Bake Bake - Academia.edu (original) (raw)

Papers by Bake Bake

Research paper thumbnail of Height, Age, and Atopy Are Associated With Fraction of Exhaled Nitric Oxide in a Large Adult General Population Sample

Chest, 2006

The fraction of exhaled nitric oxide (Feno) is elevated in subjects with asthma and atopy, and it... more The fraction of exhaled nitric oxide (Feno) is elevated in subjects with asthma and atopy, and it has been proposed to be a noninvasive marker of airway inflammation. In addition to asthma and atopy, there is limited information about the determinants of Feno in a general population. Cross-sectional. A random adult general population sample. A total of 2,200 subjects, 1,111 women and 1,089 men, aged 25 to 75 years. The subjects were examined with regard to Feno, pulmonary function, anthropometric variables, and blood samples for Ig E, and completed a respiratory questionnaire. The associations between different determinants and Feno were analyzed with multiple linear regression models. The median value of Feno was 16.0 parts per billion (ppb), ranging from 2.4 to 199 ppb. Height, age, atopy, reporting of asthma symptoms in the last month, and reported use of inhaled steroids were positively associated with Feno. Current smokers had lower values of Feno. Gender was not associated with Feno. In this random adult population sample, height, but not gender, was associated with Feno. Furthermore, asthma symptoms in the last month, reported use of inhaled steroids, and atopy were positively and independently associated with Feno, while there was a negative association with smoking.

Research paper thumbnail of Emphysematous lesions and lung function in healthy smokers 60 years of age

Respiratory Medicine, 2000

We aimed to study the occurrence of emphysematous lesions in symptom free smoking men of about 60... more We aimed to study the occurrence of emphysematous lesions in symptom free smoking men of about 60 years of age and in a matching group of never-smoking men and the relationship between pulmonary changes at high resolution computed tomography (HRCT) and lung function tests.

Research paper thumbnail of Neutrophil-associated activation markers in healthy smokers relates to a fall in DL COand to emphysematous changes on high resolution CT

Respiratory Medicine, 2001

Smoking is a risk factor for developing chronic obstructive pulmonary disease (COPD), but there a... more Smoking is a risk factor for developing chronic obstructive pulmonary disease (COPD), but there are no good indicators for early identification of subjects who will develop symptomatic COPD. The aim of this study was to investigate inflammatory mechanisms related to changes in lung function and emphysematous changes on high resolution computed tomography (HRCT) in 'healthy' smokers. Subjects were 60-year-old men from a population study. Bronchoscopy was performed in 30 smokers and 18 who had never smoked. Blood tests, lung function measurements and HRCT were carried out in 58 and 34 subjects, respectively.

Research paper thumbnail of Height, Age, and Atopy Are Associated With Fraction of Exhaled Nitric Oxide in a Large Adult General Population Sample

Chest, 2006

The fraction of exhaled nitric oxide (Feno) is elevated in subjects with asthma and atopy, and it... more The fraction of exhaled nitric oxide (Feno) is elevated in subjects with asthma and atopy, and it has been proposed to be a noninvasive marker of airway inflammation. In addition to asthma and atopy, there is limited information about the determinants of Feno in a general population. Cross-sectional. A random adult general population sample. A total of 2,200 subjects, 1,111 women and 1,089 men, aged 25 to 75 years. The subjects were examined with regard to Feno, pulmonary function, anthropometric variables, and blood samples for Ig E, and completed a respiratory questionnaire. The associations between different determinants and Feno were analyzed with multiple linear regression models. The median value of Feno was 16.0 parts per billion (ppb), ranging from 2.4 to 199 ppb. Height, age, atopy, reporting of asthma symptoms in the last month, and reported use of inhaled steroids were positively associated with Feno. Current smokers had lower values of Feno. Gender was not associated with Feno. In this random adult population sample, height, but not gender, was associated with Feno. Furthermore, asthma symptoms in the last month, reported use of inhaled steroids, and atopy were positively and independently associated with Feno, while there was a negative association with smoking.

Research paper thumbnail of Emphysematous lesions and lung function in healthy smokers 60 years of age

Respiratory Medicine, 2000

We aimed to study the occurrence of emphysematous lesions in symptom free smoking men of about 60... more We aimed to study the occurrence of emphysematous lesions in symptom free smoking men of about 60 years of age and in a matching group of never-smoking men and the relationship between pulmonary changes at high resolution computed tomography (HRCT) and lung function tests.

Research paper thumbnail of Neutrophil-associated activation markers in healthy smokers relates to a fall in DL COand to emphysematous changes on high resolution CT

Respiratory Medicine, 2001

Smoking is a risk factor for developing chronic obstructive pulmonary disease (COPD), but there a... more Smoking is a risk factor for developing chronic obstructive pulmonary disease (COPD), but there are no good indicators for early identification of subjects who will develop symptomatic COPD. The aim of this study was to investigate inflammatory mechanisms related to changes in lung function and emphysematous changes on high resolution computed tomography (HRCT) in 'healthy' smokers. Subjects were 60-year-old men from a population study. Bronchoscopy was performed in 30 smokers and 18 who had never smoked. Blood tests, lung function measurements and HRCT were carried out in 58 and 34 subjects, respectively.