B. Caterson - Academia.edu (original) (raw)
Papers by B. Caterson
A cross-sectional study between subgroups of nonspecific chronic low back pain (NSCLBP) and asymp... more A cross-sectional study between subgroups of nonspecific chronic low back pain (NSCLBP) and asymptomatic controls. To investigate NSCLBP subgroup differences in spinal position sense and trunk muscle activity when repositioning thoracic and lumbar spine into neutral (midrange) spinal position during sitting and standing. Patients with NSCLBP report aggravation of symptoms during sitting and standing. Impaired motor control in NSCLBP, associated with sitting and standing postures nearer the end range of spinal motion, may be a contributing factor. Rehabilitation improving neutral (midrange) spinal position control is advocated. Postural and motor control alterations vary in different NSCLBP subgroups, potentially requiring specific postural interventions. There is limited evidence on whether subgroup differences exist when performing neutral spine position tasks. Ninety patients with NSCLBP and 35 asymptomatic controls were recruited. Two blinded practitioners classified NSCLBP into subgroups of active extension pattern and flexion pattern. Participants were assisted into neutral spine position and asked to reproduce this position 4 times. Absolute, variable, and constant errors were calculated. Three-dimensional thoracic and lumbar kinematics quantified the repositioning accuracy and surface electromyography assessed back and abdominal muscles activity bilaterally. Irrespective of subclassification, patients with NSCLBP produced significantly greater error magnitude and variability than the asymptomatic controls, but subgroup differences were detected in the error direction. Subgroup differences in the trunk muscle activity were not consistently identified. Although both subgroups produced significantly higher abdominal activity, subclassification revealed difference in superficial multifidus activity during standing, with flexion pattern producing significantly greater activity than the asymptomatic controls. Subgroups of NSCLBP had similar neutral spinal position deficits regarding error magnitude and variability, but subclassification revealed clear subgroup differences in the direction of the deficit. The trunk muscle activation was shown to be largely nondiscriminatory between subgroups, with the exception of superficial lumbar multifidus.
Purpose: Kashin-Beck Disease (KBD) is an osteoarthropathy of uncertain etiology that is endemic t... more Purpose: Kashin-Beck Disease (KBD) is an osteoarthropathy of uncertain etiology that is endemic to the central and northwest regions of China. Affected individuals have varying degrees of joint deformity and limited joint mobility. Until now, the gold standard for the diagnosis of KBD has been based on radiographic and clinical examination features. Nevertheless, it is still difficult for grassroots health care workers and medical researchers to diagnose KBD. We studied the relationship of one of the signs of KBDbrachydactyly, and the range of motion (ROM) at 8 joint sites. Our long-term goal is to improve the sensitivity and specificity of the screening tools for KBD. Methods: 125 subjects from the Shangqiu village located in Shaanxi province were involved in this study. All study procedures were approved by the Xi'an Jiongtong University and Duke University Institutional Review Boards. Informed consent, physical examination data, and hand X-ray images were collected. At the same time, saliva and nail samples were collected for genetic and biochemical analyses. Brachydactyly was identified by the inability of the fingers (of either hand) to flex sufficiently to touch the palm beyond the transverse skin fold of the hand. ROM was quantified as normal, mildly restricted, moderately restricted or severely restricted for 8 joint sites (cervical spine, shoulder, elbow, wrist, hip, knee, tibiotalar and subtalar ankle, and metatarsalphalangeal foot joint). Non-parametric rank sum test were used to evaluate the severity of ROM abnormalities between the two groups. All statistical analyses were performed with JMP 7.0. Results: A total of 47 (37.6%) subjects met criteria for brachydactyly. The mean age and body mass index were similar for the brachydactyly and non-brachydactyly groups ). The joint ROM was significantly different between the brachydactyly and non-brachydactyly groups for all joint sites except the hip
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2010
Musculoskeletal complaints are the second most frequent reason for medical treatments. Within the... more Musculoskeletal complaints are the second most frequent reason for medical treatments. Within these diseases rheumatoid arthritis (RA) and, especially, osteoarthritis (OA) are common. Although the causes of arthritis are multifactorial and not fully understood, clinical trials have generally shown benefit from dietary n-3 polyunsaturated fatty acids. This has usually been attributed to their anti-inflammatory properties. Recently we have used in vitro model systems to study the molecular mechanism(s) by which n-3 PUFAs may act to alleviate the symptoms of arthritis. These experiments showed that n-3 PUFAs reduce expression of cartilage-degrading proteinases, cyclooxygenase-2 and inflammatory cytokines. Eicosapentaenoic acid (EPA) was more effective than docosahexaenoic acid (DHA) or alphalinolenic acid. The data provide a scientific rationale for the consumption of n-3 fatty acids as part of a healthy diet and perhaps in treating arthritis.
Osteoarthritis and Cartilage, 2009
Osteoarthritis and Cartilage, 2009
Nature, 1984
Chondroitin sulphate proteoglycans are widespread connective tissue components and chemical analy... more Chondroitin sulphate proteoglycans are widespread connective tissue components and chemical analysis of cartilage and other proteoglycans has demonstrated molecular speciation involving the degree and position of sulphation of the carbohydrate chains. This may, in turn, affect the properties of the glycosaminoglycan (GAG), particularly with respect to self-association and interactions with other extracellular matrix components. Interactions with specific molecules from different connective tissue types, such as the collagens and their associated glycoproteins, could be favoured by particular charge organizations on the GAG molecule endowed by the sulphate groups. So far, it has not been possible to identify and map chondroitins of differing sulphation in tissues, but we have now raised three monoclonal antibodies which specifically recognize unsulphated, 4-sulphated and 6-sulphated chondroitin and dermatan sulphate. These provide novel opportunities to study the in vivo distribution of chondroitin sulphate proteoglycans. We demonstrate that chondroitin sulphates exhibit remarkable connective tissue specificity and furthermore provide evidence that some proteoglycans may predominantly carry only one type of chondroitin sulphate chain.
International Journal of Experimental Pathology, 2008
Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular ba... more Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular basis of fibrosis The autumn 2003 meeting of BSMB was held at Imperial College, London, and had as its them e the molecular ...
International Journal of Experimental Pathology, 2008
Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular ba... more Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular basis of fibrosis The autumn 2003 meeting of BSMB was held at Imperial College, London, and had as its them e the molecular ...
International Journal of Experimental Pathology, 2002
described the preparation of LAMC1 knock-out mice. Carl Flannery (Cardiff University, UK) describ... more described the preparation of LAMC1 knock-out mice. Carl Flannery (Cardiff University, UK) described the detection of two chondrocyte hyaluronidases in human articular cartilage, explant cultures and cultured chondrocytes by RT-PCR.
Science, 2002
... E-mail: foxkd{at}cardiff.ac.uk. You can't teach an old dog new tricks, or can yo... more ... E-mail: foxkd{at}cardiff.ac.uk. You can't teach an old dog new tricks, or can you? On page 1248 of this issue, Pizzorusso et al. [HN1] (1) provide new data indicating that the brain of an adult animal can be persuaded to respond like a young brain to changes in visual experience. ...
A cross-sectional study between subgroups of nonspecific chronic low back pain (NSCLBP) and asymp... more A cross-sectional study between subgroups of nonspecific chronic low back pain (NSCLBP) and asymptomatic controls. To investigate NSCLBP subgroup differences in spinal position sense and trunk muscle activity when repositioning thoracic and lumbar spine into neutral (midrange) spinal position during sitting and standing. Patients with NSCLBP report aggravation of symptoms during sitting and standing. Impaired motor control in NSCLBP, associated with sitting and standing postures nearer the end range of spinal motion, may be a contributing factor. Rehabilitation improving neutral (midrange) spinal position control is advocated. Postural and motor control alterations vary in different NSCLBP subgroups, potentially requiring specific postural interventions. There is limited evidence on whether subgroup differences exist when performing neutral spine position tasks. Ninety patients with NSCLBP and 35 asymptomatic controls were recruited. Two blinded practitioners classified NSCLBP into subgroups of active extension pattern and flexion pattern. Participants were assisted into neutral spine position and asked to reproduce this position 4 times. Absolute, variable, and constant errors were calculated. Three-dimensional thoracic and lumbar kinematics quantified the repositioning accuracy and surface electromyography assessed back and abdominal muscles activity bilaterally. Irrespective of subclassification, patients with NSCLBP produced significantly greater error magnitude and variability than the asymptomatic controls, but subgroup differences were detected in the error direction. Subgroup differences in the trunk muscle activity were not consistently identified. Although both subgroups produced significantly higher abdominal activity, subclassification revealed difference in superficial multifidus activity during standing, with flexion pattern producing significantly greater activity than the asymptomatic controls. Subgroups of NSCLBP had similar neutral spinal position deficits regarding error magnitude and variability, but subclassification revealed clear subgroup differences in the direction of the deficit. The trunk muscle activation was shown to be largely nondiscriminatory between subgroups, with the exception of superficial lumbar multifidus.
Purpose: Kashin-Beck Disease (KBD) is an osteoarthropathy of uncertain etiology that is endemic t... more Purpose: Kashin-Beck Disease (KBD) is an osteoarthropathy of uncertain etiology that is endemic to the central and northwest regions of China. Affected individuals have varying degrees of joint deformity and limited joint mobility. Until now, the gold standard for the diagnosis of KBD has been based on radiographic and clinical examination features. Nevertheless, it is still difficult for grassroots health care workers and medical researchers to diagnose KBD. We studied the relationship of one of the signs of KBDbrachydactyly, and the range of motion (ROM) at 8 joint sites. Our long-term goal is to improve the sensitivity and specificity of the screening tools for KBD. Methods: 125 subjects from the Shangqiu village located in Shaanxi province were involved in this study. All study procedures were approved by the Xi'an Jiongtong University and Duke University Institutional Review Boards. Informed consent, physical examination data, and hand X-ray images were collected. At the same time, saliva and nail samples were collected for genetic and biochemical analyses. Brachydactyly was identified by the inability of the fingers (of either hand) to flex sufficiently to touch the palm beyond the transverse skin fold of the hand. ROM was quantified as normal, mildly restricted, moderately restricted or severely restricted for 8 joint sites (cervical spine, shoulder, elbow, wrist, hip, knee, tibiotalar and subtalar ankle, and metatarsalphalangeal foot joint). Non-parametric rank sum test were used to evaluate the severity of ROM abnormalities between the two groups. All statistical analyses were performed with JMP 7.0. Results: A total of 47 (37.6%) subjects met criteria for brachydactyly. The mean age and body mass index were similar for the brachydactyly and non-brachydactyly groups ). The joint ROM was significantly different between the brachydactyly and non-brachydactyly groups for all joint sites except the hip
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2010
Musculoskeletal complaints are the second most frequent reason for medical treatments. Within the... more Musculoskeletal complaints are the second most frequent reason for medical treatments. Within these diseases rheumatoid arthritis (RA) and, especially, osteoarthritis (OA) are common. Although the causes of arthritis are multifactorial and not fully understood, clinical trials have generally shown benefit from dietary n-3 polyunsaturated fatty acids. This has usually been attributed to their anti-inflammatory properties. Recently we have used in vitro model systems to study the molecular mechanism(s) by which n-3 PUFAs may act to alleviate the symptoms of arthritis. These experiments showed that n-3 PUFAs reduce expression of cartilage-degrading proteinases, cyclooxygenase-2 and inflammatory cytokines. Eicosapentaenoic acid (EPA) was more effective than docosahexaenoic acid (DHA) or alphalinolenic acid. The data provide a scientific rationale for the consumption of n-3 fatty acids as part of a healthy diet and perhaps in treating arthritis.
Osteoarthritis and Cartilage, 2009
Osteoarthritis and Cartilage, 2009
Nature, 1984
Chondroitin sulphate proteoglycans are widespread connective tissue components and chemical analy... more Chondroitin sulphate proteoglycans are widespread connective tissue components and chemical analysis of cartilage and other proteoglycans has demonstrated molecular speciation involving the degree and position of sulphation of the carbohydrate chains. This may, in turn, affect the properties of the glycosaminoglycan (GAG), particularly with respect to self-association and interactions with other extracellular matrix components. Interactions with specific molecules from different connective tissue types, such as the collagens and their associated glycoproteins, could be favoured by particular charge organizations on the GAG molecule endowed by the sulphate groups. So far, it has not been possible to identify and map chondroitins of differing sulphation in tissues, but we have now raised three monoclonal antibodies which specifically recognize unsulphated, 4-sulphated and 6-sulphated chondroitin and dermatan sulphate. These provide novel opportunities to study the in vivo distribution of chondroitin sulphate proteoglycans. We demonstrate that chondroitin sulphates exhibit remarkable connective tissue specificity and furthermore provide evidence that some proteoglycans may predominantly carry only one type of chondroitin sulphate chain.
International Journal of Experimental Pathology, 2008
Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular ba... more Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular basis of fibrosis The autumn 2003 meeting of BSMB was held at Imperial College, London, and had as its them e the molecular ...
International Journal of Experimental Pathology, 2008
Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular ba... more Page 1. British Society for Matrix Biology Meeting, London, 18–19 September 2003 The molecular basis of fibrosis The autumn 2003 meeting of BSMB was held at Imperial College, London, and had as its them e the molecular ...
International Journal of Experimental Pathology, 2002
described the preparation of LAMC1 knock-out mice. Carl Flannery (Cardiff University, UK) describ... more described the preparation of LAMC1 knock-out mice. Carl Flannery (Cardiff University, UK) described the detection of two chondrocyte hyaluronidases in human articular cartilage, explant cultures and cultured chondrocytes by RT-PCR.
Science, 2002
... E-mail: foxkd{at}cardiff.ac.uk. You can't teach an old dog new tricks, or can yo... more ... E-mail: foxkd{at}cardiff.ac.uk. You can't teach an old dog new tricks, or can you? On page 1248 of this issue, Pizzorusso et al. [HN1] (1) provide new data indicating that the brain of an adult animal can be persuaded to respond like a young brain to changes in visual experience. ...