Ayotunde Ale - Academia.edu (original) (raw)

Papers by Ayotunde Ale

Journal of Musculoskeletal Research

Purpose: The study determined the burden and characterized MSP among Nigerians with Type 2 Diabet... more Purpose: The study determined the burden and characterized MSP among Nigerians with Type 2 Diabetes (T2DM) into nociceptive or neuropathic pain. Methods: A cross-sectional study of 207 consecutively recruited T2DM subjects to assess and characterize MSP as neuropathic or nociceptive with the use of Nordic Musculoskeletal and S-LANSS standardized Questionnaires. Results: Of the 207 participants, there were 147 (71%) females with mean age of 59.7± 11.7 years. About 94.2% and 79.2% reported pain in at least one joint within 12 months and 7-day preceding the study, respectively. Ankle/foot is the most common site/region of reported pain in both the preceding 12 months and 7-day (58.5% versus 49.5%) while the least over the same period was at the elbow (22.6% versus 12.6%). Only 48.3% of the participants had restrictions in their activities of daily living (ADL) with 62.3% received treatment for self-reported pain. MSP was characterized predominantly as neuropathic among 27.5% of the par...

Endocrine Practice, Apr 1, 2019

±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. N... more ±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. None of the participants had osteoporosis or vitamin-D deficiency. There is a significant correlation between bone marker − osteocalcin and BMD, and PTH with BMD and GFR (P<0.05). Also, a nonsignificant trend was observed between calcium excretion, 25(OH)D, and estimated GFR (P=0.07, P=0.08). Conclusion PTH may be an early marker of bone loss in renal dysfunction.

Objective: To validate the Social Media Disorder scale in Nigerian adolescents by determining its... more Objective: To validate the Social Media Disorder scale in Nigerian adolescents by determining its unidimensional structure, reliability, sensitivity, specificity, and criterion validity. Methods: A total of 516 and 1213 pre-university students in two universities were randomly recruited and assessed using the 9-item Social Media Scale and the 12-item General Health Questionnaire (in the second survey only). Results: 46.3% and 56.3% of respondents in the first and second surveys met the criteria for social media disorder, respectively. Factor loading of items on the latent factor (addiction) was moderate. The model yielded a fairly acceptable fit in both samples. The averaged measure for intra-class correlation was acceptable (0.612). The internal consistency (Cronbach's alpha) was good (0.713 for sample 1 and 0.724 for sample 2). The test-retest reliability among the 113 respondents was good (r=0.696, p<0.001). The item-total correlations were all significant. Sensitivity of each item ranged from 67.7% (tolerance) to 91.3% (escape); specificity of each item ranged from 41.2% (escape) to 87.6% (displacement). For criterion validity, the total Social Media Disorder scale score correlated with General Health Questionnaire items that assess self-esteem, depression, and mood, as well as the total score. Conclusion: The 9-item Social Media Disorder scale is acceptable for screening social media disorder in pre-university students in Nigeria. The high prevalence of social media disorder should be of concern to counsellors, teachers, and mental health practitioners. Strategies for public health education on social media use are needed in Nigeria.

Gender and behaviour, Jun 1, 2020

Not much is known about dating preferences and social factors that attract substance users to col... more Not much is known about dating preferences and social factors that attract substance users to college students in Nigeria. We surveyed 230 college students from a Southwest Nigerian Institution. Comparatively, those who preferred dating alcohol users made up the highest percentage of respondents (35.2%), followed by those who preferred dating tobacco users(30.9%) . Significant differences were only seen across age groups in choice of dating partners who abuse substances. Type of substance use by partner largely accounted for dating preferences. Social attributes enhanced dating choices among college students. Keywords: dating, substance use. College students, social attraction. Preferences.

Nigerian medical journal : journal of the Nigeria Medical Association, 2019

Background: There is dearth of records on prevalence and spectrum of adult endocrine disorders in... more Background: There is dearth of records on prevalence and spectrum of adult endocrine disorders in Nigeria. Objective: To document the spectrum of endocrine disorders as seen in endocrinology, diabetes, and metabolism (EDM) outpatient clinic, Department of Medicine of Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State over a 3-year period. Methods: This was a retrospective study of the medical records of all new consultations seen in the EDM outpatient clinic between January 2016 and December 2018. All endocrinology diagnoses were classified according to the 10th revision of the International Statistical Classification of Diseases and Related Health problems (ICD-10). Information on demographic, source of referral, baseline clinical, and biochemical indices were gleaned and subjected to descriptive statistics using SPSS version 21, and results were presented as proportions (frequencies and percentages) and mean (±standard deviation). Results: Two thousand seven hundred and sixty-five patients were seen and managed at EDM outpatient clinic over the specified time frame. Eight hundred and sixty-three were new cases, age range 16–88, mean of 54.10 (±13.9) years with female preponderance 520 (60.3%) and female-to-male ratio of 1.5:1. The internal referral system constituted the main means of referral to the EDM clinic. The most common endocrine referrals were diabetes mellitus (DM) (697, 80.8%) and thyroid disorders (119, 13.8%) followed by metabolic syndrome (29, 3.36%) and hypothalamic–pituitary disorders (HPOs, 9, 1.04%). Conclusion: The common endocrine cases seen in Sagamu are DM, thyroid diseases, metabolic syndrome, and HPO similar to worldwide trend.

Nigerian Hospital Practice, 2019

Introduction. It has been reported that low normal circulating thyrotropin (TSH) levels correlate... more Introduction. It has been reported that low normal circulating thyrotropin (TSH) levels correlate with lower bone mineral density (BMD) in the Korean postmenopausal female. The goal of this study is to evaluate this relationship in different sex and age groups in a Chinese population. Materials and methods. A total of 2,957 subjects in Taiwan, 1,343 males and 1,614 females, aged from 45 to 64 years, were enrolled in this study. They were divided into four groups: group 1 was males aged between 45 and 50 years (young male, YM); group 2 was females aged between 45 and 50 years (young female, YF); group 3 was males older than 50 years (old male, OM); and group 4 was females older than 50 years (old female, OF). Plasma total thyroxine (T4) and TSH were measured. BMD was quantified at the wrist using dual energy X-ray absorptiometry. Results. YM had the highest BMD whereas OF had the lowest BMD. Among the four groups, no significant correlation between TSH level and BMD was found in the four groups, but a significant negative correlation existed between T4 and BMD in OF (r = −0.089, p = 0.005) and YM (r = −0.109, p = 0.018). Conclusion. Our study did not find significant correlations between TSH and BMD in both men and women with normal thyroid function in Taiwan. Weak negative correlations existed between T4 and BMD in postmenopausal women and young men. Further studies with measurement of FT4 and TSH and with a longitudinal design may shed light on this population difference.

Research Journal of Health Sciences, Jun 24, 2019

The role of the physician has increasingly become more expansive, and demanding. These demanding ... more The role of the physician has increasingly become more expansive, and demanding. These demanding schedules have played a heavy toll on sleep patterns and increased psychological stress. The objective of the study was to assess sleep quality and psychological morbidity among Physicians. Method: A cross-sectional survey of 95 voluntary consenting physicians from different specialties during a 2-day conference. We administered Pittsburgh Sleep Quality Index, and General Health Questionnaire-12. Results; About 13.6% (n=13 out of 95) had a score above 2 on General Health Questionnaire-12, indicating psychological morbidity. Those who reported poor sleep quality (>5) made up 36.8% (n=35) of the respondents, There were positive significant correlation between hours spent on call and total scores on GHQ at r=0.230, p=0.03. Only subjective sleep quality (component 1) was significantly correlated with total GHQ scores at p=0.001 Conclusion: The findings in our study showed a relationship between sleep quality (component 1) psychological morbidity. We observed that long work schedules was the only factor associated with psychological morbidity and sleep quality. It is imperative for work-time stress management to be instituted among physicians.

Research Journal of Health Sciences, Jul 3, 2018

The objective of this study was to compare the quality of sleep and psychological morbidity betwe... more The objective of this study was to compare the quality of sleep and psychological morbidity between medical students and paramedical students. Methods: A cross sectional survey of one hundred and eighty-six students of the College of Medicine, Olabisi Onabanjo University, Ogun State, Nigeria, were surveyed using socio-demographic questionnaires, Pittsburgh Sleep Questionnaire and General Health questionnaire. Results: The mean ages among paramedical students was 20.63±1.6 and medical students was 22.80±2.93 respectively. Medical Students had a higher percentage of those who had poor sleep quality (86.7% , 5, n=85) than the paramedical students (38.6%, n=34) and higher mean scores on General Health Questionnaire, M(SD) = 8.75(5.01) than the Paramedical group, M(SD) = 6.53(2.97) respectively. Conclusion: The findings in our study showed that medical students had poorer sleep quality and higher psychological morbidity in comparison to paramedical students, efforts should be made to reduce academic stress and improving sleep quality.

International Archives of Medicine, 2012

Introduction: Latent autoimmune diabetes in adults (LADA) is an entity characterized by the prese... more Introduction: Latent autoimmune diabetes in adults (LADA) is an entity characterized by the presence of GAD autoantibodies. LADA is largely understudied and underreported amongst Nigerians with Diabetes Mellitus (DM). We undertook to document the Prevalence, clinical and biochemical characteristics of LADA in a subset of Nigerians who hitherto had been treated for type 2 DM. Methods: This is a cross-sectional study conducted on 235 patients being managed for type 2 DM. The diagnosis of LADA was made in the presence of Glutamic Acid Decarboxylase autoantibody (GADA) positivity in the study subjects. Thereafter persons with LADA were compared with those without LADA. Clinical parameters such as demographic data, history of diabetes mellitus (DM) and its complications were obtained, biochemical parameters including Fasting blood glucose (FBG), C-peptide, glycated haemoglobin (HbA 1c) and lipid parameters were compared in both groups of Study subject. Test statistics used were Student t-test and χ 2. SPSS was used for data analysis. Results: Thirty three out of 235 of the Study subjects were GADA positive, giving a prevalence of 14%. The mean age (SD) of the subjects with LADA is 53.24(7.22) with an age range of 30-63 years. Majority (48%) of LADA subjects were in the 50-59 age category. There was no significant difference in the proportion of males and females with LADA (p = 0.3). 37% of patients with LADA were on insulin for glycaemic control. Three (3) LADA subjects had history/clinical evidence of autoimmune thyroid disease. 66% of LADA were in the overweight/obese category. LADA subjects had significant poor long term glycaemic control compared with anti-GAD negative subjects (p = 0.026). About half of LADA subjects were insulinopaenic. LADA subjects had lower levels of total cholesterol than GADA-ve subjects (p = 0.03). A higher proportion of LADA had evidence of microvascular complications of DM compared with antiGAD negative individuals. Conclusion: The diagnosis of LADA should be entertained in overweight/obese persons from the fourth decade of life presenting with DM. Pharmacotherapy with insulin is a potential means of managing hyperglycaemia in this group of patients especially since a significant proportion are insulinopaenic. The Prevalence of LADA in our patients is comparable to what obtains in Ghanaian and Caucasian populations.

IntechOpen eBooks, Jun 30, 2021

Calcium homeostasis has a pivotal role in regulating many biological processes. The interplay of ... more Calcium homeostasis has a pivotal role in regulating many biological processes. The interplay of calcium-regulating hormones, including parathyroid hormone (PTH), vitamin D, and calcitonin, is crucial in tightly maintaining serum calcium levels. Deregulation of calcium homeostasis has clinical implications resulting in hypercalcemia or hypocalcemia, which can lead to metabolic bone disease (MBD). MBD is a group of multifactorial bone diseases, caused by bone demineralization and characterized by an increased susceptibility to fracture risk. This chapter aims to provide an overview of associated risk factors and diagnostic, prevention, and recent treatment methods for MBD. The diagnosis of MBD is based on the assessment of clinical signs, radiological findings, quantitative ultrasonography, and biochemical evaluation of serum calcium, phosphate, PTH, alkaline phosphatase, and vitamin D. Current pharmacological treatments include antiresorptive and anabolic conventional therapies. Additionally, the efficacy of herbal extracts and nutritional supplements have been evaluated. Recent advances in the MBD management include drugs targeting calcium-sensing receptor and parathyroid hormone-related proteins, leading to the development of cathepsin K and Src tyrosine kinase inhibitors, calcilytics, and monoclonal antibodies against sclerostin or Dickkopf-1. Moreover, new nanomaterials have been used for improving the surgical treatment of vertebral fractures.

Indian Journal of Psychological Medicine, Aug 11, 2021

F rom antiquity, gambling has always had an attractive social appeal. 1,2 For many persons, gambl... more F rom antiquity, gambling has always had an attractive social appeal. 1,2 For many persons, gambling is a form of recreation and rewarding entertainment. However, for some subsets of the gambling population, significant problems affecting behavior have been documented. 5 The Diagnostic Statistical Manual (DSM-III) defined pathological gambling as a progressive loss of control of gambling impulses. 3 The DSM-IIV adopted a criterion-based diagnostic approach: with a minimum of five positive items for diagnosis. In the DSM-5, the illegal act criterion was excluded and a minimum of four positive items were required. 4,5 Also, in DSM-5, further development in the understanding of apparent neurobiological correlates and similarity to addictive

The Pan African medical journal, 2023

Annals of Health Research, May 17, 2020

Background: Medically unexplained symptoms are frequently encountered by physicians at the primar... more Background: Medically unexplained symptoms are frequently encountered by physicians at the primary care level. The complexity lies in the ill-defined nature of the multiple physical symptoms and the similarity to several organic disorders. Objective: To determine the prevalence of medically unexplained symptoms and relate this to physicians detection rate in a primary care setting in Southwest , Nigeria. Methods: The study was a cross-sectional, descriptive study of consecutive patients of the General Outpatient

Africa Journal of Science and Nature, Nov 10, 2020

This study aims to compare the sex hormones between women with epilepsy (WWE) and their agematche... more This study aims to compare the sex hormones between women with epilepsy (WWE) and their agematched controls. We postulated that a difference in etiology, may be associated with an unexpected hormonal profile. A case control study carried out at the University College Hospital, Ibadan, South western, Nigeria involving seventy-five WWE and age-matched controls. Blood samples for hormonal evaluation follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen, progesterone and testosterone were taken twice from all the participants during their menstrual cycle. WWE had lower BMI (p: 0.004), cycle length (p: 0.014) and more menstrual pattern irregularities (p< 0.001.) In the pre-ovulatory phase, WWE had lower FSH levels when compared with controls, (p: 0.012). Further stratification shows a higher FSH levels among WWE on medication, (p: 0.003).In the mid-luteal phase, FSH level was lowest in WWE not on medication, WWE on medication had higher levels but lower when compared to the control group, p: 0.002. FWE had lower progesterone levels when compared with the control group, (p: 0.004) with no difference with use of AEDs. Testosterone levels were lower among those with symptomatic epilepsy, (p:0.012)WWE had lower progesterone, lower FSH and more menstrual abnormalities, compare to controls in our population.

Journal Of Endocrinology, Metabolism And Diabetes Of South Africa, Nov 26, 2018

Background: Hyperthyroidism is a common endocrine disorder with multi-systemic effects, the least... more Background: Hyperthyroidism is a common endocrine disorder with multi-systemic effects, the least reported of which is bone loss and fractures. Objective: The aim was to evaluate the risk factors, pattern and frequency of bone fractures among Nigerians with hyperthyroidism. Methodology: An analytical study was undertaken of 40 patients with hyperthyroidism aged between 21 and 50 years. They were seen at the outpatient Endocrine, Diabetic and Metabolism (EDM) clinic of Lagos State University Teaching Hospital (LASUTH). Using an interviewer-administered questionnaire, information on sociodemographics, medical history, clinical and biochemical parameters and dual-energy X-ray absorptiometry (DXA) scan was obtained. Risk of fracture was assessed using WHO and ISCD risk calculators. During statistical analysis, quantitative and qualitative data were expressed as mean (SD) and percentages. Results: In all, 40 patients with hyperthyroidism were studied with a mean age of 36.16 (8.43) years. There were 32 females (80%, female:male ratio 4:1) and mean body mass index was 24.14 (4.3) kg/m. Hyperthyroidism was defined by Waynes' scoring index greater than 19 and confirmed by elevated thyroid hormones (FT4 39.44 (24.11) (pmol/l), FT3 12.13 (7.83) (pmol/l)) and suppressed TSH 0.26 (0.03) (u/U/ml). Increased bone turnover was documented by elevated bone formation markers (osteocalcin 45.7 (19.9) ng/ml and alkaline phosphatase 221.1 (143.46 IU/l)), bone resorption markers (24-hour calcium excretion 590.95 (506.1) mg/day). The mean BMD T-and Z-scores were reduced-2.0 (1.2). Bone loss was observed in 31 (72.5%) hyperthyroid subjects, but only three (7.5%) had fractures due to minor trauma. Conclusion: Bone fractures may not be uncommon in hyperthyroidism. Early screening for bone diseases should be encouraged to improve treatment outcome.

Annals of Health Research, Aug 22, 2020

Suicide-prevention Telephone Helpline Nauclea latifolia for Salmonella typhi infection Contracept... more Suicide-prevention Telephone Helpline Nauclea latifolia for Salmonella typhi infection Contraceptive use Haematological parameters of neonates Missed Opportunities for Vaccination Bacterial flora of the genital tract Early Infant Diagnosis for HIV-exposed infants Bone markers and cardiovascular risk factors Attitude to termination of pregnancies Herpes zoster ophthalmicus Neonatal hyperinsulinaemic hypoglycaemia Paediatric perineal injury www.mdcan.oouth.org.ng

World Journal of Clinical Cases

The Pan African medical journal, 2023

Bone markers and renal functional status in healthy Nigeria adults, 2022

±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. N... more ±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. None of the participants had osteoporosis or vitamin-D deficiency. There is a significant correlation between bone marker − osteocalcin and BMD, and PTH with BMD and GFR (P<0.05). Also, a nonsignificant trend was observed between calcium excretion, 25(OH)D, and estimated GFR (P=0.07, P=0.08). Conclusion PTH may be an early marker of bone loss in renal dysfunction.

Journal of Musculoskeletal Research

Purpose: The study determined the burden and characterized MSP among Nigerians with Type 2 Diabet... more Purpose: The study determined the burden and characterized MSP among Nigerians with Type 2 Diabetes (T2DM) into nociceptive or neuropathic pain. Methods: A cross-sectional study of 207 consecutively recruited T2DM subjects to assess and characterize MSP as neuropathic or nociceptive with the use of Nordic Musculoskeletal and S-LANSS standardized Questionnaires. Results: Of the 207 participants, there were 147 (71%) females with mean age of 59.7± 11.7 years. About 94.2% and 79.2% reported pain in at least one joint within 12 months and 7-day preceding the study, respectively. Ankle/foot is the most common site/region of reported pain in both the preceding 12 months and 7-day (58.5% versus 49.5%) while the least over the same period was at the elbow (22.6% versus 12.6%). Only 48.3% of the participants had restrictions in their activities of daily living (ADL) with 62.3% received treatment for self-reported pain. MSP was characterized predominantly as neuropathic among 27.5% of the par...

Endocrine Practice, Apr 1, 2019

±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. N... more ±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. None of the participants had osteoporosis or vitamin-D deficiency. There is a significant correlation between bone marker − osteocalcin and BMD, and PTH with BMD and GFR (P&lt;0.05). Also, a nonsignificant trend was observed between calcium excretion, 25(OH)D, and estimated GFR (P=0.07, P=0.08). Conclusion PTH may be an early marker of bone loss in renal dysfunction.

Objective: To validate the Social Media Disorder scale in Nigerian adolescents by determining its... more Objective: To validate the Social Media Disorder scale in Nigerian adolescents by determining its unidimensional structure, reliability, sensitivity, specificity, and criterion validity. Methods: A total of 516 and 1213 pre-university students in two universities were randomly recruited and assessed using the 9-item Social Media Scale and the 12-item General Health Questionnaire (in the second survey only). Results: 46.3% and 56.3% of respondents in the first and second surveys met the criteria for social media disorder, respectively. Factor loading of items on the latent factor (addiction) was moderate. The model yielded a fairly acceptable fit in both samples. The averaged measure for intra-class correlation was acceptable (0.612). The internal consistency (Cronbach's alpha) was good (0.713 for sample 1 and 0.724 for sample 2). The test-retest reliability among the 113 respondents was good (r=0.696, p<0.001). The item-total correlations were all significant. Sensitivity of each item ranged from 67.7% (tolerance) to 91.3% (escape); specificity of each item ranged from 41.2% (escape) to 87.6% (displacement). For criterion validity, the total Social Media Disorder scale score correlated with General Health Questionnaire items that assess self-esteem, depression, and mood, as well as the total score. Conclusion: The 9-item Social Media Disorder scale is acceptable for screening social media disorder in pre-university students in Nigeria. The high prevalence of social media disorder should be of concern to counsellors, teachers, and mental health practitioners. Strategies for public health education on social media use are needed in Nigeria.

Gender and behaviour, Jun 1, 2020

Not much is known about dating preferences and social factors that attract substance users to col... more Not much is known about dating preferences and social factors that attract substance users to college students in Nigeria. We surveyed 230 college students from a Southwest Nigerian Institution. Comparatively, those who preferred dating alcohol users made up the highest percentage of respondents (35.2%), followed by those who preferred dating tobacco users(30.9%) . Significant differences were only seen across age groups in choice of dating partners who abuse substances. Type of substance use by partner largely accounted for dating preferences. Social attributes enhanced dating choices among college students. Keywords: dating, substance use. College students, social attraction. Preferences.

Nigerian medical journal : journal of the Nigeria Medical Association, 2019

Background: There is dearth of records on prevalence and spectrum of adult endocrine disorders in... more Background: There is dearth of records on prevalence and spectrum of adult endocrine disorders in Nigeria. Objective: To document the spectrum of endocrine disorders as seen in endocrinology, diabetes, and metabolism (EDM) outpatient clinic, Department of Medicine of Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State over a 3-year period. Methods: This was a retrospective study of the medical records of all new consultations seen in the EDM outpatient clinic between January 2016 and December 2018. All endocrinology diagnoses were classified according to the 10th revision of the International Statistical Classification of Diseases and Related Health problems (ICD-10). Information on demographic, source of referral, baseline clinical, and biochemical indices were gleaned and subjected to descriptive statistics using SPSS version 21, and results were presented as proportions (frequencies and percentages) and mean (±standard deviation). Results: Two thousand seven hundred and sixty-five patients were seen and managed at EDM outpatient clinic over the specified time frame. Eight hundred and sixty-three were new cases, age range 16–88, mean of 54.10 (±13.9) years with female preponderance 520 (60.3%) and female-to-male ratio of 1.5:1. The internal referral system constituted the main means of referral to the EDM clinic. The most common endocrine referrals were diabetes mellitus (DM) (697, 80.8%) and thyroid disorders (119, 13.8%) followed by metabolic syndrome (29, 3.36%) and hypothalamic–pituitary disorders (HPOs, 9, 1.04%). Conclusion: The common endocrine cases seen in Sagamu are DM, thyroid diseases, metabolic syndrome, and HPO similar to worldwide trend.

Nigerian Hospital Practice, 2019

Introduction. It has been reported that low normal circulating thyrotropin (TSH) levels correlate... more Introduction. It has been reported that low normal circulating thyrotropin (TSH) levels correlate with lower bone mineral density (BMD) in the Korean postmenopausal female. The goal of this study is to evaluate this relationship in different sex and age groups in a Chinese population. Materials and methods. A total of 2,957 subjects in Taiwan, 1,343 males and 1,614 females, aged from 45 to 64 years, were enrolled in this study. They were divided into four groups: group 1 was males aged between 45 and 50 years (young male, YM); group 2 was females aged between 45 and 50 years (young female, YF); group 3 was males older than 50 years (old male, OM); and group 4 was females older than 50 years (old female, OF). Plasma total thyroxine (T4) and TSH were measured. BMD was quantified at the wrist using dual energy X-ray absorptiometry. Results. YM had the highest BMD whereas OF had the lowest BMD. Among the four groups, no significant correlation between TSH level and BMD was found in the four groups, but a significant negative correlation existed between T4 and BMD in OF (r = −0.089, p = 0.005) and YM (r = −0.109, p = 0.018). Conclusion. Our study did not find significant correlations between TSH and BMD in both men and women with normal thyroid function in Taiwan. Weak negative correlations existed between T4 and BMD in postmenopausal women and young men. Further studies with measurement of FT4 and TSH and with a longitudinal design may shed light on this population difference.

Research Journal of Health Sciences, Jun 24, 2019

The role of the physician has increasingly become more expansive, and demanding. These demanding ... more The role of the physician has increasingly become more expansive, and demanding. These demanding schedules have played a heavy toll on sleep patterns and increased psychological stress. The objective of the study was to assess sleep quality and psychological morbidity among Physicians. Method: A cross-sectional survey of 95 voluntary consenting physicians from different specialties during a 2-day conference. We administered Pittsburgh Sleep Quality Index, and General Health Questionnaire-12. Results; About 13.6% (n=13 out of 95) had a score above 2 on General Health Questionnaire-12, indicating psychological morbidity. Those who reported poor sleep quality (>5) made up 36.8% (n=35) of the respondents, There were positive significant correlation between hours spent on call and total scores on GHQ at r=0.230, p=0.03. Only subjective sleep quality (component 1) was significantly correlated with total GHQ scores at p=0.001 Conclusion: The findings in our study showed a relationship between sleep quality (component 1) psychological morbidity. We observed that long work schedules was the only factor associated with psychological morbidity and sleep quality. It is imperative for work-time stress management to be instituted among physicians.

Research Journal of Health Sciences, Jul 3, 2018

The objective of this study was to compare the quality of sleep and psychological morbidity betwe... more The objective of this study was to compare the quality of sleep and psychological morbidity between medical students and paramedical students. Methods: A cross sectional survey of one hundred and eighty-six students of the College of Medicine, Olabisi Onabanjo University, Ogun State, Nigeria, were surveyed using socio-demographic questionnaires, Pittsburgh Sleep Questionnaire and General Health questionnaire. Results: The mean ages among paramedical students was 20.63±1.6 and medical students was 22.80±2.93 respectively. Medical Students had a higher percentage of those who had poor sleep quality (86.7% , 5, n=85) than the paramedical students (38.6%, n=34) and higher mean scores on General Health Questionnaire, M(SD) = 8.75(5.01) than the Paramedical group, M(SD) = 6.53(2.97) respectively. Conclusion: The findings in our study showed that medical students had poorer sleep quality and higher psychological morbidity in comparison to paramedical students, efforts should be made to reduce academic stress and improving sleep quality.

International Archives of Medicine, 2012

Introduction: Latent autoimmune diabetes in adults (LADA) is an entity characterized by the prese... more Introduction: Latent autoimmune diabetes in adults (LADA) is an entity characterized by the presence of GAD autoantibodies. LADA is largely understudied and underreported amongst Nigerians with Diabetes Mellitus (DM). We undertook to document the Prevalence, clinical and biochemical characteristics of LADA in a subset of Nigerians who hitherto had been treated for type 2 DM. Methods: This is a cross-sectional study conducted on 235 patients being managed for type 2 DM. The diagnosis of LADA was made in the presence of Glutamic Acid Decarboxylase autoantibody (GADA) positivity in the study subjects. Thereafter persons with LADA were compared with those without LADA. Clinical parameters such as demographic data, history of diabetes mellitus (DM) and its complications were obtained, biochemical parameters including Fasting blood glucose (FBG), C-peptide, glycated haemoglobin (HbA 1c) and lipid parameters were compared in both groups of Study subject. Test statistics used were Student t-test and χ 2. SPSS was used for data analysis. Results: Thirty three out of 235 of the Study subjects were GADA positive, giving a prevalence of 14%. The mean age (SD) of the subjects with LADA is 53.24(7.22) with an age range of 30-63 years. Majority (48%) of LADA subjects were in the 50-59 age category. There was no significant difference in the proportion of males and females with LADA (p = 0.3). 37% of patients with LADA were on insulin for glycaemic control. Three (3) LADA subjects had history/clinical evidence of autoimmune thyroid disease. 66% of LADA were in the overweight/obese category. LADA subjects had significant poor long term glycaemic control compared with anti-GAD negative subjects (p = 0.026). About half of LADA subjects were insulinopaenic. LADA subjects had lower levels of total cholesterol than GADA-ve subjects (p = 0.03). A higher proportion of LADA had evidence of microvascular complications of DM compared with antiGAD negative individuals. Conclusion: The diagnosis of LADA should be entertained in overweight/obese persons from the fourth decade of life presenting with DM. Pharmacotherapy with insulin is a potential means of managing hyperglycaemia in this group of patients especially since a significant proportion are insulinopaenic. The Prevalence of LADA in our patients is comparable to what obtains in Ghanaian and Caucasian populations.

IntechOpen eBooks, Jun 30, 2021

Calcium homeostasis has a pivotal role in regulating many biological processes. The interplay of ... more Calcium homeostasis has a pivotal role in regulating many biological processes. The interplay of calcium-regulating hormones, including parathyroid hormone (PTH), vitamin D, and calcitonin, is crucial in tightly maintaining serum calcium levels. Deregulation of calcium homeostasis has clinical implications resulting in hypercalcemia or hypocalcemia, which can lead to metabolic bone disease (MBD). MBD is a group of multifactorial bone diseases, caused by bone demineralization and characterized by an increased susceptibility to fracture risk. This chapter aims to provide an overview of associated risk factors and diagnostic, prevention, and recent treatment methods for MBD. The diagnosis of MBD is based on the assessment of clinical signs, radiological findings, quantitative ultrasonography, and biochemical evaluation of serum calcium, phosphate, PTH, alkaline phosphatase, and vitamin D. Current pharmacological treatments include antiresorptive and anabolic conventional therapies. Additionally, the efficacy of herbal extracts and nutritional supplements have been evaluated. Recent advances in the MBD management include drugs targeting calcium-sensing receptor and parathyroid hormone-related proteins, leading to the development of cathepsin K and Src tyrosine kinase inhibitors, calcilytics, and monoclonal antibodies against sclerostin or Dickkopf-1. Moreover, new nanomaterials have been used for improving the surgical treatment of vertebral fractures.

Indian Journal of Psychological Medicine, Aug 11, 2021

F rom antiquity, gambling has always had an attractive social appeal. 1,2 For many persons, gambl... more F rom antiquity, gambling has always had an attractive social appeal. 1,2 For many persons, gambling is a form of recreation and rewarding entertainment. However, for some subsets of the gambling population, significant problems affecting behavior have been documented. 5 The Diagnostic Statistical Manual (DSM-III) defined pathological gambling as a progressive loss of control of gambling impulses. 3 The DSM-IIV adopted a criterion-based diagnostic approach: with a minimum of five positive items for diagnosis. In the DSM-5, the illegal act criterion was excluded and a minimum of four positive items were required. 4,5 Also, in DSM-5, further development in the understanding of apparent neurobiological correlates and similarity to addictive

The Pan African medical journal, 2023

Annals of Health Research, May 17, 2020

Background: Medically unexplained symptoms are frequently encountered by physicians at the primar... more Background: Medically unexplained symptoms are frequently encountered by physicians at the primary care level. The complexity lies in the ill-defined nature of the multiple physical symptoms and the similarity to several organic disorders. Objective: To determine the prevalence of medically unexplained symptoms and relate this to physicians detection rate in a primary care setting in Southwest , Nigeria. Methods: The study was a cross-sectional, descriptive study of consecutive patients of the General Outpatient

Africa Journal of Science and Nature, Nov 10, 2020

This study aims to compare the sex hormones between women with epilepsy (WWE) and their agematche... more This study aims to compare the sex hormones between women with epilepsy (WWE) and their agematched controls. We postulated that a difference in etiology, may be associated with an unexpected hormonal profile. A case control study carried out at the University College Hospital, Ibadan, South western, Nigeria involving seventy-five WWE and age-matched controls. Blood samples for hormonal evaluation follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen, progesterone and testosterone were taken twice from all the participants during their menstrual cycle. WWE had lower BMI (p: 0.004), cycle length (p: 0.014) and more menstrual pattern irregularities (p< 0.001.) In the pre-ovulatory phase, WWE had lower FSH levels when compared with controls, (p: 0.012). Further stratification shows a higher FSH levels among WWE on medication, (p: 0.003).In the mid-luteal phase, FSH level was lowest in WWE not on medication, WWE on medication had higher levels but lower when compared to the control group, p: 0.002. FWE had lower progesterone levels when compared with the control group, (p: 0.004) with no difference with use of AEDs. Testosterone levels were lower among those with symptomatic epilepsy, (p:0.012)WWE had lower progesterone, lower FSH and more menstrual abnormalities, compare to controls in our population.

Journal Of Endocrinology, Metabolism And Diabetes Of South Africa, Nov 26, 2018

Background: Hyperthyroidism is a common endocrine disorder with multi-systemic effects, the least... more Background: Hyperthyroidism is a common endocrine disorder with multi-systemic effects, the least reported of which is bone loss and fractures. Objective: The aim was to evaluate the risk factors, pattern and frequency of bone fractures among Nigerians with hyperthyroidism. Methodology: An analytical study was undertaken of 40 patients with hyperthyroidism aged between 21 and 50 years. They were seen at the outpatient Endocrine, Diabetic and Metabolism (EDM) clinic of Lagos State University Teaching Hospital (LASUTH). Using an interviewer-administered questionnaire, information on sociodemographics, medical history, clinical and biochemical parameters and dual-energy X-ray absorptiometry (DXA) scan was obtained. Risk of fracture was assessed using WHO and ISCD risk calculators. During statistical analysis, quantitative and qualitative data were expressed as mean (SD) and percentages. Results: In all, 40 patients with hyperthyroidism were studied with a mean age of 36.16 (8.43) years. There were 32 females (80%, female:male ratio 4:1) and mean body mass index was 24.14 (4.3) kg/m. Hyperthyroidism was defined by Waynes' scoring index greater than 19 and confirmed by elevated thyroid hormones (FT4 39.44 (24.11) (pmol/l), FT3 12.13 (7.83) (pmol/l)) and suppressed TSH 0.26 (0.03) (u/U/ml). Increased bone turnover was documented by elevated bone formation markers (osteocalcin 45.7 (19.9) ng/ml and alkaline phosphatase 221.1 (143.46 IU/l)), bone resorption markers (24-hour calcium excretion 590.95 (506.1) mg/day). The mean BMD T-and Z-scores were reduced-2.0 (1.2). Bone loss was observed in 31 (72.5%) hyperthyroid subjects, but only three (7.5%) had fractures due to minor trauma. Conclusion: Bone fractures may not be uncommon in hyperthyroidism. Early screening for bone diseases should be encouraged to improve treatment outcome.

Annals of Health Research, Aug 22, 2020

Suicide-prevention Telephone Helpline Nauclea latifolia for Salmonella typhi infection Contracept... more Suicide-prevention Telephone Helpline Nauclea latifolia for Salmonella typhi infection Contraceptive use Haematological parameters of neonates Missed Opportunities for Vaccination Bacterial flora of the genital tract Early Infant Diagnosis for HIV-exposed infants Bone markers and cardiovascular risk factors Attitude to termination of pregnancies Herpes zoster ophthalmicus Neonatal hyperinsulinaemic hypoglycaemia Paediatric perineal injury www.mdcan.oouth.org.ng

World Journal of Clinical Cases

The Pan African medical journal, 2023

Bone markers and renal functional status in healthy Nigeria adults, 2022

±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. N... more ±9.02 ml/min, mean serum 25(OH)D 51.53±15.45 mmol/l, and mean BMD/Z score 0.54±0.07)/0.20±1.02. None of the participants had osteoporosis or vitamin-D deficiency. There is a significant correlation between bone marker − osteocalcin and BMD, and PTH with BMD and GFR (P<0.05). Also, a nonsignificant trend was observed between calcium excretion, 25(OH)D, and estimated GFR (P=0.07, P=0.08). Conclusion PTH may be an early marker of bone loss in renal dysfunction.