Özgür Aytaç - Academia.edu (original) (raw)
Papers by Özgür Aytaç
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
18 F-FDG PET/CT has an acceptable specificity but a low sensitivity on the prediction of axillary... more 18 F-FDG PET/CT has an acceptable specificity but a low sensitivity on the prediction of axillary lymph node (ALN) metastasis in breast cancer. We analyzed the factors that could possibly affect this prediction. The records of 270 patients with T1-2 invasive breast cancer who underwent surgery, 116 of whom had been evaluated by preoperative 18 F-FDG PET/CT were reviewed. Prediction of ALN status by PET/CT according to tumor stage, estrogen receptor (ER), progesterone receptor (PgR) and HER2 status, histology, age and sentinel node properties was assessed. ALN metastasis was present in 62 of 131 T1 (43.7%) and 106 of 142 T2 tumors (74.6%), 20 of 46 (43.5%) ER(-) and 146 of 222 (65.8%) ER(+) tumors, 38 of 71 (53.5%) PgR(-) and 127 of 200 (63.5%) PgR(+) tumors. On multivariate analysis only the tumor size (>2 cm) independently correlated with ALN metastasis (Odds ratio/OR=3.1). None of the other parameters had statistical significance in terms of ALN prediction on FDG-PET/CT. Though...
Tropical doctor, 2017
Biliary fistulation from a hepatic hydatid cyst is its most frequent complication. If unrecognise... more Biliary fistulation from a hepatic hydatid cyst is its most frequent complication. If unrecognised, this may cause difficulties during and after surgical intervention. Our study looked into its incidence and also the possible risk factors in a retrospective investigation of 60 patients (34 women) who had undergone surgery or percutaneous treatment. Demographics and anatomical characteristics, such as cyst type, location, number, diameter and laboratory findings were examined. A full 50% had biliary fistulation, with increased risk if the cyst diameter was ≥8.8 cm.
12. Ulusal Meme HastalıklarıKongresi, 2013
GİRİŞ Yüz yanıkları, tüm yanık olgularının yaklaşık %5’ini oluşturur (1). Yüz yanığı varlığı, yan... more GİRİŞ Yüz yanıkları, tüm yanık olgularının yaklaşık %5’ini oluşturur (1). Yüz yanığı varlığı, yanık yüzey alanının genişliğinden bağımsız olarak çoğu hastada yanık ciddiyetinin hayati göstergesi gibidir (2,3). Yüz bölgesi, konumundan dolayı sıklıkla alev dışındaki yanık unsurlarına görece olarak daha korunaklıdır. Yüz yanıklarının çoğunun alev temasıyla oluşması, eşlik eden ölümcül inhalasyon hasarını beraberinde getirmektedir (4). Bu nedenle, göz hasarı varlığı, ileride karşılaşılabilecek görme sorunlarının dışında, genel sonucun öngörülmesi açısından da önemli bir ipucu olabilir (3,5–7). Bu varsayımdan hareketle, yüz yanıklarında göz hasarı sıklığını ve yanık türü ve oranına göre ciddiyetini geriye dönük olarak inceledik.
Sonuç: Sitologların deneyiminin artmasının, çıkarılan nodüllerde kanser ile karşılaşma oranımızın... more Sonuç: Sitologların deneyiminin artmasının, çıkarılan nodüllerde kanser ile karşılaşma oranımızın da artmasına yardımcı olacağı kanaatindeyiz. Sonuç olarak, benign nodüler guatrın cerrahi tedavisinde mümkün olduğunca geniş cerrahi yöntemler tercih edilmelidir.
BACKGROUND In patients with extensive burns, all unburned areas can be used as donor sites. In ma... more BACKGROUND In patients with extensive burns, all unburned areas can be used as donor sites. In male patients with small burns, preputial skin graft may be a good choice in order to avoid donor site problems. METHODS We retrospectively reviewed 12 patients treated in our burn center from January 1997 to August 2007 with preputial skin grafting. RESULTS In three patients, preputial skin was the only graft source. In nine patients, other donor sites were also used for split-thickness graft harvesting. In two patients, preputial skin graft was used for periareolar grafting where hyperpigmented healing was preferred. In the rest of the patients, preputial skin graft was used on various parts of the body. Overall success rate for preputial skin graft was 100%. There was no early donor site morbidity. CONCLUSION Preputial skin is a full-thickness, highly elastic and easy-to-harvest graft that should be considered in all burned male children in whom grafting is needed.
Nodüler guatr tedavisi yaklaşımları arasında cerrahi tedavinin önemli bir yeri vardır. Uygulanan ... more Nodüler guatr tedavisi yaklaşımları arasında cerrahi tedavinin önemli bir yeri vardır. Uygulanan cerrahi işlemler nodül eksizyonu, parsiyel tiroit lobektomi, total lobektomi, bilateral subtotal tiroidektomi, total lobektomi ve kontralateral subtotal lobektomi (Dunhill prosedürü), totale yakın tiroidektomi ve total tiroidektomidir (2,3). Soliter nodüler guatrda uygulanması gereken teknik, total lobektomi-istmusektomidir. Bu teknikte tiroit lobu ekstrakapsüler olarak diseke edilip nervus laringeus rekürrens korunarak total olarak eksize edilir (4). Erişkin popülasyonunda palpabl nodül %4-7 civarındadır ve her yıl %0.8 oranında yeni nodül saptanmaktadır (5,6). Multipl nodüllerden belirgin büyük olanına dominant nodül ve bu guatrlara dominant nodüllü multinodüler guatr adı verilir. Bu nodüllerin çoğunun benign olmasına karşın nodülde kanser olasılığı her zaman mevcuttur. Soliter nodüllerde ortalama %4.7, dominant nodülde %4.1, multinodüler ise %1 oranında maligniteye rastlanır. Bu oranl...
European Journal of Breast Health
Turkish Journal of Pathology
Objective: To evaluate the pathological and radiological features, immunohistochemical profile an... more Objective: To evaluate the pathological and radiological features, immunohistochemical profile and treatment methods of primary male breast carcinoma cases diagnosed at our center. Material and Method: The pathology archive between 2006 and 2019 was reviewed and the data of 27 male patients diagnosed as primary breast cancer were retrospectively evaluated. Results: The age of the patients ranged between 40-86 years. The left breast was involved in 17 patients. The mean tumor diameter was 2.35 ± 1.09 cm. Of the 27 cases, 8 were dead and 19 were alive. The mean follow-up duration was 37.45 ± 24.84 months. The mean estimated life expectancy was 65±14.7 months. The most common complaint was a swelling in the breast. The time interval between the onset of complaints and admittance to hospital ranged from three months to two years. The most common histopathological diagnosis was invasive carcinoma-no special type. The most common surgical procedure was mastectomy with lymph node dissection. Nine patients had metastatic lymph nodes. In terms of the hormone profiles, 24 were Estrogen receptor positive, 21 were Progesterone receptor positive and six were Her2/neu positive. Three patients had triple-negative tumors. Conclusion: Male breast carcinoma is a rare disease but its frequency has been increasing recently. As breast cancer is more commonly attributed to women, the diagnosis is usually delayed until later stages in males. Public awareness should therefore be increased and breast cancer should be considered in the differential diagnosis especially in the presence of breast swelling and complaints related to the breast skin so that the appropriate biopsy can be obtained without delay.
European Journal of Breast Health
Stromal tumors are the prominent mesenchymal tumors of gastrointestinal tract (GIT) (1). They are... more Stromal tumors are the prominent mesenchymal tumors of gastrointestinal tract (GIT) (1). They are more apparent in upper middle age, mostly in 5 th and 6 th decades. They occur equally in both sexes (1). Gastrointestinal Stromal Tumors (GISTs) are most commonly localized in the stomach (40-70%) and may be found in the intestine (20-32%), colon (10%) and esophagus (5%) (1, 2). They also can be seen in extra-GIT sites like mesentery, omentum and retroperitoneum (2). Major patient complaints regarding GISTs are upper abdominal pain, GIT bleeding and abdominal masses (1). Interstitial cells of Cajal (ICC), which GISTs are thought to originate from, both express tyrosine kinase receptors (c-kit) and stain with CD34 and Vimentin. KIT (CD117) is a transmembrane tyrosine kinase receptor, which is expressed in hematopoietic stem cells, germ cells, mast cells, melanocytes and ICC (2). C-Kit positivity is an important parameter in diagnosis of GIST. Recently, a specific marker, namely discovered on GIST1 (DOG-1), has been discovered for GIST diagnosis. It is shown to be positive on ICCs and gastric surface epithelium. DOG-1 is also expressed in high amounts in KIT mutation-negative cases besides typical GIST cases (3). Immunohistochemical diagnosis of GIST is adopted when mesenchymal tumors stain positive with c-Kit (CD117) and the DOG-1 where the rest of mesenchymal cell markers were negative. Demonstration of CD117 and recently DOG-1 positivity immunochemically stands for the standard technique of definitive diagnosis of GIST. CD34 is positive in 70-80% of the cases. Vimentin is diffuse and strong positive in many stromal tumors. SMA is positive in 30-40% and S100 in 5% of GISTs. Staining with desmin is rare (1). Malignant stromal tumors mostly metastasize to liver, peritoneum, lungs and bones (4). Brain and lymph node metastases are unusual (4). No breast metastasis was presented in literature before. Hereby, we present a case of GIST with liver, bone, lymph node and breast metastases and aimed to discuss its unusual metastatic reviewing literature. Case Presentation A 46 year-old woman was referred to us from another health facility with the complaint of back pain. The radiological imaging studies revealed multiple liver metastases with the largest being 5.5 cm in diameter as well as multiple bone involvements. Positron Emission
Turkish Journal of Pathology
Objective: To evaluate the pathological and radiological features, hormone profiles, surgery and ... more Objective: To evaluate the pathological and radiological features, hormone profiles, surgery and treatment methods of metaplastic breast carcinoma cases diagnosed at our center in the light of current literature. Material and Method: A total of 38 metaplastic breast cancer cases diagnosed between 2006-2018 at our center were included in the study. The patients were evaluated in terms of age, tumor size, localization, histological grade, hormone profiles (ER, PR, Her2-neu), American Joint Committee on Cancer (AJCC) Tumor, Lymph node status, Metastases (TNM) stage, progression, survival, radiological features, types of surgery and therapy modalities (chemotherapy and / or radiotherapy). Results: The age of the patients ranged between 32 and 95 years. Pathological evaluation of cases showed that 14 were pure epithelial (IC-NST + squamous cell carcinoma) and 24 were metaplastic carcinomas with mesenchymal differentiation. Ductal carcinoma in situ (DCIS) was accompanying an invasive component in twenty cases. Seventeen patients had lymph node metastasis. Twelve patients developed distant metastasis. Thirty patients were triple negative for hormone receptors. The mean follow-up period of the patients was 34 months. The estimated life expectancy was 116 months. All of the patients received chemotherapy and 28 patients received adjuvant radiotherapy. There was no correlation between tumor size and lymph node or distant metastasis in our series. Our findings are consistent with the literature. Conclusion: Metaplastic breast carcinoma is a rare entity among breast carcinomas. Metaplastic carcinomas of the breast draw attention with the differences in their clinical course and the radiological and pathological heterogeneity.
European Journal of Breast Health
Primary breast sarcomas are very rare and account less than 1% of invasive breast carcinomas. Pri... more Primary breast sarcomas are very rare and account less than 1% of invasive breast carcinomas. Primary sarcomas of breast are leiomyosarcoma, angiosarcoma, liposarcoma, fibrosarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor and pleomorphic sarcoma. Recently, a new CD10 positive group of sarcoma was identified. These tumors cannot be classified as a soft tissue sarcoma and show diffuse strong positive staining pattern with CD10 (NSCD10). Herein we report clinical and morphological characteristics of two cases diagnosed with not otherwise specified-type sarcoma with CD10 expression by histologically and immunohistochemical findings with the literature. NSCD10 shows similarity with leiomyosarcoma and sarcomatoid-type metaplastic carcinoma histomorphologically among specific sarcomas of breast. CD10 expression should be taken into consideration in the presence of not diagnosed and not specified tumors and CD10 should be added to the immunohistochemical panel.
Journal of Breast Health, 2015
This study aimed presenting a case of a 64-year-old woman with a rare diagnosis of myofibroblasto... more This study aimed presenting a case of a 64-year-old woman with a rare diagnosis of myofibroblastoma (MFB). MFB is one of the rare, benign, spindle-like stromal tumors arising from the connective tissue of the breast. MFBs are often confused with fibroadenomas and hamartomas because of their benign characteristic appearance on breast imaging and are diagnosed after excisional biopsies. Their differential diagnosis with malignant neoplasia of the breast is important because of their wide morphological spectrum. Our case also demonstrated a breast mass with benign imaging characteristics and a needle core biopsy revealing a benign, spindle-like stromal tumor. The pathological examination performed after the excision of the lump demonstrated a collagenous-/ fibrous-type MFB. This case report emphasizes the rare but important place of MFB variants of the breast in the differential diagnosis of breast mass.
Turkish Journal of Surgery, 2012
GIRIŞ Yuz yaniklari, tum yanik olgularinin yaklasik %5’ini olusturur (1). Yuz yanigi varligi, yan... more GIRIŞ Yuz yaniklari, tum yanik olgularinin yaklasik %5’ini olusturur (1). Yuz yanigi varligi, yanik yuzey alaninin genisliginden bagimsiz olarak cogu hastada yanik ciddiyetinin hayati gostergesi gibidir (2,3). Yuz bolgesi, konumundan dolayi siklikla alev disindaki yanik unsurlarina gorece olarak daha korunaklidir. Yuz yaniklarinin cogunun alev temasiyla olusmasi, eslik eden olumcul inhalasyon hasarini beraberinde getirmektedir (4). Bu nedenle, goz hasari varligi, ileride karsilasilabilecek gorme sorunlarinin disinda, genel sonucun ongorulmesi acisindan da onemli bir ipucu olabilir (3,5–7). Bu varsayimdan hareketle, yuz yaniklarinda goz hasari sikligini ve yanik turu ve oranina gore ciddiyetini geriye donuk olarak inceledik.
Turkish Journal of Surgery, 2010
GIRIŞ Bezoarlar, sindirimi olmayan maddelerin mide veya ince barsaklarda birikerek kitle olusturm... more GIRIŞ Bezoarlar, sindirimi olmayan maddelerin mide veya ince barsaklarda birikerek kitle olusturmasidir. Bezoarlar icerigine gore fitobezoar, trikobezoar, laktobezoar gibi degisik sekilde adlandirilir. En sik gorulen tur fitobezoarlardir (1). Mekanik barsak tikanikliginin nadir bir nedenidir. Gecirilmis karin ameliyati olan hastalarda barsak tikanikliginin en sik sebebi adezyonlardir. Klinik degerlendirmede bezoarlara bagli ileuslarin kendine ozgu bulgulari yoktur. Direkt grafilerde kolay taninmazlar. Bilgisayarli tomografilerin (BT) acil olgularda yaygin kullanilmaya baslamasiyla ameliyat oncesi donemde bezoara bagli ileus tanisinin konulmasi mumkun hale gelmistir (2,3). Bu calismanin amaci, barsak tikanikliklarina nadiren neden olan bezoarlarin predispozan faktorlerinin arastirilmasi ve tani konmasinda klinik ve radyolojik bulgularin gozden gecirilmesidir. GEREC VE YONTEM Aralik 1999-Mayis 2010 tarihleri arasinda Baskent Universitesi Genel Cerrahi Anabilim Dali’nda bezoarlara bagli barsak tikanikligi nedeniyle ameliyat edilen 24 hasta, geriye donuk olarak degerlendirildi. Yas, cinsiyet, radyolojik ve klinik bulgular, bezoarlarin lokalizasyonu, tedavi yontemleri ve komplikasyonlar, dosya verilerinden geriye donuk incelendi. Verilerin analizi SPSS 11.0 paket programi ile yapildi. Verilerin ortalamasi standart sapmalari ile ortancalari minimum ve maksimum degerleriyle birlikte verildi. Cerrahi alan enfeksiyonlarinin (CAE) karsilastirilmasinda Fisher’in kesin ki-kare testi, hastane yatis surelerinin karsilastirimasinda ise Mann Whitney U testi kullanildi. p<0,05 degeri anlamli olarak kabul edildi.
Balkan Medical Journal, 2015
To the Editor, Biliary leakage is an important complication that occurs after cholecystectomy (1)... more To the Editor, Biliary leakage is an important complication that occurs after cholecystectomy (1). Unless uncomplicated, it generally closes spontaneously if there is no distal obstruction (2). The therapeutic endoscopic retrograde cholangiopancreatography (ERCP) procedure is helpful in the clearance of biliary flow and lowering the biliary pressure (3). In case of insufficiency of the ERCP procedure, percutaneous biliary drainage maneuvers can help to control biliary fistulas or save time for surgery (4,5). We present a case of bile leakage which occurred after laparoscopic cholecystectomy, where we encountered an interesting cause of acute pancreatitis. A 32 year-old woman who underwent a laparoscopic cholecystectomy two weeks previously was referred to us with a drain placed in the operation wound, suggesting bile leakage. Physical examination revealed disseminated tenderness of the abdomen. Transaminase, amylase and lipase levels were normal. Computed tomography scan showed a 10 cm fluid collection in the sub-hepatic area. We followed her up for two weeks with the drainage of 200 mL of bile daily. A magnetic resonance cholangiopancreatography imaging was obtained showing some sludge and stone of 22 mm in the distal common hepatic duct (CHD). An ERCP was applied, where the pancreatic duct was found to be widened, but CHD could not be cannulated. An 8 F pigtail-locked percutaneous internal-external biliary drainage catheter (Flexima ® Drainage Catheters, Boston Scientific; Natick, MA, USA) was placed and a prominent leakage from the cystic duct stump was demonstrated in cholangiography (Figure 1a). Fluid collection diminished by the 24 th day. During the second catheter cholangiography, some small stones were pushed into the duodenum by a balloon catheter. One big stone, which remained in place, was extracted on the following day, by a successful ERCP procedure performed with the guidance of a biliary catheter (Figure 1b). Oral feeding was never paused. The intra-abdominal drainage
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
18 F-FDG PET/CT has an acceptable specificity but a low sensitivity on the prediction of axillary... more 18 F-FDG PET/CT has an acceptable specificity but a low sensitivity on the prediction of axillary lymph node (ALN) metastasis in breast cancer. We analyzed the factors that could possibly affect this prediction. The records of 270 patients with T1-2 invasive breast cancer who underwent surgery, 116 of whom had been evaluated by preoperative 18 F-FDG PET/CT were reviewed. Prediction of ALN status by PET/CT according to tumor stage, estrogen receptor (ER), progesterone receptor (PgR) and HER2 status, histology, age and sentinel node properties was assessed. ALN metastasis was present in 62 of 131 T1 (43.7%) and 106 of 142 T2 tumors (74.6%), 20 of 46 (43.5%) ER(-) and 146 of 222 (65.8%) ER(+) tumors, 38 of 71 (53.5%) PgR(-) and 127 of 200 (63.5%) PgR(+) tumors. On multivariate analysis only the tumor size (>2 cm) independently correlated with ALN metastasis (Odds ratio/OR=3.1). None of the other parameters had statistical significance in terms of ALN prediction on FDG-PET/CT. Though...
Tropical doctor, 2017
Biliary fistulation from a hepatic hydatid cyst is its most frequent complication. If unrecognise... more Biliary fistulation from a hepatic hydatid cyst is its most frequent complication. If unrecognised, this may cause difficulties during and after surgical intervention. Our study looked into its incidence and also the possible risk factors in a retrospective investigation of 60 patients (34 women) who had undergone surgery or percutaneous treatment. Demographics and anatomical characteristics, such as cyst type, location, number, diameter and laboratory findings were examined. A full 50% had biliary fistulation, with increased risk if the cyst diameter was ≥8.8 cm.
12. Ulusal Meme HastalıklarıKongresi, 2013
GİRİŞ Yüz yanıkları, tüm yanık olgularının yaklaşık %5’ini oluşturur (1). Yüz yanığı varlığı, yan... more GİRİŞ Yüz yanıkları, tüm yanık olgularının yaklaşık %5’ini oluşturur (1). Yüz yanığı varlığı, yanık yüzey alanının genişliğinden bağımsız olarak çoğu hastada yanık ciddiyetinin hayati göstergesi gibidir (2,3). Yüz bölgesi, konumundan dolayı sıklıkla alev dışındaki yanık unsurlarına görece olarak daha korunaklıdır. Yüz yanıklarının çoğunun alev temasıyla oluşması, eşlik eden ölümcül inhalasyon hasarını beraberinde getirmektedir (4). Bu nedenle, göz hasarı varlığı, ileride karşılaşılabilecek görme sorunlarının dışında, genel sonucun öngörülmesi açısından da önemli bir ipucu olabilir (3,5–7). Bu varsayımdan hareketle, yüz yanıklarında göz hasarı sıklığını ve yanık türü ve oranına göre ciddiyetini geriye dönük olarak inceledik.
Sonuç: Sitologların deneyiminin artmasının, çıkarılan nodüllerde kanser ile karşılaşma oranımızın... more Sonuç: Sitologların deneyiminin artmasının, çıkarılan nodüllerde kanser ile karşılaşma oranımızın da artmasına yardımcı olacağı kanaatindeyiz. Sonuç olarak, benign nodüler guatrın cerrahi tedavisinde mümkün olduğunca geniş cerrahi yöntemler tercih edilmelidir.
BACKGROUND In patients with extensive burns, all unburned areas can be used as donor sites. In ma... more BACKGROUND In patients with extensive burns, all unburned areas can be used as donor sites. In male patients with small burns, preputial skin graft may be a good choice in order to avoid donor site problems. METHODS We retrospectively reviewed 12 patients treated in our burn center from January 1997 to August 2007 with preputial skin grafting. RESULTS In three patients, preputial skin was the only graft source. In nine patients, other donor sites were also used for split-thickness graft harvesting. In two patients, preputial skin graft was used for periareolar grafting where hyperpigmented healing was preferred. In the rest of the patients, preputial skin graft was used on various parts of the body. Overall success rate for preputial skin graft was 100%. There was no early donor site morbidity. CONCLUSION Preputial skin is a full-thickness, highly elastic and easy-to-harvest graft that should be considered in all burned male children in whom grafting is needed.
Nodüler guatr tedavisi yaklaşımları arasında cerrahi tedavinin önemli bir yeri vardır. Uygulanan ... more Nodüler guatr tedavisi yaklaşımları arasında cerrahi tedavinin önemli bir yeri vardır. Uygulanan cerrahi işlemler nodül eksizyonu, parsiyel tiroit lobektomi, total lobektomi, bilateral subtotal tiroidektomi, total lobektomi ve kontralateral subtotal lobektomi (Dunhill prosedürü), totale yakın tiroidektomi ve total tiroidektomidir (2,3). Soliter nodüler guatrda uygulanması gereken teknik, total lobektomi-istmusektomidir. Bu teknikte tiroit lobu ekstrakapsüler olarak diseke edilip nervus laringeus rekürrens korunarak total olarak eksize edilir (4). Erişkin popülasyonunda palpabl nodül %4-7 civarındadır ve her yıl %0.8 oranında yeni nodül saptanmaktadır (5,6). Multipl nodüllerden belirgin büyük olanına dominant nodül ve bu guatrlara dominant nodüllü multinodüler guatr adı verilir. Bu nodüllerin çoğunun benign olmasına karşın nodülde kanser olasılığı her zaman mevcuttur. Soliter nodüllerde ortalama %4.7, dominant nodülde %4.1, multinodüler ise %1 oranında maligniteye rastlanır. Bu oranl...
European Journal of Breast Health
Turkish Journal of Pathology
Objective: To evaluate the pathological and radiological features, immunohistochemical profile an... more Objective: To evaluate the pathological and radiological features, immunohistochemical profile and treatment methods of primary male breast carcinoma cases diagnosed at our center. Material and Method: The pathology archive between 2006 and 2019 was reviewed and the data of 27 male patients diagnosed as primary breast cancer were retrospectively evaluated. Results: The age of the patients ranged between 40-86 years. The left breast was involved in 17 patients. The mean tumor diameter was 2.35 ± 1.09 cm. Of the 27 cases, 8 were dead and 19 were alive. The mean follow-up duration was 37.45 ± 24.84 months. The mean estimated life expectancy was 65±14.7 months. The most common complaint was a swelling in the breast. The time interval between the onset of complaints and admittance to hospital ranged from three months to two years. The most common histopathological diagnosis was invasive carcinoma-no special type. The most common surgical procedure was mastectomy with lymph node dissection. Nine patients had metastatic lymph nodes. In terms of the hormone profiles, 24 were Estrogen receptor positive, 21 were Progesterone receptor positive and six were Her2/neu positive. Three patients had triple-negative tumors. Conclusion: Male breast carcinoma is a rare disease but its frequency has been increasing recently. As breast cancer is more commonly attributed to women, the diagnosis is usually delayed until later stages in males. Public awareness should therefore be increased and breast cancer should be considered in the differential diagnosis especially in the presence of breast swelling and complaints related to the breast skin so that the appropriate biopsy can be obtained without delay.
European Journal of Breast Health
Stromal tumors are the prominent mesenchymal tumors of gastrointestinal tract (GIT) (1). They are... more Stromal tumors are the prominent mesenchymal tumors of gastrointestinal tract (GIT) (1). They are more apparent in upper middle age, mostly in 5 th and 6 th decades. They occur equally in both sexes (1). Gastrointestinal Stromal Tumors (GISTs) are most commonly localized in the stomach (40-70%) and may be found in the intestine (20-32%), colon (10%) and esophagus (5%) (1, 2). They also can be seen in extra-GIT sites like mesentery, omentum and retroperitoneum (2). Major patient complaints regarding GISTs are upper abdominal pain, GIT bleeding and abdominal masses (1). Interstitial cells of Cajal (ICC), which GISTs are thought to originate from, both express tyrosine kinase receptors (c-kit) and stain with CD34 and Vimentin. KIT (CD117) is a transmembrane tyrosine kinase receptor, which is expressed in hematopoietic stem cells, germ cells, mast cells, melanocytes and ICC (2). C-Kit positivity is an important parameter in diagnosis of GIST. Recently, a specific marker, namely discovered on GIST1 (DOG-1), has been discovered for GIST diagnosis. It is shown to be positive on ICCs and gastric surface epithelium. DOG-1 is also expressed in high amounts in KIT mutation-negative cases besides typical GIST cases (3). Immunohistochemical diagnosis of GIST is adopted when mesenchymal tumors stain positive with c-Kit (CD117) and the DOG-1 where the rest of mesenchymal cell markers were negative. Demonstration of CD117 and recently DOG-1 positivity immunochemically stands for the standard technique of definitive diagnosis of GIST. CD34 is positive in 70-80% of the cases. Vimentin is diffuse and strong positive in many stromal tumors. SMA is positive in 30-40% and S100 in 5% of GISTs. Staining with desmin is rare (1). Malignant stromal tumors mostly metastasize to liver, peritoneum, lungs and bones (4). Brain and lymph node metastases are unusual (4). No breast metastasis was presented in literature before. Hereby, we present a case of GIST with liver, bone, lymph node and breast metastases and aimed to discuss its unusual metastatic reviewing literature. Case Presentation A 46 year-old woman was referred to us from another health facility with the complaint of back pain. The radiological imaging studies revealed multiple liver metastases with the largest being 5.5 cm in diameter as well as multiple bone involvements. Positron Emission
Turkish Journal of Pathology
Objective: To evaluate the pathological and radiological features, hormone profiles, surgery and ... more Objective: To evaluate the pathological and radiological features, hormone profiles, surgery and treatment methods of metaplastic breast carcinoma cases diagnosed at our center in the light of current literature. Material and Method: A total of 38 metaplastic breast cancer cases diagnosed between 2006-2018 at our center were included in the study. The patients were evaluated in terms of age, tumor size, localization, histological grade, hormone profiles (ER, PR, Her2-neu), American Joint Committee on Cancer (AJCC) Tumor, Lymph node status, Metastases (TNM) stage, progression, survival, radiological features, types of surgery and therapy modalities (chemotherapy and / or radiotherapy). Results: The age of the patients ranged between 32 and 95 years. Pathological evaluation of cases showed that 14 were pure epithelial (IC-NST + squamous cell carcinoma) and 24 were metaplastic carcinomas with mesenchymal differentiation. Ductal carcinoma in situ (DCIS) was accompanying an invasive component in twenty cases. Seventeen patients had lymph node metastasis. Twelve patients developed distant metastasis. Thirty patients were triple negative for hormone receptors. The mean follow-up period of the patients was 34 months. The estimated life expectancy was 116 months. All of the patients received chemotherapy and 28 patients received adjuvant radiotherapy. There was no correlation between tumor size and lymph node or distant metastasis in our series. Our findings are consistent with the literature. Conclusion: Metaplastic breast carcinoma is a rare entity among breast carcinomas. Metaplastic carcinomas of the breast draw attention with the differences in their clinical course and the radiological and pathological heterogeneity.
European Journal of Breast Health
Primary breast sarcomas are very rare and account less than 1% of invasive breast carcinomas. Pri... more Primary breast sarcomas are very rare and account less than 1% of invasive breast carcinomas. Primary sarcomas of breast are leiomyosarcoma, angiosarcoma, liposarcoma, fibrosarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor and pleomorphic sarcoma. Recently, a new CD10 positive group of sarcoma was identified. These tumors cannot be classified as a soft tissue sarcoma and show diffuse strong positive staining pattern with CD10 (NSCD10). Herein we report clinical and morphological characteristics of two cases diagnosed with not otherwise specified-type sarcoma with CD10 expression by histologically and immunohistochemical findings with the literature. NSCD10 shows similarity with leiomyosarcoma and sarcomatoid-type metaplastic carcinoma histomorphologically among specific sarcomas of breast. CD10 expression should be taken into consideration in the presence of not diagnosed and not specified tumors and CD10 should be added to the immunohistochemical panel.
Journal of Breast Health, 2015
This study aimed presenting a case of a 64-year-old woman with a rare diagnosis of myofibroblasto... more This study aimed presenting a case of a 64-year-old woman with a rare diagnosis of myofibroblastoma (MFB). MFB is one of the rare, benign, spindle-like stromal tumors arising from the connective tissue of the breast. MFBs are often confused with fibroadenomas and hamartomas because of their benign characteristic appearance on breast imaging and are diagnosed after excisional biopsies. Their differential diagnosis with malignant neoplasia of the breast is important because of their wide morphological spectrum. Our case also demonstrated a breast mass with benign imaging characteristics and a needle core biopsy revealing a benign, spindle-like stromal tumor. The pathological examination performed after the excision of the lump demonstrated a collagenous-/ fibrous-type MFB. This case report emphasizes the rare but important place of MFB variants of the breast in the differential diagnosis of breast mass.
Turkish Journal of Surgery, 2012
GIRIŞ Yuz yaniklari, tum yanik olgularinin yaklasik %5’ini olusturur (1). Yuz yanigi varligi, yan... more GIRIŞ Yuz yaniklari, tum yanik olgularinin yaklasik %5’ini olusturur (1). Yuz yanigi varligi, yanik yuzey alaninin genisliginden bagimsiz olarak cogu hastada yanik ciddiyetinin hayati gostergesi gibidir (2,3). Yuz bolgesi, konumundan dolayi siklikla alev disindaki yanik unsurlarina gorece olarak daha korunaklidir. Yuz yaniklarinin cogunun alev temasiyla olusmasi, eslik eden olumcul inhalasyon hasarini beraberinde getirmektedir (4). Bu nedenle, goz hasari varligi, ileride karsilasilabilecek gorme sorunlarinin disinda, genel sonucun ongorulmesi acisindan da onemli bir ipucu olabilir (3,5–7). Bu varsayimdan hareketle, yuz yaniklarinda goz hasari sikligini ve yanik turu ve oranina gore ciddiyetini geriye donuk olarak inceledik.
Turkish Journal of Surgery, 2010
GIRIŞ Bezoarlar, sindirimi olmayan maddelerin mide veya ince barsaklarda birikerek kitle olusturm... more GIRIŞ Bezoarlar, sindirimi olmayan maddelerin mide veya ince barsaklarda birikerek kitle olusturmasidir. Bezoarlar icerigine gore fitobezoar, trikobezoar, laktobezoar gibi degisik sekilde adlandirilir. En sik gorulen tur fitobezoarlardir (1). Mekanik barsak tikanikliginin nadir bir nedenidir. Gecirilmis karin ameliyati olan hastalarda barsak tikanikliginin en sik sebebi adezyonlardir. Klinik degerlendirmede bezoarlara bagli ileuslarin kendine ozgu bulgulari yoktur. Direkt grafilerde kolay taninmazlar. Bilgisayarli tomografilerin (BT) acil olgularda yaygin kullanilmaya baslamasiyla ameliyat oncesi donemde bezoara bagli ileus tanisinin konulmasi mumkun hale gelmistir (2,3). Bu calismanin amaci, barsak tikanikliklarina nadiren neden olan bezoarlarin predispozan faktorlerinin arastirilmasi ve tani konmasinda klinik ve radyolojik bulgularin gozden gecirilmesidir. GEREC VE YONTEM Aralik 1999-Mayis 2010 tarihleri arasinda Baskent Universitesi Genel Cerrahi Anabilim Dali’nda bezoarlara bagli barsak tikanikligi nedeniyle ameliyat edilen 24 hasta, geriye donuk olarak degerlendirildi. Yas, cinsiyet, radyolojik ve klinik bulgular, bezoarlarin lokalizasyonu, tedavi yontemleri ve komplikasyonlar, dosya verilerinden geriye donuk incelendi. Verilerin analizi SPSS 11.0 paket programi ile yapildi. Verilerin ortalamasi standart sapmalari ile ortancalari minimum ve maksimum degerleriyle birlikte verildi. Cerrahi alan enfeksiyonlarinin (CAE) karsilastirilmasinda Fisher’in kesin ki-kare testi, hastane yatis surelerinin karsilastirimasinda ise Mann Whitney U testi kullanildi. p<0,05 degeri anlamli olarak kabul edildi.
Balkan Medical Journal, 2015
To the Editor, Biliary leakage is an important complication that occurs after cholecystectomy (1)... more To the Editor, Biliary leakage is an important complication that occurs after cholecystectomy (1). Unless uncomplicated, it generally closes spontaneously if there is no distal obstruction (2). The therapeutic endoscopic retrograde cholangiopancreatography (ERCP) procedure is helpful in the clearance of biliary flow and lowering the biliary pressure (3). In case of insufficiency of the ERCP procedure, percutaneous biliary drainage maneuvers can help to control biliary fistulas or save time for surgery (4,5). We present a case of bile leakage which occurred after laparoscopic cholecystectomy, where we encountered an interesting cause of acute pancreatitis. A 32 year-old woman who underwent a laparoscopic cholecystectomy two weeks previously was referred to us with a drain placed in the operation wound, suggesting bile leakage. Physical examination revealed disseminated tenderness of the abdomen. Transaminase, amylase and lipase levels were normal. Computed tomography scan showed a 10 cm fluid collection in the sub-hepatic area. We followed her up for two weeks with the drainage of 200 mL of bile daily. A magnetic resonance cholangiopancreatography imaging was obtained showing some sludge and stone of 22 mm in the distal common hepatic duct (CHD). An ERCP was applied, where the pancreatic duct was found to be widened, but CHD could not be cannulated. An 8 F pigtail-locked percutaneous internal-external biliary drainage catheter (Flexima ® Drainage Catheters, Boston Scientific; Natick, MA, USA) was placed and a prominent leakage from the cystic duct stump was demonstrated in cholangiography (Figure 1a). Fluid collection diminished by the 24 th day. During the second catheter cholangiography, some small stones were pushed into the duodenum by a balloon catheter. One big stone, which remained in place, was extracted on the following day, by a successful ERCP procedure performed with the guidance of a biliary catheter (Figure 1b). Oral feeding was never paused. The intra-abdominal drainage