Awais Malik - Academia.edu (original) (raw)
Papers by Awais Malik
European Journal of Surgical Oncology
Biosensors and Bioelectronics, 2007
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of nuclear receptors (NRs) super... more Peroxisome proliferator-activated receptor γ (PPARγ) is a member of nuclear receptors (NRs) superfamily and plays an important role for modulation of insulin sensitivity in type 2 diabetes. Ligand-dependent proteinprotein interactions between NRs and NR ...
Clinical Oncology and Research
Objective: To study the outcomes of post esophagectomy diaphragmatic hernia managed at our instit... more Objective: To study the outcomes of post esophagectomy diaphragmatic hernia managed at our institute. Methodology: We conducted a retrospective case series among patients who underwent surgical resection for esophageal cancer in the last 10 years from Jan 2010 to Dec 2019. Patient’s charts were reviewed and postoperative surveillance CT scans were reviewed for the development of post-operative diaphragmatic hernias. Demographic and variables related to diaphragmatic hernia and its management were recorded and analysed. Results: Out of 590 patients, 10 patients developed post esophagectomy diaphragmatic hernia. All patients received neo adjuvant chemo-radiotherapy. 8 patients underwent three stage esophagectomy, one had Ivor Lewis esophagectomy and one had transhiatal esophagectomy. CT scan was used as a modality of choice for the diagnosis. Two patients developed hernia during their hospital stay and 8 patients presented late. 7 patients were diagnosed due to complications of the he...
Journal of Technology in Human Services
International Journal of Medical Reviews and Case Reports
International Journal of Medical Reviews and Case Reports
Journal of Cardiac Failure
Foods
The changes in structure and digestion properties of mung bean starch due to hydrothermal treatme... more The changes in structure and digestion properties of mung bean starch due to hydrothermal treatment at various controlled temperatures were investigated. Results showed the increase in onset temperature (To) from 66.33 °C to 76.69 °C and decrease in enthalpies (∆Hg and ∆Hr) until the starch was completely gelatinized. The degree of molecular order (DMO) and degree of double helix (DDH) were significantly (p < 0.05) reduced from 1.35 to 1.01 and 1.38 to 0.98 respectively. X-ray diffraction (XRD) indicated the consecutive decrease in relative crystallinity (RC) while RVA analysis showed that peak and final viscosities were decreased significantly (p < 0.05). However, digestion kinetics indicated that degree of gelatinization increased the access of enzymes. As starch was partially gelatinized it yielded significantly lower glycemic index but no significant (p > 0.05) change in starch digestibility was observed after 70 °C. Hence, 70 °C can be considered as the critical hydrot...
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Journal of the Pakistan Medical Association
Journal of the College of Physicians and Surgeons Pakistan
The aim of this study was to determine the variations of extrahepatic arterial anatomy in 1000 Pa... more The aim of this study was to determine the variations of extrahepatic arterial anatomy in 1000 Pakistani patients undergoing CTA of the liver for various reasons.
Case Reports in Cardiology
Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose foun... more Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reactions. This is especially important in patients with myocardial infarction (MI) and mechanical circulatory support, such as a left ventricular assist device (LVAD), since anticoagulation is immediately required. Therefore, individualized assessment and preoperative planning is needed regarding the use of heparin vs. nonheparinoid products in such a population.
Journal of Cancer & Allied Specialties
Purpose: Head and neck cancers (HNC) are among the most common cancers in developing countries, e... more Purpose: Head and neck cancers (HNC) are among the most common cancers in developing countries, especially in the Southeast Asia. Oral cavity is the most commonly affected site. The risk factors are tobacco, betel nut and alcohol. The dimensions of the disease are quite different in developing countries than the western world. Poor socioeconomic status, poverty, lack of healthcare facilities and illiteracy are the factors that pose a major challenge to the management of the disease. The aim of this study is to analyse the database that has been collected over a period of 10 years showing the trends of the disease and the management outcome of these individuals.Methods: Men and women diagnosed with HNC from 2004 to 2014 from Cancer Registry Database of Shaukat Khanum Memorial Cancer Hospital and Research Centre have been retrospectively analysed.Results: In the 10 year period a total of 5027 patients presented to the head and neck clinic at our institution with a mean age + standard ...
Journal of Cancer & Allied Specialties
This is a case report of Pneumatosis intestinalis (PI), which has traditionally been associated w... more This is a case report of Pneumatosis intestinalis (PI), which has traditionally been associated with immediate operative intervention and a high mortality rate. We present a case of ulcerative colitis that developed Pneumatosis intestinalis and was managed at our hospital. A 29 year old male with known history of ulcerative colitis presented with an acute exacerbation. A week into his treatment, PI developed. Emergency total colectomy with end ileostomy was performed. Postoperatively, he remained critically ill and expired during same hospitalization after 45 days.Key words: Pneumatosis intestinalis, Ulcerative Colitis, Adalumimab
Journal of Cancer & Allied Specialties
Objective: Sentinel lymph node biopsy is the standard of care in clinically negative axilla in br... more Objective: Sentinel lymph node biopsy is the standard of care in clinically negative axilla in breast cancer patients for which frozen section (FS) is routinely performed intraoperatively. The objective of this study was to justify the use of FS in terms of number of tests performed and their impact on decision-making and cost saving. Materials and Methods: We retrospectively reviewed our prospectively maintained data from January 2014 to January 2018 for intraoperative FS in upfront breast conservation surgery patients. Results: A total of 357 patients were studied. All were female. Median age was 50 years (24–84). Mean tumour size was 29.11 mm. Numbers of sentinel lymph nodes identified were 1 in 50 (14.2%) patients, 2 in 121 (33.89%) patients and ≥3 in 186 (52%) patients. Number of positive sentinel lymph nodes was 0 in 264 (73.9%) patients, 1 in 62 (17.4%) patients, 2 in 20 (5.6%) patients and ≥3 in 11 (3.08%) patients. Axillary lymph node dissection (ALND) was offered to 30 (8....
Social Sciences & Humanities Open
This study examines the examination conducted by five government and one private board of interme... more This study examines the examination conducted by five government and one private board of intermediate and secondary education (BISE) in Sindh, Pakistan. Specifically, it examines the quality of items in the examination papers. Using a desk review approach, the ten-year examination papers from 2005 to 2016 were sampled from English, Mathematics, and Sciences (i.e., Biology, Physics, and Chemistry) of grades X and XII. Using Bloom's revised taxonomy as a theoretical framework, each item in the question papers was analyzed to determine, (1) the cognitive complexities of the item, and (2) frequency and variety in which the items are repeated in the different years. The findings suggest that most of the items assess students' memorization and comprehension. Items are frequently repeated word-to-word every year. These findings have implications for the entire secondary and higher secondary education system and beyond in Pakistan.
Journal of the American College of Cardiology
European Journal of Surgical Oncology
Biosensors and Bioelectronics, 2007
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of nuclear receptors (NRs) super... more Peroxisome proliferator-activated receptor γ (PPARγ) is a member of nuclear receptors (NRs) superfamily and plays an important role for modulation of insulin sensitivity in type 2 diabetes. Ligand-dependent proteinprotein interactions between NRs and NR ...
Clinical Oncology and Research
Objective: To study the outcomes of post esophagectomy diaphragmatic hernia managed at our instit... more Objective: To study the outcomes of post esophagectomy diaphragmatic hernia managed at our institute. Methodology: We conducted a retrospective case series among patients who underwent surgical resection for esophageal cancer in the last 10 years from Jan 2010 to Dec 2019. Patient’s charts were reviewed and postoperative surveillance CT scans were reviewed for the development of post-operative diaphragmatic hernias. Demographic and variables related to diaphragmatic hernia and its management were recorded and analysed. Results: Out of 590 patients, 10 patients developed post esophagectomy diaphragmatic hernia. All patients received neo adjuvant chemo-radiotherapy. 8 patients underwent three stage esophagectomy, one had Ivor Lewis esophagectomy and one had transhiatal esophagectomy. CT scan was used as a modality of choice for the diagnosis. Two patients developed hernia during their hospital stay and 8 patients presented late. 7 patients were diagnosed due to complications of the he...
Journal of Technology in Human Services
International Journal of Medical Reviews and Case Reports
International Journal of Medical Reviews and Case Reports
Journal of Cardiac Failure
Foods
The changes in structure and digestion properties of mung bean starch due to hydrothermal treatme... more The changes in structure and digestion properties of mung bean starch due to hydrothermal treatment at various controlled temperatures were investigated. Results showed the increase in onset temperature (To) from 66.33 °C to 76.69 °C and decrease in enthalpies (∆Hg and ∆Hr) until the starch was completely gelatinized. The degree of molecular order (DMO) and degree of double helix (DDH) were significantly (p < 0.05) reduced from 1.35 to 1.01 and 1.38 to 0.98 respectively. X-ray diffraction (XRD) indicated the consecutive decrease in relative crystallinity (RC) while RVA analysis showed that peak and final viscosities were decreased significantly (p < 0.05). However, digestion kinetics indicated that degree of gelatinization increased the access of enzymes. As starch was partially gelatinized it yielded significantly lower glycemic index but no significant (p > 0.05) change in starch digestibility was observed after 70 °C. Hence, 70 °C can be considered as the critical hydrot...
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Journal of the Pakistan Medical Association
Journal of the College of Physicians and Surgeons Pakistan
The aim of this study was to determine the variations of extrahepatic arterial anatomy in 1000 Pa... more The aim of this study was to determine the variations of extrahepatic arterial anatomy in 1000 Pakistani patients undergoing CTA of the liver for various reasons.
Case Reports in Cardiology
Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose foun... more Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reactions. This is especially important in patients with myocardial infarction (MI) and mechanical circulatory support, such as a left ventricular assist device (LVAD), since anticoagulation is immediately required. Therefore, individualized assessment and preoperative planning is needed regarding the use of heparin vs. nonheparinoid products in such a population.
Journal of Cancer & Allied Specialties
Purpose: Head and neck cancers (HNC) are among the most common cancers in developing countries, e... more Purpose: Head and neck cancers (HNC) are among the most common cancers in developing countries, especially in the Southeast Asia. Oral cavity is the most commonly affected site. The risk factors are tobacco, betel nut and alcohol. The dimensions of the disease are quite different in developing countries than the western world. Poor socioeconomic status, poverty, lack of healthcare facilities and illiteracy are the factors that pose a major challenge to the management of the disease. The aim of this study is to analyse the database that has been collected over a period of 10 years showing the trends of the disease and the management outcome of these individuals.Methods: Men and women diagnosed with HNC from 2004 to 2014 from Cancer Registry Database of Shaukat Khanum Memorial Cancer Hospital and Research Centre have been retrospectively analysed.Results: In the 10 year period a total of 5027 patients presented to the head and neck clinic at our institution with a mean age + standard ...
Journal of Cancer & Allied Specialties
This is a case report of Pneumatosis intestinalis (PI), which has traditionally been associated w... more This is a case report of Pneumatosis intestinalis (PI), which has traditionally been associated with immediate operative intervention and a high mortality rate. We present a case of ulcerative colitis that developed Pneumatosis intestinalis and was managed at our hospital. A 29 year old male with known history of ulcerative colitis presented with an acute exacerbation. A week into his treatment, PI developed. Emergency total colectomy with end ileostomy was performed. Postoperatively, he remained critically ill and expired during same hospitalization after 45 days.Key words: Pneumatosis intestinalis, Ulcerative Colitis, Adalumimab
Journal of Cancer & Allied Specialties
Objective: Sentinel lymph node biopsy is the standard of care in clinically negative axilla in br... more Objective: Sentinel lymph node biopsy is the standard of care in clinically negative axilla in breast cancer patients for which frozen section (FS) is routinely performed intraoperatively. The objective of this study was to justify the use of FS in terms of number of tests performed and their impact on decision-making and cost saving. Materials and Methods: We retrospectively reviewed our prospectively maintained data from January 2014 to January 2018 for intraoperative FS in upfront breast conservation surgery patients. Results: A total of 357 patients were studied. All were female. Median age was 50 years (24–84). Mean tumour size was 29.11 mm. Numbers of sentinel lymph nodes identified were 1 in 50 (14.2%) patients, 2 in 121 (33.89%) patients and ≥3 in 186 (52%) patients. Number of positive sentinel lymph nodes was 0 in 264 (73.9%) patients, 1 in 62 (17.4%) patients, 2 in 20 (5.6%) patients and ≥3 in 11 (3.08%) patients. Axillary lymph node dissection (ALND) was offered to 30 (8....
Social Sciences & Humanities Open
This study examines the examination conducted by five government and one private board of interme... more This study examines the examination conducted by five government and one private board of intermediate and secondary education (BISE) in Sindh, Pakistan. Specifically, it examines the quality of items in the examination papers. Using a desk review approach, the ten-year examination papers from 2005 to 2016 were sampled from English, Mathematics, and Sciences (i.e., Biology, Physics, and Chemistry) of grades X and XII. Using Bloom's revised taxonomy as a theoretical framework, each item in the question papers was analyzed to determine, (1) the cognitive complexities of the item, and (2) frequency and variety in which the items are repeated in the different years. The findings suggest that most of the items assess students' memorization and comprehension. Items are frequently repeated word-to-word every year. These findings have implications for the entire secondary and higher secondary education system and beyond in Pakistan.
Journal of the American College of Cardiology