
Current Stem Cell Research & Therapy, 2013
Cartilage disorders and injuries range from acute injuries to chronic, debilitating diseases and ... more Cartilage disorders and injuries range from acute injuries to chronic, debilitating diseases and significantly affect an individual's well-being. This results in a significant disease burden on society as a whole. In recent years there has been great interest in the cell-based treatment strategies and the potential of stem cell-based treatment options for the repair of cartilage. Being an avascular, aneural and alymphatic tissue, it is well suited to stem cell and tissue engineering applications. In this issue, we look at stem cells from various sources and discuss their isolation, proliferation and differentiation. We also consider the associated use of bioreactors, biomaterials, scaffolds and growth factors. We cover the use of stem cell applications for cartilage, and discuss the basic sciences, pre-clinical and clinical studies in the field.
Archives of Physical Medicine and Rehabilitation, 2003
Objective: To investigate whether gabitril (Tiagabine) is effective in the prophylaxis of chronic... more Objective: To investigate whether gabitril (Tiagabine) is effective in the prophylaxis of chronic daily headaches and migraine headaches. Design: Retrospective chart review analyzing the reports of headache before and after the administration of Tiagabine. Setting: Outpatient pain clinic. Participants: 5 patients with chronic daily headache with migrainous features. Intervention: Patients were treated with an initial dose of Tiagabine at 2mg/d