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Papers by B. Antmen

Research paper thumbnail of Circumcision Experience in Severe Hemophilia Patients with Inhibitors

Research paper thumbnail of Circumcision and Complications in Adolescent and Adult Patients Wiith Hemophilia in Southern Part of Turkey

20th Congress of European-Hematology-Association -- JUN 11-14, 2015 -- Vienna, AUSTRIAWOS: 000361... more 20th Congress of European-Hematology-Association -- JUN 11-14, 2015 -- Vienna, AUSTRIAWOS: 000361204904224

Research paper thumbnail of Coagulation inhibitors (protein C, protein S, and AT-III) in sickle cell anemia children in steady state

Research paper thumbnail of The Serum Trail and Trail Ligand on the Apopitotic Pathway in Childhood Acute Leukemias

Research paper thumbnail of Physical and perceptional oral health status of children with hemophilia A

Research paper thumbnail of Gene therapy in haemophilia: literature review and regional perspectives for Turkey

Therapeutic Advances in Hematology

Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by insufficient l... more Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by insufficient levels of factor VIII (FVIII; haemophilia A) or factor IX (FIX; haemophilia B) and characterized by spontaneous and trauma-related bleeding episodes. The cornerstone of the treatment, factor replacement, constitutes several difficulties, including frequent injections due to the short half-life of recombinant factors, intravenous administration and the risk of inhibitor development. While extended half-life factors and subcutaneous novel molecules enhanced the quality of life, initial successes with gene therapy offer a significant hope for cure. Although adeno-associated viral (AAV)-based gene therapy is one of the most emerging approaches for treatment of haemophilia, there are still challenges in vector immunogenicity, potency and efficacy, genotoxicity and persistence. As the approval for the first gene therapy product is coming closer, eligibility criteria for patient selection, multi...

Research paper thumbnail of Cukurova Medical Journal Effect of Water Exercise on Atrophic Muscles Associated with Limited Range of Motion in Severe Haemophilia A Patients: a Pilot Study

Purpose: Haemophilia causes musculoskeletal problems over many years secondary to recurrent hemar... more Purpose: Haemophilia causes musculoskeletal problems over many years secondary to recurrent hemarthrosis. In this study, the effects of water exercises on the musculoskeletal system of severe haemophilia A patients with muscle and joint problems were investigated. Material and Methods: Eleven severe haemophilia A patients on prophylaxis treatment participated in the study and following a regular exercise protocol. Results: Subjects displayed statistically significant increases in mid-thigh, upper thigh and calf circumference for right leg (42.0 ± 2.4, 43.0 ±2.1 ; 37.1 ±1.9, 39.0 ±1.8; 28.1 ± 1.4, 28.9 ±1.3 respectively) (mean ± SE) in mid-thigh and upper thigh for left leg (36.9 ± 1.5 , 38.9 ± 1.5 ; 41.2 ± 2.2 , 42.9 ± 2) (p<0.05). Compared to pre-exercise values, leg extensor and flexor strength as well as range of motion were increased significantly (96.6 ± 9º vs 104.5± 8º; before and after training for right knee, 98.5 ± 7.6 º vs 104 ± 7.9 º before and after training for left ...

Research paper thumbnail of Clinical Presentation and Management of Factor X Deficiency: Case Study

Research paper thumbnail of Circumcision in patients with hemophilia and the other bleeding disorders in southern part of Turkey

Research paper thumbnail of Acquired hemophilia A and the knowledge/awareness level of Turkish hematology fellows: On behalf of the Turkish Hematology Association, Acquired Hemophilia Working Group

Research paper thumbnail of National Pediatric Hematopoietic Stem Cell Transplantation Activity in Turkey

41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- MAR 22-25, 20... more 41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- MAR 22-25, 2015 -- Istanbul, TURKEYWOS: 000351632902302European Soc Blood & Marrow Transplanta

Research paper thumbnail of Experiences with Use of Port-a-Cath in Children with Hemophilia: Single Center Study

Research paper thumbnail of Posterior reversible encephalopathy syndrome following pediatric allogeneic bone marrow transplantation: a case series and review

42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- APR 03-06, 20... more 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- APR 03-06, 2016 -- Valencia, SPAINWOS: 000373357600399…European Soc Blood & Marrow Transplanta

Research paper thumbnail of Effectiveness of Radiosynovectomy in Hemophilic Synovitis

Research paper thumbnail of The peripheral blood stem cell transplantation experience in Cukurova University Department of Pediatric Hematology and Oncology

Research paper thumbnail of Mutational Repertoire in the SIPPET Cohort and Prediction of FVIII Inhibitor Risk

Research paper thumbnail of Pharmacokinetic-Guided Prophylaxis Based on Bayesian Model with Mypkfit (R) in Hemophilia A: Turkish Experience

Research paper thumbnail of National Burden of Hemophilia a in Turkey

Oksuz, Ergun/0000-0002-5723-5965WOS: 000503167003144[No abstract available

Research paper thumbnail of Successful Bilateral Cataract and Circumcision Operation Performed in a Hemophilia-A Patient with Inhibitors by Using Recombinant Factor VIIa

Blood, 2005

Objective: Prothrombin complex concentrates (PCC), active prothrombin complex concentrates (APCC;... more Objective: Prothrombin complex concentrates (PCC), active prothrombin complex concentrates (APCC;FEIBA) or recombinant Factor VIIa (rFVIIa; Novoseven) are safely used for the treatment of hemorrhages in hemophiliac patients with inhibitors or during the interventions performed in these patients. A hemophilia-A patient with inhibitors in whom bilateral cataract operation and circumcision were successfully performed by rFVIIa administration was presented. Case: The 13 year old male patient had been diagnosed with severe Hemophilia-A by the detection of a FVIII level below 1% in the factor assay performed due to echhymoses in his body when he was 6 months old. The inhibitor level of the patient who developed bilateral cataract during the follow-up period was determined as 2.95 BU; however the cataract operation had to be delayed due to the absence of an adequate increase in his factor VIII level despite the 2000 U factor replacement administered in July 2002. The patient was readmitted...

Research paper thumbnail of Timing and severity of inhibitor development in recombinant versus plasma-derived factor VIII concentrates: a SIPPET analysis

Journal of Thrombosis and Haemostasis, 2017

Research paper thumbnail of Circumcision Experience in Severe Hemophilia Patients with Inhibitors

Research paper thumbnail of Circumcision and Complications in Adolescent and Adult Patients Wiith Hemophilia in Southern Part of Turkey

20th Congress of European-Hematology-Association -- JUN 11-14, 2015 -- Vienna, AUSTRIAWOS: 000361... more 20th Congress of European-Hematology-Association -- JUN 11-14, 2015 -- Vienna, AUSTRIAWOS: 000361204904224

Research paper thumbnail of Coagulation inhibitors (protein C, protein S, and AT-III) in sickle cell anemia children in steady state

Research paper thumbnail of The Serum Trail and Trail Ligand on the Apopitotic Pathway in Childhood Acute Leukemias

Research paper thumbnail of Physical and perceptional oral health status of children with hemophilia A

Research paper thumbnail of Gene therapy in haemophilia: literature review and regional perspectives for Turkey

Therapeutic Advances in Hematology

Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by insufficient l... more Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by insufficient levels of factor VIII (FVIII; haemophilia A) or factor IX (FIX; haemophilia B) and characterized by spontaneous and trauma-related bleeding episodes. The cornerstone of the treatment, factor replacement, constitutes several difficulties, including frequent injections due to the short half-life of recombinant factors, intravenous administration and the risk of inhibitor development. While extended half-life factors and subcutaneous novel molecules enhanced the quality of life, initial successes with gene therapy offer a significant hope for cure. Although adeno-associated viral (AAV)-based gene therapy is one of the most emerging approaches for treatment of haemophilia, there are still challenges in vector immunogenicity, potency and efficacy, genotoxicity and persistence. As the approval for the first gene therapy product is coming closer, eligibility criteria for patient selection, multi...

Research paper thumbnail of Cukurova Medical Journal Effect of Water Exercise on Atrophic Muscles Associated with Limited Range of Motion in Severe Haemophilia A Patients: a Pilot Study

Purpose: Haemophilia causes musculoskeletal problems over many years secondary to recurrent hemar... more Purpose: Haemophilia causes musculoskeletal problems over many years secondary to recurrent hemarthrosis. In this study, the effects of water exercises on the musculoskeletal system of severe haemophilia A patients with muscle and joint problems were investigated. Material and Methods: Eleven severe haemophilia A patients on prophylaxis treatment participated in the study and following a regular exercise protocol. Results: Subjects displayed statistically significant increases in mid-thigh, upper thigh and calf circumference for right leg (42.0 ± 2.4, 43.0 ±2.1 ; 37.1 ±1.9, 39.0 ±1.8; 28.1 ± 1.4, 28.9 ±1.3 respectively) (mean ± SE) in mid-thigh and upper thigh for left leg (36.9 ± 1.5 , 38.9 ± 1.5 ; 41.2 ± 2.2 , 42.9 ± 2) (p<0.05). Compared to pre-exercise values, leg extensor and flexor strength as well as range of motion were increased significantly (96.6 ± 9º vs 104.5± 8º; before and after training for right knee, 98.5 ± 7.6 º vs 104 ± 7.9 º before and after training for left ...

Research paper thumbnail of Clinical Presentation and Management of Factor X Deficiency: Case Study

Research paper thumbnail of Circumcision in patients with hemophilia and the other bleeding disorders in southern part of Turkey

Research paper thumbnail of Acquired hemophilia A and the knowledge/awareness level of Turkish hematology fellows: On behalf of the Turkish Hematology Association, Acquired Hemophilia Working Group

Research paper thumbnail of National Pediatric Hematopoietic Stem Cell Transplantation Activity in Turkey

41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- MAR 22-25, 20... more 41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- MAR 22-25, 2015 -- Istanbul, TURKEYWOS: 000351632902302European Soc Blood & Marrow Transplanta

Research paper thumbnail of Experiences with Use of Port-a-Cath in Children with Hemophilia: Single Center Study

Research paper thumbnail of Posterior reversible encephalopathy syndrome following pediatric allogeneic bone marrow transplantation: a case series and review

42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- APR 03-06, 20... more 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- APR 03-06, 2016 -- Valencia, SPAINWOS: 000373357600399…European Soc Blood & Marrow Transplanta

Research paper thumbnail of Effectiveness of Radiosynovectomy in Hemophilic Synovitis

Research paper thumbnail of The peripheral blood stem cell transplantation experience in Cukurova University Department of Pediatric Hematology and Oncology

Research paper thumbnail of Mutational Repertoire in the SIPPET Cohort and Prediction of FVIII Inhibitor Risk

Research paper thumbnail of Pharmacokinetic-Guided Prophylaxis Based on Bayesian Model with Mypkfit (R) in Hemophilia A: Turkish Experience

Research paper thumbnail of National Burden of Hemophilia a in Turkey

Oksuz, Ergun/0000-0002-5723-5965WOS: 000503167003144[No abstract available

Research paper thumbnail of Successful Bilateral Cataract and Circumcision Operation Performed in a Hemophilia-A Patient with Inhibitors by Using Recombinant Factor VIIa

Blood, 2005

Objective: Prothrombin complex concentrates (PCC), active prothrombin complex concentrates (APCC;... more Objective: Prothrombin complex concentrates (PCC), active prothrombin complex concentrates (APCC;FEIBA) or recombinant Factor VIIa (rFVIIa; Novoseven) are safely used for the treatment of hemorrhages in hemophiliac patients with inhibitors or during the interventions performed in these patients. A hemophilia-A patient with inhibitors in whom bilateral cataract operation and circumcision were successfully performed by rFVIIa administration was presented. Case: The 13 year old male patient had been diagnosed with severe Hemophilia-A by the detection of a FVIII level below 1% in the factor assay performed due to echhymoses in his body when he was 6 months old. The inhibitor level of the patient who developed bilateral cataract during the follow-up period was determined as 2.95 BU; however the cataract operation had to be delayed due to the absence of an adequate increase in his factor VIII level despite the 2000 U factor replacement administered in July 2002. The patient was readmitted...

Research paper thumbnail of Timing and severity of inhibitor development in recombinant versus plasma-derived factor VIII concentrates: a SIPPET analysis

Journal of Thrombosis and Haemostasis, 2017

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