BINA GIDWANI - Academia.edu (original) (raw)
Papers by BINA GIDWANI
Reference series in phytochemistry, Dec 31, 2022
BENTHAM SCIENCE PUBLISHERS eBooks, Jul 30, 2023
Current Pharmaceutical Design, Aug 25, 2020
Cancer is the second leading cause of death globally, with every sixth death being attributable t... more Cancer is the second leading cause of death globally, with every sixth death being attributable to cancer. Nevertheless, the efficacy of conventional chemotherapeutic drugs is often limited due to their poor solubility, unfavorable pharmacokinetic profile, and lack of tumor selectivity. The use of nanotechnology provides an opportunity to enhance the efficacy of a chemotherapeutic drug by improving its bioavailability and pharmacokinetic profile while facilitating preferential accumulation at the tumor tissue. To date, a variety of platforms have been investigated as nanocarriers in oncology, which include lipid-based, polymer-based, inorganic materials, and even viruses. Among different nanocarriers, lipid-based delivery systems have been extensively used in oncology because of their biocompatibility, biodegradability, ability to encapsulate diverse drug molecules, high temporal and thermal stability, and offer prolonged and controlled drug release. This review discusses the current status of the lipid-based nanocarriers and their applications in cancer treatment as well as an overview of the different liposomal formulations commercially available for cancer therapy.
BioMed Research International, 2015
Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are a... more Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system. This paper provides an overview of limitations associated with anticancer drugs, their complexation with cyclodextrins, loading/encapsulating the complexed drugs into carriers, and various approaches used for the delivery. The present review article aims to assess the utility of cyclodextrin-based carriers like liposomes, niosomes, nanoparticles, micelles, millirods, and siRNA for delivery of antineoplastic agents. These systems based on cyclodextrin complexation and nanotechnology will camouflage the undesirable properties of drug and lead to synergistic or additive effect. Cyclodextrin-based nanotechnology seems to provide better therapeutic effect and sustain long life of healthy and recovered cells. Still, considerable study on delivery system and administration routes of cyclodextrin-based carriers is necessary with respect to their pharmacokinetics and toxicology to substantiate their safety and efficiency. In future, it would be possible to resolve the conventional and current issues associated with the development and commercialization of antineoplastic agents.
Current Molecular Medicine, Jul 27, 2023
: Truly miraculous medications and antibiotics have helped save untold millions of lives. Antibio... more : Truly miraculous medications and antibiotics have helped save untold millions of lives. Antibiotic resistance, however, is a significant issue related to health that jeopardizes the effectiveness of antibiotics and could harm everyone's health. Bacteria, not humans or animals, become antibiotic-resistant. Bacteria use quorum-sensing communication routes to manage an assortment of physiological exercises. Quorum sensing is significant for appropriate biofilm development. Antibiotic resistance occurs when bacteria establish a biofilm on a surface, shielding them from the effects of infection-fighting drugs. Acylated homoserine lactones are used as autoinducers by gram-negative microscopic organisms to impart. However, antibiotic resistance among ocular pathogens is increasing worldwide. Bacteria are a significant contributor to ocular infections around the world. Gram-negative microscopic organisms are dangerous to ophthalmic tissues. This review highlights the use of elective drug targets and treatments, for example, combinational treatment, to vanquish antibiotic-resistant bacteria. Also, it briefly portrays anti-biotic resistance brought about by gram-negative bacteria and approaches to overcome resistance with the help of quorum sensing inhibitors and nanotechnology as a promising medication conveyance approach to give insurance of anti-microbials and improve pathways for the administration of inhibitors of quorum sensing with a blend of anti-microbials to explicit target destinations and penetration through biofilms for treatment of ocular infections. It centres on the methodologies to sidestep the confinements of ocular anti-biotic delivery with new visual innovation.
International Journal of Advances in Pharmaceutical Sciences, Jan 16, 2018
Poor aqueous solubility and dissolution rates are critical problems that hinders the formulation,... more Poor aqueous solubility and dissolution rates are critical problems that hinders the formulation, development and delivery of most of BCS class II and class IV drugs. Gefitinib is a cytotoxic chemotherapeutic drug used in treatment of cancer. The object investigate the drug solubility study revealed formation of 1:1 stoichiometry binary inclusion complex. The complex was prepared by kneading met CD stronger Key
Journal of Pharmacopuncture, Mar 31, 2021
Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal inf... more Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care. Bacteria and several fungal species have shown resistance to antibiotics used in treatment to current medications. Therefore, it is a considerable field of interest in the design and development of novel compounds with antimicrobial activity. Methods: The compounds bearing a heterocyclic ring play an imperative role among other organic compounds with pharmacological activity used as drugs in human for control and cure of various infections. Thiadiazoles containing nitrogen-sulfur atom as part of their cyclic structure which shown wide-ranging application as structural units of biologically active molecules and are very useful intermediates in Medicinal Chemistry. Results: The effectiveness of the thiadiazole nucleus was established by the drugs currently used for the treatment of various infections. 1,3,4-Thiadiazoles and some of their derivatives are widely studied because of their broad spectrum of pharmacological activities. Conclusion: In the present work, a series of 1,3,4-Thiadiazole derivatives were synthesized by cyclization of a group of various benzaldehyde with thiosemicarbazide in the presence of various reagent like FeCl 3 , HCHO by losing a molecule of water. These derivatives were found to possess prominent antimicrobial activity.
CRC Press eBooks, Mar 23, 2023
Research Journal of Pharmacy and Technology, Nov 28, 2013
According to the recent estimates, approximately about 40% of new chemical entities (NCEs) are re... more According to the recent estimates, approximately about 40% of new chemical entities (NCEs) are rejected because of their poor biopharmaceutical properties. The number of poorly soluble drugs is steadily increasing day by day. A poor solubility is mainly associated with the poor bioavailability. Solubility is an important criteria for achieving the desired drug concentration to produce pharmacological response. Pharmaceutical industries utilize traditional as well novel approaches to overcome drug solubilization problem depending upon the suitability and effect on cost of finished product. Even though, selecting the optimal approach from the available solubilizing technologies is a crucial decision to make. Recently novel technology based on nanoparticles has emerged as an innovative approach to deal with the formulation problems associated with poor water and lipid-soluble drugs. This article not only reviews the existing methods and technologies but also, enlightens and deals with the novel approaches to overcome the problems associated with poor solubility for the existing and newer promising candidates including their advantages and limitations. This review article finally updates the recent technologies for countering the solubility issues and help the academicians as well researchers to utilize these technologies to achieve the desired outcomes.
Journal of inclusion phenomena and macrocyclic chemistry, Sep 15, 2017
study the enhanced release of drug betamethasone from prepared topical formulation i.e. ointment ... more study the enhanced release of drug betamethasone from prepared topical formulation i.e. ointment containing β (beta) and γ (gamma) cyclodextrin complexes. The major role of cyclodextrins in topical drug delivery lies in the enhancement of drug release and permeation; reduced dosing; drug stabilization; reduction of the adverse effects, bioconversion
Asian Journal of Research in Pharmaceutical Science, Mar 28, 2012
ABSTRACT Pharmacovigilance is the pharmacological science relating to the detection, assessment, ... more ABSTRACT Pharmacovigilance is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term side effects of medicines. It is the science of collecting, monitoring, researching, assessing and evaluating information from healthcare providers and patients on the adverse effects of medications, biological products, herbalism and traditional medicines with a view to: Identifying new information about hazards associated with medicines Preventing harm to patients. Phase IV of the evaluation of a drug starts when the marketing license is granted and extends over many years. It consists of pharmacoepidemiological studies to evaluate the effectiveness, safety, and utilization of the drug in large populations, under real-life conditions. The results confirm or disprove the effectiveness of the drug in clinical practice (confirmation of the therapeutic effect), determine whether approved uses should be expanded or restricted, any untoward interactions (pharmacovigilance) and pharmacoeconomics of the drugs.
International Journal of Pharmaceutical Research and Allied Sciences
Journal of Pharmaceutical Innovation
Journal of the Science of Food and Agriculture
International Journal of Pharmaceutical And Phytopharmacological Research
CRC Press eBooks, Mar 23, 2023
BENTHAM SCIENCE PUBLISHERS eBooks, Dec 8, 2022
Reference series in phytochemistry, Dec 31, 2022
BENTHAM SCIENCE PUBLISHERS eBooks, Jul 30, 2023
Current Pharmaceutical Design, Aug 25, 2020
Cancer is the second leading cause of death globally, with every sixth death being attributable t... more Cancer is the second leading cause of death globally, with every sixth death being attributable to cancer. Nevertheless, the efficacy of conventional chemotherapeutic drugs is often limited due to their poor solubility, unfavorable pharmacokinetic profile, and lack of tumor selectivity. The use of nanotechnology provides an opportunity to enhance the efficacy of a chemotherapeutic drug by improving its bioavailability and pharmacokinetic profile while facilitating preferential accumulation at the tumor tissue. To date, a variety of platforms have been investigated as nanocarriers in oncology, which include lipid-based, polymer-based, inorganic materials, and even viruses. Among different nanocarriers, lipid-based delivery systems have been extensively used in oncology because of their biocompatibility, biodegradability, ability to encapsulate diverse drug molecules, high temporal and thermal stability, and offer prolonged and controlled drug release. This review discusses the current status of the lipid-based nanocarriers and their applications in cancer treatment as well as an overview of the different liposomal formulations commercially available for cancer therapy.
BioMed Research International, 2015
Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are a... more Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system. This paper provides an overview of limitations associated with anticancer drugs, their complexation with cyclodextrins, loading/encapsulating the complexed drugs into carriers, and various approaches used for the delivery. The present review article aims to assess the utility of cyclodextrin-based carriers like liposomes, niosomes, nanoparticles, micelles, millirods, and siRNA for delivery of antineoplastic agents. These systems based on cyclodextrin complexation and nanotechnology will camouflage the undesirable properties of drug and lead to synergistic or additive effect. Cyclodextrin-based nanotechnology seems to provide better therapeutic effect and sustain long life of healthy and recovered cells. Still, considerable study on delivery system and administration routes of cyclodextrin-based carriers is necessary with respect to their pharmacokinetics and toxicology to substantiate their safety and efficiency. In future, it would be possible to resolve the conventional and current issues associated with the development and commercialization of antineoplastic agents.
Current Molecular Medicine, Jul 27, 2023
: Truly miraculous medications and antibiotics have helped save untold millions of lives. Antibio... more : Truly miraculous medications and antibiotics have helped save untold millions of lives. Antibiotic resistance, however, is a significant issue related to health that jeopardizes the effectiveness of antibiotics and could harm everyone's health. Bacteria, not humans or animals, become antibiotic-resistant. Bacteria use quorum-sensing communication routes to manage an assortment of physiological exercises. Quorum sensing is significant for appropriate biofilm development. Antibiotic resistance occurs when bacteria establish a biofilm on a surface, shielding them from the effects of infection-fighting drugs. Acylated homoserine lactones are used as autoinducers by gram-negative microscopic organisms to impart. However, antibiotic resistance among ocular pathogens is increasing worldwide. Bacteria are a significant contributor to ocular infections around the world. Gram-negative microscopic organisms are dangerous to ophthalmic tissues. This review highlights the use of elective drug targets and treatments, for example, combinational treatment, to vanquish antibiotic-resistant bacteria. Also, it briefly portrays anti-biotic resistance brought about by gram-negative bacteria and approaches to overcome resistance with the help of quorum sensing inhibitors and nanotechnology as a promising medication conveyance approach to give insurance of anti-microbials and improve pathways for the administration of inhibitors of quorum sensing with a blend of anti-microbials to explicit target destinations and penetration through biofilms for treatment of ocular infections. It centres on the methodologies to sidestep the confinements of ocular anti-biotic delivery with new visual innovation.
International Journal of Advances in Pharmaceutical Sciences, Jan 16, 2018
Poor aqueous solubility and dissolution rates are critical problems that hinders the formulation,... more Poor aqueous solubility and dissolution rates are critical problems that hinders the formulation, development and delivery of most of BCS class II and class IV drugs. Gefitinib is a cytotoxic chemotherapeutic drug used in treatment of cancer. The object investigate the drug solubility study revealed formation of 1:1 stoichiometry binary inclusion complex. The complex was prepared by kneading met CD stronger Key
Journal of Pharmacopuncture, Mar 31, 2021
Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal inf... more Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care. Bacteria and several fungal species have shown resistance to antibiotics used in treatment to current medications. Therefore, it is a considerable field of interest in the design and development of novel compounds with antimicrobial activity. Methods: The compounds bearing a heterocyclic ring play an imperative role among other organic compounds with pharmacological activity used as drugs in human for control and cure of various infections. Thiadiazoles containing nitrogen-sulfur atom as part of their cyclic structure which shown wide-ranging application as structural units of biologically active molecules and are very useful intermediates in Medicinal Chemistry. Results: The effectiveness of the thiadiazole nucleus was established by the drugs currently used for the treatment of various infections. 1,3,4-Thiadiazoles and some of their derivatives are widely studied because of their broad spectrum of pharmacological activities. Conclusion: In the present work, a series of 1,3,4-Thiadiazole derivatives were synthesized by cyclization of a group of various benzaldehyde with thiosemicarbazide in the presence of various reagent like FeCl 3 , HCHO by losing a molecule of water. These derivatives were found to possess prominent antimicrobial activity.
CRC Press eBooks, Mar 23, 2023
Research Journal of Pharmacy and Technology, Nov 28, 2013
According to the recent estimates, approximately about 40% of new chemical entities (NCEs) are re... more According to the recent estimates, approximately about 40% of new chemical entities (NCEs) are rejected because of their poor biopharmaceutical properties. The number of poorly soluble drugs is steadily increasing day by day. A poor solubility is mainly associated with the poor bioavailability. Solubility is an important criteria for achieving the desired drug concentration to produce pharmacological response. Pharmaceutical industries utilize traditional as well novel approaches to overcome drug solubilization problem depending upon the suitability and effect on cost of finished product. Even though, selecting the optimal approach from the available solubilizing technologies is a crucial decision to make. Recently novel technology based on nanoparticles has emerged as an innovative approach to deal with the formulation problems associated with poor water and lipid-soluble drugs. This article not only reviews the existing methods and technologies but also, enlightens and deals with the novel approaches to overcome the problems associated with poor solubility for the existing and newer promising candidates including their advantages and limitations. This review article finally updates the recent technologies for countering the solubility issues and help the academicians as well researchers to utilize these technologies to achieve the desired outcomes.
Journal of inclusion phenomena and macrocyclic chemistry, Sep 15, 2017
study the enhanced release of drug betamethasone from prepared topical formulation i.e. ointment ... more study the enhanced release of drug betamethasone from prepared topical formulation i.e. ointment containing β (beta) and γ (gamma) cyclodextrin complexes. The major role of cyclodextrins in topical drug delivery lies in the enhancement of drug release and permeation; reduced dosing; drug stabilization; reduction of the adverse effects, bioconversion
Asian Journal of Research in Pharmaceutical Science, Mar 28, 2012
ABSTRACT Pharmacovigilance is the pharmacological science relating to the detection, assessment, ... more ABSTRACT Pharmacovigilance is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term side effects of medicines. It is the science of collecting, monitoring, researching, assessing and evaluating information from healthcare providers and patients on the adverse effects of medications, biological products, herbalism and traditional medicines with a view to: Identifying new information about hazards associated with medicines Preventing harm to patients. Phase IV of the evaluation of a drug starts when the marketing license is granted and extends over many years. It consists of pharmacoepidemiological studies to evaluate the effectiveness, safety, and utilization of the drug in large populations, under real-life conditions. The results confirm or disprove the effectiveness of the drug in clinical practice (confirmation of the therapeutic effect), determine whether approved uses should be expanded or restricted, any untoward interactions (pharmacovigilance) and pharmacoeconomics of the drugs.
International Journal of Pharmaceutical Research and Allied Sciences
Journal of Pharmaceutical Innovation
Journal of the Science of Food and Agriculture
International Journal of Pharmaceutical And Phytopharmacological Research
CRC Press eBooks, Mar 23, 2023
BENTHAM SCIENCE PUBLISHERS eBooks, Dec 8, 2022