Azin Daraeian - Academia.edu (original) (raw)
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Papers by Azin Daraeian
Asian Journal of Psychiatry
Obsessive-compulsive disorder (OCD) encompasses a broad range of symptoms and is commonly conside... more Obsessive-compulsive disorder (OCD) encompasses a broad range of symptoms and is commonly considered a heterogeneous condition. Attempts were made to define discrete OCD subtypes using a range of symptom-based methods including factor and cluster analyses. The present study aims to find the most appropriate clustering model based on Yale-Brown obsessive-compulsive scale (YBOCS) checklist explaining OCD heterogeneity. Five different clustering algorithms (FCM, K-means, Ward, Ward + K-means and Complete) applied on YBOCS symptoms of 216 patients with OCD. Data studied as four different sets including item-level raw data, item-based factor scores, category-level raw data and categorybased factor scores and clustering results for 2 to 6 cluster solutions evaluated by four clustering indices (Davies-Bouldin, Calinski-Harabasz, Silhouettes and Dunn indices). Two-cluster solution was detected as the most appropriate model for item and category-based clustering analyses of YBOCS checklist symptoms. Patients in each cluster were characterized based on their clinical and demographic properties and results showed that they had similar patterns of symptoms but in different severities. Heterogenity of OCD based on the YBOCS-symptoms has been challenged as OCD patients were classified based on their symptom severity not their symptom patterns. More investigations need to find appropriate measures explaining OCD heterogeneity with clinical importance.
Psychiatry Research, 2016
Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder. This study aimed to ... more Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder. This study aimed to reach a comprehensive perspective of OCD symptoms in Iranian patients. Item-based factor analysis of Y-BOCS checklist from 216 outpatients resulted in five factors including aggression/checking, contamination/cleaning, symmetry/ordering/repeating/counting/hoarding, sexual and somatic. Regression analyses showed that miscellaneous items can be predicted by these factors. Results showed that OCD subtypes in Iranian patients resemble to those of other nations except the aggressive, sexual and religious obsessions; demonstrating the influence of the culture on obsession manifestation. The correlation analyses of factors and clinical characteristics demonstrated that aggression/checking was associated with high obsession scores and more avoidance. Contamination/cleaning was correlated with higher compulsion score. Patients with higher scores on symmetry/ordering/counting/repeating/hoarding had familial OCD pattern with earlier age of onset, lower age at assessment, higher obsession and more avoidance. Sexual factor was associated with less compulsion scores and somatic factor was associated with higher obsessions and compulsions as well as less familial history and more avoidance. These findings provide a comprehensive view of OCD symptom structure in Iranian OCD patients and will be of value to studies using symptom factor to lead investigation of its causes, correlates and treatment strategies considering cross-cultural differences.
Asian Journal of Psychiatry
Obsessive-compulsive disorder (OCD) encompasses a broad range of symptoms and is commonly conside... more Obsessive-compulsive disorder (OCD) encompasses a broad range of symptoms and is commonly considered a heterogeneous condition. Attempts were made to define discrete OCD subtypes using a range of symptom-based methods including factor and cluster analyses. The present study aims to find the most appropriate clustering model based on Yale-Brown obsessive-compulsive scale (YBOCS) checklist explaining OCD heterogeneity. Five different clustering algorithms (FCM, K-means, Ward, Ward + K-means and Complete) applied on YBOCS symptoms of 216 patients with OCD. Data studied as four different sets including item-level raw data, item-based factor scores, category-level raw data and categorybased factor scores and clustering results for 2 to 6 cluster solutions evaluated by four clustering indices (Davies-Bouldin, Calinski-Harabasz, Silhouettes and Dunn indices). Two-cluster solution was detected as the most appropriate model for item and category-based clustering analyses of YBOCS checklist symptoms. Patients in each cluster were characterized based on their clinical and demographic properties and results showed that they had similar patterns of symptoms but in different severities. Heterogenity of OCD based on the YBOCS-symptoms has been challenged as OCD patients were classified based on their symptom severity not their symptom patterns. More investigations need to find appropriate measures explaining OCD heterogeneity with clinical importance.
Psychiatry Research, 2016
Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder. This study aimed to ... more Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder. This study aimed to reach a comprehensive perspective of OCD symptoms in Iranian patients. Item-based factor analysis of Y-BOCS checklist from 216 outpatients resulted in five factors including aggression/checking, contamination/cleaning, symmetry/ordering/repeating/counting/hoarding, sexual and somatic. Regression analyses showed that miscellaneous items can be predicted by these factors. Results showed that OCD subtypes in Iranian patients resemble to those of other nations except the aggressive, sexual and religious obsessions; demonstrating the influence of the culture on obsession manifestation. The correlation analyses of factors and clinical characteristics demonstrated that aggression/checking was associated with high obsession scores and more avoidance. Contamination/cleaning was correlated with higher compulsion score. Patients with higher scores on symmetry/ordering/counting/repeating/hoarding had familial OCD pattern with earlier age of onset, lower age at assessment, higher obsession and more avoidance. Sexual factor was associated with less compulsion scores and somatic factor was associated with higher obsessions and compulsions as well as less familial history and more avoidance. These findings provide a comprehensive view of OCD symptom structure in Iranian OCD patients and will be of value to studies using symptom factor to lead investigation of its causes, correlates and treatment strategies considering cross-cultural differences.