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Papers by Lidija Banjac

Srpski Arhiv Za Celokupno Lekarstvo, Dec 31, 2022

Acta Clinica Croatica, Mar 1, 2014

-Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of sever... more -Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe disease including meningoencephalitis, sepsis syndrome, cardiovascular collapse, or hepatitis. The mechanism of heart failure in patients with enterovirus infection remains unknown. Early diagnosis may help clinicians predict complications in those infants initially presenting with severe disease. An 11-day-old male newborn was admitted to our neonatal intensive care unit because of tachycardia and crises of cyanosis. His elder brother had febrile illness. The newborn was cyanotic, in respiratory distress, with tachycardia, low blood pressure and prolonged capillary refilling time. Limb pulse oximeter was around 85%. During the first day of hospitalization, the newborn had one febrile episode. Laboratory data: elevated transaminases, markers of inflammation negative, all bacterial cultures negative. Enterovirus RNA was detected in blood sample. Other blood findings were without significant abnormalities. Electrocardiogram showed tachycardia, with narrow QRS complexes (atrial tachycardia) and heart rate up to 280/min. In order to convert the rhythm, the patient was administered adenosine and amiodarone. In the further course of hospitalization, the patient was in good general condition, eucardiac and eupneic. Newborns with tachycardia and a family history of febrile illness should be suspected to have enterovirus infection. Enterovirus infection is a highly contagious and potentially life-threatening infection if not detected early. The use of sensitive molecular-based amplification methods offers potential benefits for early diagnosis and timely treatment.

PubMed, Jun 1, 2012

The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels... more The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels at postmenstrual age of 33 weeks between preterm infants with and without retinopathy of prematurity (ROP). ROP occurs in two phases. Low serum levels of IGF-1 during ROP phase 1 have been found to correlate with the severity of ROP. ROP phase 2 begins around postmenstrual week 33. We conducted a prospective cohort study to measure serum IGF-1 levels in premature infants at postmenstrual age of 33 weeks. The study included all premature infants (N = 74), gestational age < or = 33 weeks, hospitalized at Department of Neonatology, Clinical Center of Montenegro, from April 2008 to July 2009. The incidence of ROP in the study cohort was 50.7%. Infants with ROP had a significantly lower birth weight and significantly shorter gestational age. The mean level of IGF-1 at postmenstrual age of 33 weeks was 23.7 mcg/L. Study results showed that there was no significant difference in serum IGF-1 level between newborns with and without ROP at postmenstrual age of 33 weeks (in newborns with ROP, it was the beginning of ROP phase 2). A large controlled study with repeated measurement of IGF-1 level in the neonatal period is needed to confirm that restoration of IGF-I level occurs in ROP phase 2, i.e. that the low level of IGF-1 is only a feature of ROP phase 1.

Predmet. Prematurna retinopatija (ROP) je vazoproliferativno oboljenje mrežnjače oka, najčešća bo... more Predmet. Prematurna retinopatija (ROP) je vazoproliferativno oboljenje mrežnjače oka, najčešća bolest prematuriteta i najčešći je uzrok slepila kod dece. Cilj ove studije je bio da ukaže na mogućnost rane trijaže novorođenčadi u visokom riziku za nastanak prematurne retinopatije (ROP) na osnovu serumskog nivoa insulinu-sličnog faktora rasta tip-1 (IGF-I), koji je jedan od najznačajnijih faktora u patogenezi ROP-a. Metod. Sprovedena je kohortna, longitudinalna, prospektivna studija. U studiju je uključena kohorta preterminske novorodjenčadi (74 novorođenčeta) gestacione starosti ≤33 nedelje, koja su bila hospitalizovana u Centaru za neonatologiju, Instituta za bolesti djece, Kliničkog Centra Crne Gore, od aprila 2008. do jula 2009. Uzorak krvi ispitanicima je uziman u 33oj postkoncepcijskoj nedelji, postnatalno. Vrednosti IGF-1 su određivane ELISA metodom. Rezultati. Srednje gestaciona dob u kohorti novorođenčadi sa ROP-om iznosila je 30.61± 2.12 (±SD) a novorođenčad bez ROP-a 31.8±1.43 gestacionih nedelja (p<0.01). Prosečna porodjajna telesna masa novorođenčadi sa ROP-om iznosila je 1586.94±417.99 g a novorođenčadi bez ROP-a 1821.71±369.59 g (p<0.05). Srednja vrednost serumskog IGF-I za novorođančad sa ROP-om iznosila je 23.88±6.74 μg/L a u kohorti bez ROP-a 23.79±4.85 μg/L (p>0.05). Zaključak. Koncentracije serumskog IGF-I kod preterminske novorodjenčadi gestacione starosti ≤33 nedelje koja kasnije dobiju prematurnu retinopatiju nisu značajno različite od novorodjenčadi iste starosti bez potonje prematurne retinopatije. Merenje koncetracija IGF-I u serumu ne bi trebalo da se koristi za procenu rizika za razvoj prematurne retinopatije dok se ne prikupe dodatni dokazi iz budućih kliničkih studija. Ključne reči: retinopatija prematuriteta; insulinu-sličan faktor rasta I; prospektivna studija.

Pediatric Research, Nov 1, 2010

Results: Forty patients (21 girls, 19 boys) with the median age of 5.6 years (range 0.5-19.9) exp... more Results: Forty patients (21 girls, 19 boys) with the median age of 5.6 years (range 0.5-19.9) experienced 82 episodes of FN. Underlying disease was hematologic in 55 and solid tumor in 27 episodes. Bacteremia was confirmed in 16 (19.5 %) episodes; Gram negative in 8, Gram positive in 7 and combined in 1 episode. The fever was due to local infection in 14 (17 %), viral in 9 (11 %), whereas in 41 episodes (50 %) the cause could not be identified (FUO). On day 1 the best diagnostic accuracy (AUC) was seen for IL-6 (0.765) followed by CRP (0.738), LBP (0.696) and PCT (0.666). On day 2 CRP had the best diagnostic accuracy (0.824), followed by IL-6 (0.753), PCT (0.695) and LBP (0.685).

Acta Clinica Croatica, 2020

Insulin like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating conce... more Insulin like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 premature newborns, gestational age (GA) ≤33 weeks. Quantitative determination of IGF-1 was performed in the 33 rd post-menstrual week (pmw) to make the measurements more comparable. We used an enzyme-bound immunosorbent test for quantitative determination of IGF-1. Our results showed the mean IGF-1 level in premature newborns in 33 rd pmw to be 23.1±4.56 (range 15.44-39.75) μg/L. There was no difference in IGF-1 values between male (23.1±4.98 μg/L) and female (23.1±4.87 μg/L) newborns. There was no significant difference in the average IGF-1 levels between male and female newborns with BW <50 th and BW >50 th percentile for GA either (p>0.50). Only BW <33 rd percentile newborns had a statistically significantly lower IGF-1 level compared to newborns with greater BW. Based on our results, it is concluded that serum IGF-1 level reflects intrauterine growth only in BW <33 rd percentile newborns. This fact could be used for further therapeutic purposes.

Archives of Disease in Childhood, Nov 1, 2008

Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caus... more Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caused by Epstein Barr virus (EBV). It usually lasts 2–3 weeks; complications are rare and most serious is spleen rupture. Aim The aim was to analyze frequency and characteristics of complication in hospitalized patients with EBV MI. Matherial In this prospective study from 2007 we analyzed 60 hospitalized patients aged between 3 and 18 and divided them into two age groups to better analyze complications; a preschool (age Results All patients had fever, sore throat and lymphadenopathy, almost all had splenomegaly. Most frequent complication was second bacterial throat infection (30% in both groups), caused by GABHS (group A beta hemolytic streptococcus), with higher prevalence in the first group, mild thrombocytopenia (2 cases) and upper airway obstruction (1 case) were frequent in the first age group. We had one case with peritonsillar abscess in the second age group. Other complications (pneumonia and anemia) were not age related. Conclusion The average time of hospitalization was 10 days. All patients completely recovered. We treated them with standard, symptomatic and additional therapy, when necessary (corticosteroids, antibiotics, incision in patients with peritonsillar abscess).

Journal of Neonatal Biology, Jan 17, 2017

EC Paediatrics, Apr 23, 2021

Acta Clinica Croatica, 2014

-Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of sever... more -Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe disease including meningoencephalitis, sepsis syndrome, cardiovascular collapse, or hepatitis. The mechanism of heart failure in patients with enterovirus infection remains unknown. Early diagnosis may help clinicians predict complications in those infants initially presenting with severe disease. An 11-day-old male newborn was admitted to our neonatal intensive care unit because of tachycardia and crises of cyanosis. His elder brother had febrile illness. The newborn was cyanotic, in respiratory distress, with tachycardia, low blood pressure and prolonged capillary refilling time. Limb pulse oximeter was around 85%. During the first day of hospitalization, the newborn had one febrile episode. Laboratory data: elevated transaminases, markers of inflammation negative, all bacterial cultures negative. Enterovirus RNA was detected in blood sample. Other blood findings were without significant abnormalities. Electrocardiogram showed tachycardia, with narrow QRS complexes (atrial tachycardia) and heart rate up to 280/min. In order to convert the rhythm, the patient was administered adenosine and amiodarone. In the further course of hospitalization, the patient was in good general condition, eucardiac and eupneic. Newborns with tachycardia and a family history of febrile illness should be suspected to have enterovirus infection. Enterovirus infection is a highly contagious and potentially life-threatening infection if not detected early. The use of sensitive molecular-based amplification methods offers potential benefits for early diagnosis and timely treatment.

Archives of Disease in Childhood, 2008

Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caus... more Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caused by Epstein Barr virus (EBV). It usually lasts 2–3 weeks; complications are rare and most serious is spleen rupture. Aim The aim was to analyze frequency and characteristics of complication in hospitalized patients with EBV MI. Matherial In this prospective study from 2007 we analyzed 60 hospitalized patients aged between 3 and 18 and divided them into two age groups to better analyze complications; a preschool (age Results All patients had fever, sore throat and lymphadenopathy, almost all had splenomegaly. Most frequent complication was second bacterial throat infection (30% in both groups), caused by GABHS (group A beta hemolytic streptococcus), with higher prevalence in the first group, mild thrombocytopenia (2 cases) and upper airway obstruction (1 case) were frequent in the first age group. We had one case with peritonsillar abscess in the second age group. Other complications (p...

The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels... more The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels at postmenstrual age of 33 weeks between preterm infants with and without retinopathy of prematurity (ROP). ROP occurs in two phases. Low serum levels of IGF-1 during ROP phase 1 have been found to correlate with the severity of ROP. ROP phase 2 begins around postmenstrual week 33. We conducted a prospective cohort study to measure serum IGF-1 levels in premature infants at postmenstrual age of 33 weeks. The study included all premature infants (N=74), gestational age ≤33 weeks, hospitalized at Department of Neonatology, Clinical Center of Montenegro, from April 2008 to July 2009. The incidence of ROP in the study cohort was 50.7%. Infants with ROP had a significantly lower birth weight and significantly shorter gestational age. The mean level of IGF-1 at postmenstrual age of 33 weeks was 23.7 mcg/L. Study results showed that there was no significant difference in serum IGF-1 level between newborns with and without ROP at postmenstrual age of 33 weeks (in newborns with ROP, it was the beginning of ROP phase 2). A large controlled study with repeated measurement of IGF-1 level in the neonatal period is needed to confirm that restoration of IGF-I level occurs in ROP phase 2, i.e. that the low level of IGF-1 is only a feature of ROP phase 1.

Archives of Disease in Childhood, 2008

Objective Mononucleosis infectious (MI) is a generalised lymphoproliferative disorder most comonl... more Objective Mononucleosis infectious (MI) is a generalised lymphoproliferative disorder most comonly coused by Epstein Barr virus (EBV). Acute hemolytic anemia is a rare complication, usually lasting for 1–2 months. Aim We present a patient with acute MI complicated with hemolytic anemia. Matherial Acute EBV MI was verified with a serologic ELISA test; IgM and IgG antibody against EBV VCA (viral capsid antigen) was used. We examined the patient clinically and with standard laboratory and other additional tests. Results Patient BS, female, 15 years old, was admitted to the Infectious Disease Department with symptoms of weakness, chill, fever, sore throat and abdominal pain. Symptoms started 8 days earlier. Per examination: tonsillar enlargement with pus on the left, mild eye and skin jaundice, cervical lymphadenopathy, mild liver and spleen enlargement. MI was suspected. Laboratory tests showed inflammatory factors elevated with lymphocytes predominate, low RBC, HCT, HGB, with positive...

Revista de neurologia, 2017

Acta Clinica Croatica, 2018

Premature infants are susceptible to oxidative stress that causes neonatal disease such as retino... more Premature infants are susceptible to oxidative stress that causes neonatal disease such as retinopathy of prematurity (ROP). Oxidative stress is an imbalance between the production of pro-oxidants and the ability of the body to detoxify their harmful eff ects by antioxidants. Th e proliferative phase 2 ROP occurs at around 33 rd postmenstrual week (pmw). Th e purpose of our study was to evaluate the pro-oxidant/antioxidant status in preterm infants at 33 rd pmw. Th e study included 59 premature infants. ROP was classifi ed according to the International Classifi cation of Retinopathy of Prematurity. Total oxidative status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) and paraoxonase 1 (PON1) activity were determined spectrophotometrically. Th e values of the prooxidants TOS and MDA were signifi cantly higher in infants with ROP as compared to infants without ROP (p<0.05 both). Th ere were no signifi cant diff erences in the values of TAS and PON1 between the infants with and without ROP. According to study results, TOS and MDA are good markers of oxidative stress, whereas TAS and PON1 activity are unreliable in assessing antioxidant protection.

Srpski arhiv za celokupno lekarstvo, 2018

Introduction/Objective. Currently, analysis of the stability of amputees with diabetes is lacking... more Introduction/Objective. Currently, analysis of the stability of amputees with diabetes is lacking. The aim of this case study was to examine the effects of unilateral transtibial amputation on the stability and balance confidence of patients with below-knee amputation caused by trauma and diabetes. Methods. Seventeen subjects, 12 males and five females, with the average age of 51.47 ? 12.12 years, who use a unilateral transtibial prosthesis, were examined. The balance of 10 traumatic amputees (TTA) and seven diabetic amputees (TDA) was assessed by Activities-Specific Balance Confidence (ABC) scale, Timed Up and Go (TUG) test, and One-Legged Stance Test (OLST). Plantar pressure distribution was recorded using Gaitview AFA-50. Results. For 10 TTA and one TDA, ABC scores were > 80%, the mean value of the TUG test was 11 (range: 8.08?23 seconds). All the subjects could stand on the healthy leg, two women with diabetes were unable to stand on the prosthetic leg. The distribution of lo...

Acta clinica Croatica, 2014

Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe... more Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe disease including meningoencephalitis, sepsis syndrome, cardiovascular collapse, or hepatitis. The mechanism of heart failure in patients with enterovirus infection remains unknown. Early diagnosis may help clinicians predict complications in those infants initially presenting with severe disease. An 11-day-old male newborn was admitted to our neonatal intensive care unit because of tachycardia and crises of cyanosis. His elder brother had febrile illness. The newborn was cyanotic, in respiratory distress, with tachycardia, low blood pressure and prolonged capillary refilling time. Limb pulse oximeter was around 85%. During the first day of hospitalization, the newborn had one febrile episode. Laboratory data: elevated transaminases, markers of inflammation negative, all bacterial cultures negative. Enterovirus RNA was detected in blood sample. Other blood findings were without signific...

Medical review, 2011

Introduction. Chronic lung disease in the newborn is a complication of mechanical ventilation. Th... more Introduction. Chronic lung disease in the newborn is a complication of mechanical ventilation. The diagnosis of chronic lung disease is made in children of over 36 post-conceptual weeks? age who still require additional oxygen and who have abnormal chest x-ray findings. This study was aimed at triaging newborns at risk of developing chronic lung disease. The operating study hypothesis was that the values of insulin-like growth factor I below 30 ?g/L in the 33rd post-conceptual week were associated with the development of chronic lung disease. Material and Methods. The above hypothesis was verified by a cohort, prospective study, which included preterm newborns of 33 gestational weeks? age or less who were hospitalised at the Department of Neonatology of the Clinical Centre of Montenegro from Aril 2008 to July 2009. The blood sample was taken in the 33rd post-conceptual week and the insulin-like growth factor value was determined by the method of enzyme immunoassay. Results. Our stud...

Archives of Disease in Childhood, 2014

Background and aims The term urinary tract infection (UTI) in neonates implies a significant bact... more Background and aims The term urinary tract infection (UTI) in neonates implies a significant bacteriuria with symptoms of systemic infection. The gold standard for diagnosis of UTI is urine culture taken in sterile conditions. UTI incidence in general population of neonates is 0.1–2%, increasing significantly to 10% when it comes to at-risk-newborns, especially prematurely born ones. During the neonatal period, UTI incidence is higher in boys than in girls. Objectives To determine the incidence of UTI in high-risk infants, the most common causes of infection, and estimate which infants will require further urographic examination. Methods Analysis included infants with UTI who were hospitalised at the Centre for Neonatology, from 01.01.2011. to 31.12.2012. Results From 01.01.2011. to 31.12.2012, total of 1504 newborns were hospitalised at the Centre for Neonatology. UTI was verified in 85 newborns, which is 5.6% of hospitalised newborns. 64.7% of the affected were male. Most common cause of infection was E. Coli, while Klebsiella species was the second most common. UTI are more common in term newborns, while in preterm low-birth-weight-newborns UTI is mainly manifested within sepsis. Pathological ultrasound finding of urinary tract was found in 15% of the examined neonates. Conclusion Considering the fact that among the newborn population with UTI there is a significant number of children with urinary tract anomalies, which are risk factor for development of chronic pyelonephritis or reflux nephropathy, later leading to chronic renal failure and hypertension, proper detection and timely treatment of UTI in the neonatal age is of grand importance.

Medical Journal of Montenegro, 2013

This is an open access article distributed under the terms of the Creative Commons, which permits... more This is an open access article distributed under the terms of the Creative Commons, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Downloaded

Srpski Arhiv Za Celokupno Lekarstvo, Dec 31, 2022

Acta Clinica Croatica, Mar 1, 2014

-Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of sever... more -Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe disease including meningoencephalitis, sepsis syndrome, cardiovascular collapse, or hepatitis. The mechanism of heart failure in patients with enterovirus infection remains unknown. Early diagnosis may help clinicians predict complications in those infants initially presenting with severe disease. An 11-day-old male newborn was admitted to our neonatal intensive care unit because of tachycardia and crises of cyanosis. His elder brother had febrile illness. The newborn was cyanotic, in respiratory distress, with tachycardia, low blood pressure and prolonged capillary refilling time. Limb pulse oximeter was around 85%. During the first day of hospitalization, the newborn had one febrile episode. Laboratory data: elevated transaminases, markers of inflammation negative, all bacterial cultures negative. Enterovirus RNA was detected in blood sample. Other blood findings were without significant abnormalities. Electrocardiogram showed tachycardia, with narrow QRS complexes (atrial tachycardia) and heart rate up to 280/min. In order to convert the rhythm, the patient was administered adenosine and amiodarone. In the further course of hospitalization, the patient was in good general condition, eucardiac and eupneic. Newborns with tachycardia and a family history of febrile illness should be suspected to have enterovirus infection. Enterovirus infection is a highly contagious and potentially life-threatening infection if not detected early. The use of sensitive molecular-based amplification methods offers potential benefits for early diagnosis and timely treatment.

PubMed, Jun 1, 2012

The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels... more The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels at postmenstrual age of 33 weeks between preterm infants with and without retinopathy of prematurity (ROP). ROP occurs in two phases. Low serum levels of IGF-1 during ROP phase 1 have been found to correlate with the severity of ROP. ROP phase 2 begins around postmenstrual week 33. We conducted a prospective cohort study to measure serum IGF-1 levels in premature infants at postmenstrual age of 33 weeks. The study included all premature infants (N = 74), gestational age < or = 33 weeks, hospitalized at Department of Neonatology, Clinical Center of Montenegro, from April 2008 to July 2009. The incidence of ROP in the study cohort was 50.7%. Infants with ROP had a significantly lower birth weight and significantly shorter gestational age. The mean level of IGF-1 at postmenstrual age of 33 weeks was 23.7 mcg/L. Study results showed that there was no significant difference in serum IGF-1 level between newborns with and without ROP at postmenstrual age of 33 weeks (in newborns with ROP, it was the beginning of ROP phase 2). A large controlled study with repeated measurement of IGF-1 level in the neonatal period is needed to confirm that restoration of IGF-I level occurs in ROP phase 2, i.e. that the low level of IGF-1 is only a feature of ROP phase 1.

Predmet. Prematurna retinopatija (ROP) je vazoproliferativno oboljenje mrežnjače oka, najčešća bo... more Predmet. Prematurna retinopatija (ROP) je vazoproliferativno oboljenje mrežnjače oka, najčešća bolest prematuriteta i najčešći je uzrok slepila kod dece. Cilj ove studije je bio da ukaže na mogućnost rane trijaže novorođenčadi u visokom riziku za nastanak prematurne retinopatije (ROP) na osnovu serumskog nivoa insulinu-sličnog faktora rasta tip-1 (IGF-I), koji je jedan od najznačajnijih faktora u patogenezi ROP-a. Metod. Sprovedena je kohortna, longitudinalna, prospektivna studija. U studiju je uključena kohorta preterminske novorodjenčadi (74 novorođenčeta) gestacione starosti ≤33 nedelje, koja su bila hospitalizovana u Centaru za neonatologiju, Instituta za bolesti djece, Kliničkog Centra Crne Gore, od aprila 2008. do jula 2009. Uzorak krvi ispitanicima je uziman u 33oj postkoncepcijskoj nedelji, postnatalno. Vrednosti IGF-1 su određivane ELISA metodom. Rezultati. Srednje gestaciona dob u kohorti novorođenčadi sa ROP-om iznosila je 30.61± 2.12 (±SD) a novorođenčad bez ROP-a 31.8±1.43 gestacionih nedelja (p<0.01). Prosečna porodjajna telesna masa novorođenčadi sa ROP-om iznosila je 1586.94±417.99 g a novorođenčadi bez ROP-a 1821.71±369.59 g (p<0.05). Srednja vrednost serumskog IGF-I za novorođančad sa ROP-om iznosila je 23.88±6.74 μg/L a u kohorti bez ROP-a 23.79±4.85 μg/L (p>0.05). Zaključak. Koncentracije serumskog IGF-I kod preterminske novorodjenčadi gestacione starosti ≤33 nedelje koja kasnije dobiju prematurnu retinopatiju nisu značajno različite od novorodjenčadi iste starosti bez potonje prematurne retinopatije. Merenje koncetracija IGF-I u serumu ne bi trebalo da se koristi za procenu rizika za razvoj prematurne retinopatije dok se ne prikupe dodatni dokazi iz budućih kliničkih studija. Ključne reči: retinopatija prematuriteta; insulinu-sličan faktor rasta I; prospektivna studija.

Pediatric Research, Nov 1, 2010

Results: Forty patients (21 girls, 19 boys) with the median age of 5.6 years (range 0.5-19.9) exp... more Results: Forty patients (21 girls, 19 boys) with the median age of 5.6 years (range 0.5-19.9) experienced 82 episodes of FN. Underlying disease was hematologic in 55 and solid tumor in 27 episodes. Bacteremia was confirmed in 16 (19.5 %) episodes; Gram negative in 8, Gram positive in 7 and combined in 1 episode. The fever was due to local infection in 14 (17 %), viral in 9 (11 %), whereas in 41 episodes (50 %) the cause could not be identified (FUO). On day 1 the best diagnostic accuracy (AUC) was seen for IL-6 (0.765) followed by CRP (0.738), LBP (0.696) and PCT (0.666). On day 2 CRP had the best diagnostic accuracy (0.824), followed by IL-6 (0.753), PCT (0.695) and LBP (0.685).

Acta Clinica Croatica, 2020

Insulin like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating conce... more Insulin like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 premature newborns, gestational age (GA) ≤33 weeks. Quantitative determination of IGF-1 was performed in the 33 rd post-menstrual week (pmw) to make the measurements more comparable. We used an enzyme-bound immunosorbent test for quantitative determination of IGF-1. Our results showed the mean IGF-1 level in premature newborns in 33 rd pmw to be 23.1±4.56 (range 15.44-39.75) μg/L. There was no difference in IGF-1 values between male (23.1±4.98 μg/L) and female (23.1±4.87 μg/L) newborns. There was no significant difference in the average IGF-1 levels between male and female newborns with BW <50 th and BW >50 th percentile for GA either (p>0.50). Only BW <33 rd percentile newborns had a statistically significantly lower IGF-1 level compared to newborns with greater BW. Based on our results, it is concluded that serum IGF-1 level reflects intrauterine growth only in BW <33 rd percentile newborns. This fact could be used for further therapeutic purposes.

Archives of Disease in Childhood, Nov 1, 2008

Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caus... more Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caused by Epstein Barr virus (EBV). It usually lasts 2–3 weeks; complications are rare and most serious is spleen rupture. Aim The aim was to analyze frequency and characteristics of complication in hospitalized patients with EBV MI. Matherial In this prospective study from 2007 we analyzed 60 hospitalized patients aged between 3 and 18 and divided them into two age groups to better analyze complications; a preschool (age Results All patients had fever, sore throat and lymphadenopathy, almost all had splenomegaly. Most frequent complication was second bacterial throat infection (30% in both groups), caused by GABHS (group A beta hemolytic streptococcus), with higher prevalence in the first group, mild thrombocytopenia (2 cases) and upper airway obstruction (1 case) were frequent in the first age group. We had one case with peritonsillar abscess in the second age group. Other complications (pneumonia and anemia) were not age related. Conclusion The average time of hospitalization was 10 days. All patients completely recovered. We treated them with standard, symptomatic and additional therapy, when necessary (corticosteroids, antibiotics, incision in patients with peritonsillar abscess).

Journal of Neonatal Biology, Jan 17, 2017

EC Paediatrics, Apr 23, 2021

Acta Clinica Croatica, 2014

-Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of sever... more -Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe disease including meningoencephalitis, sepsis syndrome, cardiovascular collapse, or hepatitis. The mechanism of heart failure in patients with enterovirus infection remains unknown. Early diagnosis may help clinicians predict complications in those infants initially presenting with severe disease. An 11-day-old male newborn was admitted to our neonatal intensive care unit because of tachycardia and crises of cyanosis. His elder brother had febrile illness. The newborn was cyanotic, in respiratory distress, with tachycardia, low blood pressure and prolonged capillary refilling time. Limb pulse oximeter was around 85%. During the first day of hospitalization, the newborn had one febrile episode. Laboratory data: elevated transaminases, markers of inflammation negative, all bacterial cultures negative. Enterovirus RNA was detected in blood sample. Other blood findings were without significant abnormalities. Electrocardiogram showed tachycardia, with narrow QRS complexes (atrial tachycardia) and heart rate up to 280/min. In order to convert the rhythm, the patient was administered adenosine and amiodarone. In the further course of hospitalization, the patient was in good general condition, eucardiac and eupneic. Newborns with tachycardia and a family history of febrile illness should be suspected to have enterovirus infection. Enterovirus infection is a highly contagious and potentially life-threatening infection if not detected early. The use of sensitive molecular-based amplification methods offers potential benefits for early diagnosis and timely treatment.

Archives of Disease in Childhood, 2008

Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caus... more Objective Mononucleosis infection (MI) is a generalized lymphoproliferative disorder, mostly caused by Epstein Barr virus (EBV). It usually lasts 2–3 weeks; complications are rare and most serious is spleen rupture. Aim The aim was to analyze frequency and characteristics of complication in hospitalized patients with EBV MI. Matherial In this prospective study from 2007 we analyzed 60 hospitalized patients aged between 3 and 18 and divided them into two age groups to better analyze complications; a preschool (age Results All patients had fever, sore throat and lymphadenopathy, almost all had splenomegaly. Most frequent complication was second bacterial throat infection (30% in both groups), caused by GABHS (group A beta hemolytic streptococcus), with higher prevalence in the first group, mild thrombocytopenia (2 cases) and upper airway obstruction (1 case) were frequent in the first age group. We had one case with peritonsillar abscess in the second age group. Other complications (p...

The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels... more The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels at postmenstrual age of 33 weeks between preterm infants with and without retinopathy of prematurity (ROP). ROP occurs in two phases. Low serum levels of IGF-1 during ROP phase 1 have been found to correlate with the severity of ROP. ROP phase 2 begins around postmenstrual week 33. We conducted a prospective cohort study to measure serum IGF-1 levels in premature infants at postmenstrual age of 33 weeks. The study included all premature infants (N=74), gestational age ≤33 weeks, hospitalized at Department of Neonatology, Clinical Center of Montenegro, from April 2008 to July 2009. The incidence of ROP in the study cohort was 50.7%. Infants with ROP had a significantly lower birth weight and significantly shorter gestational age. The mean level of IGF-1 at postmenstrual age of 33 weeks was 23.7 mcg/L. Study results showed that there was no significant difference in serum IGF-1 level between newborns with and without ROP at postmenstrual age of 33 weeks (in newborns with ROP, it was the beginning of ROP phase 2). A large controlled study with repeated measurement of IGF-1 level in the neonatal period is needed to confirm that restoration of IGF-I level occurs in ROP phase 2, i.e. that the low level of IGF-1 is only a feature of ROP phase 1.

Archives of Disease in Childhood, 2008

Objective Mononucleosis infectious (MI) is a generalised lymphoproliferative disorder most comonl... more Objective Mononucleosis infectious (MI) is a generalised lymphoproliferative disorder most comonly coused by Epstein Barr virus (EBV). Acute hemolytic anemia is a rare complication, usually lasting for 1–2 months. Aim We present a patient with acute MI complicated with hemolytic anemia. Matherial Acute EBV MI was verified with a serologic ELISA test; IgM and IgG antibody against EBV VCA (viral capsid antigen) was used. We examined the patient clinically and with standard laboratory and other additional tests. Results Patient BS, female, 15 years old, was admitted to the Infectious Disease Department with symptoms of weakness, chill, fever, sore throat and abdominal pain. Symptoms started 8 days earlier. Per examination: tonsillar enlargement with pus on the left, mild eye and skin jaundice, cervical lymphadenopathy, mild liver and spleen enlargement. MI was suspected. Laboratory tests showed inflammatory factors elevated with lymphocytes predominate, low RBC, HCT, HGB, with positive...

Revista de neurologia, 2017

Acta Clinica Croatica, 2018

Premature infants are susceptible to oxidative stress that causes neonatal disease such as retino... more Premature infants are susceptible to oxidative stress that causes neonatal disease such as retinopathy of prematurity (ROP). Oxidative stress is an imbalance between the production of pro-oxidants and the ability of the body to detoxify their harmful eff ects by antioxidants. Th e proliferative phase 2 ROP occurs at around 33 rd postmenstrual week (pmw). Th e purpose of our study was to evaluate the pro-oxidant/antioxidant status in preterm infants at 33 rd pmw. Th e study included 59 premature infants. ROP was classifi ed according to the International Classifi cation of Retinopathy of Prematurity. Total oxidative status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) and paraoxonase 1 (PON1) activity were determined spectrophotometrically. Th e values of the prooxidants TOS and MDA were signifi cantly higher in infants with ROP as compared to infants without ROP (p<0.05 both). Th ere were no signifi cant diff erences in the values of TAS and PON1 between the infants with and without ROP. According to study results, TOS and MDA are good markers of oxidative stress, whereas TAS and PON1 activity are unreliable in assessing antioxidant protection.

Srpski arhiv za celokupno lekarstvo, 2018

Introduction/Objective. Currently, analysis of the stability of amputees with diabetes is lacking... more Introduction/Objective. Currently, analysis of the stability of amputees with diabetes is lacking. The aim of this case study was to examine the effects of unilateral transtibial amputation on the stability and balance confidence of patients with below-knee amputation caused by trauma and diabetes. Methods. Seventeen subjects, 12 males and five females, with the average age of 51.47 ? 12.12 years, who use a unilateral transtibial prosthesis, were examined. The balance of 10 traumatic amputees (TTA) and seven diabetic amputees (TDA) was assessed by Activities-Specific Balance Confidence (ABC) scale, Timed Up and Go (TUG) test, and One-Legged Stance Test (OLST). Plantar pressure distribution was recorded using Gaitview AFA-50. Results. For 10 TTA and one TDA, ABC scores were > 80%, the mean value of the TUG test was 11 (range: 8.08?23 seconds). All the subjects could stand on the healthy leg, two women with diabetes were unable to stand on the prosthetic leg. The distribution of lo...

Acta clinica Croatica, 2014

Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe... more Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe disease including meningoencephalitis, sepsis syndrome, cardiovascular collapse, or hepatitis. The mechanism of heart failure in patients with enterovirus infection remains unknown. Early diagnosis may help clinicians predict complications in those infants initially presenting with severe disease. An 11-day-old male newborn was admitted to our neonatal intensive care unit because of tachycardia and crises of cyanosis. His elder brother had febrile illness. The newborn was cyanotic, in respiratory distress, with tachycardia, low blood pressure and prolonged capillary refilling time. Limb pulse oximeter was around 85%. During the first day of hospitalization, the newborn had one febrile episode. Laboratory data: elevated transaminases, markers of inflammation negative, all bacterial cultures negative. Enterovirus RNA was detected in blood sample. Other blood findings were without signific...

Medical review, 2011

Introduction. Chronic lung disease in the newborn is a complication of mechanical ventilation. Th... more Introduction. Chronic lung disease in the newborn is a complication of mechanical ventilation. The diagnosis of chronic lung disease is made in children of over 36 post-conceptual weeks? age who still require additional oxygen and who have abnormal chest x-ray findings. This study was aimed at triaging newborns at risk of developing chronic lung disease. The operating study hypothesis was that the values of insulin-like growth factor I below 30 ?g/L in the 33rd post-conceptual week were associated with the development of chronic lung disease. Material and Methods. The above hypothesis was verified by a cohort, prospective study, which included preterm newborns of 33 gestational weeks? age or less who were hospitalised at the Department of Neonatology of the Clinical Centre of Montenegro from Aril 2008 to July 2009. The blood sample was taken in the 33rd post-conceptual week and the insulin-like growth factor value was determined by the method of enzyme immunoassay. Results. Our stud...

Archives of Disease in Childhood, 2014

Background and aims The term urinary tract infection (UTI) in neonates implies a significant bact... more Background and aims The term urinary tract infection (UTI) in neonates implies a significant bacteriuria with symptoms of systemic infection. The gold standard for diagnosis of UTI is urine culture taken in sterile conditions. UTI incidence in general population of neonates is 0.1–2%, increasing significantly to 10% when it comes to at-risk-newborns, especially prematurely born ones. During the neonatal period, UTI incidence is higher in boys than in girls. Objectives To determine the incidence of UTI in high-risk infants, the most common causes of infection, and estimate which infants will require further urographic examination. Methods Analysis included infants with UTI who were hospitalised at the Centre for Neonatology, from 01.01.2011. to 31.12.2012. Results From 01.01.2011. to 31.12.2012, total of 1504 newborns were hospitalised at the Centre for Neonatology. UTI was verified in 85 newborns, which is 5.6% of hospitalised newborns. 64.7% of the affected were male. Most common cause of infection was E. Coli, while Klebsiella species was the second most common. UTI are more common in term newborns, while in preterm low-birth-weight-newborns UTI is mainly manifested within sepsis. Pathological ultrasound finding of urinary tract was found in 15% of the examined neonates. Conclusion Considering the fact that among the newborn population with UTI there is a significant number of children with urinary tract anomalies, which are risk factor for development of chronic pyelonephritis or reflux nephropathy, later leading to chronic renal failure and hypertension, proper detection and timely treatment of UTI in the neonatal age is of grand importance.

Medical Journal of Montenegro, 2013

This is an open access article distributed under the terms of the Creative Commons, which permits... more This is an open access article distributed under the terms of the Creative Commons, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Downloaded