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Papers by Bahareh Hassani

ChemistrySelect, Jun 1, 2023

Studies in Medical Sciences

Background & Aims: In order to investigate the effects of new drugs, we decided to investigate tw... more Background & Aims: In order to investigate the effects of new drugs, we decided to investigate twelve new derivatives with the basic structure of spirooxindoles that were previously synthesized for antimicrobial, antifungal and anticancer properties. Materials & Methods: In this experimental study, we evaluated 12 spirooxyindole derivatives. The inhibitory effect of the compounds has been studied using broth microdilution method based on CLSI protocols on 16 different species of bacteria and fungi. Then, 6 compounds have been selected and their cytotoxicity effects on 2 cell lines MCF-7 and A-549 compared to doxorubicin have been investigated by MTT method. Excel 2013 software was used to perform statistical calculations of the results obtained from each experiment, and GraphPad Curve Expert 1.4 software was used to draw graphs and determine IC50 with a significance level of 0.05. Results: At the concentration range of 1-512 μg/ml, the synthesized derivatives were not able to inhibit the growth or death of the investigated fungi and bacteria. Only the compound I12 at a concentration of 1000 μg/ml was able inhibit the growth of MFC-7 cell line by 49.23%. Conclusion: Due to the lack of effective effect of these compounds in inhibiting the growth of bacteria and fungi, for the optimal use of these compounds in the treatment of fungal and bacterial infections, it is necessary to make more changes on their structures. Cytotoxicity assay reveals that the presence of the bulky ester in the N position of the isatin ring as well as the CN attached to the pyridine ring has been beneficial in the effectiveness of these derivatives.

Journal of Biomolecular Structure and Dynamics

Oxidative Medicine and Cellular Longevity, Jul 11, 2022

Biological aging or senescence is a course in which cellular function decreases over a period of ... more Biological aging or senescence is a course in which cellular function decreases over a period of time and is a consequence of altered signaling mechanisms that are triggered in stressed cells leading to cell damage. Aging is among the principal risk factors for many chronic illnesses such as cancer, cardiovascular disorders, and neurodegenerative diseases. Taking this into account, targeting fundamental aging mechanisms therapeutically may effectively impact numerous chronic illnesses. Selecting ideal therapeutic options in order to hinder the process of aging and decelerate the progression of age-related diseases is valuable. Along therapeutic options, life style modifications may well render the process of aging. The process of aging is affected by alteration in many cellular and signaling pathways amid which mTOR, SIRT1, and AMPK pathways are the most emphasized. Herein, we have discussed the mechanisms of aging focusing mainly on the mentioned pathways as well as the role of inflammation and autophagy in aging. Moreover, drugs and natural products with antiaging properties are discussed in detail.

Life

The Latin word lupus, meaning wolf, was in the medical literature prior to the 1200s to describe ... more The Latin word lupus, meaning wolf, was in the medical literature prior to the 1200s to describe skin lesions that devour flesh, and the resources available to physicians to help people were limited. The present text reviews the ethnobotanical and pharmacological aspects of medicinal plants and purified molecules from natural sources with efficacy against lupus conditions. Among these molecules are artemisinin and its derivatives, antroquinonol, baicalin, curcumin, emodin, mangiferin, salvianolic acid A, triptolide, the total glycosides of paeony (TGP), and other supplements such as fatty acids and vitamins. In addition, medicinal plants, herbal remedies, mushrooms, and fungi that have been investigated for their effects on different lupus conditions through clinical trials, in vivo, in vitro, or in silico studies are reviewed. A special emphasis was placed on clinical trials, active phytochemicals, and their mechanisms of action. This review can be helpful for researchers in design...

Frontiers in Materials

Mesoporous silica nanoparticles (MSNs) are considered as suitable delivery vehicles considering t... more Mesoporous silica nanoparticles (MSNs) are considered as suitable delivery vehicles considering their unique characteristics. Various physicochemical characteristics of MSNs govern their pharmacokinetic parameters which affect the disposition of these nanoparticles in the body. Along with the advantages of MSNs, the toxicity of nanoparticles entering the body is a major concern. Various factors such as particle size, surface charge, route of administration, etc., may affect organ toxicity of MSNs. The main target organs involved in the metabolism and elimination of MSNs are the kidney and the liver as well as the hematopoietic system. In this review, we first introduced the physicochemical characteristics of MSNs which affect the pharmacokinetic properties including drug absorption and bio-distribution. Thereafter, we discussed the mechanisms by which organ toxicity may occur. In this regard, the effects of various factors on organ-based MSNs toxicities and molecular mechanisms have...

Oxidative Medicine and Cellular Longevity