Bruno Furquim - Academia.edu (original) (raw)

Papers by Bruno Furquim

Journal of Oral & Facial Pain and Headache

Aims: To determine whether there is an association between gene polymorphisms and patients with p... more Aims: To determine whether there is an association between gene polymorphisms and patients with painful temporomandibular joint (TMJ) clicking when compared to patients with painless TMJ clicking and a healthy control group. Methods: In this pilot study, the genotypic and allelic frequencies of candidate single-nucleotide polymorphisms (SNP) were compared among 60 individuals divided equally into three groups: patients with painful TMJ clicking (n = 20); patients with painless TMJ clicking (n = 20); and healthy controls (n = 20). Participants were genotyped for the following SNPs using real-time polymerase chain reaction: MMP1-16071G/2G, COMT Val158Met, TNFα-308, IL1β +3954, IL6-174, and IL10-1082. The pressure pain threshold (PPT) of the TMJ was also assessed. All variables were compared among groups. Results: Patients with painful TMJ clicking had a significant association and a higher frequency of MMP1-16071G/2G (P = .042), COMT Val158Met (P = .030), and TNFα-308 (P = .016) when compared to the other groups, as well as a lower frequency of IL10-1082. Considering PPT values, a progressively lower mean was found in individuals with painful TMJ clicking, followed sequentially by the painless TMJ clicking and the control groups. Conclusion: This pilot study showed that patients with painful TMJ clicking had a significant association with mutant genotypes related to degradation of extracellular matrix components, pain, proinflammation, and anti-inflammation. Furthermore, these patients also had significantly lower TMJ PPT values in all comparisons.

Revista Clínica de Ortodontia Dental Press, 2021

Cauby Maia Chaves Junior

This retrospective study aimed to conduct a cephalometric evaluation of the skeletal, dental and ... more This retrospective study aimed to conduct a cephalometric evaluation of the skeletal, dental and sot tissue efects resulting from treatment of adult patients presenting Class II malocclusion, performed with a Mandibular Protraction Appliance (MPA) combined with a ixed orthodontic appliance. Methods: The sample consisted of teleradiographs obtained before and ater treatment of 9 adult patients (initial mean age of 22.48 years) with bilateral Class II, division 1, malocclusion. Paired t test (p < 0.05) was applied to compare initial and inal values. Results: t test revealed an increase in anteroinferior facial height and posterior facial height. The dental changes include: extrusion of upper incisors, buccal inclination, protrusion of lower incisors, mesialization and extrusion of mandibular molars. Regarding the sot tissue component, there was an increase in nasolabial angle in addition to upper lip retrusion. Conclusions: The efects of treating Class II malocclusion adult patients, by means of using Mandibular Protraction Appliance (MPA) combined with a ixed appliance were mostly observed in the mandibular arch, and consisted of buccal inclination, protrusion and intrusion of incisors, and mesialization and extrusion of the molars.

Special Care in Dentistry, 2020

AIMS This case report aimed to discuss the multifactorial etiology and also the management of tem... more AIMS This case report aimed to discuss the multifactorial etiology and also the management of temporomandibular disorders (TMD) by addressing important associated psychosocial and biological factors, emphasizing the interaction between these factors and a probable genetic predisposition. METHODS AND RESULTS A 21-year-old female patient was evaluated according to Research Diagnostic Criteria for TMD and diagnosed with arthralgia, myofascial pain, disc displacement without reduction, and temporomandibular joint (TMJ) degenerative disease. TMJ alterations were confirmed through magnetic resonance imaging and cone-beam computed tomography. Pressure pain threshold of masticatory structures was evaluated using a pressure algometer. Sleep bruxism, poor sleep quality, migraine with aura, mild anxiety, and history of facial trauma were also identified through anamnesis and clinical examination. Following this, genetic analysis was performed to evaluate the presence of single nucleotide polymorphisms (SNPs) already associated with TMD: SNP COMT Val158 Met (rs4680), MMP1-1607 (rs1799750), and tumor necrosis factor alpha-308 (rs1800629), which were all present. A personalized treatment for TMD management was performed, and it included self-management programs, occlusal appliance therapy, pharmacotherapy, anxiety management, and stress control. An 8-year follow-up demonstrated long-term stabilization of TMJ degenerative disease. CONCLUSION Genetic evaluation, added to anamnesis and clinical examination, could be useful for TMD prognosis and management.

Revista Clínica de Ortodontia Dental Press, 2020

Ricardo Tesch se graduou pela UFRJ (Universidade Federal do Rio de Janeiro), em 1992. Especializo... more Ricardo Tesch se graduou pela UFRJ (Universidade Federal do Rio de Janeiro), em 1992. Especializou-se em Ortodontia, pela Associação dos Cirurgiões-Dentistas de Campinas (SP), em 1999. De lá, seguiu para a vida acadêmica, fazendo o mestrado e o doutorado, em Medicina, com área de concentração em Cirurgia de Cabeça e Pescoço, pelo Hospital Higienópolis (SP) e Clínica Médica, em Neurologia, pela UFRJ, respectivamente. É professor adjunto da Unifase (Faculdade de Medicina de Petrópolis), onde exerce também o cargo de coordenador dos cursos de Especialização em DTM e Dor Orofacial e Ortodontia, além de ser diretor do Centro de Medicina Regenerativa. Ele coordena, também, o curso de especialização em DTM e Dor Orofacial da PUC, na República Dominicana.

Archives of Oral Biology, 2020

OBJECTIVE The aim of this study was to assess the correlation of inflammatory and pain genes poly... more OBJECTIVE The aim of this study was to assess the correlation of inflammatory and pain genes polymorphisms with the presence of temporomandibular disorder (TMD) patients and with pressure pain sensitivity. DESIGN Data was collected from 268 consecutive subjects at Bauru School of Dentistry. Subjects aged younger than 20 years, with dental and neuropathic pain, sinusitis, cognitive and neurologic disorder were excluded. Included subjects were evaluated using the Research Diagnostic Criteria for Temporomandibular disorders and divided into two groups: TMD cases and healthy controls. Groups were submitted to pressure pain threshold (PPT) test for the temporomandibular joint, anterior temporalis and masseter muscles and genotyped for Val158Met, IL6-174, IL-1β-3954 and TNFA-308. Student's t-test and Pearson chi-square test were used to comparisons between groups. A linear multiple regression was used to evaluate the influence of genetics variables on the PPT and a bivariate analysis was used to assesses the influence of genetics variables on pain sensitivity below the PPT cut off of the structures in TMD group. RESULTS TMD group showed significantly lower PPT values for all structures when compared with control group (p < 0.001). SNP IL6-174 predicted higher pain sensitivity in the temporomandibular joint (p < 0.005) and in anterior temporalis muscle (p < 0.044) and SNP Val158Met in the masseter muscle (p < 0.038); when TMD group was divided according to PPT cut-off values the SNP Val158Met influenced increase pain sensibility in the masseter muscle. CONCLUSION TNFA-308 was associated with TMD and SNP IL6-174 and SNP Val158Met influenced pain sensitivity of patients with TMD.

Revista Clínica de Ortodontia Dental Press, 2018

Journal of Clinical Dentistry and Research, 2018

Dental Press Journal of Orthodontics, 2018

Professor Ambrosina Michelotti is one of the most important researchers in the field of Orthodont... more Professor Ambrosina Michelotti is one of the most important researchers in the field of Orthodontics, Temporomandibular Disorders and Orofacial Pain. I'm following her publications since I first read the revision article about the role of Orthodontics in Temporomandibular Disorders, published in 2010 on the Journal of Oral Rehabilitation, which helps to elucidate in a very didactic way the concepts based on scientific evidence that link these two areas. As I am involved on the same field of research, I became very enthusiastic of her work and competence. When in 2011 we had the opportunity to meet at a congress of the European Academy of Orofacial Pain, I had the chance to face another and even more important characteristic of Professor Ambrosina: her sympathy, happiness and cordiality. Since then, we have met in many congresses and recently, in last June, Professor Ambrosina attended the Sociedade Brasileira de Disfunção Temporomandibular e Dor Orofacial (SBDOF) meeting in São Paulo, where she lectured for more than 700 participants. I would like to highlight that Professor Ambrosina was one of the members of the team of professionals responsible for updating the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) last September in Newark, USA. And finally, I would like to thank the Dental Press Journal of Orthodontics for the opportunity of coordinating this interview, and also the professionals who contributed to this text. I am sure that DPJO readers will appreciate this interview, due to the broad scientific and clinical experience of this great lady of Orthodontics, TMD and Orofacial Pain. Enjoy it!

Dental Press Journal of Orthodontics, 2018

It was with great joy that I accepted the invitation from the Dental Press Journal of Orthodontic... more It was with great joy that I accepted the invitation from the Dental Press Journal of Orthodontics to coordinate an interview with Dr. Jeffrey Okeson. I have known Dr. Okeson for over 14 years. All started when I had the fantastic opportunity to be one of his residents for 3 years, and ever since, he has been my mentor and my friend. Dr. Jeffrey Okeson, despite of being a very famous and tremendously talented professional, continues to be an extremely nice and simple person. Due to these and many other reasons, I call him "my American Father"!!! He is married for 48 years to Mrs. Barbara Okeson, and they have two sons and one granddaughter. Dr. Okeson has a twin brother who is also a dentist. He enjoys jogging and has continued to jog for over 40 years. He also enjoys traveling and meeting people. Dr. Okeson has more than 240 professional publications. One of his textbooks, Management of Temporomandibular Disorders and Occlusion, is used in most of the United States dental schools and has been translated into eleven different foreign languages. Dr. Okeson has presented more than 1,200 invited lectures on the subject of TMD and orofacial pain in all 50 U.S. states

Dental press journal of orthodontics

The aim of this study was to compare the skeletal, dental, and soft tissue effects of the Mandibu... more The aim of this study was to compare the skeletal, dental, and soft tissue effects of the Mandibular Protraction Appliance (MPA) application in adolescent and adult Class II malocclusion patients. The sample comprised the pretreatment and posttreatment lateral cephalograms of 39 subjects presenting Class II malocclusion treated with the MPA and fixed appliances. Sample was divided into two groups: Group 1 comprised 23 subjects (10 male; 13 female), at a mean pretreatment age of 11.75 years, with a mean treatment time of 3.32 years; Group 2 included 16 subjects (7 male; 9 female), at a mean pretreatment age of 22.41 years, with a mean treatment time of 4.24 years. Intergroup comparison of the initial and final stages and treatment changes between the groups was performed with t tests, at p< 0.05. The adults showed less significant amounts of skeletal, dentoalveolar and soft tissue changes than the adolescents. There was significantly greater palatal tipping of the maxillary inciso...

Rev Clin Ortodon Dental Press, 2013

Objetivo: o objetivo do presente estudo foi avaliar a visao de clinicos gerais (CG), especialista... more Objetivo: o objetivo do presente estudo foi avaliar a visao de clinicos gerais (CG), especialistas em Ortodontia (EO) e especialistas em Disfuncao Temporomandibular e Dor Orofacial (EDTM), por meio de questionario, quanto a inter-relacao tratamento ortodontico e DTM. Metodos: foi enviado questionario via correio eletronico a 9.490 cirurgioes-dentistas de diferentes regioes do Brasil. Resultados: dos 132 profissionais que responderam a pesquisa, 75% relatou examinar, usualmente, seus pacientes quanto a sinais e sintomas de DTM previamente ao tratamento odontologico. A maioria dos profissionais (55%) afirmou acreditar que tratamento ortodontico pode prevenir DTM; 68% dos EDTM nao concordam com essa opiniao. A maior parte (62%) associou tratamento ortodontico a causa da DTM e nao acredita que Ortodontia possa tratar a referida desordem (56%). A maioria dos CG (64%), no entanto, considera que se pode tratar DTM por meio de Ortodontia. Conclusao: a maioria dos profissionais acredita que tratamento ortodontico pode prevenir DTM, mas que, ao mesmo tempo, nao pode curar e pode ainda causar tal desordem. Foi encontrada diferenca estatisticamente significativa em relacao as respostas das tres areas de interesse (CG, EO e EDTM). (AU)

Rev Clin Ortodon Dental Press, Jul 1, 2011

Journal of Applied Oral Science, 2010

Dedico este trabalho à minha querida esposa, Flávia, mulher da minha vida, minha melhor amiga e m... more Dedico este trabalho à minha querida esposa, Flávia, mulher da minha vida, minha melhor amiga e mãe extraordinária; que, com sua simplicidade e amor, faz todos à sua volta mais felizes. E ao meu filhão, Felipe, a razão da minha vida e minha maior alegria. AGRADECIMENTOS A Deus, por iluminar o meu caminho. Aos meus pais, por toda sua dedicação, doação, carinho e, acima de tudo, por serem minhas referências éticas e o meu porto seguro. À minha querida irmã, Rachel, por saber que sempre poderei contar com sua cumplicidade, carinho e amizade. Ao meu cunhado e amigo, Fernando, por cuidar tão bem da Rachel e do meu afilhado Vittório. Aos meus avós, Dona Iria e Seu André, que com garra, bom-humor e fé nos inspiram a enfrentar as adversidades e a valorizar a vida. Aos meus sogros, Paulo e Rosângela, por terem me adotado como filho. E aos meus cunhados, Paulo e Octávio, pelo respeito e amizade com que sempre me trataram. Aos meus tios, tias, primos e primas, por proporcionarem tantos momentos felizes de convívio e por sempre estarem do meu lado. Aos meus amigos de infância, Gustavo, Thiago, Felipe, Maikiel, Michel, Reginaldo, Juliana, Renata, Camila e Letícia, por tantas risadas. Aos amigos e parceiros profissionais, Adilson Luiz Ramos e Rafael Santos Silva, pela confiança no meu trabalho e pela oportunidade de produzir e aprender com profissionais tão competentes. A toda a equipe da Dental Press, pelo comprometimento em sempre fazer melhor, e por entender a minha ausência. Em especial ao nosso produtor editorial Júnior Bianchi, pela liderança e generosidade, e ao meu primo Ronis Siqueira, por sua sempre sensata e valiosa contribuição intelectual nas mais diferentes questões.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2016

Tumor necrosis factor alpha (TNF-α) levels are significantly upregulated in the synovial fluid of... more Tumor necrosis factor alpha (TNF-α) levels are significantly upregulated in the synovial fluid of patients with temporomandibular joint disorder (TMD). The TNF-α influences pain generation and maintenance. Therefore, the aim of this study was to investigate the influence of single nucleotide polymorphism TNFA-308 (rs1800629) on TMD risk and on the pressure pain threshold. The genotypic and allelic frequencies of candidate single nucleotide polymorphisms were compared among 152 TMD patients and 91 sex- and age-matched healthy subjects in the control group using the real-time polymerase chain reaction technique. The pressure pain threshold in the temporomandibular joint, anterior fascicle of the temporal muscle, masseter muscle, and Achilles tendon were recorded with an algometer. After the pressure test, all participants received a complete physical examination, including masticatory muscle evaluation, temporomandibular joint palpation, and assessment of mandibular range of motion. T...

Journal of Research in Dentistry, Feb 28, 2014

... Fernanda, Fernanda, Laura, Diogo, Laura, Diogo, Laura, Diogo, Karina, Daniel, Márcio, Renata ... more ... Fernanda, Fernanda, Laura, Diogo, Laura, Diogo, Laura, Diogo, Karina, Daniel, Márcio, Renata e Karina, Daniel, Márcio, Renata e ... Á Prof. Dra. Maria Aparecida Maria Aparecida Maria Aparecida de Andrade Moreira de Andrade Moreira de Andrade Moreira Machado, ...

Dental press journal of orthodontics

This review aims at presenting a current view on the physiopathologic mechanisms associated with ... more This review aims at presenting a current view on the physiopathologic mechanisms associated with temporomandibular disorders (TMDs). While joint pain is characterized by a well-defined inflammatory process mediated by tumor necrosis factor-α and interleukin, chronic muscle pain presents with enigmatic physiopathologic mechanisms, being considered a functional pain syndrome similar to fibromyalgia, irritable bowel syndrome, interstitial cystitis and chronic fatigue syndrome. Central sensitization is the common factor unifying these conditions, and may be influenced by the autonomic nervous system and genetic polymorphisms. Thus, TMDs symptoms should be understood as a complex response which might get worse or improve depending on an individual's adaptation.

Journal of Oral & Facial Pain and Headache

Aims: To determine whether there is an association between gene polymorphisms and patients with p... more Aims: To determine whether there is an association between gene polymorphisms and patients with painful temporomandibular joint (TMJ) clicking when compared to patients with painless TMJ clicking and a healthy control group. Methods: In this pilot study, the genotypic and allelic frequencies of candidate single-nucleotide polymorphisms (SNP) were compared among 60 individuals divided equally into three groups: patients with painful TMJ clicking (n = 20); patients with painless TMJ clicking (n = 20); and healthy controls (n = 20). Participants were genotyped for the following SNPs using real-time polymerase chain reaction: MMP1-16071G/2G, COMT Val158Met, TNFα-308, IL1β +3954, IL6-174, and IL10-1082. The pressure pain threshold (PPT) of the TMJ was also assessed. All variables were compared among groups. Results: Patients with painful TMJ clicking had a significant association and a higher frequency of MMP1-16071G/2G (P = .042), COMT Val158Met (P = .030), and TNFα-308 (P = .016) when compared to the other groups, as well as a lower frequency of IL10-1082. Considering PPT values, a progressively lower mean was found in individuals with painful TMJ clicking, followed sequentially by the painless TMJ clicking and the control groups. Conclusion: This pilot study showed that patients with painful TMJ clicking had a significant association with mutant genotypes related to degradation of extracellular matrix components, pain, proinflammation, and anti-inflammation. Furthermore, these patients also had significantly lower TMJ PPT values in all comparisons.

Revista Clínica de Ortodontia Dental Press, 2021

Cauby Maia Chaves Junior

This retrospective study aimed to conduct a cephalometric evaluation of the skeletal, dental and ... more This retrospective study aimed to conduct a cephalometric evaluation of the skeletal, dental and sot tissue efects resulting from treatment of adult patients presenting Class II malocclusion, performed with a Mandibular Protraction Appliance (MPA) combined with a ixed orthodontic appliance. Methods: The sample consisted of teleradiographs obtained before and ater treatment of 9 adult patients (initial mean age of 22.48 years) with bilateral Class II, division 1, malocclusion. Paired t test (p < 0.05) was applied to compare initial and inal values. Results: t test revealed an increase in anteroinferior facial height and posterior facial height. The dental changes include: extrusion of upper incisors, buccal inclination, protrusion of lower incisors, mesialization and extrusion of mandibular molars. Regarding the sot tissue component, there was an increase in nasolabial angle in addition to upper lip retrusion. Conclusions: The efects of treating Class II malocclusion adult patients, by means of using Mandibular Protraction Appliance (MPA) combined with a ixed appliance were mostly observed in the mandibular arch, and consisted of buccal inclination, protrusion and intrusion of incisors, and mesialization and extrusion of the molars.

Special Care in Dentistry, 2020

AIMS This case report aimed to discuss the multifactorial etiology and also the management of tem... more AIMS This case report aimed to discuss the multifactorial etiology and also the management of temporomandibular disorders (TMD) by addressing important associated psychosocial and biological factors, emphasizing the interaction between these factors and a probable genetic predisposition. METHODS AND RESULTS A 21-year-old female patient was evaluated according to Research Diagnostic Criteria for TMD and diagnosed with arthralgia, myofascial pain, disc displacement without reduction, and temporomandibular joint (TMJ) degenerative disease. TMJ alterations were confirmed through magnetic resonance imaging and cone-beam computed tomography. Pressure pain threshold of masticatory structures was evaluated using a pressure algometer. Sleep bruxism, poor sleep quality, migraine with aura, mild anxiety, and history of facial trauma were also identified through anamnesis and clinical examination. Following this, genetic analysis was performed to evaluate the presence of single nucleotide polymorphisms (SNPs) already associated with TMD: SNP COMT Val158 Met (rs4680), MMP1-1607 (rs1799750), and tumor necrosis factor alpha-308 (rs1800629), which were all present. A personalized treatment for TMD management was performed, and it included self-management programs, occlusal appliance therapy, pharmacotherapy, anxiety management, and stress control. An 8-year follow-up demonstrated long-term stabilization of TMJ degenerative disease. CONCLUSION Genetic evaluation, added to anamnesis and clinical examination, could be useful for TMD prognosis and management.

Revista Clínica de Ortodontia Dental Press, 2020

Ricardo Tesch se graduou pela UFRJ (Universidade Federal do Rio de Janeiro), em 1992. Especializo... more Ricardo Tesch se graduou pela UFRJ (Universidade Federal do Rio de Janeiro), em 1992. Especializou-se em Ortodontia, pela Associação dos Cirurgiões-Dentistas de Campinas (SP), em 1999. De lá, seguiu para a vida acadêmica, fazendo o mestrado e o doutorado, em Medicina, com área de concentração em Cirurgia de Cabeça e Pescoço, pelo Hospital Higienópolis (SP) e Clínica Médica, em Neurologia, pela UFRJ, respectivamente. É professor adjunto da Unifase (Faculdade de Medicina de Petrópolis), onde exerce também o cargo de coordenador dos cursos de Especialização em DTM e Dor Orofacial e Ortodontia, além de ser diretor do Centro de Medicina Regenerativa. Ele coordena, também, o curso de especialização em DTM e Dor Orofacial da PUC, na República Dominicana.

Archives of Oral Biology, 2020

OBJECTIVE The aim of this study was to assess the correlation of inflammatory and pain genes poly... more OBJECTIVE The aim of this study was to assess the correlation of inflammatory and pain genes polymorphisms with the presence of temporomandibular disorder (TMD) patients and with pressure pain sensitivity. DESIGN Data was collected from 268 consecutive subjects at Bauru School of Dentistry. Subjects aged younger than 20 years, with dental and neuropathic pain, sinusitis, cognitive and neurologic disorder were excluded. Included subjects were evaluated using the Research Diagnostic Criteria for Temporomandibular disorders and divided into two groups: TMD cases and healthy controls. Groups were submitted to pressure pain threshold (PPT) test for the temporomandibular joint, anterior temporalis and masseter muscles and genotyped for Val158Met, IL6-174, IL-1β-3954 and TNFA-308. Student's t-test and Pearson chi-square test were used to comparisons between groups. A linear multiple regression was used to evaluate the influence of genetics variables on the PPT and a bivariate analysis was used to assesses the influence of genetics variables on pain sensitivity below the PPT cut off of the structures in TMD group. RESULTS TMD group showed significantly lower PPT values for all structures when compared with control group (p < 0.001). SNP IL6-174 predicted higher pain sensitivity in the temporomandibular joint (p < 0.005) and in anterior temporalis muscle (p < 0.044) and SNP Val158Met in the masseter muscle (p < 0.038); when TMD group was divided according to PPT cut-off values the SNP Val158Met influenced increase pain sensibility in the masseter muscle. CONCLUSION TNFA-308 was associated with TMD and SNP IL6-174 and SNP Val158Met influenced pain sensitivity of patients with TMD.

Revista Clínica de Ortodontia Dental Press, 2018

Journal of Clinical Dentistry and Research, 2018

Dental Press Journal of Orthodontics, 2018

Professor Ambrosina Michelotti is one of the most important researchers in the field of Orthodont... more Professor Ambrosina Michelotti is one of the most important researchers in the field of Orthodontics, Temporomandibular Disorders and Orofacial Pain. I'm following her publications since I first read the revision article about the role of Orthodontics in Temporomandibular Disorders, published in 2010 on the Journal of Oral Rehabilitation, which helps to elucidate in a very didactic way the concepts based on scientific evidence that link these two areas. As I am involved on the same field of research, I became very enthusiastic of her work and competence. When in 2011 we had the opportunity to meet at a congress of the European Academy of Orofacial Pain, I had the chance to face another and even more important characteristic of Professor Ambrosina: her sympathy, happiness and cordiality. Since then, we have met in many congresses and recently, in last June, Professor Ambrosina attended the Sociedade Brasileira de Disfunção Temporomandibular e Dor Orofacial (SBDOF) meeting in São Paulo, where she lectured for more than 700 participants. I would like to highlight that Professor Ambrosina was one of the members of the team of professionals responsible for updating the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) last September in Newark, USA. And finally, I would like to thank the Dental Press Journal of Orthodontics for the opportunity of coordinating this interview, and also the professionals who contributed to this text. I am sure that DPJO readers will appreciate this interview, due to the broad scientific and clinical experience of this great lady of Orthodontics, TMD and Orofacial Pain. Enjoy it!

Dental Press Journal of Orthodontics, 2018

It was with great joy that I accepted the invitation from the Dental Press Journal of Orthodontic... more It was with great joy that I accepted the invitation from the Dental Press Journal of Orthodontics to coordinate an interview with Dr. Jeffrey Okeson. I have known Dr. Okeson for over 14 years. All started when I had the fantastic opportunity to be one of his residents for 3 years, and ever since, he has been my mentor and my friend. Dr. Jeffrey Okeson, despite of being a very famous and tremendously talented professional, continues to be an extremely nice and simple person. Due to these and many other reasons, I call him "my American Father"!!! He is married for 48 years to Mrs. Barbara Okeson, and they have two sons and one granddaughter. Dr. Okeson has a twin brother who is also a dentist. He enjoys jogging and has continued to jog for over 40 years. He also enjoys traveling and meeting people. Dr. Okeson has more than 240 professional publications. One of his textbooks, Management of Temporomandibular Disorders and Occlusion, is used in most of the United States dental schools and has been translated into eleven different foreign languages. Dr. Okeson has presented more than 1,200 invited lectures on the subject of TMD and orofacial pain in all 50 U.S. states

Dental press journal of orthodontics

The aim of this study was to compare the skeletal, dental, and soft tissue effects of the Mandibu... more The aim of this study was to compare the skeletal, dental, and soft tissue effects of the Mandibular Protraction Appliance (MPA) application in adolescent and adult Class II malocclusion patients. The sample comprised the pretreatment and posttreatment lateral cephalograms of 39 subjects presenting Class II malocclusion treated with the MPA and fixed appliances. Sample was divided into two groups: Group 1 comprised 23 subjects (10 male; 13 female), at a mean pretreatment age of 11.75 years, with a mean treatment time of 3.32 years; Group 2 included 16 subjects (7 male; 9 female), at a mean pretreatment age of 22.41 years, with a mean treatment time of 4.24 years. Intergroup comparison of the initial and final stages and treatment changes between the groups was performed with t tests, at p< 0.05. The adults showed less significant amounts of skeletal, dentoalveolar and soft tissue changes than the adolescents. There was significantly greater palatal tipping of the maxillary inciso...

Rev Clin Ortodon Dental Press, 2013

Objetivo: o objetivo do presente estudo foi avaliar a visao de clinicos gerais (CG), especialista... more Objetivo: o objetivo do presente estudo foi avaliar a visao de clinicos gerais (CG), especialistas em Ortodontia (EO) e especialistas em Disfuncao Temporomandibular e Dor Orofacial (EDTM), por meio de questionario, quanto a inter-relacao tratamento ortodontico e DTM. Metodos: foi enviado questionario via correio eletronico a 9.490 cirurgioes-dentistas de diferentes regioes do Brasil. Resultados: dos 132 profissionais que responderam a pesquisa, 75% relatou examinar, usualmente, seus pacientes quanto a sinais e sintomas de DTM previamente ao tratamento odontologico. A maioria dos profissionais (55%) afirmou acreditar que tratamento ortodontico pode prevenir DTM; 68% dos EDTM nao concordam com essa opiniao. A maior parte (62%) associou tratamento ortodontico a causa da DTM e nao acredita que Ortodontia possa tratar a referida desordem (56%). A maioria dos CG (64%), no entanto, considera que se pode tratar DTM por meio de Ortodontia. Conclusao: a maioria dos profissionais acredita que tratamento ortodontico pode prevenir DTM, mas que, ao mesmo tempo, nao pode curar e pode ainda causar tal desordem. Foi encontrada diferenca estatisticamente significativa em relacao as respostas das tres areas de interesse (CG, EO e EDTM). (AU)

Rev Clin Ortodon Dental Press, Jul 1, 2011

Journal of Applied Oral Science, 2010

Dedico este trabalho à minha querida esposa, Flávia, mulher da minha vida, minha melhor amiga e m... more Dedico este trabalho à minha querida esposa, Flávia, mulher da minha vida, minha melhor amiga e mãe extraordinária; que, com sua simplicidade e amor, faz todos à sua volta mais felizes. E ao meu filhão, Felipe, a razão da minha vida e minha maior alegria. AGRADECIMENTOS A Deus, por iluminar o meu caminho. Aos meus pais, por toda sua dedicação, doação, carinho e, acima de tudo, por serem minhas referências éticas e o meu porto seguro. À minha querida irmã, Rachel, por saber que sempre poderei contar com sua cumplicidade, carinho e amizade. Ao meu cunhado e amigo, Fernando, por cuidar tão bem da Rachel e do meu afilhado Vittório. Aos meus avós, Dona Iria e Seu André, que com garra, bom-humor e fé nos inspiram a enfrentar as adversidades e a valorizar a vida. Aos meus sogros, Paulo e Rosângela, por terem me adotado como filho. E aos meus cunhados, Paulo e Octávio, pelo respeito e amizade com que sempre me trataram. Aos meus tios, tias, primos e primas, por proporcionarem tantos momentos felizes de convívio e por sempre estarem do meu lado. Aos meus amigos de infância, Gustavo, Thiago, Felipe, Maikiel, Michel, Reginaldo, Juliana, Renata, Camila e Letícia, por tantas risadas. Aos amigos e parceiros profissionais, Adilson Luiz Ramos e Rafael Santos Silva, pela confiança no meu trabalho e pela oportunidade de produzir e aprender com profissionais tão competentes. A toda a equipe da Dental Press, pelo comprometimento em sempre fazer melhor, e por entender a minha ausência. Em especial ao nosso produtor editorial Júnior Bianchi, pela liderança e generosidade, e ao meu primo Ronis Siqueira, por sua sempre sensata e valiosa contribuição intelectual nas mais diferentes questões.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2016

Tumor necrosis factor alpha (TNF-α) levels are significantly upregulated in the synovial fluid of... more Tumor necrosis factor alpha (TNF-α) levels are significantly upregulated in the synovial fluid of patients with temporomandibular joint disorder (TMD). The TNF-α influences pain generation and maintenance. Therefore, the aim of this study was to investigate the influence of single nucleotide polymorphism TNFA-308 (rs1800629) on TMD risk and on the pressure pain threshold. The genotypic and allelic frequencies of candidate single nucleotide polymorphisms were compared among 152 TMD patients and 91 sex- and age-matched healthy subjects in the control group using the real-time polymerase chain reaction technique. The pressure pain threshold in the temporomandibular joint, anterior fascicle of the temporal muscle, masseter muscle, and Achilles tendon were recorded with an algometer. After the pressure test, all participants received a complete physical examination, including masticatory muscle evaluation, temporomandibular joint palpation, and assessment of mandibular range of motion. T...

Journal of Research in Dentistry, Feb 28, 2014

... Fernanda, Fernanda, Laura, Diogo, Laura, Diogo, Laura, Diogo, Karina, Daniel, Márcio, Renata ... more ... Fernanda, Fernanda, Laura, Diogo, Laura, Diogo, Laura, Diogo, Karina, Daniel, Márcio, Renata e Karina, Daniel, Márcio, Renata e ... Á Prof. Dra. Maria Aparecida Maria Aparecida Maria Aparecida de Andrade Moreira de Andrade Moreira de Andrade Moreira Machado, ...

Dental press journal of orthodontics

This review aims at presenting a current view on the physiopathologic mechanisms associated with ... more This review aims at presenting a current view on the physiopathologic mechanisms associated with temporomandibular disorders (TMDs). While joint pain is characterized by a well-defined inflammatory process mediated by tumor necrosis factor-α and interleukin, chronic muscle pain presents with enigmatic physiopathologic mechanisms, being considered a functional pain syndrome similar to fibromyalgia, irritable bowel syndrome, interstitial cystitis and chronic fatigue syndrome. Central sensitization is the common factor unifying these conditions, and may be influenced by the autonomic nervous system and genetic polymorphisms. Thus, TMDs symptoms should be understood as a complex response which might get worse or improve depending on an individual's adaptation.