BUBUN BANERJEE - Academia.edu (original) (raw)
Papers by BUBUN BANERJEE
Physical Sciences Reviews
This review deals with the latest developments on the synthesis of biologically promising organot... more This review deals with the latest developments on the synthesis of biologically promising organotellurim scaffolds reported during last two decades.
Physical Sciences Reviews, 2021
Saccharomyces cerevisiae, commonly known as baker’s yeast, has gained significant importance as a... more Saccharomyces cerevisiae, commonly known as baker’s yeast, has gained significant importance as a mild, low-cost, environmentally benign biocatalyst. Initially it was mostly employed as an efficient catalyst for the enantioselective reduction of carbonyl compounds. Over the last decade, baker’s yeast has found versatile catalytic applications in various organic transformations. Many multicomponent reactions were also catalyzed by baker’s yeast. Various heterocyclic scaffolds with immense biological activities were synthesized by employing baker’s yeast as catalyst at room temperature. In this communication, we have summarized baker’s yeast catalyzed various organic transformations focusing primarily on heterocyclic synthesis.
Molecular Crystals and Liquid Crystals, 2015
N,N-dicyclohexylcarbamoyl-2-(thiophen-2-yl)acetamide (C 19 H 28 N 2 O 2 S), was prepared using 1,... more N,N-dicyclohexylcarbamoyl-2-(thiophen-2-yl)acetamide (C 19 H 28 N 2 O 2 S), was prepared using 1,3-dicyclohexylurea. The compound has been characterized by IR, and single-crystal X-ray diffraction followed by a detailed Hirshfeld surface analysis. The compound crystallizes in the monoclinic space group P2 1 /c, with cell parameters a = 9.0969(3) Å,
Physical Sciences Reviews, 2022
The present review summarizes all the multi-component reaction strategies reported during last tw... more The present review summarizes all the multi-component reaction strategies reported during last two decades for the synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives.
Anti-Cancer Agents in Medicinal Chemistry
Worldwide cancer is regarded as a great threat to mankind. It leads to abnormal growth of the tis... more Worldwide cancer is regarded as a great threat to mankind. It leads to abnormal growth of the tissues by uncontrolled cell divisions. It was well established that cancer is a disease associated with unsuppressed growth and the spread of anomalistic cells [1]. It is quite unfortunate that, till now, there is no specific potent medicine with a 100% success rate for cancer treatments. Though, a large number of drugs have been used for the treatment of various cancers. In some instances, these available drugs are causing side effects [2]. Efforts have been made to design new drug molecules or modify the existing drugs to reduce the side effects of these drugs [3]. On the other hand, more than half of the commercially available drugs consist of different heterocyclic skeletons [4]. Along with other biological activities, various synthetic heterocyclic scaffolds also showed significant anti-cancer activities [5-11]. Interestingly, it has been observed that the majority of the commercially available anti-cancer drugs possess heterocyclic moiety either as the main structural unit or as an important subunit [12]. Under this purview, during the last three decades, the screening of anti-cancer efficacy of various heterocyclic scaffolds has increased rapidly. Several naturally occurring, semi-synthetic and synthetic heterocyclic compounds have passed in clinical or preclinical anticancer trials [12]. Few of them showed significant anti-tumor activities and thus they are available in the market as promising drugs [13]. This thematic issue titled 'Role of the heterocycles to design anti-cancer agents' has covered a large number of literature related to the potent anti-cancer activities of structurally diverse heterocyclic scaffolds. This thematic issue highlights an up-to-date literature on the following selected eight topics contributed by the eminent research groups. The first contribution titled 'Heterocyclic compounds: Importance in anticancer drug discovery' by Kumar and Goel deals with the role of various heterocyclic skeletons in the design and developments of anti-cancer drugs [14].
Heterocyclic Anticancer Agents
Laboratory of Natural Products & Organic Synthesis, Department of Chemistry, Visva-Bharati (a Cen... more Laboratory of Natural Products & Organic Synthesis, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan-731 235, West Bengal, India E-mail : brahmg2001@yahoo.co.in, brahmg2001@gmail.com Post-Graduate Department of Physics & Electronics, University of Jammu, Jammu Tawi-180 006, Jammu & Kashmir, India E-mail : vivek_gupta2k2@hotmail.com Manuscript received online 04 November 2014, accepted 20 February 2015 The present communication deals with the eco-friendly synthesis, spectral properties and X-ray crystal structure of an alpha-amino acid, 2-(4-chlorophenyl)-2-(4-fluorophenylamino)acetonitrile (1). The title compound (m.f. C<sub>14</sub>H<sub>10</sub>ClFN<sub>2</sub> ) crystallizes in the orthorhombic space group Pbcn with the unit-cell parameters : <em>a</em> = 13.9791(4), <em>b</em> = 6.9972(2), <em>c</em> = 25.0724(6) Å and Z = 8. The crystal structure was solved by direct methods using...
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Related Article: Suresh Sharma, Bubun Banerjee, Goutam Brahmachari, Rajni Kanta, Vivek K. Gupta|2... more Related Article: Suresh Sharma, Bubun Banerjee, Goutam Brahmachari, Rajni Kanta, Vivek K. Gupta|2016|Kristallografiya|61|1051|doi:10.1134/S1063774516070105
Crystallography Reports, 2015
Crystal structure of 2-Amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8tetrahydro-4H-chromene-3-... more Crystal structure of 2-Amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8tetrahydro-4H-chromene-3-carbonitrile hemihydrate 3.1 Introduction Pyridine Since the early twentieth century, pyridine derivatives have been commercially important, but most prominently so during World War II and thereafter. Many pyridines of commercial interest find application in market areas where bioactivity is important, as in medicinal drugs and in agricultural products such as herbicides, insecticides, fungicides and plant growth regulators. However, pyridines also have significant market applications outside the realm of bioactive ingredients. For instance, polymers made from pyridine-containing monomers are generally sold on the basis of their unique physical properties and function, rather than for any bioactivity. Pyridines can be classified as specialty chemicals because of a relatively lower sales volume than commodity chemicals. They are most often sold in the market place as chemical intermediates used to manufacture final consumer products. Chromene Chromene compounds have employed as useful intermediate in the synthesis of a wide range of natural products (Coujon et al., 2002). Tetrahydro-4-chromene is an extensive class of bioactive compounds with antimicrobial, antifungal and antioxidant properties (Alvey et al., 2009; Narender & Gupta, 2009; Symeonidis et al., 2009). Compounds such as 4H-chromenes and fused 4H-chromenes are a great class of organic drugs due to their wide applications in chemotherapy. These compounds exhibit anticancer activities (Abd-El-Aziz et al.
Advances in Science, Technology & Innovation, 2021
Physical Sciences Reviews
This chapter describes the importance and activity of a huge number of commercially available nat... more This chapter describes the importance and activity of a huge number of commercially available naturally occurring, natural product derived or synthetic heterocyclic anti-cancer drugs.
Camphor sulfonic acid catalyzed a straightforward, efficient, and general method has been develop... more Camphor sulfonic acid catalyzed a straightforward, efficient, and general method has been developed for the synthesis of 3,3'-(arylmethylene)<i>bis</i>(4-hydroxy-2<i>H</i>-chromen-2-ones), 3,3'-(arylmethylene)<i>bis</i>(2-hydroxynaphthalene-1,4-diones) and 3,3'-(2-oxoindoline-3,3-diyl)<i>bis</i>(2-hydroxynaphthalene-1,4-dione) derivatives in aqueous ethanol at room temperature from the reactions of various aromatic aldehydes and 4-hydroxycoumarin or 2-hydroxynaphthalene-1,4-dione respectively. Mild reaction conditions, use of metal-free organocatalyst, good to excellent yields, high atom-economy, environmentally benign, easy isolation of products, and no column chromatographic separation are some of the major benefits of this developed protocol.
This chapter deals with the latest developments in the synthesis of biologically relevant heteroc... more This chapter deals with the latest developments in the synthesis of biologically relevant heterocycles using heterogeneous magnetic nanocatalysts in water. These catalysts are easily separable from the reaction mixture by using an external magnet and can be reused several times without any significant loss in their catalytic activities. As a result, it becomes a fascinating topic for today's organic chemists. The present chapter will surely make some impact and become a valuable document for those working in this direction.
Physical Sciences Reviews
This review deals with the latest developments on the synthesis of biologically promising organot... more This review deals with the latest developments on the synthesis of biologically promising organotellurim scaffolds reported during last two decades.
Physical Sciences Reviews, 2021
Saccharomyces cerevisiae, commonly known as baker’s yeast, has gained significant importance as a... more Saccharomyces cerevisiae, commonly known as baker’s yeast, has gained significant importance as a mild, low-cost, environmentally benign biocatalyst. Initially it was mostly employed as an efficient catalyst for the enantioselective reduction of carbonyl compounds. Over the last decade, baker’s yeast has found versatile catalytic applications in various organic transformations. Many multicomponent reactions were also catalyzed by baker’s yeast. Various heterocyclic scaffolds with immense biological activities were synthesized by employing baker’s yeast as catalyst at room temperature. In this communication, we have summarized baker’s yeast catalyzed various organic transformations focusing primarily on heterocyclic synthesis.
Molecular Crystals and Liquid Crystals, 2015
N,N-dicyclohexylcarbamoyl-2-(thiophen-2-yl)acetamide (C 19 H 28 N 2 O 2 S), was prepared using 1,... more N,N-dicyclohexylcarbamoyl-2-(thiophen-2-yl)acetamide (C 19 H 28 N 2 O 2 S), was prepared using 1,3-dicyclohexylurea. The compound has been characterized by IR, and single-crystal X-ray diffraction followed by a detailed Hirshfeld surface analysis. The compound crystallizes in the monoclinic space group P2 1 /c, with cell parameters a = 9.0969(3) Å,
Physical Sciences Reviews, 2022
The present review summarizes all the multi-component reaction strategies reported during last tw... more The present review summarizes all the multi-component reaction strategies reported during last two decades for the synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives.
Anti-Cancer Agents in Medicinal Chemistry
Worldwide cancer is regarded as a great threat to mankind. It leads to abnormal growth of the tis... more Worldwide cancer is regarded as a great threat to mankind. It leads to abnormal growth of the tissues by uncontrolled cell divisions. It was well established that cancer is a disease associated with unsuppressed growth and the spread of anomalistic cells [1]. It is quite unfortunate that, till now, there is no specific potent medicine with a 100% success rate for cancer treatments. Though, a large number of drugs have been used for the treatment of various cancers. In some instances, these available drugs are causing side effects [2]. Efforts have been made to design new drug molecules or modify the existing drugs to reduce the side effects of these drugs [3]. On the other hand, more than half of the commercially available drugs consist of different heterocyclic skeletons [4]. Along with other biological activities, various synthetic heterocyclic scaffolds also showed significant anti-cancer activities [5-11]. Interestingly, it has been observed that the majority of the commercially available anti-cancer drugs possess heterocyclic moiety either as the main structural unit or as an important subunit [12]. Under this purview, during the last three decades, the screening of anti-cancer efficacy of various heterocyclic scaffolds has increased rapidly. Several naturally occurring, semi-synthetic and synthetic heterocyclic compounds have passed in clinical or preclinical anticancer trials [12]. Few of them showed significant anti-tumor activities and thus they are available in the market as promising drugs [13]. This thematic issue titled 'Role of the heterocycles to design anti-cancer agents' has covered a large number of literature related to the potent anti-cancer activities of structurally diverse heterocyclic scaffolds. This thematic issue highlights an up-to-date literature on the following selected eight topics contributed by the eminent research groups. The first contribution titled 'Heterocyclic compounds: Importance in anticancer drug discovery' by Kumar and Goel deals with the role of various heterocyclic skeletons in the design and developments of anti-cancer drugs [14].
Heterocyclic Anticancer Agents
Laboratory of Natural Products & Organic Synthesis, Department of Chemistry, Visva-Bharati (a Cen... more Laboratory of Natural Products & Organic Synthesis, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan-731 235, West Bengal, India E-mail : brahmg2001@yahoo.co.in, brahmg2001@gmail.com Post-Graduate Department of Physics & Electronics, University of Jammu, Jammu Tawi-180 006, Jammu & Kashmir, India E-mail : vivek_gupta2k2@hotmail.com Manuscript received online 04 November 2014, accepted 20 February 2015 The present communication deals with the eco-friendly synthesis, spectral properties and X-ray crystal structure of an alpha-amino acid, 2-(4-chlorophenyl)-2-(4-fluorophenylamino)acetonitrile (1). The title compound (m.f. C<sub>14</sub>H<sub>10</sub>ClFN<sub>2</sub> ) crystallizes in the orthorhombic space group Pbcn with the unit-cell parameters : <em>a</em> = 13.9791(4), <em>b</em> = 6.9972(2), <em>c</em> = 25.0724(6) Å and Z = 8. The crystal structure was solved by direct methods using...
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Related Article: Suresh Sharma, Bubun Banerjee, Goutam Brahmachari, Rajni Kanta, Vivek K. Gupta|2... more Related Article: Suresh Sharma, Bubun Banerjee, Goutam Brahmachari, Rajni Kanta, Vivek K. Gupta|2016|Kristallografiya|61|1051|doi:10.1134/S1063774516070105
Crystallography Reports, 2015
Crystal structure of 2-Amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8tetrahydro-4H-chromene-3-... more Crystal structure of 2-Amino-7,7-dimethyl-5-oxo-4-(pyridin-4-yl)-5,6,7,8tetrahydro-4H-chromene-3-carbonitrile hemihydrate 3.1 Introduction Pyridine Since the early twentieth century, pyridine derivatives have been commercially important, but most prominently so during World War II and thereafter. Many pyridines of commercial interest find application in market areas where bioactivity is important, as in medicinal drugs and in agricultural products such as herbicides, insecticides, fungicides and plant growth regulators. However, pyridines also have significant market applications outside the realm of bioactive ingredients. For instance, polymers made from pyridine-containing monomers are generally sold on the basis of their unique physical properties and function, rather than for any bioactivity. Pyridines can be classified as specialty chemicals because of a relatively lower sales volume than commodity chemicals. They are most often sold in the market place as chemical intermediates used to manufacture final consumer products. Chromene Chromene compounds have employed as useful intermediate in the synthesis of a wide range of natural products (Coujon et al., 2002). Tetrahydro-4-chromene is an extensive class of bioactive compounds with antimicrobial, antifungal and antioxidant properties (Alvey et al., 2009; Narender & Gupta, 2009; Symeonidis et al., 2009). Compounds such as 4H-chromenes and fused 4H-chromenes are a great class of organic drugs due to their wide applications in chemotherapy. These compounds exhibit anticancer activities (Abd-El-Aziz et al.
Advances in Science, Technology & Innovation, 2021
Physical Sciences Reviews
This chapter describes the importance and activity of a huge number of commercially available nat... more This chapter describes the importance and activity of a huge number of commercially available naturally occurring, natural product derived or synthetic heterocyclic anti-cancer drugs.
Camphor sulfonic acid catalyzed a straightforward, efficient, and general method has been develop... more Camphor sulfonic acid catalyzed a straightforward, efficient, and general method has been developed for the synthesis of 3,3'-(arylmethylene)<i>bis</i>(4-hydroxy-2<i>H</i>-chromen-2-ones), 3,3'-(arylmethylene)<i>bis</i>(2-hydroxynaphthalene-1,4-diones) and 3,3'-(2-oxoindoline-3,3-diyl)<i>bis</i>(2-hydroxynaphthalene-1,4-dione) derivatives in aqueous ethanol at room temperature from the reactions of various aromatic aldehydes and 4-hydroxycoumarin or 2-hydroxynaphthalene-1,4-dione respectively. Mild reaction conditions, use of metal-free organocatalyst, good to excellent yields, high atom-economy, environmentally benign, easy isolation of products, and no column chromatographic separation are some of the major benefits of this developed protocol.
This chapter deals with the latest developments in the synthesis of biologically relevant heteroc... more This chapter deals with the latest developments in the synthesis of biologically relevant heterocycles using heterogeneous magnetic nanocatalysts in water. These catalysts are easily separable from the reaction mixture by using an external magnet and can be reused several times without any significant loss in their catalytic activities. As a result, it becomes a fascinating topic for today's organic chemists. The present chapter will surely make some impact and become a valuable document for those working in this direction.