Ayush naik - Academia.edu (original) (raw)

Papers by Ayush naik

Global Journal For Research Analysis (GJRA), Aug 22, 2020

Journal of Water and Health, 2020

Safe water, sanitation, and hygiene (WASH) is critical for the prevention of postpartum infection... more Safe water, sanitation, and hygiene (WASH) is critical for the prevention of postpartum infections. The aim of this study was to characterize the WASH conditions women are exposed to following cesarean section in rural Rwanda. We assessed the variability of WASH conditions in the postpartum ward of a district hospital over two months, the WASH conditions at the women's homes, and the association between WASH conditions and suspected surgical site infection (SSI). Piped water flowed more consistently during the rainy month, which increased availability of water for drinking and handwashing (p < 0.05 for all). Latex gloves and hand-sanitizer were more likely to be available on weekends versus weekdays (p < 0.05 for both). Evaluation for suspected SSI after cesarean section was completed for 173 women. Women exposed to a day or more without running water in the hospital were 2.6 times more likely to develop a suspected SSI (p = 0.027). 92% of women returned home to unsafe WAS...

Reports of Practical Oncology & Radiotherapy, 2020

Aim: To analyse the interfractional bladder and rectal volume changes and the influence on prosta... more Aim: To analyse the interfractional bladder and rectal volume changes and the influence on prostate position. Background: Interfractional displacement of prostate due to variation in bladder and rectal volume is usual. It is only rational to study the bladder and rectal volume changes and their effects on prostate position during intensity modulated radiotherapy of prostate cancer. Materials and Methods: A prospective study was conducted on twenty patients with localized prostate cancer during the first phase of radiotherapy, where 50 gray in 25 fractions was delivered by the IMRT technique with daily cone beam computed tomography Bladder and rectum volumes were delineated on CBCT images and their volumes were noted. Prostate position was noted on each set of CBCT images with respect to specific reference points defined on the ileum and coccyx, and daily prostate displacement was noted. Results: Mean setup errors in vertical, longitudinal and lateral directions were noted as 1.49, 0.498 and 0.17 cm, respectively. Mean change in bladder and rectal volumes in daily CBCT images with respect to that on the first day CT images was noted as 101.94 and 10.22, respectively. Mean lateral and vertical displacement in prostate position was noted as 0.53 and 0.49 cm respectively. No considerable changes in dosimetric parameters were observed because of bladder and rectal volume changes. Conclusions: Daily CBCT should be done for accurate treatment delivery by the IMRT technique for prostate radiotherapy as prostate shifts physiologically with changes in rectal and bladder volumes.

Journal of Cancer Research and Therapeutics, 2018

Background: Advancement in diagnostic and therapeutic modalities lead to increased cancer survivo... more Background: Advancement in diagnostic and therapeutic modalities lead to increased cancer survivors who have 20% higher risk of developing second primary malignancy (SPM). Aim: To look for the incidence, epidemiological factors, treatment-related factors, and common risk factors responsible for the development of the SPM in Malwa region. Materials and Methods: Records of 7709 patients who visited the Department of Oncology between May 2008 and August 2015 were analyzed and looked for the presence of SPM based on Warren and Gates criteria for head and neck and International Agency for Research on Cancer definition for other sites. Data pertaining age at diagnosis of each tumor, gender, site, histology, the duration between primary and secondary tumors, treatment received for each malignancy, smoking and drinking habits, and metastasis sites were recorded. Results: Of 7709 patients, 56 developed SPM (11 synchronous and 45 metachronous) with an overall incidence of 0.726%. For metachronous SPM, the interval of 10–312 months was observed, with a mean time of 103.32 months (standard deviation 65.9 months). About 71.42% patients with SPM belonged to fifth, sixth, and seventh age decade. The median age of diagnosis for the second primary neoplasm was 57 years (range: 34–85 years). Maximum SPM were observed among head and neck tumors (33.93%) followed by breast (26.78%). The most common sites for SPM are head and neck (32.14%) followed by digestive system (19.64%). Breast as the first or the second location was seen associated with almost all systems. For the treatment of first primary, six received surgery, three received chemotherapy (CT), one received radiotherapy (RT) alone, and rest 46 patients received combined modality. For the treatment of SPM, 37 patients received combined modality, ten received CT, three with RT, and two with surgery while four patients received no treatment. Thirty-two patients had habits of tobacco, smoking and alcohol intake with twenty patients continued these after treatment for the first primary neoplasm. Conclusions: Patients with breast and head and neck cancer have a higher risk of developing SPM. The possibility of SPM should be considered and excluded during pretreatment evaluation and during follow-up of treated cancer patients.

GLOBAL JOURNAL FOR RESEARCH ANALYSIS, 2020

Background: Microvascular free ap transfers have become a preferred reconstructive technique; ho... more Background: Microvascular free ap transfers have become a preferred reconstructive technique; however, rare complica-tions may still prove devastating. Aim: The objective of this study was to evaluate the clinical outcomes in Head and neck cancer patients undergoing different microvascular free ap reconstructions . Materials and Methods: his study analyzed the surgical out-come and complications of 200 microvascular free aps head and neck reconstruction. In most cases, after resection of the malignant tumor, reconstruction was undertaken . Four types of free ap were performed as follows: Anterolateral thigh (80%), radial forearm (15%), bula (4%), and jejunum (1%). The most commonly used as recipient vessels for anastomosis were superior thyroid artery and the external jugular vein. The incidence of perioperative complications and Patient-related characteristics (age, sex, diagnosis, comorbidity, level, tumor stage, defect site, primary versus secondary reconstruction, and histo...

Brachytherapy, 2019

the whole group.There was no statistically significant difference between preoperative and postop... more the whole group.There was no statistically significant difference between preoperative and postoperative indexes of D90, V100 and V150 (P values were 0.100, 0.628 and 0.971, respectively). Conclusion: Imaging-guided radioactive 125I seed implantation for advanced breast cancer was a safe and feasible method with good shortterm efficacy.

Medical Journal of Dr. D.Y. Patil University, 2016

Background: Radiation sequelae can be early or late depending on the duration of occurrence. Earl... more Background: Radiation sequelae can be early or late depending on the duration of occurrence. Early reactions are temporary, but late reactions tend to be permanent and occur many years after treatment. Late reactions can be seen in skin, subcutaneous tissue, muscle, and bone in the irradiated area. Materials and Methods: We present here a report in which we saw all the late reactions in a single patient, 18 years after radiotherapy to pelvis for cancer cervix. Results: Our patient had bone fracture, new bone formation, bone marrow widening, muscle hypertrophy, subcutaneous fibrosis, and angiokeratoma after 18 years of radiotherapy to pelvic area. Conclusion: All these types of late toxicities are rarely seen in the same patient and we could not find any such reports in the literature.

The British journal of radiology, Jan 31, 2016

To compare dosimetric parameters and acute toxicity rates between whole-pelvic (WP) and prostate-... more To compare dosimetric parameters and acute toxicity rates between whole-pelvic (WP) and prostate-only (PO) volumetric-modulated arc therapy (VMAT) in patients with localized prostate cancer. A total of 224 consecutive patients treated with definitive VMAT to 78 Gy in 39 fractions were enrolled. Of these, 119 patients received initial WP VMAT at 46.8 Gy in 26 fractions using a simultaneous integrated boost technique, and 105 patients received PO VMAT. Image-guided radiotherapy was practised with daily cone beam CT. The mean rectal dose, the rectal volume receiving ≥30 Gy (V30Gy), rectal V50Gy, the mean bladder dose, bladder V30Gy and bladder V50Gy were significantly increased in the WP group (p < 0.05 each); however, the rectal V70Gy did not differ between groups (p = 0.101), and the bladder V70Gy was significantly lower in the WP group (p = 0.029). The WP group experienced a significantly increased frequency of acute grade 2 diarrhoea relative to the PO group (5.9% vs 0%; p = 0.0...

Indian Journal of Dermatology, 2016

Angiokeratoma including vulvar angiokeratoma is a very rare complication of radiation. Exact inci... more Angiokeratoma including vulvar angiokeratoma is a very rare complication of radiation. Exact incidence is still unknown, we report a case that developed radiation-induced angiokeratoma of skin in the vulvar region along with other late radiation sequelae in the form of bone fracture, new bone formation, bone marrow widening, muscle hypertrophy, and subcutaneous fibrosis, 18 years after radiotherapy to the pelvic region for the treatment of carcinoma cervix. All these late radiation sequel are rare to be seen in a single patient, and none of the case reports could be found in the world literature.

Reports of Practical Oncology & Radiotherapy, 2016

Aim: To analyse the dosimetric parameters of Co-60 based high dose rate (HDR) brachytherapy plans... more Aim: To analyse the dosimetric parameters of Co-60 based high dose rate (HDR) brachytherapy plans for patients of carcinoma uterine cervix. Background: Co-60 high dose rate (HDR) brachytherapy unit has been introduced in past few years and is gaining importance owing to its long half life, economical benefits and comparable clinical outcome compared to Ir-192 HDR brachytherapy. Materials and methods: A study was conducted on ten patients with locally advanced carcinoma of the uterine cervix (Ca Cx). Computed tomography (CT) images were taken after three channel applicator insertions. The planning for 7 Gray per fraction (7 Gy/#) was done for Co-60 HDR brachytherapy unit following the American Brachytherapy Society (ABS) guidelines. All the patients were treated with 3# with one week interval between fractions. Results: The mean dose to high risk clinical target volumes (HRCTV) for D 90 (dose to 90% volume) was found to be 102.05% (Standard Deviation (SD): 3.07). The mean D 2cc (dose to 2 cubic centimeter volume) of the bladder, rectum and sigmoid were found to be 15.9 Gy (SD:

Journal of Radiotherapy in Practice, 2015

BackgroundFor chest wall irradiation in breast cancer patients, three-dimensional conformal radio... more BackgroundFor chest wall irradiation in breast cancer patients, three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) have made tremendous changes in treatment delivery.PurposeThe purpose of this study is to compare the dosimetric parameters in IMRT and 3DCRT plans.Materials and methodsIMRT and 3DCRT plans were generated for 25 randomly selected postmastectomy breast cancer patients. The prescribed dose (PD) was 50 Gray (Gy) in 25 fractions (#) at the rate of 2 Gy/# with 5#/week. Dose volume histogram was evaluated for planning target volume (PTV) coverage and dose to organs at risk (OARs). All the dosimetric parameters were compared using unpaired student’st-test.ResultsPTV coverage was significantly better in IMRT, although the 90% of PTV was well covered by 90% of PD in all plans by both the techniques. Homogeneity index and conformity index were better in IMRT. V5 Gyand Dmeanof contralateral lung, contralateral breast and heart (right side ...

The Journal of Obstetrics and Gynecology of India, 2015

Introduction Although the incidence of cancer cervix has reduced in India during the last two dec... more Introduction Although the incidence of cancer cervix has reduced in India during the last two decades, still most of the patients presenting in tertiary care centers are in advanced stages. Material and Methods At this center, we see 6% of cancer cervix cases every year, and most of these cases are in stage III and IVa. All these patients have squamous cell carcinoma and were treated with a combination of external and intracavitary radiotherapy along with concurrent cisplatin given once weekly. Eightynine point nine % patients had achieved a complete response. Results Local recurrence was seen in 17.9% at a median duration of 10.5 months, and 8.17% developed distant metastasis involving lung, liver, bone, and supraclavicular lymph nodes. Three patients developed metastasis at unusual sites involving breast, paraspinal muscles, and duodenum which are very rarely involved. These patients were treated with chemotherapy using carboplatin and Paclitaxel combination but succumbed within 8-10 months of development of metastasis.

Chinese Journal of Cancer, 2009