Babar Malik - Academia.edu (original) (raw)
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King AbdulAziz University (KAU) Jeddah, Saudi Arabia
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Papers by Babar Malik
Emerging Infectious Diseases, 2010
Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4... more Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4.5% in 2009 (p<0.01). To understand the epidemiology, we genotyped selected strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats, and IS6110 restriction fragment length polymorphism analysis. E mergence and spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are facilitated by inadequate detection and treatment (1). TB detection and treatment are more diffi cult in countries, like Pakistan, that are facing complex emergencies, including humanitarian crises and confl icts (2). Published data report an increasing prevalence of MDR TB and emergence of XDR TB strains in Pakistan (3). This study documents an increasing trend of XDR resistance within MDR TB isolates in Pakistan. To obtain better insight into the epidemiology of these strains, we genotyped selected XDR TB strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR), and IS6110 restriction fragment length polymorphism (RFLP) analysis.
Emerging Infectious Diseases, 2010
Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4... more Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4.5% in 2009 (p<0.01). To understand the epidemiology, we genotyped selected strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats, and IS6110 restriction fragment length polymorphism analysis. E mergence and spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are facilitated by inadequate detection and treatment (1). TB detection and treatment are more diffi cult in countries, like Pakistan, that are facing complex emergencies, including humanitarian crises and confl icts (2). Published data report an increasing prevalence of MDR TB and emergence of XDR TB strains in Pakistan (3). This study documents an increasing trend of XDR resistance within MDR TB isolates in Pakistan. To obtain better insight into the epidemiology of these strains, we genotyped selected XDR TB strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR), and IS6110 restriction fragment length polymorphism (RFLP) analysis.