Bülent Genç - Academia.edu (original) (raw)

Papers by Bülent Genç

Research paper thumbnail of Kronik Obstrüktif Akciğer Hastalarında Görsel Uyarılmış Potansiyeller

SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1999 Haziran; 6(2) Kronik Obstruktif Akciger ... more SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1999 Haziran; 6(2) Kronik Obstruktif Akciger Hastalarinda Gorsel Uyarilmis Potansiyeller Savas Yasar, Bulent Oguz Genc, Emine Genc, Orhan Demir, Mecit Suerdem Ozet Kronik obstruktif akciger hastaliginda (KOAH) periferik sinirlerin etkilendigi bilinmektedir.Gorme yollarinda benzer bir etkilenme olup olmadigini arastirmak amaciyla KOAH'h 40 hastada (yas ort. 63.5±6.6) gorsel uyarilmis potansiyeller (VEP) kayitlandi. 'Pattern reversal' (PR), VEP Pm latanslari kontrol grubuna gore anlamli olcude uzun bulundu. Bu sonucun endonoral hipoksi, endonoral mikroanjiyopati, demiyelinizasyon ve aksonal dejenerasyon ile iliskili olabilecegi dusunuldu. Anahtar Kelimeler: Kronik obstruktif akciger hastaligi, kronik hipoksi, gorsel uyarilmis potansiyeller Abstract Visual Evoked Potentials in Chronic Obstructive Pulmonary Disease Nerve conduction studies in patients with chronic obstructive pulmonary disease (COPD) have shown that periphe...

Research paper thumbnail of Adjunctive lacosamide treatment for adult focal-onset epilepsy: focus on comorbid intellectual/developmental disorders and differing responses

Therapeutics and clinical risk management, 2018

Data regarding lacosamide treatment as an adjunctive therapy in patients representative of a foca... more Data regarding lacosamide treatment as an adjunctive therapy in patients representative of a focal-onset epilepsy population including those with and without intellectual/developmental disorders (IDDs) are limited. To evaluate the retention rates of lacosamide in focal-onset epilepsy patients with and without IDD. We retrospectively reviewed all consecutive electronic and paper medical records of patients diagnosed with focal-onset epilepsy who were treated with lacosamide in two tertiary epilepsy centers. One hundred and thirty-six patients who met the inclusion criteria were studied. Number of patients with IDD was 46 (33.8%). Median lacosamide dose was 300 mg/day. A total of 39 patients (28.7%) experienced side effects, and 22 of them (16.2%) discontinued lacosamide. The 1-, 2-, and 3-year retention rates of lacosamide in patients with IDD were 68%, 62%, and 53%, respectively. Kaplan-Meier survival analysis showed that the retention rates were significantly lower in patients with...

Research paper thumbnail of Efficacy, tolerability, and retention rates of zonisamide in older adult patients with focal-onset epilepsy: Experiences from two tertiary epilepsy centers

Epilepsy & Behavior, 2017

The objective of this study was to evaluate the efficacy, tolerability, and retention rates for z... more The objective of this study was to evaluate the efficacy, tolerability, and retention rates for zonisamide (ZNS) in older adult patients with focal-onset epilepsy. Patients and methods: Chart reviews of patients aged 60 years and older with focal-onset epilepsy treated with ZNS in two tertiary epilepsy centers were analyzed retrospectively. Results: Eighty-five patients (41 males, 44 females) aged over 60 years (range: 60-81) with focal-onset epilepsy treated with ZNS were identified; 55.3% of the patients (n = 47) were on monotherapy. The median and average doses of ZNS doses were 200 mg/day (range: 100-400) and 212.9 ± 84.2 mg/day, respectively. With ZNS treatment, 67.1% of the patients (n = 57) were seizure-free for a median of 28 months (range: 10-56) whereas 20% (n = 17) of the patients had seizures that were unresponsive to ZNS treatment. Best seizure control was achieved in patients with poststroke epilepsy; seizure freedom was 80% in this subgroup. Overall retention rate was found to be 83.5%. There was no significant relation between receiving poly-or monotherapy and discontinuation of ZNS (p = 0.18). Thirty-two of the patients (37.6%) lost weight. Median weight loss was 8 kg (range: 2-16). There was no significant correlation between weight loss and the administered doses of ZNS (r = 0.34; p = 0.12). Conclusion: Despite limitations due to the retrospective design of the study, the results show that ZNS is a wellretained drug with high efficacy in older adult patients with epilepsy.

Research paper thumbnail of Associaton between hemispheric asymmetry and horizontal rapid eye movements during rem sleep

Journal of Neurological Sciences (Turkish), 2014

Research paper thumbnail of Airway management in neonates with Pierre Robin sequence

The Turkish journal of pediatrics

Neonates with Pierre Robin sequence (PRs) suffer from varying degrees of airway obstruction and f... more Neonates with Pierre Robin sequence (PRs) suffer from varying degrees of airway obstruction and feeding difficulties, the courses of which differ from patient to patient, due to mandibular deficiency. We aimed to evaluate the course and prognosis of upper airway obstruction in 20 newborns with PRs. Among 15 isolated and 5 syndromic cases, 7 patients fell into Group I, 5 into Group II and 8 into Group III, respectively, according to the clinical classification system proposed by Caouette-Laberge. The 12 patients in Groups I and II were treated with positioning and gavage feeding, whereas the 6 patients in Group III underwent bilateral mandibular distraction. Decannulation or avoidance of tracheostomy was achieved in all of them. A patient who had a significant comorbidity was managed with tracheostomy and one patient expired due to pulmonary problems. When conservative measures fail, mandibular distraction osteogenesis should be considered to obviate tracheostomy in newborns with mic...

Research paper thumbnail of Retrograde flow in the left inferior petrosal sinus and blood steal of the cavernous sinus associated with central vein stenosis: MR angiographic findings

AJNR. American journal of neuroradiology, 2003

We attempted to identify the cause of abnormal venous flow seen during arterial MR angiography in... more We attempted to identify the cause of abnormal venous flow seen during arterial MR angiography in the inferior petrosal sinus by use of in three female patients (aged 51, 48, and 70 years, respectively). Arterial 3D time-of-flight MR angiography was performed with a tilted optimized nonsaturating excitation pulse sequence (TR/TE, 31/7; flip angle, 20 degrees; section thickness, 65 mm; effective thickness, 1 mm; number of sections, 1 to 2); no magnetization transfer pulse sequence was used. Contrast-enhanced 3D MR angiography of the neck was performed with a 3D fast low-angle shot pulse sequence (TR/TE, 4.6/1.8; flip angle, 40 to 45 degrees; section thickness, 80 mm; intersection gap, 1.5 mm; acquisition matrix, 180 x 256; acquisition time, 27 s) on a system with a whole-body coil. In all three patients, 3D time-of-flight MR angiography revealed abnormal vascular signal originating from the left cavernous sinus, continuing through the inferior petrosal sinus, and ending in the proxim...

Research paper thumbnail of Two-Plane Injection of Botulinum Toxin for the Treatment of Glabellar Frown Lines

Plastic and Reconstructive Surgery, 2002

Research paper thumbnail of Cleft Lip/Nose Deformity and Rhinolith

Plastic and Reconstructive Surgery, 2004

Correspondence and brief communications are welcomed and need not concern only what has been publ... more Correspondence and brief communications are welcomed and need not concern only what has been published in this journal. We shall print items of interest to our readers, such as experimental, clinical, and philosophical observations; reports of work in progress; educational notes; and travel accounts relevant to plastic surgery. We reserve the right to edit communications to meet requirements of space and format. Any financial interest relevant to the content of the correspondence must be disclosed. Submission of a letter constitutes permission for the American Society of Plastic Surgeons and its licensees and assignees to publish it in the journal and in any other form or medium. The views, opinions, and conclusions expressed in the Letters to the Editor represent the personal opinions of the individual writers and not those of the publisher, the Editorial Board, or the sponsors of the journal. Any stated views, opinions, and conclusions do not reflect the policy of any of the sponsoring organizations or of the institutions with which the writer is affiliated, and the publisher, the Editorial Board, and the sponsoring organizations assume no responsibility for the content of such letters.

Research paper thumbnail of 4-41-03 Is vestibular excitability increased in migraine?

Journal of the Neurological Sciences, 1997

or sitting up are strongly suggestive for BPPV. However, in our neurotology clinic, we had patien... more or sitting up are strongly suggestive for BPPV. However, in our neurotology clinic, we had patients who presented with ill defined vertigo in whom the final diagnosis was BPPV. The objective of this study was to assess cases of atypical presentation of BPPV. Methods: We reviewed the records of 36 BPPV patients diagnosed in our neurotology clinic in the past eight months. Results: We identified 11 (31%) patients in whom the paroxysmal nature of the vertigo and its positioning precipitating factor were not spontaneously reported. ill defined and even bizarre sensations of imp&ion, falling, floating, or head heaviness, pressure, burning or tingling inside the head with no clear spinning sensation were reported by 7/36 (19%). Neck pain and headache were reported by 1 O/36 (28%) patients as cardinal symptoms that accompanied vertigo. When referral, suspected diagnosis included cervical, unspecified and psychogenic diuinesslvertigo. Conclusions: Non-paroxysmal,

Research paper thumbnail of 2-41-04 How does oculomotor system behave during reading process in the deaf-mute?

Journal of the Neurological Sciences, 1997

Recent pathological evidence suggests that this syndrome is due to a vasculitis that affects the ... more Recent pathological evidence suggests that this syndrome is due to a vasculitis that affects the small vessels of the brain, retina, and membranous labyrinth. Treatment depends on the presentation. For the devastating form (psychiatric/neurological), treatment includes intravenous steroids, immunoglobulin therapy, and cyclophc-sphamide. For less severe forms, including recurrent branch retinal artery occlusions, treatment is uncertain. Anticoagulants are not effective.

Research paper thumbnail of Bilateral Mesial Temporal Sclerosis and Kernicterus

Journal of Computer Assisted Tomography, 2004

Two children with mental retardation, choreoathetosis, dystonia, and muscle rigidity are reported... more Two children with mental retardation, choreoathetosis, dystonia, and muscle rigidity are reported. They had a history of severe hyperbilirubinemia after birth as a result of Rh isoimmunization. The history and clinical picture suggested the diagnosis of kernicterus. The magnetic resonance imaging examination showed a bilateral signal intensity increase in the globus pallidus on T2-weighted images. Additionally, our patients showed symmetric bilateral hyperintensity and volume loss in the hippocampus, which is known to be another characteristic area of bilirubin deposition in kernicterus.

Research paper thumbnail of Neuro-Behçet's syndrome presenting with features mimicking acute tuberculous meningitis

International Journal of Infectious Diseases, 2009

Research paper thumbnail of Two cases of total arm–thorax synechia after severe burn

Burns, 2006

Debridement and application of graft form the surgical basis of the operative therapy in the full... more Debridement and application of graft form the surgical basis of the operative therapy in the full thickness burn injury of the upper extremity [1,2]. Postoperative physical therapy and application of appropriate splints minimize the deformities and therefore the need for reconstructive interventions [3]. Burn contractures, in cases where the early surgical treatment cannot be established, lead to both social and functional disabilities. Many problems may be encountered in the treatment of burn contractures in the upper extremity. A vast number of therapeutic approaches like skin grafts, local and distant flaps have been defined in the treatment of upper extremity and axillary burn contractures [4,5]. But burn sequelae where the arm and the thorax show a total synechiae and their surgical therapy has not been mentioned in the literature.

Research paper thumbnail of A New Flap for Reconstruction of Pilonidal Sinus

Annals of Plastic Surgery, 2007

&... more "Adipofascial turnover flap" is a well-known procedure, but it is generally not used for the surgical treatment of pilonidal sinus disease. The "lumbar adipofascial turnover flap" has been used in this study for the reconstruction of uncomplicated pilonidal sinus disease. Ten cases (8 male and 2 female patients) were operated on by this technique. The reconstruction was performed with the lumbar adipofascial turnover flap. The flap sizes ranged from 4 x 7 cm to 5 x 9 cm (mean, 4.5 x 8 cm), and they were elevated with length-to-base ratio below 2:1. The follow-up period was 14 to 26 months. Postoperative magnetic resonance imaging, computed tomography scan, and power Doppler ultrasound examinations revealed viability of the flaps in all patients. There was no distortion of anatomic landmarks in any of the cases. The esthetic results were satisfying for all patients as well. There was no recurrence in any cases. The hospital stay and mean time off work were shorter compared with other methods of reconstruction and there was no recurrence. We advocate that the lumbar adipofascial turnover flap is an excellent choice for reconstruction of cases with uncomplicated pilonidal sinus disease.

Research paper thumbnail of A New Skin Flap Design for the Repair of Proximal Phalanx Base Defects in Flexion Contractures of Adjacent Fingers

Annals of Plastic Surgery, 2005

A random-pattern cutaneous flap with its base at the highly vascularized dorsal web space has bee... more A random-pattern cutaneous flap with its base at the highly vascularized dorsal web space has been designed to decrease donor site deformity and to increase securely flap mobilization in contractures involving more than 1 adjacent proximal phalanx base. Rectangular flaps facing each other on the lateral sides of adjacent fingers have been raised on a single pedicle in the second, third, or fourth web space. The anatomic integrity of the web space was maintained and exposure of the metacarpophalangeal joints was avoided. Flap donor sites were reconstructed with full-thickness skin grafts. Since September 2000, 22 flaps were raised during a single-stage operation in 13 patients with an average age of 11 years at the time of surgery, and a total of 38 fingers have been reconstructed. The follow-up period averaged 24 months. The postoperative course was uneventful for all patients; all the flaps survived and the donor sites healed without complications. This flap, with its wide arc of rotation and minimal donor site morbidity, is easy to perform and is a good alternative in the reconstruction of multiple proximal phalanx base region flexion contractures of adjacent second, third, fourth, or fifth fingers.

Research paper thumbnail of Amazia with Midface Anomaly: Case Report

Aesthetic Plastic Surgery, 2007

Amazia, the absence of the mammary gland, is a very rare congenital anomaly of the breasts. Bilat... more Amazia, the absence of the mammary gland, is a very rare congenital anomaly of the breasts. Bilateral absence of the breasts may occur as an isolated anomaly or may be associated with a syndrome or a cluster of other anomalies. Although the literature examining pediatric breast abnormalities is replete with case reports and series, bilateral amazia together with skeletal anomalies has not yet been described. An unusual case of amazia associated with face, limb, and vertebrae anomalies is presented.

Research paper thumbnail of The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study

Acta Neurologica Scandinavica, 2009

A, Ö z M. The effects of chronic administration of sumatriptan and dipyrone on serotonergic syste... more A, Ö z M. The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study.

Research paper thumbnail of Kronik Obstrüktif Akciğer Hastalarında Görsel Uyarılmış Potansiyeller

SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1999 Haziran; 6(2) Kronik Obstruktif Akciger ... more SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1999 Haziran; 6(2) Kronik Obstruktif Akciger Hastalarinda Gorsel Uyarilmis Potansiyeller Savas Yasar, Bulent Oguz Genc, Emine Genc, Orhan Demir, Mecit Suerdem Ozet Kronik obstruktif akciger hastaliginda (KOAH) periferik sinirlerin etkilendigi bilinmektedir.Gorme yollarinda benzer bir etkilenme olup olmadigini arastirmak amaciyla KOAH'h 40 hastada (yas ort. 63.5±6.6) gorsel uyarilmis potansiyeller (VEP) kayitlandi. 'Pattern reversal' (PR), VEP Pm latanslari kontrol grubuna gore anlamli olcude uzun bulundu. Bu sonucun endonoral hipoksi, endonoral mikroanjiyopati, demiyelinizasyon ve aksonal dejenerasyon ile iliskili olabilecegi dusunuldu. Anahtar Kelimeler: Kronik obstruktif akciger hastaligi, kronik hipoksi, gorsel uyarilmis potansiyeller Abstract Visual Evoked Potentials in Chronic Obstructive Pulmonary Disease Nerve conduction studies in patients with chronic obstructive pulmonary disease (COPD) have shown that periphe...

Research paper thumbnail of Adjunctive lacosamide treatment for adult focal-onset epilepsy: focus on comorbid intellectual/developmental disorders and differing responses

Therapeutics and clinical risk management, 2018

Data regarding lacosamide treatment as an adjunctive therapy in patients representative of a foca... more Data regarding lacosamide treatment as an adjunctive therapy in patients representative of a focal-onset epilepsy population including those with and without intellectual/developmental disorders (IDDs) are limited. To evaluate the retention rates of lacosamide in focal-onset epilepsy patients with and without IDD. We retrospectively reviewed all consecutive electronic and paper medical records of patients diagnosed with focal-onset epilepsy who were treated with lacosamide in two tertiary epilepsy centers. One hundred and thirty-six patients who met the inclusion criteria were studied. Number of patients with IDD was 46 (33.8%). Median lacosamide dose was 300 mg/day. A total of 39 patients (28.7%) experienced side effects, and 22 of them (16.2%) discontinued lacosamide. The 1-, 2-, and 3-year retention rates of lacosamide in patients with IDD were 68%, 62%, and 53%, respectively. Kaplan-Meier survival analysis showed that the retention rates were significantly lower in patients with...

Research paper thumbnail of Efficacy, tolerability, and retention rates of zonisamide in older adult patients with focal-onset epilepsy: Experiences from two tertiary epilepsy centers

Epilepsy & Behavior, 2017

The objective of this study was to evaluate the efficacy, tolerability, and retention rates for z... more The objective of this study was to evaluate the efficacy, tolerability, and retention rates for zonisamide (ZNS) in older adult patients with focal-onset epilepsy. Patients and methods: Chart reviews of patients aged 60 years and older with focal-onset epilepsy treated with ZNS in two tertiary epilepsy centers were analyzed retrospectively. Results: Eighty-five patients (41 males, 44 females) aged over 60 years (range: 60-81) with focal-onset epilepsy treated with ZNS were identified; 55.3% of the patients (n = 47) were on monotherapy. The median and average doses of ZNS doses were 200 mg/day (range: 100-400) and 212.9 ± 84.2 mg/day, respectively. With ZNS treatment, 67.1% of the patients (n = 57) were seizure-free for a median of 28 months (range: 10-56) whereas 20% (n = 17) of the patients had seizures that were unresponsive to ZNS treatment. Best seizure control was achieved in patients with poststroke epilepsy; seizure freedom was 80% in this subgroup. Overall retention rate was found to be 83.5%. There was no significant relation between receiving poly-or monotherapy and discontinuation of ZNS (p = 0.18). Thirty-two of the patients (37.6%) lost weight. Median weight loss was 8 kg (range: 2-16). There was no significant correlation between weight loss and the administered doses of ZNS (r = 0.34; p = 0.12). Conclusion: Despite limitations due to the retrospective design of the study, the results show that ZNS is a wellretained drug with high efficacy in older adult patients with epilepsy.

Research paper thumbnail of Associaton between hemispheric asymmetry and horizontal rapid eye movements during rem sleep

Journal of Neurological Sciences (Turkish), 2014

Research paper thumbnail of Airway management in neonates with Pierre Robin sequence

The Turkish journal of pediatrics

Neonates with Pierre Robin sequence (PRs) suffer from varying degrees of airway obstruction and f... more Neonates with Pierre Robin sequence (PRs) suffer from varying degrees of airway obstruction and feeding difficulties, the courses of which differ from patient to patient, due to mandibular deficiency. We aimed to evaluate the course and prognosis of upper airway obstruction in 20 newborns with PRs. Among 15 isolated and 5 syndromic cases, 7 patients fell into Group I, 5 into Group II and 8 into Group III, respectively, according to the clinical classification system proposed by Caouette-Laberge. The 12 patients in Groups I and II were treated with positioning and gavage feeding, whereas the 6 patients in Group III underwent bilateral mandibular distraction. Decannulation or avoidance of tracheostomy was achieved in all of them. A patient who had a significant comorbidity was managed with tracheostomy and one patient expired due to pulmonary problems. When conservative measures fail, mandibular distraction osteogenesis should be considered to obviate tracheostomy in newborns with mic...

Research paper thumbnail of Retrograde flow in the left inferior petrosal sinus and blood steal of the cavernous sinus associated with central vein stenosis: MR angiographic findings

AJNR. American journal of neuroradiology, 2003

We attempted to identify the cause of abnormal venous flow seen during arterial MR angiography in... more We attempted to identify the cause of abnormal venous flow seen during arterial MR angiography in the inferior petrosal sinus by use of in three female patients (aged 51, 48, and 70 years, respectively). Arterial 3D time-of-flight MR angiography was performed with a tilted optimized nonsaturating excitation pulse sequence (TR/TE, 31/7; flip angle, 20 degrees; section thickness, 65 mm; effective thickness, 1 mm; number of sections, 1 to 2); no magnetization transfer pulse sequence was used. Contrast-enhanced 3D MR angiography of the neck was performed with a 3D fast low-angle shot pulse sequence (TR/TE, 4.6/1.8; flip angle, 40 to 45 degrees; section thickness, 80 mm; intersection gap, 1.5 mm; acquisition matrix, 180 x 256; acquisition time, 27 s) on a system with a whole-body coil. In all three patients, 3D time-of-flight MR angiography revealed abnormal vascular signal originating from the left cavernous sinus, continuing through the inferior petrosal sinus, and ending in the proxim...

Research paper thumbnail of Two-Plane Injection of Botulinum Toxin for the Treatment of Glabellar Frown Lines

Plastic and Reconstructive Surgery, 2002

Research paper thumbnail of Cleft Lip/Nose Deformity and Rhinolith

Plastic and Reconstructive Surgery, 2004

Correspondence and brief communications are welcomed and need not concern only what has been publ... more Correspondence and brief communications are welcomed and need not concern only what has been published in this journal. We shall print items of interest to our readers, such as experimental, clinical, and philosophical observations; reports of work in progress; educational notes; and travel accounts relevant to plastic surgery. We reserve the right to edit communications to meet requirements of space and format. Any financial interest relevant to the content of the correspondence must be disclosed. Submission of a letter constitutes permission for the American Society of Plastic Surgeons and its licensees and assignees to publish it in the journal and in any other form or medium. The views, opinions, and conclusions expressed in the Letters to the Editor represent the personal opinions of the individual writers and not those of the publisher, the Editorial Board, or the sponsors of the journal. Any stated views, opinions, and conclusions do not reflect the policy of any of the sponsoring organizations or of the institutions with which the writer is affiliated, and the publisher, the Editorial Board, and the sponsoring organizations assume no responsibility for the content of such letters.

Research paper thumbnail of 4-41-03 Is vestibular excitability increased in migraine?

Journal of the Neurological Sciences, 1997

or sitting up are strongly suggestive for BPPV. However, in our neurotology clinic, we had patien... more or sitting up are strongly suggestive for BPPV. However, in our neurotology clinic, we had patients who presented with ill defined vertigo in whom the final diagnosis was BPPV. The objective of this study was to assess cases of atypical presentation of BPPV. Methods: We reviewed the records of 36 BPPV patients diagnosed in our neurotology clinic in the past eight months. Results: We identified 11 (31%) patients in whom the paroxysmal nature of the vertigo and its positioning precipitating factor were not spontaneously reported. ill defined and even bizarre sensations of imp&ion, falling, floating, or head heaviness, pressure, burning or tingling inside the head with no clear spinning sensation were reported by 7/36 (19%). Neck pain and headache were reported by 1 O/36 (28%) patients as cardinal symptoms that accompanied vertigo. When referral, suspected diagnosis included cervical, unspecified and psychogenic diuinesslvertigo. Conclusions: Non-paroxysmal,

Research paper thumbnail of 2-41-04 How does oculomotor system behave during reading process in the deaf-mute?

Journal of the Neurological Sciences, 1997

Recent pathological evidence suggests that this syndrome is due to a vasculitis that affects the ... more Recent pathological evidence suggests that this syndrome is due to a vasculitis that affects the small vessels of the brain, retina, and membranous labyrinth. Treatment depends on the presentation. For the devastating form (psychiatric/neurological), treatment includes intravenous steroids, immunoglobulin therapy, and cyclophc-sphamide. For less severe forms, including recurrent branch retinal artery occlusions, treatment is uncertain. Anticoagulants are not effective.

Research paper thumbnail of Bilateral Mesial Temporal Sclerosis and Kernicterus

Journal of Computer Assisted Tomography, 2004

Two children with mental retardation, choreoathetosis, dystonia, and muscle rigidity are reported... more Two children with mental retardation, choreoathetosis, dystonia, and muscle rigidity are reported. They had a history of severe hyperbilirubinemia after birth as a result of Rh isoimmunization. The history and clinical picture suggested the diagnosis of kernicterus. The magnetic resonance imaging examination showed a bilateral signal intensity increase in the globus pallidus on T2-weighted images. Additionally, our patients showed symmetric bilateral hyperintensity and volume loss in the hippocampus, which is known to be another characteristic area of bilirubin deposition in kernicterus.

Research paper thumbnail of Neuro-Behçet's syndrome presenting with features mimicking acute tuberculous meningitis

International Journal of Infectious Diseases, 2009

Research paper thumbnail of Two cases of total arm–thorax synechia after severe burn

Burns, 2006

Debridement and application of graft form the surgical basis of the operative therapy in the full... more Debridement and application of graft form the surgical basis of the operative therapy in the full thickness burn injury of the upper extremity [1,2]. Postoperative physical therapy and application of appropriate splints minimize the deformities and therefore the need for reconstructive interventions [3]. Burn contractures, in cases where the early surgical treatment cannot be established, lead to both social and functional disabilities. Many problems may be encountered in the treatment of burn contractures in the upper extremity. A vast number of therapeutic approaches like skin grafts, local and distant flaps have been defined in the treatment of upper extremity and axillary burn contractures [4,5]. But burn sequelae where the arm and the thorax show a total synechiae and their surgical therapy has not been mentioned in the literature.

Research paper thumbnail of A New Flap for Reconstruction of Pilonidal Sinus

Annals of Plastic Surgery, 2007

&... more "Adipofascial turnover flap" is a well-known procedure, but it is generally not used for the surgical treatment of pilonidal sinus disease. The "lumbar adipofascial turnover flap" has been used in this study for the reconstruction of uncomplicated pilonidal sinus disease. Ten cases (8 male and 2 female patients) were operated on by this technique. The reconstruction was performed with the lumbar adipofascial turnover flap. The flap sizes ranged from 4 x 7 cm to 5 x 9 cm (mean, 4.5 x 8 cm), and they were elevated with length-to-base ratio below 2:1. The follow-up period was 14 to 26 months. Postoperative magnetic resonance imaging, computed tomography scan, and power Doppler ultrasound examinations revealed viability of the flaps in all patients. There was no distortion of anatomic landmarks in any of the cases. The esthetic results were satisfying for all patients as well. There was no recurrence in any cases. The hospital stay and mean time off work were shorter compared with other methods of reconstruction and there was no recurrence. We advocate that the lumbar adipofascial turnover flap is an excellent choice for reconstruction of cases with uncomplicated pilonidal sinus disease.

Research paper thumbnail of A New Skin Flap Design for the Repair of Proximal Phalanx Base Defects in Flexion Contractures of Adjacent Fingers

Annals of Plastic Surgery, 2005

A random-pattern cutaneous flap with its base at the highly vascularized dorsal web space has bee... more A random-pattern cutaneous flap with its base at the highly vascularized dorsal web space has been designed to decrease donor site deformity and to increase securely flap mobilization in contractures involving more than 1 adjacent proximal phalanx base. Rectangular flaps facing each other on the lateral sides of adjacent fingers have been raised on a single pedicle in the second, third, or fourth web space. The anatomic integrity of the web space was maintained and exposure of the metacarpophalangeal joints was avoided. Flap donor sites were reconstructed with full-thickness skin grafts. Since September 2000, 22 flaps were raised during a single-stage operation in 13 patients with an average age of 11 years at the time of surgery, and a total of 38 fingers have been reconstructed. The follow-up period averaged 24 months. The postoperative course was uneventful for all patients; all the flaps survived and the donor sites healed without complications. This flap, with its wide arc of rotation and minimal donor site morbidity, is easy to perform and is a good alternative in the reconstruction of multiple proximal phalanx base region flexion contractures of adjacent second, third, fourth, or fifth fingers.

Research paper thumbnail of Amazia with Midface Anomaly: Case Report

Aesthetic Plastic Surgery, 2007

Amazia, the absence of the mammary gland, is a very rare congenital anomaly of the breasts. Bilat... more Amazia, the absence of the mammary gland, is a very rare congenital anomaly of the breasts. Bilateral absence of the breasts may occur as an isolated anomaly or may be associated with a syndrome or a cluster of other anomalies. Although the literature examining pediatric breast abnormalities is replete with case reports and series, bilateral amazia together with skeletal anomalies has not yet been described. An unusual case of amazia associated with face, limb, and vertebrae anomalies is presented.

Research paper thumbnail of The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study

Acta Neurologica Scandinavica, 2009

A, Ö z M. The effects of chronic administration of sumatriptan and dipyrone on serotonergic syste... more A, Ö z M. The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study.