Attila Jakab - Academia.edu (original) (raw)
Papers by Attila Jakab
Orvosi Hetilap, Mar 1, 2017
Human Reproduction Open, 2020
International journal of ophthalmology & eye science, Aug 25, 2015
Ultrasound in Obstetrics & Gynecology, Sep 1, 2012
Systems Biology in Reproductive Medicine, Aug 14, 2014
Human Reproduction, Jul 1, 2003
PLOS ONE, May 4, 2017
Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gesta... more Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gestation times to assess the availability of plasminogen activator for aiding potential corneal wound healing processes during pregnancy. PAA was measured by a spectrophotometric method. The analysis used 91 tear samples from pregnant and non-pregnant women, supplemented with 10 additional tear PAA measurements from non-pregnant women obtained in a previous study. Tear levels of PAA in pregnant women formed a bimodal distribution. Either the tear PAA level was zero or non-zero during pregnancy. When non-zero, the tear PAA level was dissociated from gestation time and not different than non-pregnant and post-pregnant levels. The frequency of occurrence of zero level tear PAA increased with gestation: 16%, 17% and 46% had zero tear PAA in samples taken from women in the first, second and third trimester, respectively. Overall, of the tear samples taken from women during pregnancy, a total of 26% were at zero tear PAA. The remaining tear samples had non-zero tear PAA values throughout gestation equivalent to non-pregnant tear PAA values, suggesting local control of the source of PAA in tears. Given the importance of the plasminogen activator system in tears to wound healing in the cornea, and the high occurrence of zero tear PAA in our sample of pregnant women, elective corneal surgery would be contraindicated. If corneal surgery is nevertheless necessary, the tear PAA level would be worth checking and patients with low level should be closely observed during the postoperative period.
Human Reproduction, Jul 21, 2014
Purpose: We retrospectively analyzed how the presence of thyroid autoimmunity (TAI positive) affe... more Purpose: We retrospectively analyzed how the presence of thyroid autoimmunity (TAI positive) affected reproductive parameters in eighty-six (86) TAI positive women referred to IVF treatment. Methods: All participants diagnosed with subclinical or overt hypothyroidism, while euthyroid on thyroxine replacement. Sixty-nine (69) female patients in the same IVF program, with no thyroid abnormalities served as controls (TAI negative group). Results: Statistically significant baseline hormone profile differences were found in multiple parameters between the two groups. TAI positive women were older (mean age 34.7±5.42 vs. 32.32±5.04 years; p=0.002), had higher FSH (8.4±3.49 U/L vs. 7.04±2.32 U/L; p=0.024), higher E2 (53.94±47.61 vs. 42.93±18.92 pg/ml; p=0.025) levels, while their AMH (2.88±2.62 vs. 3.6±1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64±0.96 vs. 1.66±0.65 uIU/ml; p= 0.652) between the two groups, FT3 (2.63±0.58 vs. 2.98±0.55 pg/ml; p=0.002) was l...
Reproductive Sciences
Endocrine disorders negatively influence the ovarian function, and increasing incidence of endocr... more Endocrine disorders negatively influence the ovarian function, and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders, the laboratory parameters were corrected before IVF treatment. One hundred sixty one patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32.5%), diminished ovarian reserve (23.8%), insulin resistance (22.5%), PCOS (15.2%), hyperprolactinaemia (13.4%), obesity (12.1%), hypogonadotropic hypogonadism (0.8%) and congenital adrenal hyperplasia (0.2%). Before the IVF treatment, systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI and FSH were found in the study group, while AMH level was lower. There were no...
Orvosi Hetilap, May 1, 2022
Diagnostics
Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected... more Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and discovering potential novel therapeutic targets. Examining molecular processes of eutopic endometrium is likely to be a convenient method to compare it with the molecular alterations observed in ectopic tissues. The aim of the present study was to determine what proportion of the surgically resected eutopic endometrial samples is suitable for further experiments so that these can be comparable with endometriosis. Final hospital reports and histopathology reports of a 3-year-long period (1162 cases) were analysed. The application of a retrospective screening method promoted the categorization of these cases, and quantification of the categorized cases was accomplished. In addition, results obtained from cultured endometrium samples were als...
BMC Endocrine Disorders, 2020
Background Thyroid associated orbitopathy (TAO) is the most common extrathyroidal complication of... more Background Thyroid associated orbitopathy (TAO) is the most common extrathyroidal complication of Graves’ disease. The disease course ranges from mild, where symptomatic therapy is sufficient, to severe, where high dose steroid administration or orbital decompression surgery is required. Women of their reproductive age are more likely to be affected. Although pregnancy is a state of enhanced immune tolerance, TAO may develop or worsen in 0.2–0.4% of pregnant women. Case presentation We present the case of a 19-year-old woman who has developed hyperthyroidism and progressive TAO during the second trimester of her third pregnancy, which has improved postpartum. The possible mechanisms and the importance of follow up in pregnancy is discussed. Conclusions Expectant mothers with Graves’ disease require follow up of eye signs throughout pregnancy, preferably in the setting of a thyroid-eye clinic.
Obstetrics and Gynaecology Cases - Reviews, 2020
Archives of Gynecology and Obstetrics, 2019
PloS one, 2017
Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gesta... more Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gestation times to assess the availability of plasminogen activator for aiding potential corneal wound healing processes during pregnancy. PAA was measured by a spectrophotometric method. The analysis used 91 tear samples from pregnant and non-pregnant women, supplemented with 10 additional tear PAA measurements from non-pregnant women obtained in a previous study. Tear levels of PAA in pregnant women formed a bimodal distribution. Either the tear PAA level was zero or non-zero during pregnancy. When non-zero, the tear PAA level was dissociated from gestation time and not different than non-pregnant and post-pregnant levels. The frequency of occurrence of zero level tear PAA increased with gestation: 16%, 17% and 46% had zero tear PAA in samples taken from women in the first, second and third trimester, respectively. Overall, of the tear samples taken from women during pregnancy, a total of 2...
Orvosi Hetilap, Mar 1, 2017
Human Reproduction Open, 2020
International journal of ophthalmology & eye science, Aug 25, 2015
Ultrasound in Obstetrics & Gynecology, Sep 1, 2012
Systems Biology in Reproductive Medicine, Aug 14, 2014
Human Reproduction, Jul 1, 2003
PLOS ONE, May 4, 2017
Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gesta... more Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gestation times to assess the availability of plasminogen activator for aiding potential corneal wound healing processes during pregnancy. PAA was measured by a spectrophotometric method. The analysis used 91 tear samples from pregnant and non-pregnant women, supplemented with 10 additional tear PAA measurements from non-pregnant women obtained in a previous study. Tear levels of PAA in pregnant women formed a bimodal distribution. Either the tear PAA level was zero or non-zero during pregnancy. When non-zero, the tear PAA level was dissociated from gestation time and not different than non-pregnant and post-pregnant levels. The frequency of occurrence of zero level tear PAA increased with gestation: 16%, 17% and 46% had zero tear PAA in samples taken from women in the first, second and third trimester, respectively. Overall, of the tear samples taken from women during pregnancy, a total of 26% were at zero tear PAA. The remaining tear samples had non-zero tear PAA values throughout gestation equivalent to non-pregnant tear PAA values, suggesting local control of the source of PAA in tears. Given the importance of the plasminogen activator system in tears to wound healing in the cornea, and the high occurrence of zero tear PAA in our sample of pregnant women, elective corneal surgery would be contraindicated. If corneal surgery is nevertheless necessary, the tear PAA level would be worth checking and patients with low level should be closely observed during the postoperative period.
Human Reproduction, Jul 21, 2014
Purpose: We retrospectively analyzed how the presence of thyroid autoimmunity (TAI positive) affe... more Purpose: We retrospectively analyzed how the presence of thyroid autoimmunity (TAI positive) affected reproductive parameters in eighty-six (86) TAI positive women referred to IVF treatment. Methods: All participants diagnosed with subclinical or overt hypothyroidism, while euthyroid on thyroxine replacement. Sixty-nine (69) female patients in the same IVF program, with no thyroid abnormalities served as controls (TAI negative group). Results: Statistically significant baseline hormone profile differences were found in multiple parameters between the two groups. TAI positive women were older (mean age 34.7±5.42 vs. 32.32±5.04 years; p=0.002), had higher FSH (8.4±3.49 U/L vs. 7.04±2.32 U/L; p=0.024), higher E2 (53.94±47.61 vs. 42.93±18.92 pg/ml; p=0.025) levels, while their AMH (2.88±2.62 vs. 3.6±1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64±0.96 vs. 1.66±0.65 uIU/ml; p= 0.652) between the two groups, FT3 (2.63±0.58 vs. 2.98±0.55 pg/ml; p=0.002) was l...
Reproductive Sciences
Endocrine disorders negatively influence the ovarian function, and increasing incidence of endocr... more Endocrine disorders negatively influence the ovarian function, and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders, the laboratory parameters were corrected before IVF treatment. One hundred sixty one patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32.5%), diminished ovarian reserve (23.8%), insulin resistance (22.5%), PCOS (15.2%), hyperprolactinaemia (13.4%), obesity (12.1%), hypogonadotropic hypogonadism (0.8%) and congenital adrenal hyperplasia (0.2%). Before the IVF treatment, systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI and FSH were found in the study group, while AMH level was lower. There were no...
Orvosi Hetilap, May 1, 2022
Diagnostics
Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected... more Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and discovering potential novel therapeutic targets. Examining molecular processes of eutopic endometrium is likely to be a convenient method to compare it with the molecular alterations observed in ectopic tissues. The aim of the present study was to determine what proportion of the surgically resected eutopic endometrial samples is suitable for further experiments so that these can be comparable with endometriosis. Final hospital reports and histopathology reports of a 3-year-long period (1162 cases) were analysed. The application of a retrospective screening method promoted the categorization of these cases, and quantification of the categorized cases was accomplished. In addition, results obtained from cultured endometrium samples were als...
BMC Endocrine Disorders, 2020
Background Thyroid associated orbitopathy (TAO) is the most common extrathyroidal complication of... more Background Thyroid associated orbitopathy (TAO) is the most common extrathyroidal complication of Graves’ disease. The disease course ranges from mild, where symptomatic therapy is sufficient, to severe, where high dose steroid administration or orbital decompression surgery is required. Women of their reproductive age are more likely to be affected. Although pregnancy is a state of enhanced immune tolerance, TAO may develop or worsen in 0.2–0.4% of pregnant women. Case presentation We present the case of a 19-year-old woman who has developed hyperthyroidism and progressive TAO during the second trimester of her third pregnancy, which has improved postpartum. The possible mechanisms and the importance of follow up in pregnancy is discussed. Conclusions Expectant mothers with Graves’ disease require follow up of eye signs throughout pregnancy, preferably in the setting of a thyroid-eye clinic.
Obstetrics and Gynaecology Cases - Reviews, 2020
Archives of Gynecology and Obstetrics, 2019
PloS one, 2017
Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gesta... more Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gestation times to assess the availability of plasminogen activator for aiding potential corneal wound healing processes during pregnancy. PAA was measured by a spectrophotometric method. The analysis used 91 tear samples from pregnant and non-pregnant women, supplemented with 10 additional tear PAA measurements from non-pregnant women obtained in a previous study. Tear levels of PAA in pregnant women formed a bimodal distribution. Either the tear PAA level was zero or non-zero during pregnancy. When non-zero, the tear PAA level was dissociated from gestation time and not different than non-pregnant and post-pregnant levels. The frequency of occurrence of zero level tear PAA increased with gestation: 16%, 17% and 46% had zero tear PAA in samples taken from women in the first, second and third trimester, respectively. Overall, of the tear samples taken from women during pregnancy, a total of 2...